• Journal of the Korea Society for Simulation
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• v.16 no.1
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• pp.21-29
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• 2007

In this paper, we present a method of detecting the boundary of the intima-media complex for automated measurement based on dynamic programming from carotid artery B-mode ultrasound images and then show the experimental results. We apply the dynamic programming for determining the optimal locations that a cost function is minimized. The cost function includes cost terms which are representing image features such as intensity, intensity gradient and geometrical continuity of the vessel interfaces. Moreover, we improve the boundary continuity by applying the B-spline to smooth the rough boundary due to noise such as speckle, dropout and weak edges. The proposed method has obtained more accurate reproducible results than conventional edge-detection by considering multiple image features and ensures efficient automated measurement by solving the problems of the inter- and intra-observer variability and its inefficiency due to manual measurement.

• The Journal of the Korea institute of electronic communication sciences
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• v.8 no.9
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• pp.1325-1332
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• 2013

The first frame of a GOP, an I frame, is encoded in intra mode which generates a larger number of bits. In addition, the I frame is used for the inter mode encoding of the following frames. Thus the intial QP for the I frame affects the first frame as well as the following frames. In our previous work, we analyzed the number of bits for an I frame and showed that the ratio of the number of bits which maximizes the PSNR of a GOP maintains similar value regardless of GOP's. In this paper, we propose a R-Q model which can be used for the calculation of the initial QP given the amount of bits for an I frame. The proposed model is simple and adaptively modifies model parameters, so it can be applicable to the real-time application. It is shown by experimental results that the proposed model captures initial QP characteristics effectively and the proposed method for model parameters accurately estimates the real values.

• Journal of the Korean Ceramic Society
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• v.44 no.7
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• pp.343-348
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• 2007

Alumina/silver nanocomposites were fabricated using a soaking method through a sol-gel route to construct an intra-type nanostructure. The pulse electric-current sintering (PECS) technique was used to sinter the nanocomposites. Several specimens were annealed after sintering. The microstructure, mechanical properties, critical frontal process zone (FPZ) size, and thermo-mechanical properties of the nanocomposites were estimated. The relative densities of the specimens sintered at 1350 and $1450^{\circ}C$ were 95% and 99%, respectively. The maximum value of the three-point bending strength was found to be 780 MPa for the $2{\times}2{\times}10 mm$ specimen sintered at $1350^{\circ}C$. The fracture toughness of the specimen sintered at $1350^{\circ}C$ was measured to be $3.60 MPa{\cdot}m^{1/2}$ using the single-edge V-notched beam (SEVNB) technique. The fracture mode of the nanocomposites was transgranular, in contrast to the intergranular mode of monolithic alumina. The fracture morphology suggested that dislocations were generated around the silver nanoparticles dispersed within the alumina matrix. The specimens sintered at $1350^{\circ}C$ were annealed at $800^{\circ}C$ for 5 min, following which the maximum fracture strength became 810 MPa and the fracture toughness improved to $4.21 MPam^{1/2}$. The critical FPZ size was the largest for the specimen annealed at $800^{\circ}C$ for 5 min. Thermal conductivity of the alumina/silver nanocomposites sintered at $1350^{\circ}C$ was 38 W/mK at room temperature, which was higher than the value obtained with the law of mixture.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.13 no.10
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• pp.2071-2078
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• 2009

The first frame is encoded in intra mode which generates a larger number of bits. In addition, the first frame is used for the inter mode encoding of the following frames. Thus the intial QP (Quantization Parameter) for the first frame affects the first frame as well as the following frames. Traditionally, the initial QP is determined among four constant values only depending on the bpp. In the case of low bit rate video coding, the initial QP value is fixed to 35 regardless of the output bandwidth. Although this initialization scheme is simple, yet it is not accurate enough. An accurate intial QP prediction scheme should not only depends on bpp but also on the complexity of the video sequence and the output bandwidth. In the proposed scheme, we use a linear model because there is a linear inverse proportional relationship between the output bandwidth and the optimal intial QP. Model parameters of the model are determined depending on the spatial complexity of the first frame. It is shown by experimental results that the new algorithm can predict the optimal initial QP more accurately and generate the PSNR performance better than that of the existing JM algorithm.

• Journal of Biomedical and Translational Research
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• v.19 no.4
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• pp.130-139
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• 2018

This study aimed to analyze a high-performance liquid chromatography (HPLC) separation using a pentafluorophenyl column of parent drug hydroxychloroquine (HCQ) and its active metabolite, desethylhydroxchloroquine (DHCQ) applying to determine bioequivalence of two different formulations administered to patients. A rapid, simple, sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for bioanalysis of HCQ and its metabolite DHCQ in human whole blood using deuterium derivative $hydroxychloroquine-D_4$ as an internal standard (IS). A triple-quadrupole mass spectrometer was operated using electrospray ionization in multiple reaction monitoring (MRM) mode. Sample preparation involves a two-step precipitation of protein techniques. The removed protein blood samples were chromatographed on a pentafluorophenyl (PFP) column ($50mm{\times}4.6mm$, $2.6{\mu}m$) with a mobile phase (ammonium formate solution containing dilute formic acid) in an isocratic mode at a flow rate of 0.45 mL/min. The standard curves were found to be linear in the range of 2 - 500 ng/mL for HCQ; 2 - 2,000 ng/mL for DHCQ in spite of lacking a highly sensitive MS spectrometry system. Results of intra- and inter-day precision and accuracy were within acceptable limits. A run time of 2.2 min for HCQ and 2.03 min for DHCQ in blood sample facilitated the analysis of more than 300 human whole blood samples per day. Taken together, we concluded that the assay developed herein represents a highly qualified technology for the quantification of HCQ in human whole blood for a parallel design bioequivalence study in a healthy male.

• Mass Spectrometry Letters
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• v.10 no.1
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• pp.38-42
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• 2019

Damaurone D belongs to the genus Rosa and is a traditional medicinal product used for the treatment of depression, inflammation, and infectious diseases. The purpose of this study was to develop a simple liquid chromatography-tandem mass spectrometry method for the detection of damaurone D in rat plasma and to demonstrate its application in pharmacokinetic studies. Damaurone D and berberine (internal standard) were extracted with acetonitrile using a protein precipitation method. Mass transition was monitored in multiple reaction monitoring mode at m/z $323.2{\rightarrow}267.0$ for damaurone D and m/z $336.1{\rightarrow}320.0$ for berberine in positive ion mode. Analytical validation was conducted by evaluating the specificity, linearity, accuracy, precision, matrix effect, extraction recovery, and stability. The calibration curves were linear over 2-1000 ng/mL. The intra- and inter-day precision and accuracy of quality control samples were 4.79-13.33% and 86.23-102.75%, respectively. The matrix effect and extraction recovery were 96.11-98.47% and 96.11-102.25%, respectively. In the pharmacokinetic study after intravenous administration of damaurone D at a dose of 3 mg/kg in rats, the area under the curve and clearance of damaurone D in rat plasma were $16750.26{\pm}2676.10min{\cdot}ng/mL$ and $182.44{\pm}31.36mL/min/kg$, respectively.

• Physical Therapy Korea
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• v.29 no.4
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• pp.262-268
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• 2022

Background: Virtual reality (VR) programs based on motion capture camera are the most convenient and cost-effective approaches for remote rehabilitation. Assessment of physical function is critical for providing optimal VR rehabilitation training; however, direct muscle strength measurement using camera-based kinematic data is impracticable. Therefore, it is necessary to develop a method to indirectly estimate the muscle strength of users from the value obtained using a motion capture camera. Objects: The purpose of this study was to determine whether the pedaling speed converted using the VR engine from the captured foot position data in the VR environment can be used as an indirect way to evaluate knee muscle strength, and to investigate the validity and reliability of a camera-based VR program. Methods: Thirty healthy adults were included in this study. Each subject performed a 15-second maximum pedaling test in the VR and built-in speedometer modes. In the VR speedometer mode, a motion capture camera was used to detect the position of the ankle joints and automatically calculate the pedaling speed. An isokinetic dynamometer was used to assess the isometric and isokinetic peak torques of knee flexion and extension. Results: The pedaling speeds in VR and built-in speedometer modes revealed a significantly high positive correlation (r = 0.922). In addition, the intra-rater reliability of the pedaling speed in the VR speedometer mode was good (ICC [intraclass correlation coefficient] = 0.685). The results of the Pearson correlation analysis revealed a significant moderate positive correlation between the pedaling speed of the VR speedometer and the peak torque of knee isokinetic flexion (r = 0.639) and extension (r = 0.598). Conclusion: This study suggests the potential benefits of measuring the maximum pedaling speed using 3D depth camera in a VR environment as an indirect assessment of muscle strength. However, technological improvements must be followed to obtain more accurate estimation of muscle strength from the VR cycling test.

• The Bulletin of The Korean Astronomical Society
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• v.38 no.2
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• pp.43.2-43.2
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• 2013

AGN are known for irregular variability on all time scales, down to intra-day variability with relative variations of a few percent within minutes to hours. In the shortest time scale of AGN activity, unexplored territory still exists: first, the existence of a shortest time scale of AGN activity and secondly the shape of high frequency end of AGN power spectrum. Also the spectral variations at the shortest timescale. Here, we present the preliminary results of AGN fast photometry performed with Korean VLBI Network(KVN). Observations were done in a 'anti-correlated' mode using two antennas, with always either one antenna pointing at the target. This results in an effective time resolution of 3 minutes. We used all four KVN frequencies, 22, 43, 86, and 129 GHz, in order to trace spectral variability. We have been able to derive high-quality light curves for 3C111 and 3C279 at 22 and 86 GHz observed on 31st of May and 30th of Nov. in 2012. We are currently performing detailed statistical analysis in order to assess the levels of variability or the corresponding upper limits.

• Korean Journal of Materials Research
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• v.26 no.5
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• pp.229-234
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• 2016

In this study, the degree of particle melting in $Y_2O_3$ plasma spraying and its effects on coating characteristics have been investigated in terms of microstructural features, microhardness and scratch resistance. Plasma sprayed $Y_2O_3$ coatings were formed using two different powder feeding systems: a system in which the powder is fed inside the plasma gun and a system in which the powder is fed externally. The internal powder spraying method generated a well-defined lamellae structure that was characterized by a thin porous layer at the splat boundary and microcracks within individual splats. Such micro-defects were generated by the large thermal contraction of splats from fully-molten droplets. The external powder spraying method formed a relatively dense coating with a particulate deposition mode, and the deposition of a higher fraction of partially-melted droplets led to a much reduced number of inter-splat pores and intra-splat microcracks. The microhardness and scratch resistance of the $Y_2O_3$ coatings were improved by external powder spraying; this result was mainly attributed to the reduced number of micro-defects.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2013.06a
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• pp.296-299
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• 2013

디스플레이 기술이 발전함에 따라 다양한 크기의 디스플레이를 탑재한 장치들이 등장하게 되었고, 다양한 디스플레이 크기만큼 다양한 해상도를 사용하고 있다. 때문에 비디오 코덱과 scaler는 보편적으로 함께 사용된다. 그러나 기존의 scaler는 비디오 코덱의 복호화기와 화면 해상도 변환 모듈이 독립적으로 구성되고, 서로 간에 정보를 이용하지 않으므로 시스템의 성능 개선에 한계가 존재하였다. 즉, 비디오 코덱의 복호화기는 비트스트림으로부터 복호한 정보를 바탕으로 영상을 복원하고, 복원영상은 up/down scaler에서 확대/축소를 수행한다. 하지만 비디오 코덱의 비트스트림에 존재하는 정보는 영상의 특성을 반영하기 때문에 up/down scaler에서 비디오 코덱의 복호화기에서 복호된 정보를 이용하면 복잡도의 증가 없이 효율적인 확대/축소를 수행할 수 있다. 이에 본 논문에서는 비디오 코덱 중 차세대 비디오 코덱인 H.264/AVC 복호화기에서 생성된 복원 영상에 대해서 별도로 영상의 특성을 계산하는 모듈 없이 H.264/AVC 복호화기에서 복원된 정보 중 인트라 모드 정보를 바탕으로 영상의 특성에 맞는 up/down scaler를 구현하는 방법을 제안한다. 이 방법은 기존의 scaler들보다 물체의 경계영역을 더 선명하게 확대하는 효과를 보인다.