• Nutrition Research and Practice
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• v.2 no.4
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• pp.317-321
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• 2008

Macrophages play a key role in iron metabolism by recycling iron through erythrophagocytosis. Ferroportin-l (FPN1) is a transporter protein that is known to mediate iron export from macrophages. Since divalent metals often interact with iron metabolism, we examined if divalent metals could regulate the expression of FPN1 in macrophages. J774 macrophage cells were treated with copper, manganese, zinc, or cobalt at 10, 50, or $100\;{\mu}M$ for 16 to 24 h. Then, FPN1 mRNA and protein levels were determined by quantitative real-time PCR and Western blot analyses, respectively. In addition, effects of divalent metals on FPN1 promoter activity were examined by luciferase reporter assays. Results showed that copper significantly increased FPN1 mRNA levels in a dose-dependent manner. The copper-induced expression of FPN1 mRNA was associated with a corresponding increase in FPN1 protein levels. Also, copper directly stimulated the activity of FPN1 promoter-driven reporter construct. In contrast, manganese and zinc had no effect on the FPN1 gene expression in J774 cells. Interestingly, cobalt treatment in J774 cells decreased FPN1 protein levels without affecting FPN1 mRNA levels. In conclusion, our study results demonstrate that divalent metals differentially regulate FPN1 expression in macrophages and indicate a potential interaction of divalent metals with the FPN1-mediated iron export in macrophages.

• Korean Journal of Community Nutrition
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• v.11 no.6
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• pp.808-813
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• 2006

Until now, South Korea does not have either fortification or enrichment program as intervention tools although the addition of micronutrients to foods is for the most part not regulated. The aim of this study was to determine which scenario would most effectively reduce the proportion of the population with low iron intake while not putting other population groups at risk of excessive intakes. In order to investigate potential dietary consequences of iron fortification we analyzed 2 day dietary record data (n=3,955) from the 2001 National Nutrition Surveys. The Proportion of the population consuming dietary iron less than the estimated average requirement (EAR) ranged from $12.4{\sim}87.5%$ depending upon gender and age group. Iron fortification at the level of 100% of Recommended Intake (RI) per 100g to breads and instant o. dried noodles was estimated to result in a 15% decrease of proportion of those with iron less than EAR, while putting 1.4 % of the population greater than the Upper Limit (UL). Iron fortification appeared to be the most effective for the $15{\sim}19$ year old age group, showing 39% reduction of iron intake insufficiency. The results suggest that carefully designed fortification or enrichment to staple foods may contribute to increase dietary iron intakes of Koreans, especially for the young population with a high prevalence of iron inadequacy. As the estimation in this study was based solely upon dietary intake data, iron intake from supplements should be considered in further studies.

• International Commerce and Information Review
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• v.9 no.2
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• pp.161-182
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• 2007

The objective of this paper is to examine the competitiveness of Korean export firms in EU market. In this study, market share index, RCA index, trade specialization index, and market competitiveness index were used as an analytical tool. On the market share index, Korea had a large market share in the SITC section 7(machinery and transport equipment) market in EU. On the RCA index, Korea appeared to have high export competitiveness in the electrical machinery, apparatus and appliances, n.e.s.(not elsewhere specified[stated]), and electrical parts thereof (77), travel goods, handbags and similar containers(83), textile yarn, fabrics, made-up articles, n.e.s., and related products(65), and iron and steel(67) division. On the trade specialization index, however, Korea appeared to tend to decline generally. On the market competitiveness index, Korea appeared to have competitive advantage in the iron and steel(67), machinery specialized for particular industries(72), office machines and automatic data-processing machines(75), electrical machinery, apparatus and appliances, n.e.s., and electrical parts thereof(77), road vehicles(78), and other transport equipment(79) division; but in 29 divisions, the index indicates that Korean firms' competitiveness was low. Finally, the authors discuss the implications of these findings and offer directions for future study.

• Asia-Pacific Journal of Business
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• v.8 no.2
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• pp.57-73
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• 2017

In this paper RCA and TSI has been analyzed based on Korean and Chinese lists of export (HS 6 units) and list of companies and products with competitive advantage has been deduced. The results of RCA and TSI analysis are as follows. From the list of 20 most exported items from Korea to China the RCA index for eleven of them (based on common items from 2011-2015) is bigger than 1, thus showing comparative advantage. As for the TSI index, all of the items has shown (+) value, and has been analyzed as specialization in export. In other words, companies in the fields of mineral fuel; mineral oil; organic chemicals; electrical equipment and parts; as well as optical, precision and medical instrument are industries with competitive advantage. From the list of 20 most exported items from China to Korea the RCA index for twelve of them (based on common items form 2011-2015) is bigger than 1, thus also showing comparative advantage, and the TSI index has also shown (+) value for all of the specified items, meaning specialization in export. Industries of mineral fuel; mineral oil; iron and steel, articles of iron and steel; machinery and mechanical parts, electrical equipment and parts; as well as optical, precision and medical instruments have shown competitive advantage.

• Journal of Korea Port Economic Association
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• v.36 no.3
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• pp.115-136
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• 2020

This study aims to analyze the impact of China's iron ore imports and exports on the tramper freight rate of China. The import volume of iron ore in China, the export volume of steel products in China, and exogenous variables were used as independent variables. The dependent variables were BDI, BCI, C5, C10, C14, BSI, S2, and S3. Correlation analysis and regression analysis were conducted. The correlation analysis showed that China's iron ore imports were not related to the remaining BDI, BCI, BSI, C5, C10, S2, and S3, except for the C14 index. However, there was a positive correlation between the ship's space and international oil prices, and it was not related to China's Purchasing Managers Index (PMI). The export volume of steel products was negatively correlated with BDI, BCI, BSI, C5, C10, C14, S2, S3, and international oil prices, and was not related to iron ore imports, ship space, and China's PMI. In the verification of the hypothesis between China's iron ore imports and exogenous variables, China's PMI was rejected within the hypothesis. However, the hypothesis on international oil prices and ship space was adopted. In the verification of the hypothesis between China's steel export volume and exogenous variables, the hypothesis on BDI and the S3 index was adopted, and the hypothesis on BSI and S2 was rejected. In the analysis results of this study, the ship space and oil prices were adopted in all the hypothesis results. Domestic companies participating in the tramper shipping market will need to be prepared through continuous monitoring of related indicators.

• Biomolecules & Therapeutics
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• v.10 no.4
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• pp.293-302
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• 2002

The classical concept for iron uptake into mammalian cells has been the endocytosis of transferrin( $T_{f}$ )-bound F $e^{3+}$ via the $T_{f}$ - $T_{f}$ receptor cycle. In this case, we could not explain the uptake of F $e^{2＋}$ ion and the export of iron from endosome. Studies on iron transport revealed that other transport system exists in epithelial cells of the intestine. One of non- $T_{f}$ -receptor-mediated transport systems is Nramp2/DMT1/DCT1 which transports M $n^{＋＋}$, $Mg^{＋＋}$, Z $n^{＋＋}$, $Co^{＋＋}$, N $i^{＋＋}$ or C $u^{＋＋}$ ion as well as F $e^{+2}$ ion. DMT1 was cloned from intestines of iron-deficient rats and shown to be a hydrogen ion-coupled iron transporter and a protein regulated by absorbed dietary iron. DMT1 is founded in other cells such as cortical and hippocampal glial cells as well as endothelial cells in duodenum. Two F $e^{3+}$ ion bound to transferrin( $T_{f}$ ) are taken up via the $T_{f}$ - $T_{f}$ receptor cycle in the intestinal epithelial cell. F $e^{3+}$ in endosome was converted to F $e^{2＋}$ ion, and then exported to cytosol via DMT1. F $e^{2＋}$ ion is taken up into cytosol via DMT1. Several other transporters such as FET, FRE, CCC2, AFT1, SMF, FTR, ZER, ZIP, ZnT and CTR have been reported recently and dysfunction of the transporters are related with diseases containing Wilson's disease, Menkes disease and hemochromatosis. Evidences from several studies strongly suggest that DMT1 is the major transporter of iron in the intestine and functions critically in transport of other metal ions.

• Journal of Advanced Technology Convergence
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• v.2 no.2
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• pp.9-14
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• 2023

This study is shown the result of the first year to develop an export 1050MPa-class lightweight ductile iron castings Austempered control arm through the research process to obtain the following results. First, the structure of the optimal design Layout design and development of the component, and then achieve them through the Control Arm rigidity and optimal structure design and robust design of the focus areas of the expected stress Control Arm. Second, to develop a Control Arm reflects the high rigidity and high performance lightweight structures. Control Arm them developed to meet the design and rigidity as required by the consumer through the hollow, and to develop a process for the Core. Third, through optimum alloy composition and heat treatment methods will be derived to derive the amount of iron alloy (Cu, Ni, Mo) and Austempered heat treated and tempered condition. Fourth, through the development of optimum molding technology development component to develop the optimum ADI for the low-stiffness, high-rigidity component development, it attempts to develop a high-strength casting forming technology..

• Journal of Nutrition and Health
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• v.42 no.5
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• pp.434-441
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• 2009

Ferroportin-1 (FPN) is a transporter protein that is known to mediate iron export from macrophages. The purpose of this study was to investigate the effect of copper on the regulation of FPN gene expression in J774 mouse macrophage cells. J774 cells were treated with various concentrations of $CuSO_4$ and RT-PCR analyses were performed to measure the steady-state levels of mRNAs for FPN and divalent metal transporter 1 (DMT1, an iron importer). Copper treatment significantly increased FPN mRNAs in a dose-dependent manner, but didn't change the levels of DMT1 mRNA. Experiments with transcriptional inhibitor actinomycin D (0.5 ${\mu}g$/mL) revealed that copper treatment did not affect the half-life of FPN mRNAs in J774 cells. On the other hand, results from luciferase reporter assays showed that copper directly stimulated the promoter activity of FPN. In summary, our data showed copper induced FPN mRNA of macrophages via a transcriptional rather than post-transcriptional mechanisms.

• International Commerce and Information Review
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• v.11 no.1
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• pp.95-116
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• 2009

Korea-Us FTA negotiation started in February 2006 with a view to overcoming those uncertainties in the global market and was finally concluded in April, 2007. The Agreement was officially signed between ministers two month later and it is expected to be ratified this year even though the process is most likely to be painful in both countries by the political resistances. For the new President of the United States, effective leadership will depends largely on how to encourage domestic industries such as Automobile industry and Iron and Steel industry from the financial crisis. Many trading partners of US worry about US foreign trade policy changes to protectionism that might be unequal to bear. Korea textile industry is one of the major industry in Korea as it occupies 15% of total number of manufacturers, 11% of total employment and 5% of national GDP. Korea-US FTA will provide a breakthrough for bouncing back by exploring new market. US agreed to remove all tariff and non-tariff barriers to 87% of textile items under trading. This study shows that Korean textile industry has been losing it's competitiveness as textile quota system abolished in the year 2005 and has been traced by pursuers such as China, India and Vietnam. In case of woven fabric which was a representing export item of Korea lost price competitiveness against China after 2005. This study seeks the strategy of Korea textile industry in the US market by utilizing the capacity of KOTRA offices in US. All possible statistical data obtained in the US were used for analysing the competitiveness. Fabrics and Garments are analysed independently with a view to finding out real trends of textile market in US. This study also suggest Korea's textile industry strategic ideas obtained from the potential buyers to show the way to penetrate into US market.

• Journal of the Korean Geographical Society
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• v.45 no.6
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• pp.766-787
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• 2010

This study seeks to clarify the process of development and the change of freight flows in the influence areas of Pyeongtaek and Dangjin Port, which opened lately. The results of analysis are as follows: from development period to growth period, the relation between the development of the port and the change of the hinterland and foreland shows no great change and the freight concentration rates of the first hinterland and foreland decreased, but those of periphery region increased. While the composition rate of import and export freight of vehicle, fuel and energy decreased, the rate of imported freights (iron or steel, other textile articles, rag and organic compounds) and exported freight (manufacture of basic metals) increased. The reasons for such changes in influence areas of port were the increase of export to China and the U.S.A. in the development period, the increase of import from China in the growth period and the diversification of nations from which fuel and energy were imported.