• 동의생리병리학회지
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• 제37권1호
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• pp.14-18
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• 2023

Jukyeo (竹茹; Bambusae Caulis in Taeniam: BCT) is an herbal medicine made from the inner part of the bamboo stem of Phyllostachys nigra Munro var. henonis Stapf ex Rendle or Phyllostachys bambusoides Siebold et Zuccarini. Although medical literature published in China and Korea decades ago introduced BCT as a remedy for reducing vomiting, fever, and hematemesis, decoctions containing BCT as a main herb (君藥) in Korea have been approved only for treating neurologic symptoms. Here, we discuss the anti-inflammatory function of BCT. Combined with the clinical usage of a BCT-containing decoction in treating inflammatory diseases in Japan, we raise the possibility of repurposing the BCT-containing decoctions for treating inflammatory diseases. The anti-inflammatory activity of BCT was mainly assessed by using RAW 264.7 cells. The regulation of NF-κB, Nrf2 and A20 activities was determined by western blot and quantitative RT-PCR. The list of decoctions containing BCT currently approved in Korea was obtained from the Korean Ministry of Food and Drug Safety (KFDA). BCT suppressed the activity of pro-inflammatory factor NF-κB elicited by LPS, activated an anti-inflammatory factor Nrf2, and induced A20 that is known to block several inflammatory pathways simultaneously, suggesting that BCT can suppress inflammation via at least 3 different pathways. KFDA approved 11 decoctions containing BCT as a major herb, including Gamiondam-tang (加味溫膽湯; GOT), for treating neurologic disorders. Interestingly, Jukyeoondam-tang (竹茹溫膽湯; JOT), whose composition is almost identical to GOT except for one herb, has been used to treat inflammatory pulmonary disorders including Covid-19 pulmonary infection in Japan Given the anti-inflammatory function of BCT evidenced by medical literature and experimental results and the clinical usage of JOT in treating inflammatory pulmonary disorders, we suggest a repurposing and extension of the BCT-containing decoctions approved in Korea to treating inflammatory diseases.

• 한국산림과학회지
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• 제85권3호
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• pp.347-359
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• 1996

이 연구(硏究)는 고속도로(高速道路) 절토(切土)비탈면에 1차적으로 도입된 식생의 생육상황(生育狀況)과 자연상태로 방치된 절토(切土)비탈면의 2차식생천이상황(次植生遷移狀況)을 파악하기 위하여 1989년과 1995년에 중부고속도로(中部高速道路)를 대상으로 실시되었다. 절토(切土)비탈면에 자연 침입하여 생육이 왕성한 초본류(草本類)는 참억새, 쑥, 솔새 등이었으며, 목본류(木本類)로는 산딸기, 아까시나무, 칡, 소나무 등이었다. 또한 녹화공법 적용 단계에서 파종된 식생중 외래목초류로는 Weeping lovegrass의 생육이 우세하였다. 절토(切土)비탈면에 평떼붙이기공법에 의해 적용된 잔디(Zoysia japonica)의 생육비율은 비탈면 조성후 유지관리(維持管理)가 수반되지 않은 상태에서는 현저하게 감소하거나, 침입식생에 의해 피압 소멸되었으며, 주변식생의 영향으로 천이가 진행되어 초본류(다년생초본(多年生草本), 1년생초본(年生草本))의 비율은 감소하였으며, 목본류(관목류(灌木類), 교목류(喬木類))의 출현비율이 증가하였다. 따라서 비탈면에 적용된 식생은 계속적인 유지관리(維持管理)가 수반되어야 하며, 녹화공법(綠化工法) 적용시 생활력(生活力)이 강한 초본류(草本類)(야생초화류(野生草花類) 포함) 및 목본류(木本類)의 도입이 요망된다.

• 원예과학기술지
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• 제28권5호
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• pp.871-876
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• 2010

자생허브 및 도입허브를 몇 가지 선발하여 추출물의 DPPH에 대한 전자공여능으로 항산화 활성과 배지 희석법으로 장내세균과 부패세균에 대한 항균활성을 분석하였다. 선발된 허브는 백리향, 구절초, 삼백초 등 7종의 자생허브와 로즈마리, 케모마일 등 4종의 도입허브로 삼백초를 제외한 대부분이 꿀풀과와 국화과에 속하였다. 또한 대부분이 다년초로서 실생과 삽목방법에 의해 번식하며, 7-10월에 걸쳐 개화하고 식용, 약용, 향료 등으로 이용되었다. DPPH를 이용한 전자공여능을 측정한 결과 자생허브는 69.7-78.7%의 범위에서 평균 74.21%를 나타냈으나 도입허브는 67.4-75.4%의 범위에서 평균 70.67%로 도입허브보다는 자생허브에서 3.54% 높았다. 자생허브 중에는 배초향 78.7%, 삼백초 77.8% 등의 전자공여능이 높았으며, 서양허브 중에는 케모마일이 75.4%로 가장 높았다. 장내세균과 부패세균에 대한 항균활성으로 Gram positive인 $Enterococcus$ $faecalis$에 항균활성 효과가 있는 허브 추출물은 구절초, 삼백초, 울릉미역취 등이었다. 이들 추출물은 50%이상 colony수 감소율을 나타냈으며, 그 중 삼백초 추출물이 $E.$ $faecalis$에 항균활성 효과가 80%로 가장 높았다. Gram negative인 $Citrobacter$ $freundii$에 항균 활성 효과가 있는 허브 추출물은 구절초, 울릉미역취, 배암차즈기, 감국, 로즈마리, 케모마일, 라벤더 등 7종이었다. 특히, 구절초와 케모마일은 $C.$ $freundii$에 항균활성 효과가 가장 높게 나타났는데, 구절초 추출물은 $10^2mg{\cdot}L^{-1}$에서 90.7%, $10^3mg{\cdot}L^{-1}$에서 99.45%의 colony수가 감소되었으며, 케모마일 추출물은 $10^2mg{\cdot}L^{-1}$에서 89.4%, $10^3mg{\cdot}L^{-1}$에서 99.1%의 colony수가 감소되는 결과를 얻었다. 또한 Gram negative인 $Escherichia$ $coli$에 항균활성 효과가 있는 허브 추출물은 백리향, 울릉미역취, 배암차즈기, 로즈마리, 라벤더 등 5종이었다.

• 대한본초학회지
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• 제27권4호
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• pp.33-44
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• 2012

Objectives : There is a pressing need to determine the clinical and scientific validity of herbal therapies for animal model with atopic dermatitis since some differences in systemic cytokine polarization between in animal model and in patients with atopic dermatitis has been reported. New studies for tang, medicinal herb itself or effective ingradients of medicinal herb showing anti-atopic dermatitis effectiveness are reviewed in terms of cytokine regulation. Methods : Those herbal therapies used to treat atopic dermatitis in animal model were introduced and the expression pattern of cytokine and the activity of mast cell were compared in both animal model and patients with atopic dermatitis. Results : In case of atopic dermatitis in human, there is a biphasic pattern of cytokine expression in atopic dermatitis, with acute skin inflammation associated with a predominance of IL-4 and IL-13 expression from Th2 cells, and chronic inflammation associated with increased IL-5 from Th2-cells and IFN-${\gamma}$ from Th1-cells. However, a pattern of cytokine expression in animal model with atopic dermatitis is not matched well to the biphasic pattern of cytokine expression in patients with atopic dermatitis. In addition, a kind of cytokine is different by animal model with atopic dermatitis. These differences would make herbal medicines, showing their effectiveness on atopic dermatitis, difficult to apply to patients with atopic dermatitis. Conclusion : The pattern of local cytokine expression plays an important role in modulating tissue inflammation, and in atopic dermatitis this pattern depends on the acuity or duration of the skin lesion. Thus, in order to develop medicinal herb itself or effective ingradients of medicinal herb showing anti-atopic dermatitis effectiveness, biphasic pattern of cytokine expression should be considered in animal model with atopic dermatitis.

• Journal of Microbiology and Biotechnology
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• 제27권5호
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• pp.975-982
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• 2017

Curcumin, a hydrophobic polyphenol derived from the rhizome of the herb Curcuma longa, possesses diverse pharmacological properties, including anti-inflammatory, antioxidant, antiproliferative, and antiangiogenic activities. Two curcuminoids (dicinnamoylmethane and bisdemethoxycurcumin) were synthesized from glucose in Escherichia coli. PAL (phenylalanine ammonia lyase) or TAL (tyrosine ammonia lyase), along with Os4CL (p-coumaroyl-CoA ligase) and CUS (curcumin synthase) genes, were introduced into E. coli, and each strain produced dicinnamoylmethane or bisdemethoxycurcumin, respectively. In order to increase the production of curcuminoids in E. coli, the shikimic acid biosynthesis pathway, which increases the substrates for curcuminoid biosynthesis, was engineered. Using the engineered strains, the production of bisdemethoxycurcumin increased from 0.32 to 4.63 mg/l, and that of dicinnamoylmethane from 1.24 to 6.95 mg/l.

• Journal of Biosystems Engineering
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• 제13권2호
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• pp.51-62
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• 1988

Bulk-type dryers which are widely used for drying special agricultural products such as tobaco leaf, red pepper, mushroom, ginseng, medicinal herb, etc, began to be distributed on a full scale since 1980 and the total number of dryers introduced to farms reached to about 36,600 units as of the end of 1986. In this study a survery was carried on the farmers cultivating special crops, dryer manufacturers and related administrative institutes and associations by means of on-the-spot investigation, mail or interview to collect data on scales and patterns of farming, utilization of bulk-type dryers, production and price streams of the special crops etc. Based on the analysis of the data surveyed predictions were made for the total demand on the bulk-type dryers and for annual demand over five-year span.

• 한국자원식물학회지
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• 제22권6호
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• pp.546-551
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• 2009

We examined the growth characteristics, fresh tuber yield, rotenone content of two yam beans (Pachyrhizus erosus and P. ahipa) introduced from Mexico. P. erosus species showed better adaptable ability than P. ahipa species in seed productivity and tuber yield. Rotenone content in the P. erosus species extracted with chloroform was 3.6 folds much more extracted than ethanol extraction. The order of rotenone content found in crude extract obtained by different solvent extraction from the highest to the lowest was mature seed (484.7 ${\mu}g$) and leaves (17.2 ${\mu}g$) of the P. erosus species, respectively.

• 한국농림기상학회지
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• 제4권2호
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• pp.86-94
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• 2002

본 연구의 목적은 폐광지의 환경 친화적인 식생 복원에 이용할 향토 수종 및 내성 수종을 선발하기 위하여 탄광 폐석지에 나타난 자연 이입종과 주변 산림 식생과의 연관성을 밝히는데 있다. 강원도 태백에 위치한 폐광지 주변 산림의 식생을 조사한 결과, 소도동의 교목층에서는 9종류, 아교목층에서는 13종류, 관목 층에서는 23종류 그리고 초본층에서는 23종류가 출현 하였다. 싸리재의 경우, 교목층에서는 6종류, 아교목층에서는 15종류, 관목층에서는 31종류 그리고 초본층에서는 25종류가 출현하였다. 1차 천이적인 단계에 있는 폐석지에서 출현한 종을 조사한 결과, 소도동에서는 31종류가 자연 이입종으로 나타났으며, 싸리재에서는 30종류가 출현하였다. 폐석지에서 출현한 종은 대조구인 소도동의 45종, 싸리재의 54종보다 훨씬 적었다. 탄광 폐석지와 주변 산림에서 공통으로 출현한 수종은 소도동의 경우 박달나무 등 6종, 싸리재의 경우 거제수나무 등 4종이었다. 즉 탄광 폐석지는 주변 산림의 상층림을 형성하고 있는 수종에서 종자가 이입되어 생존을 시도하고 있는 것으로 평가되었다. 특히 싸리재의 거제수나무는 주변 산림과 폐석지 경계부터 군집을 형성하고 있어 식생의 주변 효과를 나타냈으며, 소도동에서는 박달나무 등의 종자가 이입되어 자연적인 식생 복원이 이루어지고 있었다. 이러한 결과로 미루어 볼 때 교란된 지역에서의 식생 복원은 주변 산림 구 성종과 밀접한 관계가 있는 것으로 추정되었다.

• The Korean Journal of Physiology and Pharmacology
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• 제11권2호
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• pp.65-70
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• 2007

Chinese herb medicines have traditionally been used to treat or alleviate the symptom of various diseases. The rationale for use of certain herbs to certain disorder is now getting unveiled by modern technology. In the present study, we investigated whether herb mix extract(HMX), which is alleged to be useful for gastric ulcer, protects stomach from oxidative stress. Rats were allowed to normal diet with and without HMX (1, 5, 10 mg/kg) for 30 days. To induce gastric ulcer, ethanol (75%, 1.5 ml) or acidified aspirin (100 mg/kg in 0.2 N HCl) was administered by oral route in 24 h-fasted rats and examined the gastric ulceration(bleeding) by measuring the size 1 h after the treatment. Results indicated the area of gastric bleeding was significantly less in HMX fed rats than in normal diet fed ones, and it was dependent on the duration and amount of HMX. To investigate the underlying mechanism by which HMX protects stomach from oxidative stress, expression of enzymes like heme oxygenase (HO), cyclooxygenase (COX), and inducible nitric oxide (iNOS) were investigated in MKN-74 cells, where aspirin or H. pylori was introduced. The results were compared with RAW 264.7 cells to check if there's cell specificities exist. The expression of HO-1 but not COX-2, iNOS was significantly increased by HMX. Furthermore, HO-1 inhibitor, SnPP IX reduced the HO-1 activity and reversed the survival rate in HMX-treated MKN-74 cells. There's no difference between RAW 264.7 cells and MKN-74 cells. We, thus, concluded that HMX is beneficial for protection from oxidative injury, and induction of HO-1 by HMX in gastric cells is, at least, responsible for protection from oxidative stress such as ethanol, aspirin and possibly H. pylori infection.

• 식물분류학회지
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• 제48권1호
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• pp.43-47
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• 2018

Pimpinella saxifraga L. (Scarlet pimpernel or Burnet saxifrage), a newly introduced species, was found from Baekyakyi oreum (a parasitic cone or cinder cone) in Seogwipo, Jejudo Island. This species is native to Europe and western Asia and is reported as a widely invasive species around the world. Pimpinella saxifraga is distinguished from other related Korean taxa by leaves that are pinnately compound with 3-7 pairs of segments, which vary from simple, ovate, to 2-pinnatisect, with linear lobes. The vernacular name of "Baek-yak-yi-cham-na-mul" was assigned after the name of the cinder cone where it was initially discovered. We provide descriptions of the morphological characters, photographs and a key to allied taxa in Korea. The geographical origin and introduction routes are unknown, but it is highly likely that it was introduced as fodder given its high nutritious value for sheep and cattle or as a medicinal herb. This species invades commonly grasslands and woodlands and prefers dry, well-drained, and calcareous soils. The distribution of this species was analyzed by searching extensively in surrounding Baekyakyi oreum and adjacent cinder cones, but no other populations were observed. It is protected commonly at the edges or inside of the patchy pine forest in the cinder cone from grazing by cattle; given the worldwide invasive nature of this species, special monitoring and management plans should be developed.