• Asian Pacific Journal of Cancer Prevention
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• v.17 no.9
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• pp.4199-4204
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• 2016

Cancer is a complex disease caused by a progressive accumulation of multiple genetic mutations. Consumption of fruits is associated with lower risk of several cancers, which is mainly associated to their phytochemical content. The use of functional foods and chemopreventive compounds seems to contribute in this process, acting by mechanisms of antioxidant, anti-inflammatory, anti-angiogenic and hormonal. The Psidium Guajava has high potential functional related to pigments who are involved in the process of cancer prevention by having antioxidant activity. The aim of the present review is to expose some chemical compounds from P. Guajava fractions and their association with anti-carcinogenic function. The evidences supports the theory of anticancer properties of P. Guajava, although the mechanisms are still not fully elucidated, but may include scavenging free radicals, regulation of gene expression, modulation of cellular signalling pathways including those involved in DNA damage repair, cell proliferation and apoptosis.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.24 no.69
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• pp.87-92
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• 2001

A significant number of all reported accidents in Korea involved education and training Based on the Labor Ministry data, statistics, show the education cause was directly involved in 38% of major accidents, Since safety managers have in charge of safety education at the factory, occupational safety curriculum must be studied to train safety manager effectively. In this study an analysis on relative importance of industrial safety curriculum for a good safety manager was performed by Analytic Hierarchy Process(AHP) The results showed that relative importance of industrial safety curriculum by AHP was safety management(w=0.240) ergonomics and system safety(w=0.201) construction safety(w=0.182) mechanic safety(w=0.139) electronic safety(w=0.134) and chemical safety(w=0.104) in order. The results could be used for industrial safety curriculum planning in university and safety organization such as Korea Occupational safety and Health Agency.

• Journal of the Korean Institute of Educational Facilities
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• v.17 no.2
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• pp.23-30
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• 2010

At present, the necessity of new design guidelines, evaluation and operation system for school facilities are on the rise according to re-edition of school curriculum in Korea. Moreover, it is necessary to procedure of the design, an institutional device and an ex post facto evaluation system for school facilities as a public building with the space planning that is suitable for various situations, which are able to collect users' various demands and opinions. Under the present situation, England has introduced and operated DQI system for the users' participation design of its. The present study will derive the meaning DQI system of England and how to operate it, and percuss the possibility of the application of design procedure of the education facilities in Korea.

• Journal of the Korean Institute of Navigation
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• v.20 no.1
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• pp.59-79
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• 1996

Waterfront redevelopment is an element in the process of inner-city regeneration now widespread in many ports of the world. Academic interest in the processes involved has yielded a literature biased towards specific locations rather than towards the analysis of processes and issues. The redevelopment of urban waterfronts does not, of course, occur exclusively in port cities but is found as a continuous process in most places where settlement and water are juxtaposed, whether or not commercial port activity is or was present. Port cities, however, as a result of the concentration and juxtaposition of urban and maritime influences, generally present the major issues involved in waterfront redevelopment most clearly. In this context, the general aim is to explore Korean dimensions of waterfront redevelopment in a range of port cities in a context of inner-urban renewal; and a specific objective is to examine the views of decision-makers in Korean port cities on the processes involved by a questionnaire method. The focus is on comparative strategies, and in particular upon the factors affecting the balance between social goals and commercial interests. To test the response of four categories of decision-makers in Korean port cities on a number of issues perceived as underpinning the processes involved in waterfront redevelopment, four catergories of respondents-port authority representatives(PO), urban planners(UP), port specialists(PS) and city-government official(GO)-were asked to fill in a questionnaire form. In three out of ten cases, the overall result broadly confirmed the a priori expectation; in six cases the confirmation was partial; and in one other the view of respondent was generally contrary to those anticipated. In many, but by no means all, cases there was substantial agreement between the four categories of respondents, but the range of scores was generally much wider than expected.

• International Commerce and Information Review
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• v.9 no.1
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• pp.3-21
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• 2007

The explosive growth of e-marketplace transactions requires an appropriate trust measuring framework to protect involving transacting entities such as buyers and sellers. As a strategic competitive edge, e-marketplace service providers have been adopting various system features that make sure no one transacting entity takes a major risk in online transactions involved. In this paper, an improved trust measuring method using fuzzy theory for an e-marketplace is proposed. The proposed methodology incorporates fuzzy set and calculation concepts to help build trust matrices and models, which are used to measure the level of risk involved in a specific e-marketplace transaction concerned. The proposed framework can be utilized to optimize the transaction costs by recommending a differentiated transaction process according to the risk level involved in each online transaction.

• Journal of the Korean Society of Clothing and Textiles
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• v.27 no.1
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• pp.29-39
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• 2003

The purpose of this study was to investigate the effects of service quality of apparel stores, evaluative criteria and clothing involvement on the consumer satisfaction. Data were collected from 481 women consumers living in Busan and analysed by frequency analysis, factor analysis, Cronbach's , cluster analysis, t-test and discriminant analysis. The results showed that consumers who highly involved symbolism of apparel were more influenced by salesperson service and store atmosphere, and were more effected by prestige/brand royalty of apparel than those who highly involved pleasure of apparel. Those who had high scores in symbolism involvement were more satisfied with consumer satisfaction in apparel buying behaviors than those who highly involved pleasure of apparel. The service quality was the influenced variable on consumer satisfaction related to apparel products than the others. Especially, salesperson service and store atmosphere in service quality were important to the satisfaction perceived by consumers in apparel buying process.

• Journal of Biomedical Engineering Research
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• v.27 no.4
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• pp.180-188
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• 2006

Bristles for the prosthetic and periodontally involved patients are investigated based on previous studies. Specifically, the ideal location and dimensions of bristles for the patients who were installed with fixed prostheses and severely involved periodontitis were investigated. 3D (Three-Dimensional) scanner was used to develop 3D visual models of bristles and teeth. These models were used for designing the ideal bristles. In the design, the interproximal area of dental arch and bristle must be maximized and the standard teeth may have to be chosen from many gypsum molds. During the design process the factors that influence plaque removal by the bristle were considered.

• Biomolecules & Therapeutics
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• v.31 no.5
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• pp.559-565
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• 2023

Ataxia-telangiectasia mutated (ATM), a master kinase of the DNA damage response (DDR), phosphorylates a multitude of substrates to activate signaling pathways after DNA double-strand breaks (DSBs). ATM inhibitors have been evaluated as anticancer drugs to potentiate the cytotoxicity of DNA damage-based cancer therapy. ATM is also involved in autophagy, a conserved cellular process that maintains homeostasis by degrading unnecessary proteins and dysfunctional organelles. In this study, we report that ATM inhibitors (KU-55933 and KU-60019) provoked accumulation of autophagosomes and p62 and restrained autolysosome formation. Under autophagy-inducing conditions, the ATM inhibitors caused excessive autophagosome accumulation and cell death. This new function of ATM in autophagy was also observed in numerous cell lines. Repression of ATM expression using an siRNA inhibited autophagic flux at the autolysosome formation step and induced cell death under autophagy-inducing conditions. Taken together, our results suggest that ATM is involved in autolysosome formation and that the use of ATM inhibitors in cancer therapy may be expanded.

• Bulletin of the Korean Chemical Society
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• v.13 no.5
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• pp.504-507
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• 1992

fac-RuH(NO)(ttp) is fluxional in the range between 180 K and 303 K. The structures involved in this fluxional process are found to be a mixture of two square pyramids and a trigonal bipyramid from the low temperature NMR spectra and the line shape analysis using DNMR 3 program and the activation parameters of this process were determined by using the simulated data. The mechanism of this fluxional process is proposed to be a pathway known as Turnstile Rotation.

• Mycobiology
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• v.43 no.1
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• pp.37-42
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• 2015

A mutant library of Cordyceps militaris was constructed by improved Agrobacterium tumefaciens-mediated transformation and screened for degradation features. Six mutants with altered characters in in vitro and in vivo fruiting body production, and cordycepin formation were found to contain a single copy T-DNA. T-DNA flanking sequences of these mutants were identified by thermal asymmetric interlaced-PCR approach. ATP-dependent helicase, cytochrome oxidase subunit I and ubiquitin-like activating enzyme were involved in in vitro fruiting body production, serine/threonine phosphatase involved in in vivo fruiting body production, while glucose-methanol-choline oxidoreductase and telomerase reverse transcriptase involved in cordycepin formation. These genes were analyzed by bioinformatics methods, and their molecular function and biology process were speculated by Gene Ontology (GO) analysis. The results provided useful information for the control of culture degeneration in commercial production of C. militaris.