• Biomolecules & Therapeutics
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• 제17권4호
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• pp.412-417
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• 2009

In the course of screening for antioxidant compounds by measuring the radical scavenging effect on DPPH (1,1-diphenyl- 2-picrylhydrazyl), a total extract of the twigs of Vitex rotundifolia (Verbenaceae) was found to show potent antioxidant activity. Subsequent activity-guided fractionation of the methanolic extract led to the isolation of three iridoid compounds, 10-O-vanilloylaucubin (1), 10-O-p-hydroxybenzoylaucubin (2) and aucubin (3), two C-glycoside flavones, vitexin (4) and orientin (5), and a quinic acid derivative, 3,4-di-O-caffeoylquinic acid (6). Their structures were elucidated by spectroscopic studies. Among them, compounds 5 and 6 showed the significant antioxidative effects on DPPH free radical scavenging test. In riboflavin-NBT-light and xanthine-NBT-xanthine oxidase systems, compounds 5 and 6 exhibited the formation of the blue formazan in a dose-dependent manner. Compounds 5 and 6 showed better superoxide quenching activities than vitamin C.

• 생약학회지
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• 제12권2호
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• pp.82-87
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• 1981

A novel iridoid glucoside was isolated from the root of Phlomis umbrosa Turcz. (Labiatae) 'Sok-dan' and named as Umbroside. It was obtained as amorphous powder and its molecular formula is C_{19}H_{18}O_{12}$. By enzyme hydrolysis it produced a stable aglucone and ${\beta}-D-glucose$. The structure of Umbroside was determined as 8-O-acetyl shanzhiside methyl ester. Antitumor activity of Labiatae plants was also tested.

• 생약학회지
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• 제40권4호
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• pp.334-338
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• 2009

Six iridoids were isolated from the 70% ethanol extract of Lonicera Caulis (Caprifoliaceae) and their structures were identified as epialyxialactone (1), secologanin dimethyl acetal (2), sweroside (3), loganin (4), loganic acid (5) and demethylsecologanol (6). The chemical structures of these compounds were identified on the basis of spectroscopic methods and comparison with literature values. This is the first report of the iridolactone, epialyxialactone (1), from the Caprifoliaceae plants and loganic acid (5) and demethylsecologanol (6) from Lonicera Caulis.

• 생약학회지
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• 제14권1호
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• pp.5-8
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• 1983

Phlomis umbrosa Turcz. ('Sok-dan') is a perennial herb in Labiatae plants. Shanzhiside methyl ester was isolated from butanol extract of this plant. It was obtained as amorphous powder and its molecular formula is $C_{17}H_{26}O_{11}$. Its structure was determined by chemical reactions, spectral analysis and compared with authentic sample of its pentaacetate.

• 생약학회지
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• 제25권1호
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• pp.24-27
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• 1994

Two flavonoids, diosmetin 7-0-glucoside and lonicerin, and an iridoid, vogeloside have been isolated from the aerial parts of Lonicera japonica(Caprifoliaceae). The structures of these isolates have been determined by chemical transformations and interpretation of the spectral data. This is the first report of the isolation of diosmetin 7-O-glucoside from this plant.

• Bulletin of the Korean Chemical Society
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• 제30권6호
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• pp.1407-1409
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• 2009

• 생약학회지
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• 제53권2호
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• pp.57-63
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• 2022

Five secoiridoids (1-3, 5, 10), a iridoid (4) three flavonol glycosides (7-9) and a coumarin (6), were isolated from the flowers of Hydrangea paniculata. Their chemical structures were elucidated as kingiside (1), morroniside (2), sweroside (3), loganin (4), vogeloside (5), umbelliferone (6), quercetin-3-O-sambubioside (7), quercetin-3-O-neohesperidoside (8), kaempferol 3-O-sambubioside (9) and secologanin dimethyl acetal (10), respectively, by spectroscopic analysis. All isolated compounds 1-10 were assessed for their ability to induce C2C12 myotube hypertrophy. Among them, loganin (4) and kaempferol 3-O-sambubioside (9) increase the diameter of C2C12 myotubes. All isolated compounds 1-10 were firstly reported from the flowers of Hydrangea paniculata, and the skeletal muscle hypertrophic activity of 4 and 9 was also reported for the first time.

• Archives of Pharmacal Research
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• 제21권6호
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• pp.785-786
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• 1998

The aerial parts of Teucrium yemense yielded two iridoid glycosides. Their structures were elucidated by spectral means as teucardosid and 8-O-acetylharpagid.

• Restorative Dentistry and Endodontics
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• 제22권2호
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• pp.710-719
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• 1997

Aucubin, an iridoid glucoside, which is isolated from Aucuba japonica, has some biological effects. This study was to investigate the effect of aucubin on the remainig pulp tissues after pulpotomy. Mongrel dog's coronal pulps were mechanically exposed with a sterile round bur and excised with sterile sharp excarvator. After bleeding was controlled, in control group, $Ca(OH)_2$ powder was applied on the remaining pulps and the cavities were sealed with Z.O.E. cement. In experimental group 1, mixed powder with $Ca(OH)_2$ and aucubin(l : 1 by weight) was applied on the pulpotomized pulp surfaces. After the cavities were covered with sterile aluminum foil, they were sealed with Z.O.E. cement. In experimental group 2, only aucubin powder was applied on the remaining pulps and then they were treated the same as experimental group 1. In the all groups, the pulps were histopathologically observed by light microscope at the time intervals of 1, 2 and 4 weeks after experiment. The results were as follows : 1. In control and experimental groups, mild vascular congestion and bleeding were found in most of the specimens. Less inflammatory infiltration was observed in experimental groups than in control group. 2. Dentin bridge formation was found after 1 week at both control and experimental group 1. Dentin birdge had discontinuous osteodentin like appearance or contained some dentin chips. In experimental group 2, dentin bridge was not seen. 3. The coagulation necrosis layer on the remaining pulp tissues was seen in all groups. In experimental group 2, the thickest layer was observed. And in control group, coagulation necrosis layer was similar as in experimental group 1.

• 생약학회지
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• 제12권1호
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• pp.15-18
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• 1981

In continuation of the previous papers, the presence of alkaloid, flavonoid, iridoid, terpenoid, steroid and saponin were screened with the usual test methods in another 53 species of Korean medicinal plants. The result is presented in the Table I.