• 한국지반환경공학회 논문집
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• 제8권2호
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• pp.11-18
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• 2007

철도 연변 사면의 활동은 열차 노선의 사용성과 안전성에 상당한 영향을 미치고 있다. 따라서 사면안정 문제는 철도 노선 운용에 있어 큰 관심사항이다. 본 연구에서는 철도연변 사면의 활동이 발생하는 조건에서의 강우정보를 분석하였으며 침투해석과 한계평형해석을 통하여 강우를 고려한 사면의 안정성 분석 기법을 제시하고자 한다. 강우량 분석결과 사면활동이 발생하기까지 누적강우량은 150~500mm 사이에 분포하고 있었고 강우지속시간은 3~24시간으로 나타났다. 분석된 강우량을 바탕으로 무한사면 조건에서의 침투해석과 강체거동 분석을 수행하고 무한사면의 심도는 2m를 가정하였으며 다중의 파괴면은 2m 심도로부터 16.7cm 간격으로 모델링이 되었다. 한계파괴심도인 2m는 안전율이 수렴하는 심도이다. 해석결과 기존의 사면안정성 평가 기준에서 고려하고 있는 우기시 해석조건의 결과보다 현실적인 안전율을 보였다. 또한 누적강우량, 강우지속시간, 안전율을 축으로 하는 3차원 공간상에 안전율 변화 추이를 도시한 결과 강우를 고려한 사면의 안전성 분석 시 일반적으로 고려하는 강우강도 뿐만 아니라 누적강우량(강우지속시간) 또한 고려되어야 할 것으로 판단되었다.

• 대한토목학회논문집
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• 제3권2호
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• pp.127-135
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• 1983

옹벽(擁壁)의 안정해석(安定解析)에 있어, 신뢰도(信賴度)의 척도(尺度)로 종래(從來)의 안전율(安全率)(factor of safety) 대신 파괴확률(破壞確率)(probability of failure)이란 새로운 개념(槪念)을 도입(導入)하였다. 종래(從來)의 안정해석(安定解析)에 내포(內包)되어 있는 많은 불확실성(不確實性)(uncertainty)을 통계적(統計的) 처리(處理)에 의하여 합리적(合理的)으로 해석(解析)에 반영(反映)하고, simulation을 통하여 현실에 근사한 신뢰도(信賴度)(reliability)를 수치(數値)로 확인(確認)하였다. 흙의 강도정수(强度定數)(내부마찰각(內部摩擦角), 점착력(粘着力))는 일반(一般) Beta 분포(分布)를 따르는 확률변수(破率變數)로 취급(取扱)하였으며, 최우추정법(最尤推定法)에 의하여 구간(區間) [A, B]를 결정(決定)하였다. Rejection Method에 의해 Beta 분포(分布)를 따르는 난수(亂數)들을 생성(生成)하여 이에 대응(對應)하는 강도정수(强度定數)를 구(求)하는 방법(方法)을 제시(提示)하였다. 이렇게 하여 얻어진 강도정수(强度定數)를 써서, Monte Simulation 방법(方法)을 사용(使用)하여 다음과 같이 정의(定義)되는 옹벽(擁壁)의 파괴확률(破壞確率)을 구하였다. $$P_f=\frac{M}{N}$$ 여기서, N : simulation 여행(旅行) 회수(回數) M : simulation 결과(結果) 파괴회수(破壞回數) 상기(上記)한 해석방법(解析方法)에 따라 Computer Program을 개발(開發)하였으며, 예제(例題)를 개발(開發)된 Program으로 풀어 파괴확률(破壞確率)을 구하였다.

• 대한교통학회지
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• 제31권3호
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• pp.55-64
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• 2013

교통부문에서 온실가스 배출량은 주로 연료사용량에 의해 산정되었다(Tier 1 방식). 그러나 이 방법은 연료사용량을 측정할 수 없는 도로 구간에서 발생하는 배출량 산정에 사용되기 어렵다. 도로구간의 대기오염물질 배출량 또한 연료사용량에 의해 정확히 측정되어질 수 없는데 이는 대기오염물질 배출량이 속도, 차종, 차령, 유종 등의 함수이기 때문이다. 이러한 배경에서 본 연구의 목적은 ITS 정보를 이용하여 지역 간 도로에서 발생되는 이산화탄소와 질소산화물의 배출량을 Tier 3 수준으로 산정하는 방법론을 정립하는 것이다. 이 방법론은 집계단위가 작은 ITS 검지기 정보를 이용하기 때문에 배출계수의 오목한 형태에서 기인하는 과소추정의 오류를 피할 수 있는 장점을 갖는다. 제시된 방법론을 4개 사례 도로구간에 적용한 결과는 중차량의 속도관리가 이산화탄소 또는 질소산화물 배출량 관리에 매우 중요함을 시사하였다.

• Korean Journal of Radiology
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• 제24권8호
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• pp.761-771
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• 2023

Objective: To investigate the association among the electrode placement method, electrode type, and local tumor progression (LTP) following percutaneous radiofrequency ablation (RFA) for small hepatocellular carcinomas (HCCs) and to assess the risk factors for LTP. Materials and Methods: In this retrospective study, we enrolled 211 patients, including 150 males and 61 females, who had undergone ultrasound-guided RFA for a single HCC < 3 cm. Patients were divided into four combination groups of the electrode type and placement method: 1) tumor-puncturing with an internally cooled tip (ICT), 2) tumor-puncturing with an internally cooled wet tip (ICWT), 3) no-touch with ICT, and 4) no-touch with ICWT. Univariable and multivariable Cox proportional-hazards regression analyses were performed to evaluate the risk factors for LTP. The major RFA-related complications were assessed. Results: Overall, 83, 34, 80, and 14 patients were included in the ICT, ICWT, no-touch with ICT, and no-touch with ICWT groups, respectively. The cumulative LTP rates differed significantly among the four groups. Compared to tumor puncturing with ICT, tumor puncturing with ICWT was associated with a lower LTP risk (adjusted hazard ratio [aHR] = 0.11, 95% confidence interval [CI] = 0-0.88, P = 0.034). However, the cumulative LTP rate did not differ significantly between tumor-puncturing with ICT and no-touch RFA with ICT (aHR = 0.34, 95% CI = 0.03-1.62, P = 0.188) or ICWT (aHR = 0.28, 95% CI = 0-2.28, P = 0.294). An insufficient ablative margin was a risk factor for LTP (aHR = 6.13, 95% CI = 1.41-22.49, P = 0.019). The major complication rates were 1.2%, 0%, 2.5%, and 21.4% in the ICT, ICWT, no-touch with ICT, and no-touch with ICWT groups, respectively. Conclusion: ICWT was associated with a lower LTP rate compared to ICT when performing tumor-puncturing RFA. An insufficient ablation margin was a risk factor for LTP.

• 농업과학연구
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• 제43권4호
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• pp.650-655
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• 2016

Gears are components of transmission which transmit the power of an engine to a machine and offer numerous speed ratios, a compact structure, and high efficiency of power transmission. Gear train design in the automotive industry uses simulation software. However, PTO (Power Take-Off) gear design for agricultural applications uses the empirical method because of the wide range of load fluctuations in agricultural fields. The PTO is an important part of agricultural tractors which transmits the power to various tractor implements. Therefore, a simulation was essential to the optimal design of the PTO. When the PTO gear is optimally designed, there are many advantages such as low cost, reduced size, and light weight. In this study, we conducted the bending and contact safety factor simulation for the PTO gear of an agricultural tractor. The bending and contact safety factors were calculated on ISO 6336 : 2006 by decreasing the face widths of the PTO pinion and wheel gear from 18 mm at an interval of 1 mm. The safety factor of the PTO gear decreased as the face width decreased. The contact safety factors of the pinion and wheel gear were 1.45 and 1.53, respectively, when the face width was 18 mm. The simulation results showed that the face width of the PTO gear should be greater than 9 mm to maintain the bending and contact safety factors higher than 1. It would be possible to reduce the weight of the PTO gear for different uses and working conditions. This study suggests that the possibility of designing an optimal PTO gear decreases as its face width decreases.

• Asian Pacific Journal of Cancer Prevention
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• 제16권15호
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• pp.6569-6573
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• 2015

Objective: To evaluate the application value of serum CA19-9, CEA, CA125 and CA242 in diagnosis and prognosis of pancreatic cancer cases treated with concurrent chemotherapy. Materials and Methods: 52 patients with pancreatic cancer, 40 with benign pancreatic diseases and 40 healthy people were selected. The electrochemiluminescence immunoassay method was used for detecting levels of CA19-9, CEA and CA125, and a CanAg CA242 enzyme linked immunoassay kit for assessing the level of CA242. The Kaplan-Meier method was used for analyzing the prognostic factors of patients with pancreatic cancer. The Cox proportional hazard model was applied for analyzing the hazard ratio (HR) and 95% confidential interval (CI) for survival time of patients with pancreatic cancer. Results: The levels of serum CA19-9, CEA, CA125 and CA242 in patients with pancreatic cancer were significantly higher than those in patients with benign pancreatic diseases and healthy people (P<0.001). The sensitivity of CA19-9 was the highest among these, followed by CA242, CA125 and CEA. The specificity of CA242 is the highest, followed by CA125, CEA and CA19-9. The sensitivity and specificity of joint detection of serum CA19-9, CEA, CA125and CA242 were 90.4% and 93.8%, obviously higher than single detection of those markers in diagnosis of pancreatic cancer. The median survival time of 52 patients with pancreatic cancer was 10 months (95% CI7.389~12.611).. Patients with the increasing level of serum CA19-9, CEA, CA125, CA242 had shorter survival times (P=0.047. 0.043, 0.0041, 0.029). COX regression analysis showed that CA19-9 was an independent prognostic factor for patients with pancreatic cancer (P=0.001, 95%CI 2.591~38.243). Conclusions: The detection of serum tumor markers (CA19.9, CEA, CA125 and CA242) is conducive to the early diagnosis of pancreatic cancer and joint detection of tumor markers helps improve the diagnostic efficiency. Moreover, CA19-9 is an independent prognostic factor for patients with pancreatic cancer.

• Clinical and Experimental Reproductive Medicine
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• 제23권3호
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• pp.367-377
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• 1996

Genes on the long arm of Y chromosome, particularly interval 6, are believed to playa critical role in human spermatogenesis. The objective of this study was to validate a sequenced-tagged site(STS)-mapping strategy for the detection of Yq microdeletion and to use this method to determine the proportion of men with Yq microdeletions in idiopathic, obstructive, nonobstructive azoospermia, severe OATS and in normal males. We analyzed three STS markers mapped to interval 6 within long arm of the Y chromosome from 106 nonobstructive, 30 obstructive azoospermia, 15 severe OATS patients, and normal 42 males in Korean men. By PCR, we tested leukocyte DNA, for the presences of STS markers(DAZ, sY129 and sY134) and SRY gene as internal control. And PCR results were confirmed by Southern hybridization, and were investigated by SSCP analysis for DAZ gene mutation. None of 42 normal males and 30 obstructive azoospermia had microdeletions, Of the 15 severe OATS typed with DAZ, sY129 and sY134, 3(20.0%) patients failed to amplify 1 or more STS markers, and of the 106 nonobstructive azoospermia typed with DAZ, sY129 and sY134, 12(11.3%) patients failed to amplify 1 or more STS markers. From these results, high prevalence(12.4%) of Yq deletion(DAZ, sY129, sY134) in men with nonobstructive idopathic azoospermia and severe OATS were observed in Korean infertility patients. To avoid the infertile offspring by assisted reproductive technique using ICSI or ROSI, genetic diagnosis will be needed in IVF-ET program.

• Korean Journal of Radiology
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• 제24권5호
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• pp.384-394
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• 2023

Objective: Mammographic density is an independent risk factor for breast cancer that can change after neoadjuvant chemotherapy (NCT). This study aimed to evaluate percent changes in volumetric breast density (ΔVbd%) before and after NCT measured automatically and determine its value as a predictive marker of pathological response to NCT. Materials and Methods: A total of 357 patients with breast cancer treated between January 2014 and December 2016 were included. An automated volumetric breast density (Vbd) measurement method was used to calculate Vbd on mammography before and after NCT. Patients were divided into three groups according to ΔVbd%, calculated as follows: Vbd (post-NCT - pre-NCT)/pre-NCT Vbd × 100 (%). The stable, decreased, and increased groups were defined as -20% ≤ ΔVbd% ≤ 20%, ΔVbd% < -20%, and ΔVbd% > 20%, respectively. Pathological complete response (pCR) was considered to be achieved after NCT if there was no evidence of invasive carcinoma in the breast or metastatic tumors in the axillary and regional lymph nodes on surgical pathology. The association between ΔVbd% grouping and pCR was analyzed using univariable and multivariable logistic regression analyses. Results: The interval between the pre-NCT and post-NCT mammograms ranged from 79 to 250 days (median, 170 days). In the multivariable analysis, ΔVbd% grouping (odds ratio for pCR of 0.420 [95% confidence interval, 0.195-0.905; P = 0.027] for the decreased group compared with the stable group), N stage at diagnosis, histologic grade, and breast cancer subtype were significantly associated with pCR. This tendency was more evident in the luminal B-like and triple-negative subtypes. Conclusion: ΔVbd% was associated with pCR in breast cancer after NCT, with the decreased group showing a lower rate of pCR than the stable group. Automated measurement of ΔVbd% may help predict the NCT response and prognosis in breast cancer.

• 지구물리와물리탐사
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• 제19권3호
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• pp.136-144
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• 2016

탄성파 자료의 역산은 파동방정식에 기초하고 있으므로 파동방정식의 해를 정확하게 구하는 것이 가장 중요하다. 특히, 전파형역산은 파동장 전체를 이용하기 때문에 정문제에 해당하는 모델링이 정확하게 이루어져야 신뢰할 수 있는 결과를 얻게 된다. 파동방정식의 수치해를 구하는 대표적인 기법인 유한차분법과 유한요소법은 해의 수렴성을 보장할 수 있어야 하는데, 해의 수렴성은 이론적으로 일반화된 증명이 되어 있으나 실제 문제에 적용할 경우 일관성과 안정성을 분석해야 한다. 모델링 결과의 일관성은 송신원 함수의 구현이 매우 중요한 부분인데, 유한차분법은 디랙 델타 함수(Dirac delta function)를 나타낼 때 격자 간격으로 표준화된 싱크 함수(sinc function)를 사용해야 하는 반면 유한요소법은 격자 간격에 관계없이 기저함수 값을 사용하면 된다. 주파수 영역 파동방정식을 사용할 경우 송신 파형 함수의 스펙트럼을 정확하게 표현하기 위해 샘플링 이론으로 정의되는 시간 간격보다 더 조밀한 샘플링 간격을 사용하고 나이퀴스트(Nyquist) 주파수보다 더 높은 주파수를 최대 주파수로 사용해야 한다. 또한, 복소 각주파수를 사용하는 경우 감쇠 파동방정식을 만족하기 위해서는 송신 파형 함수를 먼저 감쇠한 후 사용해야 한다. 이러한 요건들이 모두 만족되었을 때 신뢰할 수 있는 역산 알고리즘 개발이 가능하다.

• Structural Engineering and Mechanics
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• 제37권4호
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• pp.427-442
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• 2011

In fatigue life design of mechanical components, uncertainties arising from materials and manufacturing processes should be taken into account for ensuring reliability. A common practice is to apply a safety factor in conjunction with a physics model for evaluating the lifecycle, which most likely relies on the designer's experience. Due to conservative design, predictions are often in disagreement with field observations, which makes it difficult to schedule maintenance. In this paper, the Bayesian technique, which incorporates the field failure data into prior knowledge, is used to obtain a more dependable prediction of fatigue life. The effects of prior knowledge, noise in data, and bias in measurements on the distribution of fatigue life are discussed in detail. By assuming a distribution type of fatigue life, its parameters are identified first, followed by estimating the distribution of fatigue life, which represents the degree of belief of the fatigue life conditional to the observed data. As more data are provided, the values will be updated to reduce the credible interval. The results can be used in various needs such as a risk analysis, reliability based design optimization, maintenance scheduling, or validation of reliability analysis codes. In order to obtain the posterior distribution, the Markov Chain Monte Carlo technique is employed, which is a modern statistical computational method which effectively draws the samples of the given distribution. Field data of turbine components are exploited to illustrate our approach, which counts as a regular inspection of the number of failed blades in a turbine disk.