• Journal of the Korean Society for Precision Engineering
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• v.27 no.4
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• pp.20-26
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• 2010

Any relative deformation between the cutting tool and the workpiece at the machining point, results directly in form and dimensional errors. The source of relative deformations between the cutting tool and the workpiece at the contact point may be due to thermal, weight, and cutting forces. This paper presents an investigation into dry and fluid machining with the objective of evaluating shape accuracy effect for the turning process of Al6061. The thermal distribution of cutting tool and cutting force was predicted using finite element method after measuring the temperature of the tool holder. To reach this goal, shape accuracy turning experiments are carried out according to cutting conditions with dry and fluid machining methods. The variable cutting conditions are cutting speed, depth of cutting and feed rate.

• Journal of Pharmaceutical Investigation
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• v.22 no.4
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• pp.281-287
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• 1992

Omeprazole (OMZ) is very unstable in acidic solution, which selectively inhibit the release of the gastric juice in the gastric mucosa, In order to stabilize (OMZ) in oral solid dosage form, the enteric-coated microcapsules and compression-coated OMZ tablets containing lysine or arginine as stabilizer were prepared and their dissolution and stability test were performed. The haif life of OMZ microcapsules containing arginine was 194 days at $30^{\circ}C$ and OMZ was completely released in 60 min. The half-lives of enteric coated and non-coated compression-coated OMZ tablets with lysine were 292 and 95 days at $30^{\circ}C$, respectively. The half-lives of enteric coated and non-coated compression-coated tablets with arginine were 1752 and 293 days at $30^{\circ}C$, respectively, and OMZ were released completely in 20 min in the 2nd fluid of K.P.VI. Consequently, the enteric-coated compression-coated OMZ tablets with arginine as stabilizer provided a good formulation for oral solid dosage form.

• Korean Institute of Interior Design Journal
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• no.15
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• pp.79-85
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• 1998

Woods have been the familiar constructional materials because they were well suited to natural environments of Korea in terms of history regionalism and nationality. Since the modernization of Korea the wooden structure have mostly disappeared because of constructional costs regulations and convenience. But wooden constructions will reappear because of a prediction of wood demand and supply various choices for life circumstances and various investigations. There are many such cases. Among them Japan became an interesting object of investigation. New wooden constructional structures with new materials and modern skills may be observed in Japan. The purpose of this study is to trace architects' consciousness and to analyze constructions with the combination of wooden and other materials in Japan. Thus we explore a possibility to construct a new wooden structure which is suitable in modern Korea. The results were as follows: First the consciousness of Japanese architects' mixed wooden construction corresponds to the close relations between society and environment. Second the space of a structure with mixed wooden constructions in present Japan is chosen as the best way to consider functions and environments according to the form of need space scale and quality. Third the structure wooden constructional structure is a part of roof open space. in this case woods are represented and composed of japanese traditional wooden structure with new technique. Forth a mixed wooden construction has been used through a merit of each material by mixed of different materials as well as beauty of form.

• Journal of Pharmaceutical Investigation
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• v.27 no.1
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• pp.15-22
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• 1997

The mucosal route of administration(nasal, buccal, conjunctival and vaginal) has recently been considered as an alternative to parenteral delivery for many peptide drugs because enzymatic degradation of these agents may be partly avoided. The objective of these study was to establish the optimal mucosal administration dosage form of $LHRH/[D-Ala^6]LHRH$, based on presystemic metabolism. We reported previously the peptidase inhibition effect of medium chain fatty acid salts(sodium caprylate, soadium caprate and sodium laurate), EDTA and STDHF on the proteolysis of $LHRH/[D-Ala^6]LHRH$ in rabbit mucosal homgenates. We also reported that EDTA, STDHF and sodium laurate markedly increased the potency of $LHRH/[D-Ala^6]LHRH$ solution applied vaginally. In the present study, by administration of polycarbophil hydrogel containing LHRH the ovulation inducing activity was 3.3 times greater than solution. These results indicate not only peptidase inhibitor but also polycarbophil hydrogel significantly improved the absorption of this drug. The results of this study would provide the feasibility as a rational dosage form for improving bioavailability and self administration of this hydrogel by the vaginal application.

• Journal of Pharmaceutical Investigation
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• v.38 no.5
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• pp.289-293
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• 2008

To develop a poloxamer-based solid suppository with poloxamer and polyethylene glycol mixtures, the melting point of various formulations composed of P 188 and propylene glycol were investigated. The dissolution and antitumor activity of clotrimazole delivered by the poloxamer-based suppository were performed. The poloxamer mixtures composed of P 188 and propylene glycol were homogeneous phases. P 188 greatly affected the melting point of poloxamer mixtures. In particular, the poloxamer mixture [P 188/propylene glycol(70/30%)] with the melting point of about $32^{\circ}C$ was a solid form at room temperature and instantly melted at physiological temperature. Furthermore, the ratio of P 188/propylene glycol greatly affected the dissolution rates of clotrimazole from poloxamer-based suppository. It gave the more effective anti-tumor activity than conventional PEG-based suppository due to fast dissolution. Thus, the clotrimazole-Ioaded poloxamer-based solid suppository was an effective rectal dosage form with anti-tumor activity.

• Korean Institute of Interior Design Journal
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• v.17 no.6
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• pp.3-10
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• 2008

The basestone is a kind of foundation part of the building and can be said to deliver the loads from the upper part to ground. It is the explanation of structural role for the basestone. But the basestone has been used as the decorative element in a building. So this study is on design of the basestone. First the type division can be studied as form of the basestones. Also the investigation of development aspect of them needs to as times and the spatial characteristics. Another goal of this study is on the design characteristics of the basestone from the comparison to the basestone in ancient Japan was initiated in the architectural technology from Korea. The results are as follows. In Baekje rectangular basestones were used in static space for ceremony and circular ones were used in dynamic space for life. Also the basestones with joojwa(smoothing surface for sitting on column) were used for accessory buildings rather than main. In Silla the same type of basestone was made in a temple but according to hierarchy of buildings the sizes of them seem to have been different. The other side in Japan carved basestones were for the main buildings and for the accessory natural stones were used to. According to the hierarchy of the buildings the kinds of stones were different.

• Journal of Satellite, Information and Communications
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• v.9 no.1
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• pp.70-73
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• 2014

We have designed high performance flexible prism light-guide plate (LGP) in 5 inch TFT-LCD for mobile applications. We adopted novel material such as methacrylate and butyl acrylate mixture, as it called KURARITY. It has good flexibility by addition of butyl acrylate. And it has also good transmissivity because methacrylate is a major compound. Then, we achieved good test result to embody high brightness and flexible BLU in case of LGP of base and upper surface with 5 inch, thickness 1.5mm adding prism construct, it is superior brightness improvement than previous flexible LGP. It shows significant improvement than previous printing form about some 5% and in this course to flexible embody actual material it succeeded prism LGP production by 5 inch injection form process.

• Journal of Pharmaceutical Investigation
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• v.8 no.4
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• pp.23-36
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• 1978

Since the active center of digestive enzymetic preparations, while under storage, lose their activity and potency by the exposure to moisture, colorization, solidifying and other physical changes. It is more important than beautiful package form that protected packaging form from moisture to get a pharmaceutical safety preparations and to maintain a definite potency. Then, in order to get a desirable conditions of storage and packaging, we used shellac and $AEA^{\circledR}$ as a coating base, and blister package, foil and bottle container as a packaging material. Temperature were set on room temperature and $37^{\circ}C$, moisture was adjusted to 40% RH and 80 % RH as a accelerated conditions. Accelerated test was carried out 6 times. The results are as follows: 1) The effect of packaging conditions give great influence on the maintenace of the stable potency. 2) Best result was produced with bottle container package. 3) $AEA^{\circledR}$ is more useful than shellac as a coating base of prevention from moisture. 4) Absorption of moisture gave considerable effects on potency and it has a limited point. 5) Difference in potency between optimal and worst condition is 472 u/2T, and difference in effective period is about 44 months.

• Journal of Pharmaceutical Investigation
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• v.32 no.4
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• pp.327-330
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• 2002

Alginate based polymeric matrices were designed for controlled release and stabilization of cefaclor in gastrointestinal fluid. Cefaclor is known to be acid stable and subjected to be degraded at neutral and alkaline pHs. In order to achieve an effective release profile of cefaclor in gastrointestinal tract, a particular strategy in dosage form design should be required from the view point of maintaining its activity. The amphiphilic nature of cefaclor allowed its controlled release using ionic polymers based on ionic interaction between the drug and polymers. The thrust of this study was to develop a technique that delivers cefaclor keeping effective release rate in the intestinal tract. Considering the fast degradation of cefaclor in the intestinal fluid, the matrices were designed to release surplus amount of cefaclor. The alginate based matrices demonstrated increase in release rate in the simulated intestinal fluid, which was favorable to compensate the degraded portion of cefaclor. In addition, stabilization of cefaclor in the intestinal fluid was obtained by employing citric acid that provides an local acidic environment. The matrices might be valuably used for the development of an oral cefaclor dosage form.

• Journal of Pharmaceutical Investigation
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• v.13 no.1
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• pp.1-9
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• 1983

The effect of humidity on crystallization and polymorphic transformation of hydrous aluminum oxide under various humidity at $37^{\circ}$ was examined by means of X-ray diffraction, scanning electron micrograph, IR spectra and DTA. The humidity was an important factor influencing crystallization of hydrous aluminum oxide. The growth or crystal was strongly accelerated by humidity. The aging process is assumed that it is composed of two seperate steps, an increase of the diffraction around $36{\sim}42^{\circ}$, and an appearance and its development of the peak at $18{\sim}20^{\circ}$ of $2{\theta}$ value. The former is considered to be nucleation and the latter correspond to the growth period on crystallization. The crystalline form of aging products was various depending on the degree of humidity, directly it leads to the eventual formation of bayerite in more than 72%, $b{\"{o}}hmite$ in 50% and resembled to Nordstandite in 0% relative humidity, respectively but once formed, it was mostly stable in each surroundings and does not transform to the other more stable form in solid state even after aging for five years. The mechanism responsible for aging is further polymerization process of six-membered rings by deprotonation-dehydration reaction in which positively charged polynuclear hydroxy aluminum complexes formed in the presence of moisture are joined at their edges by double hydroxide bridges.