• Advances in concrete construction
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• v.9 no.1
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• pp.71-82
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• 2020

One of the most suitable methods in structural design is seismic separator. Lead-Rubber Bearing (LRB) is one of the most well-known separation systems which can be used in different types of structures. This system mitigates the earthquake acceleration prior to transferring to the structure efficiently. However, the performance of this system in concrete structures with different heights have not been evaluated thoroughly yet. This paper aims to evaluate the performance of LRB separation system in concrete structures with different heights. For this purpose, three, 16, and 23 story concrete structures are equipped by LRB and exposed to a far-field earthquake. Next, a time history analysis is conducted on each of the structures. Finally, the performance of the concrete structures is compared with each other in the term of their response to the earthquakes and the formation of plastic hinges. The results of the paper show that the rate of change in acceleration response and the ratio of drift along the height of 8 and 23 stories concrete structures are more than those of the 16-stories, and the use of LRB reduces the formation of plastic joints.

• Earthquakes and Structures
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• v.7 no.4
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• pp.511-525
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• 2014

The main object of this study is to determine and compare the structural behavior of base isolated long span highway bridge, $G\ddot{u}lburnu$ Highway Bridge, using single concave friction pendulum (SCFP) and triple concave friction pendulum (TCFP). The bridge is seismically isolated in the design phase to increase the main period and reduce the horizontal forces with moments using SCFP bearings. In the content of the paper, firstly three dimensional finite element model (FEM) of the bridge is constituted using project drawings by SAP2000 software. The dynamic characteristics such as natural frequencies and periods, and the structural response such as displacements, axial forces, shear forces and torsional moments are attained from the modal and dynamic analyses. After, FEM of the bridge is updated using TCFP and the analyses are performed. At the end of the study, the dynamic characteristics and internal forces are compared with each other to extract the TCFP effect. To emphasize the base isolation effect, the non-isolated structural analysis results are added to graphics. The predominant frequencies of bridge non-isolated, isolated with SCFP and isolated with TCFP conditions decreased from 0.849Hz to 0.497Hz and 0.338Hz, respectively. The maximum vertical displacements are obtained as 57cm, 54cm and 44cm for non-isolated, isolated with SCFP and isolated with TCFP conditions, respectively. The maximum vertical displacement reduction between isolated with TCFP bearing and isolated with SCFP bearing bridge is %23. Maximum axial forces are obtained as 60619kN, 18728kN and 7382kN, maximum shear forces are obtained as 23408kN, 17913kN and 16249kN and maximum torsional moments are obtained as 24020kNm, 7619kNm and 3840kNm for non-isolated, isolated with SCFP and isolated with TCFP conditions, respectively.

• Korean Journal of Pharmacognosy
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• v.17 no.2
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• pp.168-177
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• 1986

Bioassay-directed isolation has yielded some cytotoxic substances against L1210 cell from the Korean traditional medicine. These include 5,2'-dihydroxy-6,7,8,6'-teramethoxyflavone $(IV,\;scutellaria\;root,\;ED_{50}\;=\;1.7\;{mu}g/ml)$, 7-geranyloxycoumarin $(XXXII,\;poncirus\;fruit,\;10.2\;{mu}g/ml) $and panaxydol $(I,\;white\;ginseng,\;0.03\;{mu}g/ml)$. IV, XXXII and their derivatives were synthesized in the purpose of in vivo tests and for observation of structure-activity relations. Among the flavone derivatives, 5,2',6'-trihydroxy-6,7,8-trimethoxy flavone (XVIII), 5-hydroxy-6,7,8-trimethoxy-6'-benzyloxyflavone (XVII) and 5,8-dihydroxy-6,7-dimethoxyflavone (X) showed the cytotoxicity which has no correlation to the flavone structures. Of the coumarins synthesized, 7,8-dihydroxycoumarin (XXVI), 6-7-dihydroxycoumarin (XXIX) and 6-hydroxy-5,7-dimethoxycoumarin (XXXI) showed considerable activities. Acetylated XXXI has moderate activity $(ED_{50}=17.2\;{mu}g/ml)$. Monobydroxycoumarins or their methyl and allyl ether were inactive. IV inhibits the growth of the solid form of S-180 by 70% at 40 mg/kg and shows T/C of 166% on the ascitic S-180 at 40 mg/kg. It strongly inhibits the activity of the membrane bounded ATPase from L1210 cell. The most cytotoxic fraction of the antitumor materials studied is the one from the trichosanthes root showing $ED_{50}=0. 0003\;{mu}g/ml$ against L1210 cell. This fraction, obtained from ethyl acetate extract, showed T/C of 130 and 135%, on ICR mice bearing S-180 and $BDF_1$ mice bearing L1210 at 10 mg/kg and 7.5 mg/kg, respectively.

• Journal of the Earthquake Engineering Society of Korea
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• v.20 no.7_spc
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• pp.453-460
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• 2016

The Gyeong-Ju earthquake in the magnitude of 5.8 on the Richter scaleoccurred in September 12, 2016. Because there are many nuclear power plants (NPP) near the epicenter of the Gyeong-Ju earthquake, the seismic stability of nuclear power plants is becoming a social problem. In order to evaluate the safety of seismically isolated NPP, the seismic response of a NPP subjected to the Gyeong-Ju earthquake was compared with those of 30 sets of artificial earthquakes corresponding to the nuclear standard design spectrum (NSDS). A 2-node model and a simple beam-stick model were used for the seismic analysis of seismically isolated NPP structures. Using 2-node model, the effect of internal temperature rise, decrease of shear stiffness, increase of lateral displacement and decrease of vertical stiffness according to nonlinear behavior of lead-rubber bearing (LRB) were evaluated. The displacement response, the acceleration response, and the shear force response of the seismically isolated nuclear containment structure were evaluated using the simple beam-stick model. It can be observed that the seismic responses of the isolated nuclear structure subjected to Gyeong-Ju earthquake is significantly less than those to the artificial earthquakes corresponding to NSDS.

• Journal of Korean Association for Spatial Structures
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• v.4 no.1 s.11
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• pp.49-59
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• 2004

A previous study evaluated the seismic response of typical multi-span simply supported (MSSS) and multi-span continuous (MSC) steel-girder bridges in the central and southeastern United States. The results showed that the bridges were vulnerable to damage resulting from impact between decks, and large ductility demands on nonductile columns. Furthermore, fixed and expansion bearings were likely to fail during strong ground motion. In this paper, several retrofit measures to improve the seismic performance of typical multi-span simply supported and multi-span continuous steel girder bridges are evaluated, including the use of elastomeric bearings, lead-rubber bearings, and restrainer cables. It is determined that iead-rubber bearings are the most effective retrofit measure for reducing the seismic vulnerability of typical bridges. While isolation provided by elastomeric bearings limits the forces into the columns, the added flexibility results in pounding between decks in the MSSS steel-girder bridge. Restrainer cables, which are becoming a common retrofit measure, are only moderately effective in reducing the seismic vulnerability of MSSS and MSC steel girder bridges.

• Earthquakes and Structures
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• v.22 no.6
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• pp.625-635
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• 2022

High-rise buildings (HRBs) are considered one of the most common structures nowadays due to the population growth, especially in crowded towns. The lack of land in crowded cities has led to the convergence of the HRBs and the absence of any gaps between them, especially in lands with weak soil (e.g., liquefaction-prone soil), but then during earthquakes, these structures may be exposed to the risk of collision between them due to the large increase in the horizontal displacements, which may be destructive in some cases to the one or both of these adjacent buildings. To evaluate methods of reducing the risk of collision between adjacent twin HRBs, this research investigates three vibration control methods to reduce the risk of collision due to five different earthquakes for the case of two adjacent reinforced concrete (RC) twin high-rise buildings of 15 floors height without gap distance between them, founded on raft foundation supported on piles inside a liquefaction-prone soil. Contact pounding elements between the two buildings (distributed at all floor levels and at the raft foundation level) are used to make the impact strength between the two buildings realistic. The mitigation methods investigated are the base isolation, the tuned mass damper (TMD) method (using traditional TMDs), and the pounding tuned mass damper (PTMD) method (using PTMDs connected between the two buildings). The results show that the PTMD method between the two adjacent RC twin high-rise buildings is more efficient than the other two methods in mitigating the earthquake-induced pounding risk.

• Journal of the Korea Concrete Institute
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• v.17 no.6 s.90
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• pp.975-982
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• 2005

Scientific community agrees about the fact that base Isolation provides interesting solutions to minimize the seismic risk. Reliability of such a technique is nowadays proofed by a large number of applications like public buildings, nuclear plants, bridges, etc. This paper reports the results of performance verification tests of the base isolated RC building with the laminated rubber bearings which is manufactured by enterprise in Korea. The shaking table tests were performed using a three story model scaled to 1/3 of the prototype RC apartment building. Several major earthquake records were scaled to different peak ground accelerations and used as input base excitations. Especially in this study, effect of earthquake characteristics on response reduction and effect of the intensity of excitations are studied. Through the verification tests, the validity of the applied base isolaion device and the response reduction effect against earthquakes are confirmed.

• BMB Reports
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• v.48 no.5
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• pp.295-300
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• 2015

Stress and its related hormones epinephrine (E) and norepinephrine (NE) play a crucial role in tumor progression. Macrophages in the tumor microenvironment (TME) polarized to M2 is also a vital pathway for tumor deterioration. Here, we explore the underlying role of macrophages in the effect of stress and E promoting breast cancer growth. It was found that the weight and volume of tumor in tumor bearing mice were increased, and dramatically accompanied with the rising E level after chronic stress using social isolation. What is most noteworthy, the number of M2 macrophages inside tumor was up-regulated with it. The effects of E treatment appear to be directly related to the change of M2 phenotype is reproduced in vitro. Moreover, E receptor $ADR{\beta}2$ involved in E promoting M2 polarization was comprehended simultaneously. Our results imply psychological stress is influential on specific immune system, more essential for the comprehensive treatment against tumors. [BMB Reports 2015; 48(5): 295-300]

• Smart Structures and Systems
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• v.20 no.1
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• pp.23-33
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• 2017

Variable Curvature Friction Pendulum (VCFP) bearing is one of the alternatives to control excessive induced responses of isolated structures subjected to near-fault ground motions. The curvature of sliding surface in this isolator is varying with displacement and its function is non-spherical. Selecting the most appropriate function for the sliding surface depends on the design objectives and ground motion characteristics. To date, few polynomial functions have been experimentally tested for VCFP however it needs comprehensive parametric study to find out which one provides the most effective behavior. Herein, seismic performance of the isolated structure mounted on VCFP is investigated with two different polynomial functions of the sliding surface (Order 4 and 6). By variation of the constants in these functions through changing design parameters, 120 cases of isolators are evaluated and the most proper function is explored to minimize floor acceleration and/or isolator displacement under different hazard levels. Beside representing the desire sliding surface with adaptive behavior, it was shown that the polynomial function with order 6 has least possible floor acceleration under seven near-field ground motions in different levels.

• Structural Engineering and Mechanics
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• v.58 no.2
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• pp.259-276
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• 2016

Lead-rubber bearings (LRBs) have been used worldwide in seismic design of buildings and bridges owing to their stable mechanical properties and good isolation effect. We have investigated the effectiveness of LRBs in framed underground structures on controlling structural seismic responses. Nonlinear dynamic time history analyses were carried out on the well-documented Daikai Station, which collapsed during the 1995 Hyogoken-Nanbu earthquake. Influences of strength ratio (ratio of yield strength of LRBs to yield strength of central column) and shear modulus of rubber on structural seismic responses were studied. As a displacement-based passive energy dissipation device, LRBs reduce dynamic internal forces of framed underground structures and improve their seismic performance. An optimal range of strength ratios was proposed for the case presented. Within this range, LRBs can dissipate maximum input earthquake energy. The maximum shear and moment of the central column can achieve more than 50% reduction, whereas the maximum shear displacement of LRBs is acceptable.