• 대한수의학회지
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• 제37권1호
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• pp.59-69
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• 1997

The histological and histochemical study of the body of axis and 1st intervertebral disc in the Korean native cattle fetus was attempted to early developmental process. The experimental animals used in this study were collected from fetus of the Korean native cattle ranging from 50mm to 180mm in Crown-Rump length(CR-length). The results were summerized as follows: 1. The ossification centers appeared centrum 1 and centrum 2 of the axis in 110mm CR-length fetus of the Korean native cattle. The centrum 2 was formed little earlier than the centrum 1. 2. The histochemical reactions for collagenous fibers in the axis revealed negative in 50mm CR-length, mild positive in 90mm CR-length, and strong positive in 110mm CR-length, respectively. 3. Dense collagenous fibers were observed in the notochord through the centrum 2, and intervertebral disc developed into cuneiform dorsoventrally, It's contour looks like an annual ring. These fiber bundle arranged lamellar formation. 4. The intervertabral disc of 50mm CR-length fetus was composed mainly mesenchymal cells, and these cell showed aggregation in the central portion. The intervertebral disc of 110mm CR-length fetus was consisted of pricipally fibroblast, and notochordal sheath formed with two layers in the center.

• 한방재활의학과학회지
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• 제15권2호
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• pp.67-75
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• 2005

Objectives : Straight leg raising test(SLR) is useful clinical test to diagnose herniated lumbar intervertebral disc. The purpose of this study is to analyse diagnostic value of straight leg raising test between traffic accident patients group and non-traffic accident patients group. Methods : The study involved 26 traffic accident patients group and 45 non-traffic accident patients group with low back pain or radiating pain into the leg. All had a result of straight leg raising test and lumbar computed tomography(CT) or magnetic resonance imaging(MRI). The associations between straight leg raising test and herniated lumbar intervertebral disc were analysed. Results and Conclusions : 1. There is not significant associations between straight leg raising test and herniated lumbar intervertebral disc in traffic accident patients group. 2. There is significant associations between straight leg raising test and herniated lumbar intervertebral disc in non-traffic accident patients group. 3. In traffic accident patients group, and negative predictive value are higher than non-traffic accident patients group. 4. In non-traffic accident patients group, sensitivity, positive predictive value and odds ratios are higher than traffic accident patients-group.

• Journal of Korean Neurosurgical Society
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• 제30권2호
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• pp.144-149
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• 2001

Objective : Spinal nerve root compression occurs commonly in conditions, such as herniated nucleus pulposus, spinal stenosis, intervertebral foraminal stenosis, and trauma. However, the pathophysiolosy of the symptoms and signs related to spinal nerve root compression is poorly understood. The purpose of the present study was to assess and compare the changes of various pressures of intervertebral foraminal pressure before and after decompression. Method : After laminetomy without foraminotomy was performed, pressure sensor tip of Camino parenchymal type was located at the middle-central portion of the intervertebral foramen and anterior portion of nerve root for the foraminal pressure before decompression of the intervertebral foramen. After laminectomy with foraminotomy, the same method was used for the foraminal pressure after decompression. The authors studied 40 consecutive patients (57 disc spaces) with severe constant root pain to the lower leg, pain unrelived by bed rest, and minimal tension signs, diagnosed by MRI. Results : In patients with intervertebral foraminal stenosis, the intraforaminal pressure was decreased from $86{\pm}2.23mmHg$ to $17.1{\pm}1.51mmHg$ and in patients without stenosis, from $55.9{\pm}1.08mmHg$ to $11.9{\pm}1.25mmHg$. All patients below 20mmHg after decompression showed good outcome, but 4 cases who showed poor outcome had foraminal stenosis, posterolateral type of the herniated disc, and above 30mmHg of foraminal pressure after decompression. Conclusion : These findings suggest that if the foraminal pressure falls below 20mmHg after decompression, good outcome can be anticipated. Central type of the herniated disc shows better outcome compared to the posterolateral type.

• Anatomy and Cell Biology
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• 제56권3호
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• pp.382-393
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• 2023

Cell clusters are a histological hallmark feature of intervertebral disc degeneration. Clusters arise from cell proliferation, are associated with replicative senescence, and remain metabolically, but their precise role in various stages of disc degeneration remain obscure. The aim of this study was therefore to investigate small, medium, and large size cell-clusters. For this purpose, human disc samples were collected from 55 subjects, aged 37-72 years, 21 patients had disc herniation, 10 had degenerated non-herniated discs, and 9 had degenerative scoliosis with spinal curvature <45°. 15 non-degenerated control discs were from cadavers. Clusters and matrix changes were investigated with histology, immunohistochemistry, and Sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE). Data obtained were analyzed with spearman rank correlation and ANOVA. Results revealed, small and medium-sized clusters were positive for cell proliferation markers Ki-67 and proliferating cell nuclear antigen (PCNA) in control and slightly degenerated human discs, while large cell clusters were typically more abundant in severely degenerated and herniated discs. Large clusters associated with matrix fissures, proteoglycan loss, matrix metalloproteinase-1 (MMP-1), and Caspase-3. Spatial association findings were reconfirmed with SDS-PAGE that showed presence to these target markers based on its molecular weight. Controls, slightly degenerated discs showed smaller clusters, less proteoglycan loss, MMP-1, and Caspase-3. In conclusion, cell clusters in the early stages of degeneration could be indicative of repair, however sustained loading increases large cell clusters especially around microscopic fissures that accelerates inflammatory catabolism and alters cellular metabolism, thus attempted repair process initiated by cell clusters fails and is aborted at least in part via apoptosis.

• 대한기계학회논문집A
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• 제36권1호
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• pp.29-35
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• 2012

척추관 협착증은 감압술과 융합술 그리고 인공추간판 치환술 등이 있으며, 2000년대 중반부터는 인공추간판 치환술이 널리 시술되고 있다. 인공추간판의 연구는 추간판의 자유도 및 추체의 굴곡-신전, 측굴전, 축회전에 대한 해석이 핵심기술이지만, 시술 후 수년이 경과하여 발생하는 피로파손이 새롭게 큰 문제점으로 대두되고 있다. 따라서 인공추간판 연구는 슬라이딩 코어의 피로특성 및 내구성 향상에 집중되어야 한다. 본 연구에서는 세계적으로 가장 많이 사용되는 인공추간판 제품(SB Charit$\acute{e}$ III)을 기초로 유한요소모델을 제작하고, 슬라이딩 코어의 곡률반경과 마찰계수의 변화가 von-Mises 응력과 접촉압력에 미치는 영향을 평가하였다. 이와 같은 결과를 바탕으로 새로운 인공추간판 모델들 (Model-I, -II, -III)을 제안하고 일정수명 후 발생할 수 있는 슬라이딩 코어의 피로파손 거동에 대해 SB Charit$\acute{e}$ III의 결과와 비교 평가하였다.

• 척추신경추나의학회지
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• 제2권2호
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• pp.123-130
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• 2007

Objectives: The object of this study is to report a clinical effect of chuna manual theraphy for the soft herniated intervertebral cervical disc. Methods: The patient was treated by cervical traction technique which is one of the chuna manual theraphy with other conservative treatments including acupuncture, herbal mixture, bee-venom theraphy and TENS(Transcutaneous Electrical Nerve Stimulation). Visual analogue scale(VAS) have been used for result report. Results: After the cervical traction technique, the VAS was significantly improved. Conclusions: It is thought that the chuna manual theraphy might be effective to the patient with soft herniated intervertebral cervical disc.

• Journal of Acupuncture Research
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• 제18권1호
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• pp.226-236
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• 2001

Objects : To evaluate clinical efficiency of The A-Shi point for the herniated lumbar intervertebral disc. Methods : The patients who had a diagnosis of herniated lumbar intervertebral disc by lumber CT and MRI, and were observed from the twentieth March 2000 to the tenth Novemsber 2000, were divided into two classes ; the "A" group was 15 cases practiced with Acupuncture treatment used of A-Shi point and the twelve-Meridian, the "B"group 15cases only Acupuncture treatment used of twelve-Meridian, Results : the most type of low back pain was, the Gall bladder channel of Foot-souyang 15 cases (50%) and the Gall-Bladder Meridian Muscle was 45 cases the most in the existence part of A-Shi point On the result of treatment due to clinical symptoms, the "A" group was 57.9% as excellent and "B" group 19.8%. On the measurement of Lumber flexion, the "A" group proceed more excellent result than the "B group at the whole grade. Conclusion : These results suggest that The A-shi point was effective treatment of herniated intervertebral disc.

• Journal of Acupuncture Research
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• 제25권4호
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• pp.171-181
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• 2008

Purpose : In order to estimate clinical effects of Oriental Medicine Treatment with acupotomy therapy of herniated lumbar intervertebral Disc patient needed operation. Methods : From 17th April, 2008 to 17th April, 2008, 1 female patient diagnosed as herniated lumbar intervertebral Disc at L4/5(right postero-lateral extrusion type)was treated with general oriental medicine therapy(acupuncture, moxibustion, cupping, physical therapy, herbal medication) and acupotomy. Results : The patient's chief complaints - Low back pain, both buttock pain, Right. leg paresthesia were remarkably improved. Conclusions : This study demonstrates that oriental medical treatment with acuputomy therapy has notable effect in improving functional disability and symptoms of lumbar radiculopathy. as though we had not wide experience in this treatment, more research is needed.

• 한국임상수의학회지
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• 제41권1호
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• pp.1-7
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• 2024

The intervertebral disc is a crucial structure located between each vertebral body, except C1 and C2 and the fused sacral vertebrae, which provides cushioning and stability. However, sometimes these discs may bulge or extrude, causing painful conditions and various neurological problems such as ataxia, paresis, motor or sensorimotor paralysis. As a result, dogs affected by intervertebral disc disease (IVDD) can suffer a significant decrease in their quality of life. The main objective of this study was to provide comprehensive data on the body size of several IVDD-susceptible dog breeds commonly bred in South Korea, which could help develop supportive devices for IVDD patients. Using standardized measurements, the study aimed to design appropriate support tools, taking into account the mobility challenges faced by IVDD patients. The findings provide valuable data to improve the quality of life of patients with IVDD. In addition, it may lay the foundation for research to establish the correlation between body size and IVDD through future research.

• Journal of Korean Neurosurgical Society
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• 제44권5호
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• pp.327-333
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• 2008

Objective: The purpose of this study is to verify the usefulness of the rabbit model for disc degeneration study. Materials: The L1-L2, L2-L3, L3-L4. or L4-L5 lumbar intervertebral disc (IVD) of 9 mature male New Zealand White rabbits were injured by inserting a 16-gauge needle to a depth of 5 mm in the left anterolateral annulus fibrosus while leaving L5-L6 IVD uninjured. Three other rabbits also received intradiscal injections of rabbit disc cells transfected with adenovirus and bone morphogenetic protein-2 (ad-BMP-2) at L4-L5 in addition to injury by 16-gauge needle at the L1-L2 level. Using digitized radiographs, measurements of IVD height were made and analyzed by using the disc height index (DHI). Magnetic resonance imaging (MRI) scans of the injured discs, injected discs, and uninjured L5-L6 discs were performed at 15 weeks post surgery and compared with preoperative MRI scans. Results: All twelve rabbits showed consistent results of disc degeneration within 15 weeks following annular puncture. DHIs of injured discs were significantly lower than that of the uninjured L5-L6 discs (p<0.05). The mean value of disc degeneration grade of injured discs was significantly higher than that of uninjured discs (p<0.05). The injection of disc cell transfected with ad-BMP-2 did not induce disc regeneration at 15 weeks after injection. Conclusion: This study showed that the injured disc had a significant change in DHI on simple lateral radiograph and disc degeneration grade on MRI scans within 15 weeks in all rabbits. Rabbit annular puncture model can be useful as a disc degeneration model in vivo.