• Journal of Pharmaceutical Investigation
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• v.32 no.2
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• pp.73-80
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• 2002

Cefuroxime axetil is a cephalosporin antibiotic having a high activity against a wide spectrum of Grampositive and Gram-negative microorganisms. It is a cephalosporin antibiotic which exist as 2 diastereoisomers: diastereoisomer A and B. It shows polymorphism of three forms: a crystalline form having a melting point of about $180^{\circ}C$, a substantially amorphous form having a high melting point of about $135^{\circ}C$ and a substantially amorphous form having a low melting point of about 70^{\circ}C$. The crystalline form of cefuroxime axetil is slightly soluble in water because diastereoisomer A has lower solubility than B in water. Substantially amorphous form of which there are no difference in solubility between diastereoisomer A and B has better solubility than crystalline form, but it forms a thicker gel than crystalline form upon contact with an aqueous medium. Based on this reason, cefuroxime axetil is not readily absorbable in the gastrointestinal tract, rendering its bioavailability on oral administration very low. The object of this study was to develop an improved non-crystalline cefuroxime axetil composition having a high physicochemical stability and bioavailability. A non-crystalline cefuroxime axetil solid dispersant showing no peak on a Differential Scanning Calorimetry (DSC) scan is prepared by dissolving cefuroxime axetil and a surfactant in an organic solvent; suspending a water-insoluble inorganic carrier in the resulting solution; and spray drying the resulting suspension to remove the organic solvent, said solid dispersant having an enhanced dissolution and stability of cefuroxime axetil and being useful for the preparation of a pharmaceutical composition for oral administration. Tablet was formulated with this cefuroxime axetil solid dispersant, disintegrants and other ingredients. It disintegrated and dissolved easily and dynamically in dissolution medium, so showed a good dissolution profile.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.33 no.4
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• pp.1315-1326
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• 2013

Geometric form of a suspension bridge that uses load-sensitive cables takes on not only resisting loads but also becoming a visually sensible shillouette. This study has proposed a preliminary structural form planning for a suspension bridge following force flow by adopting the two possibilities of the graphic statics. First, the force polygon allows alternative load paths for the same loading condition. Second, a new structural form for the newly developed load path can be constructed using the reciprocal principle that exits between a structure space and the corresponding force polygon. Major structural form parameters that affect both structural and aesthetic aspecs are first identified. The relationships between structural forms and the corresponding force polygons are then investigated for the identified parameters. Upon the investigation, a stepwise process is developed for a preliminary structural form planning for a suspension bridge. The proposed structural form planning method is general that can be easily expanded to generate design alternatives of similar form-active structural systems. It is also expected that this method will be used as an educational tool to explain the interrelationships between structural forms and their force flows.

• Journal of Pharmaceutical Investigation
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• v.40 no.1
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• pp.15-21
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• 2010

Sibutramine is an orally administered centrally-acting antiobesity agent and inhibits both noradrenaline(norephinephirine) and serotonin(5-HT) reuptake. These effects are contributed by its active metabolites, M1 and M2. However, as the free base form of sibutramine is an oil form in room temperature, it had the problem of handling and stability. Thus, this drug should be used in the form of acid salt form in the pharmaceutical application. Unfortunately, anhydrous sibutramine hydrochloride is highly hygroscopic and unstable. In order to solve the hygroscopicity of the anhydrous salt form, another sibutramine acid salt form must be developed as a hydrate form. In this study. to overcome these problems, various of sibutramine acid salt forms were prepared with the pharmaceutically available salts such as maleate, esylate, mandelate, camsylate, besylate, salicylate, tartrate, isethionate and malate forms, and their physicochemical properties were investigated. Sibutramine malate was selected for excellent solubility and stability among the listed salt forms above. Its pharmacokinetic parameters were evaluated in rats comparing with sibutramine HCl, resulting in similar parameters. In vitro dissolution study of sibutramine malate-loaded capsule was performed comparison with commercial product ($Reductil^{(R)}$) in pH 1.2, pH 4.0, pH 6.8 and water medium. Our results indicated that there were no significant differences in their dissolution profiles were similar in all tested medium. Thus, sibutramine malate-loaded capsule should be a potential candiate due to its excellent solubility, good stability and biosimilar absorption.

• Fashion & Textile Research Journal
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• v.18 no.5
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• pp.708-715
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• 2016

This study researched the sizing system of dress form for apparel manufacturing in the domestic market. It aims to be used as basic data for the development of a dress form that could be used by manufacturers of senior men's clothing. Research focused on the sizes presented on the homepages of 17 dress form manufacturers in the USA, France, Japan, and Korea. Body measurement was made for senior men in their 50's over men (n=134). Six items were measured by the 'Standard body measurement of Size Korea'. The type of dress form in the domestic market can be classified into half-body type (upper body type and lower body type), torso, and whole-body type; in addition, each type is divided into upper arm, arm, crotch, and thigh. Korean dress form manufacturers produced/sold diverse kinds (size 7-9) for women; however, they used large/small sizes or product sizes for men without defining sizes. The chest size (93-105cm) has not been standardized while the rates of waist circumference, hip circumference and shoulder length (in accordance with the chest size) were all different. Global dress form brands manufactured reflecting body dimensions by the state organization USA ASTM. Japan JIS. For this reason, most domestic clothing businesses depend on imported dress forms. Especially, there were no dress forms for senior men. With the growing market for seniors, it would be necessary to produce senior dress forms for clothing production that reflect the body shapes and sizes of seniors.

• Journal of the Korean Society of Costume
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• v.57 no.8
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• pp.75-88
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• 2007

Nowadays, geometrical form expressed on costume is recognizing as a part of modeling art, at the same time is working to develop it. Also the geometrical form is affording the coinciding lifestyle and sensitivity of customers keeping their pace. As a result, our study is researching on the geometrical form that is used in the pattern, silhouette, and detail of the costume to show the texture in sense of touch and the effect of optical illusion used in variable designs, in order to present the expansion our capability of infinite development included in the study of costume. Specially, geometrical form included in sports wear is very effective since the geometrical form includes short and simple beauty as well as practical design. Thus, this study is wishing to know if satisfying the practical and psychological urge of present human beings may be applied to the golf wear market, which is a type of sport that geometrical form is sent in the fastest way in domestic market. Also we are urged to know what type of design technique is the geometrical form nowadays used and changed to discriminate the artificial commerce and improve the identity of such unique brand. The source of this thesis is wishing to investigate the specialization and the most effective geometrical shape and preference of each type in domestic golf wear goods that applied geometrical goods in $2002{\sim}2006$ and analyze its way of expression.

• Journal of Global Scholars of Marketing Science
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• v.16 no.2
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• pp.55-75
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• 2006

This study aims to identify the unknown essential condition to form the blue ocean market, in addition to the innovation of customer value which does not become a sufficient condition though it is one of the essential conditions to form a blue ocean market, and induce companies to take a firm foothold in the blue ocean market after going to the blue ocean market by segmenting the market after setting up appropriate strategies. On the basis of those goals of this study, we dealt with subjects like the problem of approaching the market that possesses factors of differentiated value innovation, the segmentation of value innovative market, the problem about the major variables that shed light on the character of blue ocean optical illusion market, the strategy for following companies to enter the market, which we applied to the actual analysis based on the investigation into the literature related to value innovation and blue ocean strategy, investigation into the actual cases and objective data. We analysed a domestic refrigerator market and a domestic chewing gum market as representative examples of durables and nondurables and segmented each market on a value innovation market. We discovered the blue ocean and the blue ocean's illusive market of the two markets. I've mentioned and studied the characters of those positively.

• Journal of the Korean housing association
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• v.25 no.4
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• pp.39-46
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• 2014

This research was for the investigation and analysis of the illustration of modular construction application which is different use by each school facility since modular construction related examples are rare in domestic situation, and it has a limitation because of its being basic research material for generating the basic form of modular construction. The research results are as followings. First, in case of school facility from illustration investigation results, module measurement of class modulation is as similar as $3m{\times}10m$, but in resident facility the planning of more flexible plane shape can be possible since modules of 6 cases are free and various, and facade form of various types can be appeared by combination of module unit. Second, as a result of the generated characteristics in compared analysis of representative examples, school facilities were highly indicated for movability and duration reduction areas, and the flexibility, economic efficiency, and environment-friendliness was indicated low relatively. Third, the basic planning types of modular construction can be largely divided into layered type, horizontal (straightway) type, and compound type. The layered type has a short traffic line and facility system and is appropriate for the low-rise form unless separate construction method is used since it is susceptible to load. The horizontal type is advantageous for securing an opening since it has wide extent in light but has a long traffic line and facility system. Finally, the compound type can be possible for planning of various forms but needs the combination of various unit modules and traffic line and facility plan for it can be difficult.

• Journal of Korea Society of Industrial Information Systems
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• v.2 no.1
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• pp.103-123
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• 1997

This dissertation provides a theoretic study on the network security in general , the firewall in particular. In fact the firewall has been recognized as a very promising option to obtain the security inthe real work network environment . The dissertation provides a throuth theoretic investigation on the various problems raised in the computer network, and also explores a methodology of the security against IP spoofing. Moreover, it investigates a systematic procddure to make analysis and plans of the firewall configuration . Based on the above investigation and analysis, this dissertation provides two approaches to network security , which address anumber of issuesboth at the network and at applicatino level. At the network level, a new method is proposed which uses packet filtering based on the analysis of the counter plot about the screen router.On the other hand, at the application level, a novel method is explored which employs secureity software. Firewall-1 , on Bastion host. To demonstrate the feasibililty and the effectiveness of the proposed methodologties , a prototype implementation is made The experiment result shows that the screen router employing the proposed anti-IP spoofing method at the network level is effective enough for the system to remain secure without being invaded by any illegal packets entering form external hackers. Meanwhile , at the application level, the proposed software approach employing Firewall-1 is proved to be robust enugh to prevent hackings from the outer point the point protocal connnection . Theoretically, it is not possible to provide complete security to the network system, because the network security involve a number of issues raised form low level network equipments form high level network protocol. The result inthis dissertation provides a very promising solution to network security due to its high efficiency of the implementation and superb protectiveness from a variety of hacking.

• Journal of Pharmaceutical Investigation
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• v.37 no.2
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• pp.119-126
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• 2007

Tablet splitting is used in pharmacy practice to adjust the dose to be administered. However, it also causes several problems such as undesirable effect for sustained release or enteric-coated dosage form, inaccuracy of dose, and pharmacist's safety by splitting hazardous drugs. This study investigated the current status of oral dosage form splitting for patients older than 19 years by analyzing Korea National Health Insurance Claims Database. Out of oral solid drugs prescribed (N=1,486,584) 9.8% of them included tablets (or capsules) split. There were some splitting cases even in sustained release (4.9%), enteric-coated forms (1.3%) and hazardous drugs (2.7%) that were selected by NIOSH (The National Institute for Occupational Safety and Health). The most frequently split drugs were antihistamines, neuropsychotics and steroids. In case of digoxin and warfarin, unit doses in a domestic market were not diverse compared to foreign markets. Guidelines for splitting oral solid dosage forms, approval of diverse doses and conducting dose-response studies for the commonly splitting ingredients on Korean people are needed for the saff and effective use of oral solid drugs.

• Journal of Korean Society of Forest Science
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• v.95 no.3
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• pp.282-290
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• 2006

Forest vegetation types were studied by the phytosociological investigation and the TWINSPAN method in Ulleung Island, Korea. Two hundred thirty-two releves were sampled with $100m^2$ plots. Two main vegetation types, the mountain forest(Acer okamotoanum community group) and maritime forest(Artemisia scoparia community group), have been distinguished and typified twenty-two vegetation units. The former was divided in 4 communities, 11 groups and 7 subgroups. The latter was 2 communities and 5 groups. In a case of life-forms of mountain and maritime vegetation type, the composition ratio of species that had featured trees and herbs, hemicrypthophyte, a seed dispersion-type by wind or nature falling and erection form was high in the mountain vegetation type. Species that had featured shrubs, chamaephyte, disseminated mainly by a wind in the herbs, and animals and man or no special modification in the woody, narrowest extent of rhizomatous growth and the clonal growth by stolons and struck roots and procumbent form were abundantly distributed in the maritime bluff vegetation type. Particularly, the composition ratio of Sambucus sieboldiana var. pendula community(A6), disturbed vegetation type of middle-lower slope of mountain, that had featured a seed dispersion-type by wind, moderate and narrowest extent of rhizomatous growth and Tussock form was high.