• Asian Pacific Journal of Cancer Prevention
• /
• 제13권11호
• /
• pp.5421-5426
• /
• 2012

A monosomal karyotype (MK), defined as ${\geq}2$ autosomal monosomies or a single monosomy in the presence of additional structural abnormalities, was recently identified as an independent prognostic factor conveying an extremely poor prognosis in patients with acute myeloid leukemia (AML). In the present study, after excluding patients with t(15;17), t(8;21), inv(16) and normal karyotypes, 324 AML patients with cytogenetic abnormalities were the main subject of analysis. The incidences of MK were 13% in patients aged 15 to 60 years and 18% in those between 15 and 88 years old. MK was much more prevalent among elderly patients (p < 0.001) and was significantly associated with the presence of -7, -5, del(5q), abn12p, abn17p, -18 or 18q-, -20 or 20q- and CK (for all p < 0.001 except for abn12p p=0.009), and +8 or +8q was less frequent in MK+ AML(p=0.007). No correlation was noted between monosomal karyotype and FAB subtype (p > 0.05); MK remained significantly associated with worse overall survival among patients with complex karyotype (p=0.032); A single autosomal monosomy contributed an additional negative effect in OS of patients with structural cytogenetic abnormalities (P=0.008). This report presents the prevalence, feature and prognostic impact of MK among a large series of Chinese AML patients from a single center for the first time.

• 유통과학연구
• /
• 제13권9호
• /
• pp.95-101
• /
• 2015

Purpose - This study provides evidence of the impact of the mandatory adoption of Korean equivalents to International Financial Reporting Standards (K-IFRS) on accounting quality. K-IFRS uses fair value as a basis of measurement and is characterized by principle-based standards. These characteristics can lead to a decrease in conservatism. Therefore, this study aims to examine whether or not there is a change in the level of conservatism before and after the enforcement of K-IFRS (2007~2014). By comparing 2007 through 2008 and 2013 through 2014 (excluding 2009 to 2012), we test "the temporary adjustment phenomenon" and document an overall decline in the degree of conservatism after the adoption of K-IFRS. Research design, data, and methodology - Our sample is comprised of data of all listed Korea Composite Stock Price Index (KOSPI) manufacturing distribution companies in Korea from 2007 to 2014, which yields the pooled sample of 4,412 (panel A) and 1,915 (panel B) firm-year observations for hypotheses 1 and 2. In line with recent literature, we adopt the Givoly and Hayn (2000) model, which recomputes the non-operating accruals, excluding two components that are most likely to capture the effect of restructuring activities: special items and gains or losses from discontinued operations. In addition, we also use these variables: SIZE, LEV, INV_CYCLE, ROA, OWN, and FOR. Results - Our sample period spans 2007 to 2014. This offers evidence on the effect of the mandatory adoption of IFRS on conservatism. Our findings can be summarized as follows. First, in panel A, for mandatory K-IFRS adoption (2011), we do not find any significant evidence of conservatism. We can guess that the "temporary adjustment phenomenon" is the reason that we do not find significant evidence of conservatism. Second, we investigate panel B from 2009 to 2012. We document an overall decline in the degree of conservatism after the adoption of K-IFRS. We can assume that these results are due to "the temporary adjustment phenomenon." Conclusions - This study finds that conservatism significantly decreased after IFRS adoption. In particular, this study makes the initial effort to elucidate "the temporary adjustment phenomenon" to analyze the effect of K-IFRS on conservative accounting. We argue that K-IFRS are conceptually conservative but that inappropriate application of the conservatism principles is likely to prevent financial reporting from reaching the level of conservatism targeted by the IASB. Overall, this paper contributes to the literature on IFRS and can be useful to capital market supervisors who are monitoring the trends of the firms implementing K-IFRS. Additionally, our results inform stakeholders of the potentially negative effect of the greater flexibility permitted by IFRS and/or lack of appropriate enforcement on key dimensions of accounting quality. This has important implications for Korean regulators and standard setters as they review the cost and benefits of IFRS. Our study also sheds light on the importance of the institutional environment in achieving the targeted objectives for improving financial reporting quality.

• Journal of Plant Biotechnology
• /
• 제45권2호
• /
• pp.90-101
• /
• 2018

Strawberry (Fragaria ${\times}$ ananassa) is a globally-cultivated and popular fruit crop, prized for its flavor and nutritional value. Sweetness, a key determinant of fruit quality, depends on the sugar composition and concentration. We selected eight strawberry cultivars based on the fruit soluble solids content to represent high and low sugar content groups. The average soluble solid content was $13.6^{\circ}Brix$ (Okmae, Geumsil, Aram, and Maehyang) and $2.9^{\circ}Brix$ (Missionary, Camino Real, Portola, and Gilgyung53), for the high and low sugar content groups, respectively. Sucrose was the main sugar in the cultivars with high sugar content, whereas fructose was the main component in the low sugar content cultivars. Fruit starch concentration ranged from $3.247{\pm}0.056$ to $3.850{\pm}0.055g/100g$, with a 12% higher concentration in the high sugar content cultivars. Additionally, we identified 41 sugar metabolism-related genes in Fragaria ${\times}$ ananassa and analyzed the relationship between their transcripts and the sugar accumulation in fruit. FaGPT1, FaTMT1, FaHXK1, FaPHS1, FaINVA-3, and FacxINV2-1 were highly expressed in the high sugar content cultivars, while FapGlcT, FaTMT2-1, FaPHS2-1, FaSUSY1-1, and FaSUSY1-2 were highly expressed in the low sugar content cultivars. In general, a greater number of genes encoding sugar transporters or involved in sugar synthesis were highly expressed in the high sugar content cultivars. Contrarily, genes involved in sugar degradation were preferentially transcribed in the low sugar content cultivars. Although gene expression was not perfectly proportional to sugar content or concentration, our analysis of the genes involved in sugar metabolism and accumulation in strawberries provides a framework for further studies and for the subsequent engineering of sugar metabolism to enhance fruit quality.

• 한국동물위생학회지
• /
• 제32권1호
• /
• pp.61-76
• /
• 2009

At the present study, it was aimed to explore the molecular genetic characterization of multiple antimicrobial resistant Salmonella spp. isolates from pigs and cattle. A total of 138 Salmonella Typhimurium (S. Typhimurium) isolates were typed with phage, among them, 83.3% of S. Typhimurium tested could divide into a 10 phage types. Definitive type 193 (DT193) (25.4%) and DT195 (24.6%) were exhibited as the dominant types. DT104 and U302 were found from pigs and cattle. On the other hand, S. Enteritidis had 6 phage types, of them, phage type 21 (PT21) and PT11b were the popular types. In the plasmid profiles, 135 of S. Typhimurium isolates were exhibited 1 to 6 plasmid bands which molecular weight ranged from 90 to 2kb. 35 isolates (25.4%) harbored a 90kb plasmid which is thought to be the serotype specific virulence plasmid. Two of twenty five S. Enteritidis had common plasmids at 2 and 1.5kb. With multiplex polymerase chain reaction, virulence genes (invA and spvC) were detected from all Salmonella spp. from 167 of S. Typhimurium, S. Enteritidis and chloramphenicol resistant S. Schwarzengrund, but some drug resistant genes, such as PSE-1, cml/tetR and flo were not determined but other drug resistant genes, for example TEM and int were found. The detection rates of spvC, TEM and int gene was 35.3%, 29.3% and 72.5%, respectively. The TEM gene was highly popular in S. Typhimurium, which was detected from ampicillin and amoxicillin resistant strains as 95.9%. int gene was able to detect from all the isolates identified as multidrug resistsnt (MDR), particularly DT193 was thought as the most prevalent virulence and multidrug resistance isolate. The major plasmid profile and drug resistance pattern of DT193 were 90, 40, 10.5, 6.3, 3.0kb and ACCbDNaPSSuT, respectively. MDR was commonly found in other phage types, particularly DT104, U302 and DT203.

• 한국해양생명과학회지
• /
• 제6권2호
• /
• pp.58-65
• /
• 2021

노화가 진행될수록 활성산소종으로 인하여 피부 보습은 떨어지고 피부 장벽은 붕괴되어 피부가 손상된다. 본 연구에서는 인천 동막 해변에 서식하는 염생식물인 갯끈풀(Spartina anglica; SAE)과 갯메꽃(Calystegia soldanella; CSE)을 70% 에탄올(EtOH)로 추출하여 피부 보습 및 피부 장벽 기능 강화에 대한 효능을 평가하였다. 이 추출물들에 대한 피부 각질형성세포(HaCaT cell)에서 세포독성을 WST-8 assay를 이용하여, 세포 생존율이 90% 이상을 보이는 농도를 선별하여 추가 실험을 진행하였다. ABTS 라디칼 소거능을 통해 항산화 효과를 확인한 결과, SAE와 CSE는 높은 라디칼 소거능을 보였다. 피부 보습과 관련된 인자들인 filaggrin (FGL), aquaporin 3(AQP3), hyaluronan synthase 2 (HAS2)과 피부 장벽 기능과 연관 있는 transglutaminase 1 (TGM1)과 involucrin (INV)의 유전자 수준에서의 발현 변화를 측정한 결과, SAE에 의해 AQP3, HAS2, TGM1의 발현이 증가하였으나, CSE는 변화가 없는 것을 확인할 수 있었다. SAE에 의한 세포 내 신호전달 경로를 확인하기 위해 western blot 분석을 수행하였다. Extracellular signal regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38 mitogen activated protein kinase의 활성이 SAE에 의하여 상향 조절되었음을 확인하였다. 이러한 결과는 갯끈풀 추출물이 피부 보습 및 피부 장벽 기능 강화를 위한 화장품의 기능성 소재로 사용될 수 있음을 시사한다.

• 대한화장품학회지
• /
• 제34권2호
• /
• pp.93-99
• /
• 2008

지금까지 (-)-epigallocatechin-3-gallate(EGCG)는 인간의 피부에 유용한 녹차 카테킨 중에서 가장 강력한 항산화 성분으로 알려져 왔다. 본 연구팀은 용매, 온도, 압력 등 다양한 조건을 변화시키며, 멸균과정(autoclaving) 중에 발생하는 이성질체화(epimerization) 과정을 연구하여, gallocatechin-3-gallate(GCG) 함량이 크게 증가된 열전환-EGCG-복합체(heat-epimerzied-EGCG-mixture, HE-EGCG-mix)를 순수한 EGCG로부터 조제 하였다. 이러한 열전환-EGCG-복합체는 무모쥐 SKH-1을 이용한 실험에서, 손상된 피부 장벽의 회복 시에 인보루크린 7(involucrin 7) 단백질의 발현량을 EGCG 처리 시보다 증가시킴을 확인하였다. 또한, in vitro 실험을 통하여 GCG는 $PPAR-{\alpha}$에 대한 전이활성(transactivation) 효과가 EGCG보다 뛰어남을 확인하였다. 이러한 결과는 열전환-EGCG-복합체에 함유된 고함량의 GCG 성분에 의해서, 피부 장벽 손상 회복 시 PPAR에 의해 매개된 각질형성세포(keratinocyte)의 분화가 더욱 촉진될 수 있음을 암시한다. 따라서, EGCG의 C-2 에피머(epimer)인 GCG는 녹차 카테킨을 이용한 피부 장벽 개선 용도의 화장품과 건강식품 개발 시 주요 소재로 활용될 수 있다.

• 대한전자공학회논문지SD
• /
• 제44권7호통권361호
• /
• pp.71-80
• /
• 2007

본 논문에서는 와이브로 (WiBro) 무선 인터넷 시스템의 보안 부계층 (Security Sub-layer)을 지원하는 와이브로 보안 프로세서 (WBSec)의 효율적인 하드웨어 설계에 관해 기술한다. 설계된 WBSec 프로세서는 AES (Advanced Encryption Standard) 블록암호 알고리듬을 기반으로 하여 데이터 암호 복호, 인증 무결성, 키 암호 복호 등 무선 네트워크의 보안기능을 처리한다. WBSec 프로세서는 ECB, CTR, CBC, CCM 및 key wrap/unwrap 동작모드를 가지며, 암호 연산만을 처리하는 AES 코어와 암호 복호 연산을 처리하는 AES 코어를 병렬로 사용하여 전체적인 성능이 최적화되도록 설계되었다. 효율적인 하드웨어 구현을 위해 AES 코어 내부의 라운드 변환 블록에 하드웨어 공유기법을 적용하여 설계하였으며, 또한 하드웨어 복잡도에 가장 큰 영향을 미치는 S-box를 체 (field) 변환 방법을 적용하여 구현함으로써 LUT (Look-Up Table)로 구현하는 방식에 비해 약 25%의 게이트를 감소시켰다. Verilog-HDL로 설계된 WBSec 프로세서는 22,350 게이트로 구현되었으며, key wrap 모드에서 최소 16-Mbps의 성능과 CCM 암호 복호 모드에서 최대 213-Mbps의 성능을 가져 와이브로 시스템 보안용 하드웨어 설계에 IP 형태로 사용될 수 있다.

• 마케팅과학연구
• /
• 제20권2호
• /
• pp.135-148
• /
• 2010

阿拉伯人联合抵制丹麦产品, 澳大利亚人联合抵制法国产品, 而中国人厌恶日本产品, 这些是国家间的敌对行为影响消费行为的案例. 敌意文献中已考查过消费者对其他国家敌对行为的反应, 以及这种敌意如何影响消费者对敌对国家产品的态度和倾向. 例如, 中国消费者不愿购买日本产品, 是由于日本人在第二次世界大战中的暴行, 以及不平等的经济往来(Klein, Ettenson and Morris 1998). 然而在市场营销文献中, 却没有考查过那些对他国实施敌对行为的国家消费者的反应, 这些敌对行为是否会影响他们购买受害国产品的态度. 社会心理学文献认为, 消费者面对这样的敌对行为时, 会产生一种集体犯罪感. 集体犯罪感源于当组织成员认为组织要对伤害其他组织的行为负责时所产生的痛苦感(Branscombe, Slugoski, and Kappenn 2004). 案例包括美国人由于美军在Abu Ghraib监狱的暴行而产生犯罪感(Iyer, Schamder and Lickel 2007), 荷兰由于过去对印度尼西亚的占领而产生犯罪感(Doosje et al. 1998). 本研究的主要目的是考查当国家成员对他国有敌对行为时消费者的感知, 这种感知是否会影响他们对敌对国家产品的态度. 更准确的说, 本研究的目标之一是考查集体犯罪感的感知前提, 以及当国家成员对他国有敌对行为时, 人们的情绪反应. 另一个目标是考查集体犯罪感如何影响消费者对敌对国产品的感知和倾向. 如果集体犯罪感能起到明显的预言作用, 敌对国双方的公司可能会从这类不幸的事件中受益. 本研究利用了由Klein, Ettenson and Morris (1998)提出并经Klein (2002)发展的敌意模式. Klein发现美国消费者对日本人怀有敌意, 起因是二战期间的事件(如日军偷袭珍珠港)和近年来日本的经济威胁. 因此本研究认为, 二战间的事件(如广岛长崎的原子弹爆炸)可能导致美国消费者的集体犯罪感. 曾有过一系列的三个假设, 第一个假设关于集体犯罪感的前提. 之前有研究认为当消费者感知到侵害造成的非法伤害, 并且认为侵犯者来自的国家应为此负责, 集体犯罪感就产生了(Wohl, Branscombe, and Klar 2006). 因此提出下列假设: 假设1a: 感知到的伤害非法性越高, 集体犯罪感越强烈. 假设1b: 责任越大, 集体犯罪感也肯定越强烈. 第二个和第三个假设关于集体犯罪感对倾向日本产品的影响. Klein (2002)发现对日本的敌意越强, 相比较韩国产品对日本产品的倾向越小, 但相比较美国产品对日本产品的倾向并未变小. 这些结果说明集体犯罪感存在时, 消费者在购买日本产品和韩国产品时会更倾向于前者, 但在购买日本产品和美国产品时并未受影响. 假设2: 集体犯罪感与购买日本产品的倾向大于韩国产品有关, 但与购买日本产品的倾向大于美国产品无关. 假设3: 集体犯罪感与购买日本产品的倾向大于韩国产品有关, 并且对产品的判断和敌意保持不变. 有过一个实验测试这个假设. 使被调查者面临发生在二战中的敌对事件, 从而产生非法伤害和责任. 该实验由一家美国的消费者调查小组收集数据, 将调查对象随机分配到低等级责任和违法情况(n=259)或高等级责任和违法情况(n=268). 测试假设关系时, 运用到潜在变量结构方程模式(LVSEM). 第一个假设得到了支持, 美国人因二战中对日本人的伤害而产生的伤害非法性和责任都对集体犯罪感有积极影响. 第二个假设也得到了支持, 集体犯罪感与购买日本产品的倾向大于韩国产品有关, 但与购买日本产品的倾向大于美国产品无关. 最后, 第三个假设也得到了支持, 集体犯罪感与购买日本产品的倾向大于韩国产品有关, 同时还影响人们对日本产品的判断和敌意. 由这些研究的结果可得出结论. 第一, 伤害的非法性和责任是集体犯罪感的前提. 第二, 当消费者面临来自敌对行为目标国家的产品和其他外国产品之间的选择时, 会受到集体犯罪感的影响. 但当他们面临来自敌对行为目标国家的产品和本国产品时, 不受集体犯罪感的影响. 这一结果意味着当竞争对手来自国外时, 利用集体犯罪感对那些受到敌对行为的国家的公司是可行的, 但当竞争对手来自国内时则不可行.