• 제목/요약/키워드: jeonnam

Search Result 1,594, Processing Time 0.021 seconds

Antidepressant-like and Hypnotic Effects of the Herbal Extract Combination of Stauntonia hexaphylla and Vaccinium bracteatum Fruit in Mice

  • Oh, Dool-Ri;Kim, Yujin;Jo, Ara;Im, Sojeong;Kim, Cho Een;Jung, Myung-A;Shin, Jawon;Kang, Huwon;Choi, Eun Jin;Kim, Jaeyong;Choi, Chulyung
    • Journal of Physiology & Pathology in Korean Medicine
    • /
    • v.34 no.2
    • /
    • pp.88-96
    • /
    • 2020

  • Stauntonia hexaphylla (SH) and Vaccinium bracteatum (VB) are herbal extracts widely used in food and traditional herbal medicine, and have the ability to perform a wide range of biological activities. We aimed to investigate the effects of the SH and VB combination (SHVB) on mice models of chronic restraint stress (CRS) and pentobarbital-induced sleeping behaviors to elucidate its possible mechanisms of action. CRS-exposed mice treated with SHVB showed significantly decreased immobility time, increased swimming and climbing times in the forced swim test (FST), and increased locomotor activity in the open field test (OFT). SHVB decreased serum CORT levels, but enhanced brain monoamine neurotransmitters. SHVB significantly decreased the sleep latency and increased total sleep duration in pentobarbital-induced sleeping behavior in mice. SHVB showed inhibitory effect on 5-HT2A receptor-mediated ERK1/2 phosphorylation. These results suggest that SHVB has antidepressant and hypnotic effects by regulating the 5-HT2A receptor.

  • https://doi.org/10.15188/kjopp.2020.04.34.2.88 인용 PDF KSCI

Antidepressant Effects of Cynanchum wilfordii Hemsley, Phlomis umbrosa Turcz, and Angelica gigas Nakai via Inhibition of 5-HT6 Receptor-mediated cyclic AMP Activity

  • Oh, Kyo-nyeo;Oh, Dool-Ri;Jung, Myung-A;Kim, Yujin;Choi, Eun Jin;Hong, Ji Ae;Kim, Jaeyong;Choi, Chul-yung
    • Journal of Physiology & Pathology in Korean Medicine
    • /
    • v.32 no.4
    • /
    • pp.247-254
    • /
    • 2018

  • A This study evaluated the antidepressant effects of the herbal mixture CPAE(Cynanchum wilfordii Hemsley, Phlomis umbrosa Turcz, and Angelica gigas Nakai) using several tests, including a test for serotonin 6($5-HT_6$) receptor activity, the forced swimming test(FST), and tests for corticosterone(CORT) and monoamine levels. CPAE showed antagonistic effects on the $5-HT_6$ receptor in a stable $5-HT_6$ receptor-expressing cell line. We subsequently confirmed the antidepressant effects of CPAE in chronic stress model in mice and explored the underlying mechanisms of its action. Specifically, we observed that CPAE treatment significantly reduced immobility time in the FST and effectively restored abnormal levels of CORT in plasma and of monoamines(serotonin, dopamine, and norepinephrine) in hippocampus and prefrontal cortex. These results suggest that CPAE has significant antidepressant effects.

  • https://doi.org/10.15188/kjopp.2018.08.32.4.247 인용 PDF KSCI

Laxative Activity of the Hot-Water Extract Mixture of Hovenia dulcis Thunb. and Phyllostachys pubescens Mazel in Chronic Constipation Model SD Rats

  • Oh, Kyo-Nyeo;Kim, Yujin;Choi, Eun Jin;Lee, Hyunmi;Hong, Ji Ae;Kim, Miri;Oh, Dool-Ri;Jung, Myung-A;Park, Ro-Dong;Kim, Seong-il;Yong, Ju-seon;Lee, Hui-Seop;Ban, SangOh;Choi, Chul-yung
    • Journal of Microbiology and Biotechnology
    • /
    • v.30 no.5
    • /
    • pp.649-661
    • /
    • 2020

  • This study examined the laxative effects of hot-water extracts of Hovenia dulcis Thunb. (HD), Phyllostachys pubescens Mazel (PM), and a 2:8 mixture of both (HP) in two chronic constipation models. For the loperamide-induced constipation model, animals were divided into an untreated group, negative control group (loperamide 4 mg/kg), positive control group (bisacodyl 4 mg/kg) group, and six treatment groups (HP 100 or 400, HD 50 or 100, and PM 100 or 400 mg/kg). For the low-fiber diet-induced constipation model, animals were divided into an untreated group (normal diet), negative control group (low-fiber diet), positive control group (Agio granule, 620 mg/kg), and the same treatment groups. Fecal number, weight, fecal water content, and intestinal transit ratio were higher in the groups treated with HP, HD, and PM than in the groups treated with loperamide or low-fiber diet. Thickness of colon mucosa and muscle layers were increased in the treated groups. Colon tension increased in the HP groups, and [Ca2+]i measurements using fura-2 as an indicator showed that HP inhibits ATP-mediated Ca2+ influx in IEC-18 cells. These results showed that the HP mixture has laxative activity by increased mucin secretion and inducing contractile activity and relaxation. It may be a useful therapeutic strategy for ameliorating in chronic constipation.

  • https://doi.org/10.4014/jmb.1911.11051 인용 PDF KSCI