• Korean Chemical Engineering Research
• /
• 제51권6호
• /
• pp.677-684
• /
• 2013

혼합냉매를 사용하여 천연가스를 액화하는 혼합냉매공정(Mixed refrigerant cycle, MRC)은 공정이 간단하고 장치비가 적게 들며 운전 또한 용이하여 널리 채택되고 있는 공정이다. MRC에서 중요한 기술 중 하나는 혼합냉매를 선택하고 최적의 혼합비를 결정하는 것이다. 본 연구에서는 일반적인 MRC에서 혼합냉매와 혼합냉매의 혼합비가 공정의 성능에 미치는 효과를 살펴보았다. 이를 위해 통계적 기법 중 실험계획법의 하나인 혼합물 설계와 반응 표면법을 이용하여 전체 공정의 에너지 소비가 최소가 되게 하는 최적의 냉매를 선택하고 그 혼합비를 결정하였다. 여러 냉매와 혼합비에 따른 MRC 공정의 모사는 Aspen HYSYS를 사용하였으며 혼합물설계와 반응 표면법은 Minitab을 사용하였다. 연구결과 냉매로는 methane ($C_1$), ethane ($C_2$), propane ($C_3$)과 nitrogen ($N_2$)가 선택되었으며 에너지 소비를 최소화하는 혼합비(몰 비) 또한 구할 수 있었다.

• Journal of Periodontal and Implant Science
• /
• 제26권4호
• /
• pp.1013-1021
• /
• 1996

There are many important factors in periodontal inflammation. $IL-1{\beta}$, $PGE_2$ and collagenase are predorminantly key factors. These inflammatory mediators induce gingival tissue and alveolar bone destruction. For the prevention and treatment of periodontal disease, it is necessary to inhibit $IL-1{\beta}$, $PGE_2$ production and collagenase activity. Ursodeoxycholic acid(UDCA) has immunomodulatory properties, and there is evidence that some natural extracts show antiinflammatory activity to some degree. The purpose of this study was to assess the inhibitory effect of UDCA and its mixture with natural extracts on $IL-1{\beta}$, $PGE_2$ production and collagenase activity. Accordingly we assessed the effect of UDCA and its mixture combined with some natural extracts on inhibition of $IL-1{\beta}$, $PGE_2$ production and collagenase activity. For the $IL-l{\beta}$ inhibition study, cultured cells were exposed to $25{\mu}g/ml$ LPS. $IL-1{\beta}$ activity was measured by $IL-1{\beta}$ enzyme immunoassay system. Human gingival fibroblasts were prepared and cells (l05/well) were seeded into culture plates. $rhIL-1{\beta}$ was added to induce $PGE_2$. The amount of $PGE_2$ in sample media was measured using enzyme immunoassay system. Crude collagenase was prepared from Porphyromonas gingivalis and collagenolytic activity was determined using a Collageno kit CLN-100. The test inhibitor was added to the assay mixture consisting of 0.1ml of 50mM Tris buffer(pH 7.5) and 0.2ml of substrate solution. UDCA and UDCA combined with natural extracts generally inhibited $IL-1{\beta}$ production. groups above 0.01% UDCA strongly inhibited $IL-l{\beta}$ synthesis. Both groups inhibited $IL-1{\beta}-induced$ synthesis of $PGE_2$. In low concentration, the degree of inhibition was as same as prednisolone. In high concentration, each group was superior to prednisolone. UDCA group and UDCA mixture group exerted a moderate inhibition of collagenolytic enzyme. The present study suggested that UDCA and its mixture with natural extracts could be further investigated as antiinflammatory drug for periodontal disease.

• 동의생리병리학회지
• /
• 제19권1호
• /
• pp.159-166
• /
• 2005

We observed the efficacy of natural herbs and mixture in treating atopic dermatitis using anti-human IgE treated Human HMC-I cell and NCNga mice model. First, we selected three herbs, Cynonchum witfordii, Diospyros kaki, Ilite which were used to treat skin disease in Traditional Korea Medicine. Using Human HMC-I cell treated with anti-human IgE, we investigate in vitro whether each herb effects on IL-4, IL-13, $TNF-{\alpha}$ expression and $TNF-{\alpha}$, Histamine secretion value. Finally, we conducted study whether the mixture of the selected herbs is more effective than each herb which consist the mixture and control group. The results show that the mixture is better in improving atopic dermatitis condition.

• 한국통신학회논문지
• /
• 제31권9C호
• /
• pp.853-858
• /
• 2006

음성인식에서 TMHMM(Tied Mixture Hidden Markov Model)은 자유 매개변수의 수를 감소시키기 위한 좋은 접근이지만, GPDF(Gaussian Probability Density Function) 군집화 오류에 의해 음성인식의 오류를 발생시켰다. 본 논문은 TMHMM에서 발생하는 군집화 오류를 최소화하기 위하여 HCNN(Homogeneous Centroid Neural Network) 군집화 알고리즘을 제안한다. 제안된 알고리즘은 CNN(Centroid Neural Network)을 TMHMM상의 음향 특징벡터에 활용하였으며, 다른 상태에 소속된 확률밀도가 서로 겹쳐진 형태의 이질군집 지역에 더 많은 코드벡터를 할당하기 위해서 본 논문에서 새로 제안이 제안되는 이질성 거리척도를 사용 하였다. 제안된 알고리즘을 한국어 고립 숫자단어의 인식문제에 적용한 결과, 기존 K-means 알고리즘이나 CNN보다 각각 14.63%, 9,39%의 오인식률의 감소를 얻을 수 있었다.

• Journal of Pharmaceutical Investigation
• /
• 제39권2호
• /
• pp.107-110
• /
• 2009

To investigate the interaction and skin damage of valsartan with polysorbate 80, the physical mixture of valsartan and polysorbate 80 was prepared and then its adhesion, dispersibility, DSC and skin damage in nude rats were investigated. The physical mixture of valsartan and polysorbate 80 appeared as an aggregated form and could hardly be dispersed in water. The DSC curve showed that physical mixture disappeared the intrinsic peaks of valsartan and polysorbate 80 at about $115^{\circ}C$ and $170^{\circ}C$, respectively. It appeared a new relatively broad endothermic peak at about $150^{\circ}C$, suggesting that valsartan was chemically interacted with polysorbate 80. Furthermore, it induced the severe skin irritation and damage in nude mice. Thus, polysorbate 80 must not be used in the preparation of valsartan-loaded pharmaceutical dosage forms.

• 유기물자원화
• /
• 제9권2호
• /
• pp.58-65
• /
• 2001

매립지의 재자연화와 조경을 위한 토양을 폐기물을 원료로 하여 생산하기 위해서 폐 콘크리트에 여러 가지 유기성 폐기물을 혼합하였다. 이 혼합물이 식물의 성장토로 사용될 수 있는 지의 여부를 알기 위해서 혼합물의 고형물과 침출수에 함유된 물질을 독일의 폐기물학회에서 규정한 항목에 따라서 분석, 평가하였고, 이 혼합물에 식물실험을 하여 수확량을 측정하였다. 실험의 결과 이 혼합물은 매립지의 재자연화를 위한 최종복토용으로, 경우에 따라서는 공원이나 정원의 조경용으로 사용될 수 있고, 폐 콘크리트 85%, 하수슬러지 10% 그리고 제지슬러지 5%의 혼합물이 가장 효과적이었다.

• 한국해양공학회지
• /
• 제28권2호
• /
• pp.140-146
• /
• 2014

This study investigated the engineering characteristics of non-sintering binder-stabilized mixtures consisting of different ratios of a hardening agent(3%, 6%, 9%, 12%) for recycling industrial by-products through several series of laboratory tests. The hardening agents consisted of two kinds of non-sintering binders(NSB-1, NSB-2), which were developed by using inter-chemical reactions among blast furnace slag, phospho-gypsum, and an alkali activator. In addition, ordinary Portland cement(OPC) was used to compare the engineering characteristics of the stabilized mixture. An unconfined compressive test showed that the unconfined compressive strength increased with the curing time and mixing ratio. Experimental test results indicated that the 7-day strength of the NSB-1 mixture was similar to that of the OPC mixture. However, its 28-day strength was higher than that of the OPC mixture. The secant module of elasticity showed a range of $E_{50}=(42-109)q_u$ regardless of the agents. Based on the results of triaxial tests, the cohesion and friction angle increased with the mixing ratio.

• Computers and Concrete
• /
• 제19권5호
• /
• pp.555-566
• /
• 2017

Recently some efforts have been performed to combine the advantages of light-weight and self-compacting concrete in one package called Light-Weight Self-Compacting Concrete (LWSCC). Accurate prediction of hardened properties from fresh state characteristics is vital in design of concrete structures. Considering the lack of references in mixture design of LWSCC, investigating the proper mixture components and their effects on mechanical properties of LWSCC can lead to a reliable basis for its application in construction industry. This study utilizes wide range of existing data of LWSCC mixtures to study the individual and combined effects of the components on the compressive strength. From sensitivity of compressive strength to the proportions and interaction of the components, two equations are proposed to estimate the LWSCC compressive strength. Predicted values of the equations are in good agreement with the experimental data. Application of lightweight aggregate to reduce the density of LWSCC may bring some mixing problems like segregation. Reaching a higher strength by lowered density is a challenging problem that is investigated as well. The results show that, the compressive strength can be improved by increasing the of mixture density of LWSCC, especially in the range of density under $2000Kg/m^3$.

• 한국세라믹학회지
• /
• 제31권5호
• /
• pp.552-560
• /
• 1994

A composite of TiB2-Al2O3 system was successfully prepared from a mixture of TiO2, B2O3, and Al by self-propagating high temperature synthesis (SHS) with a novel characteristic, utilizing the internal oxidation heat of aluminium metal of the mixture, instead of by a conventional technique, externally heating a mixture of Ti, B and Al2O3. From a mixture with B/Ti molar ratio of =2.0, pure two phases of TiB2 and $\alpha$-Al2O3 with good crystallinity and small, uniform sizes were formed. However, when the B/Ti molar ratio of the mixture goes to a value less than 2.0, in addition to the above main minerals, a small smounts of metastable phases such as TiB and Ti3B4 were formed. It was found that about 60%, the optimum green density of compacts gave their highest reaction rate and temperature during SHS process. TiB2-Al2O3 system composite with B/Ti molar ratio of =2.0 could be pressurelessly sintered even at 190$0^{\circ}C$ under Ar gas flows without any addition of sintering aids, showing their good properties such as 91.2% in relative density, 2750 kgf/$\textrm{mm}^2$ in Vickers hardness and 2620 kgf/$\textrm{cm}^2$ in flexural strength.

• 대한기계학회논문집B
• /
• 제25권10호
• /
• pp.1311-1317
• /
• 2001

To investigate only the effects of the stratified mixture distribution on initial flame propagation and combustion characteristics, the instantaneous equivalence ratio in the spark plug gap and combustion pressure were measured simultaneously In a constant volume chamber, To induce the stratified propane-air mixture distribution near the spark plug, counter-flow typed mixture injection system was used under the constant mean equivalence ratio $\Phi$$\_$mean/= 1.0 The instantaneous equivalence ratio was measured by a single-shot Raman scattering with narrow-band KrF excimer laser. The measuring error was within the limit of $\pm$ 3.5% provided that the proposed method was applied to the measured Raman signals. Judging from mass fraction burned derived from the measured pressure, the optimum combustion characteristics were shown under the condition that the local equivalence ratio in the spark plug was near 1.28$\pm$0.04, and these characteristics were more remarkable at the initial stage of combustion.