• Title/Summary/Keyword: iodide

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A Formal Synthesis of Sirenin

  • Jun, Jong-Gab;Mundy, Bradford P.
    • Bulletin of the Korean Chemical Society
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    • 제9권3호
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    • pp.135-136
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    • 1988
  • Cleavage of exo-7-substituted-6,8-dioxabicyclo[3.2.1]octanes with acetyl iodide in the predominance of the trans alkene product. This bicyclic ketal fragmentation methodology is utilized to a formal synthesis of sirenin.

Efficient Synthesis of Benzoprostacyclins Using Free-Radical and Palladium-Catalyzed Tandem Alkene Insertion Strategies

  • 이남호
    • Bulletin of the Korean Chemical Society
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    • 제22권8호
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    • pp.857-866
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    • 2001
  • Efficient syntheses of PGI2 analogue 2a and its epimer 3 have been accomplished. Using aryl iodide 6 as the common intermediate, either radical or palladium-assisted tandem alkene insertion strategies have been employed for construction of the benzoprostacyclin framework.

An improved synthesis of 2'-fluoro-2'-deoxyarabinofuranosyl pyrimidine nucleosides

  • Chun, Moon-Woo
    • Archives of Pharmacal Research
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    • 제6권1호
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    • pp.79-81
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    • 1983
  • Several potent anti-herpes virus nucleosides, 2'fluoro-2'-deoxyarabinofuranosyl pyrimidine nucleosides, were prepared in good yields by a new condensation method using sodium iodide and a new solvent system, and FMAU could be also prepared directly from thymine by this method.

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Binary Compound Formation upon Copper Dissolution: STM and SXPS Results

  • Hai, N.T.M.;Huemann, S.;Hunger, R.;Jaegermann, W.;Broekmann, P.;Wandelt, K.
    • Corrosion Science and Technology
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    • 제6권4호
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    • pp.198-205
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    • 2007
  • The initial stages of electrochemical oxidative CuI film formation on Cu(111), as studied by means of Cyclic Voltammetry (CV), in-situ Scanning Tunneling Microscopy (STM) and ex-situ Synchrotron X-ray Photoemission Spectroscopy (SXPS), indicate a significant acceleration of copper oxidation in the presence of iodide anions in the electrolyte. A surface confined supersaturation with mobile CuI monomers first leads to the formation of a 2D-CuI film via nucleation and growth of a Cu/I-bilayer on-top of a pre-adsorbed iodide monolayer. Structurally, this 2D-CuI film is closely related to the (111) plane of crystalline CuI (zinc blende type). Interestingly, this film causes no significant passivation of the copper surface. In an advanced stage of copper dissolution a transition from the 2D- to a 3D-CuI growth mode can be observed.

저산소증으로 유발된 지연성 신경세포사에 우황청심원이 미치는 영향 (The Effect of Woohwangcheongsim-won on Delayed Neuronal Death in Hypoxia)

  • 김민석;정승현;신길조;문일수;이원철
    • 대한한의학회지
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    • 제23권3호
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    • pp.145-163
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    • 2002
  • Objectives: The purpose of this investigation was to evaluate the effects of Woohwangcheongsim-won and to study the mechanism for neuronal death protection in hypoxia with Embryonic day 20 (E20) cortical cells of a rat (Sprague Dawley). Methods: E20 cortical cells were dissociated in neurobasal media and grown for 14 days in vitro (DIV). On 14 DIV, Woohwangcheongsim-won was added to the culture media for 24 hrs or 72 hrs. On 17 DIV, cells were given a hypoxic shock and further incubated in normoxia for another three days. On 20 DIV, Woohwangcheongsim-won's effects for neuronal death protection were evaluated by LDH assay, propidium iodide stain and phospho-H2AX immunostain and the mechanisms were studied by Bcl-2, Bak, Bax, caspase family, PKCα, ca1pain I. Results & Conclusions : 1. This study indicated that Woohwangcheongsim-won's effects for neuronal death protection in hypoxia were confirmed by LDH assay, propidium iodide stain and phospho-H2AX immunostain in culture method of Embryonic day 20(E20) cortical neuroblasts. 2. Woohwangcheongsim-won's mechanisms for neuronal death protection in hypoxia are to reduce the membrane damage fraction, to restrain DNA truncate, to restrain inflow of cytochrome c into cellularity caused by Bak diminution, to reduce the caspase cascade intiator caspase-8 and the effector caspase-3, to reduce the calpain I activity and to increase PKCand its activity in the membrane fraction. (J Korean Oriental Moo 2002;23(3):145~163)

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