• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3865-3869
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• 2013

Background: Cigarette per day (CPD) use is a key smoking behaviour indicator. It reflects smoking intensity which is directly proportional to the occurrence of tobacco induced cancers. Self reported CPD assessment in surveys may suffer from digit bias and under reporting. Estimates from such surveys could influence the policy decision for tobacco control efforts. In this context, this study aimed at identifying underlying factors of digit bias and its implications for Global Adult Tobacco Surveillance. Materials or Methods: Daily manufactured cigarette users CPD frequencies from Global Adult Tobacco Survey (GATS) - India data were analyzed. Adapted Whipple Index was estimated to assess digit bias and data quality of reported CPD frequency. Digit bias was quantified by considering reporting of '0' or '5' as the terminal digits in the CPD frequency. The factors influencing it were identified by bivariate and logistic regression analysis. Results: The mean and mode of CPD frequency was 6.7 and 10 respectively. Around 14.5%, 15.1% and 15.2% of daily smokers had reported their CPD frequency as 2, 5 and 10 respectively. Modified Whipple index was estimated to be 226.3 indicating poor data quality. Digit bias was observed in 38% of the daily smokers. Heavy smoking, urban residence, North, South, North- East region of India, less than primary, secondary or higher educated and fourth asset index quintile group were significantly associated with digit bias. Discussion: The present study highlighted poor quality of CPD frequency data in the GATS-India survey and need for its improvement. Modeling of digit preference and smoothing of the CPD frequency data is required to improve quality of data. Marketing of 10 cigarette sticks per pack may influence CPD frequency reporting, but this needs further examination. Exploring alternative methods to reduce digit bias in cross sectional surveys should be given priority.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.20 no.5
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• pp.502-509
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• 2010

A test facility which can simultaneously measure turbocharger operating condition variables and vibro-acoustic emission in the situations that are quite similar to real internal combustion engine operating conditions has been introduced. Using this facility, a new method sweeping from full open throttle to deep surge region along constant speed curves can be utilized instead of the stationary method that has been traditionally used to obtain turbocharger compressor maps. Data covering an extensive range of the compressor performance map have been collected and analyzed. An experimental study is performed to define a noise diagram that correlates vibro-acoustic measurements to aerothermodynamic operating conditions. An instrumentation set in the facility allows the automatic definition of the operating point on the turbine and compressor map of the turbocharger. Also, radiated sound pressure and casing vibration data corresponding to the point are obtained by a microphone in the vicinity of the compressor casing and an accelerometer on the casing. The major source(s) of noise at specific operating point on the map can be easily identified with these maps. Also, acoustic characteristics of a given turbocharger at the vicinity of the surge as well as in the surge are also defined. Finally, the possibility to define mild surge region of a turbocharger using vibro-acoustic measurements is studied.

• Molecules and Cells
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• v.38 no.6
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• pp.540-547
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• 2015

Attention deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders, affecting approximately 5% of children. However, the neural mechanisms underlying its development and treatment are yet to be elucidated. In this study, we report that an ADHD mouse model, which harbors a deletion in the Git1 locus, exhibits severe astrocytosis in the globus pallidus (GP) and thalamic reticular nucleus (TRN), which send modulatory GABAergic inputs to the thalamus. A moderate level of astrocytosis was displayed in other regions of the basal ganglia pathway, including the ventrobasal thalamus and cortex, but not in other brain regions, such as the caudate putamen, basolateral amygdala, and hippocampal CA1. This basal ganglia circuit-selective astrocytosis was detected in both in adult (2-3 months old) and juvenile (4 weeks old) $Git1^{\check{s}/\check{s}}$ mice, suggesting a developmental origin. Astrocytes play an active role in the developing synaptic circuit; therefore, we performed an immunohistochemical analysis of synaptic markers. We detected increased and decreased levels of GABA and parvalbumin (PV), respectively, in the GP. This suggests that astrocytosis may alter synaptic transmission in the basal ganglia. Intriguingly, increased GABA expression colocalized with the astrocyte marker, GFAP, indicative of an astrocytic origin. Collectively, these results suggest that defects in basal ganglia circuitry, leading to impaired inhibitory modulation of the thalamus, are neural correlates for the ADHD-associated behavioral manifestations in $Git1^{\check{s}/\check{s}}$ mice.

• Journal of Korean Medical classics
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• v.21 no.3
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• pp.69-81
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• 2008

Gwae(卦氣) theory was one of the main theoretical foundation of yiology in the Han(漢)-dynasty. It was based on the concept that the trigram or hexagram of the book of change corresponds to the seasonal point such as 24 solar terms in one year, so there was so much influence from astronomy and divination system of that time in the development of theoretical principle of Gwae(卦氣) theory. Since Han(漢) Dynasty, the theoretical method such as Gwae(卦氣) theory that correlates the astronomy and divination system with the book of change, had become one of the main academic thoughts throughout the entire history in China, and it was also like that in medicine. Nevertheless there still exists the skeptical sights that Gwae(卦氣) theory was not a part of orthodox yiology, that had been developed by Confucian scholar and had also been recognized as the right path to the study of the book of change. Nowadays because of the new opportunity such as the excavation of the ancient silk script, this kind of controversy has moved on its another step. With regard to this problem, this article will treat the current thoughts about the Gwae(卦氣) theory and think about the substantial basis of each point of view.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.12
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• pp.5035-5042
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• 2014

Background: Knowledge and individual perceptions about adverse effects of all forms of tobacco exert direct influence on the level of tobacco consumption in various socio-demographic groups. The objective of this study was to determine the nature, extent and demographic correlates of knowledge, attitudes and perceptions of use of tobacco among adults in low and middle income countries. Materials and Methods: The Global Adult Tobacco Survey, conducted in fourteen different countries from 2008-2010, was sourced for the data analyzed in this study. Descriptive statistical analyses were conducted to determine the prevalent knowledge and individual perceptions amongst adults about all forms of tobacco consumption. Results: There was relatively high awareness about the harmful effects of smoking tobacco with main awareness being about its relationship with lung cancer (>90% in most countries). In contrast, there was relatively low awareness about harmful effects of smokeless tobacco (< 90% in all countries except India and Bangladesh), and observed correlation of smoking tobacco with heart attack (40.6% in China, 65.1% in India) and stroke (28.2% in China, 50.5% in India). Conclusions: A large proportion of adults living in low and middle income countries possess adequate knowledge about smoking tobacco but have inadequate awareness as well as false perceptions about smokeless forms of tobacco. Popular beliefs of inverse relationships of tobacco consumption with knowledge, attitudes and perception of populations towards tobacco are challenged by the findings of this study.

• The Bulletin of The Korean Astronomical Society
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• v.39 no.2
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• pp.60.1-60.1
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• 2014

In the center of an Active Galactic Nuclei(AGN) is a supermassive black hole which accretes matter from its surroundings. The radio-loud AGN launch two relativistic jets perpendicular to the accretion disk which terminates into radio lobes located up to megaparsec away. Blazars form a small subset of radio-loud AGNs with one of two relativistic jets pointing toward the observer's line of sight. Many blazars often show flares at different frequencies. And these flares at different frequencies are known that they often correlate with each other. In 2013 December, there was a gamma-ray flare in 3C 279, one of the brightest blazars, Dec 2013. So we want to reveal that whether this flare correlates with radio flare or not, and where the flare originate. With polarization observation at radio frequencies, we can study the physical properties of the magnetic field in the innermost regions of the relativistic jets. Therefore, we have conducted polarization monitoring of this source from Dec. 2013 to Jun. 2014 with KVN(Korea VLBI Network) radio telescopes at 22, 43 and 86GHz. Here we present the initial results of the monitoring of 3C 279. We prospect that we can reveal the origin of this gamma-ray flare by comparing with our radio data.

• BMB Reports
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• v.53 no.8
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• pp.431-436
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• 2020

Alpha-fetoprotein (AFP) is one of the most commonly used and reliable biomarkers for Hepatocellular carcinoma（HCC). However, the underlying mechanism of AFP expression in HCC is poorly understood. In this study, we found that TCP10L, a gene specifically expressed in the liver, is down-regulated in HCC and that its expression inversely correlates with AFP expression. Moreover, overexpression of TCP10L suppresses AFP expression whereas knockdown of TCP10L increases AFP expression, suggesting that TCP10L might be a negative regulator of AFP. We found that TCP10L is associated with the AFP promoter and inhibits AFP promoter-driven transcriptional activity. Taken together, these results indicate that TCP10L negatively regulates AFP expression in HCC and that it could be a potential prognostic marker and therapeutic target for HCC.

• Steel and Composite Structures
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• v.8 no.6
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• pp.457-473
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• 2008

Yielding of the internal steel reinforcement is an important mechanism that influences the Intermediate Crack-induced debonding (IC debonding) behavior in FRP-strengthened RC members since the FRP is required to carry additional forces beyond the condition of steel yielding. However, rational design practice dictates an appropriate limit state is defined when steel yielding is assured prior to FRP debonding. This paper proposes a criterion which correlates the occurrence of IC debonding to the formulation of a critical steel yielding length. Once this length is exceeded the average bond stress in the FRP/concrete interface exceeds its threshold value, which proves to correlate with the average bond resistance in an FRP/concrete joint under simple shear loading. This proposed IC debonding concept is based on traditional sections analysis which is conventionally applied in design practice. Hence complex bond stress-slip analyses are avoided. Furthermore, the proposed model incorporates not only the bond properties of FRP/concrete interface but also the beam geometry, and properties of steel and FRP reinforcement in the analysis of IC debonding strength. Based upon a solid database, the validity of the proposed simple IC debonding criterion is demonstrated.

• Korean Journal of Adult Nursing
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• v.15 no.4
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• pp.617-627
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• 2003

Purpose: The purpose of this study is to investigate fatigue and its related factors in cancer patients receiving radiotherapy. Method: The subjects of this study consisted of 98 patients receiving radiotherapy. Subjects were recruited from C University Hospital radiation oncology unit located in Gwangju from March to May, 2001. Questionnaire and medical records were used for data collection. The obtained data was analyzed using SAS program that included descriptive statistics, t-test, ANOVA, Post-hoc test(Fisher's LSD) and Pearson's correlation coefficients. Result: The fatigue perceived by the subjects was middle level ($5.59{\pm}1.59$) and 72.4% of them reported greater than 5 points. The subjects in no religion, low income, and spouse caregiver groups experienced the higher fatigue than another groups, respectively. The subjects in nasopharyngeal cancer, head & neck radiation site, and analgesics medication groups did, experience fatigue as well. The fatigue not only positively correlated with symptom distress, disruption of usual activity, sleep dissatisfaction, and mood state, but also negatively with less family support. Conclusion: Cancer patients receiving radiotherapy experience the middle level of fatigue and it correlates with the multi-dimensional factors. However, further research is needed to identify the changes in fatigue over the radiotherapy period through longitudinal design and to develop nursing intervention for fatigue decrease.

• Journal of Korea Multimedia Society
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• v.20 no.2
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• pp.205-215
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• 2017

The brain magnetic resonance images (MRI) is an important imaging biomarker in Alzheimer's disease (AD) as the cerebral atrophy has been shown to strongly associate with cognitive symptoms. The decrease of volume estimates in different structures of the medial temporal lobe related to memory correlates with the decline of cognitive functions in neurodegenerative diseases. During the past decades several methods have been developed for quantifying the disease related atrophy of hippocampus from MRI. Special effort has been dedicated to separate AD and mild cognitive impairment (MCI) related modifications from normal aging for the purpose of early detection and prediction. We trained a multi-class support vector machine (SVM) with probabilistic outputs on a sample (n = 58) of 20 normal controls (NC), 19 individuals with MCI, and 19 individuals with AD. The model was then applied to the cross-validation of same data set which no labels were known and the predictions. This study presents data on the association between MRI quantitative parameters of hippocampus and its quantitative structural changes examination use on the classification of the diseases.