• Journal of Hospice and Palliative Care
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• 제17권1호
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• pp.18-26
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• 2014

목적: 식욕부진은 호스피스 암환자의 흔한 증상이며 여러 문헌에서 먹는 행동(feeding behavior)을 조절하는데 있어 visfatin의 가능성을 제시하고 있다. 본 연구에서는 말기암환자에서 증가한 visfatin 농도가 식욕조절과 영양상태 항상성 조절에 관여할 것이라 가설을 세웠다. 방법: 2009년 7월부터 2010년 7월까지 13개월 동안, 만 20세 이상의 말기암환자 69명을 대상으로 혈장 visfatin 농도를 측정하였다. 나이, 성별, 체질량 지수, 활력 징후, 원발암 부위, 암 치료 경력, 투약상황, ECOG(Eastern Cooperative Oncology Group) 수행지수, 혈색소, 백혈구 수, C-반응성 단백질, 총 콜레스테롤, 알부민, 림프구수, 혈당, 혈액요소질소, 크레아티닌, TNF-${\alpha}$ (tumor necrosis factor-alpha), Interukin-6, 렙틴 등의 혈액검사를 시행하였다. 결과: 대상자의 평균 나이는 65.5세였고 단변량 분석상 맥박, ECOG 수행 지수, opioid 사용여부, visfatin 농도에 따라 식욕부진이 있는 군과 없는 군의 차이를 보였다. Visfatin 농도는 단변량 분석결과 식욕부진과 관련이 있는 것으로 나타났으나(P=0.0323) 식욕부진에 영향을 주는 인자들을 보정한 다중 로지스틱 회귀 분석 결과에서는 통계학적인 관련성이 사라졌다. 영양지표들 중 체질량 지수, 렙틴, 총 콜레스테롤과는 관련이 없었으나 림프구수(P=0.0198) 혈중 albumin 농도(P=0.0013)와 중간 정도의 음의 관련성을 나타냈다. 결론: 호스피스 암환자에서 visfatin과 식욕부진의 관련성은 통계적으로 유의하지 않았다. 향후 기전에 대한 연구와 전향적 연구가 필요할 것으로 생각된다.

• 치위생과학회지
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• 제21권1호
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• pp.45-51
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• 2021

Background: Periodontal disease, also known as gum disease, is a major dental inflammatory disease with a very high prevalence; it is the main cause of tooth loss. Therefore, diagnostic biomarkers that can monitor gum inflammation are important for oral healthcare. Since the gingival crevicular fluid (GCF) adequately reflects changes in the periodontal environment, they have become a target for the development of effective diagnostic biomarkers for periodontitis. In the present study, the level of the target molecules suggested as diagnostic biomarkers for periodontitis were analyzed in GCF samples collected from healthy individuals and periodontitis patients. In addition, useful targets for the diagnosis of periodontitis were evaluated. Methods: GCF samples were collected from healthy individuals and periodontitis patients using absorbent paper points. SDS-PAGE and Coomassie staining were performed for protein analysis. The protein concentrations of GCF specimens were determined using the Bradford method. The levels of the target molecules appropriate for diagnosing periodontal disease were measured by ELISA, according to the manufacturer's protocol. Results: The protein concentration of GCF collected from periodontitis patients was 3.72 fold higher than that in an equal volume of GCF collected from healthy individuals. ELISA analysis showed that the level of interukin-6 (IL-6), IL-8, metalloproteinases 2 (MMP-2), MMP-9, tumor necrosis factor-alpha (TNF-α), azurocidin, and odontogenic ameloblast-associated protein (ODAM) were higher in the GCF samples from the periodontitis patients than in those from the healthy individuals. However, the level of IL-6 and TNF-α were relatively low (> 5 pg/ml). The prostaglandin E2 (PGE2) levels were not significantly different between the two GCF samples. Conclusion: These results indicate that IL-8, MMP-2, MMP-9, azurocidin, and ODAM are potentially useful diagnostic biomarkers for periodontitis; combining multiple biomarkers will improve the diagnostic accuracy of periodontitis.

• 대한통합의학회지
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• 제8권1호
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• pp.159-168
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• 2020

Purpose : To provide data on exercise prescription for obesity management and prevention of cardiovascular disease in girl's high school and to prepare basic data for more effective exercise program for lifestyle improvement and prevention of lifestyle-related diseases. This study examines the effects on brain nerve growth factor and inflammatory factors, and the relationship between obesity factor and brain neuron cell production factor and inflammatory factor changes by complex exercise. Methods : The subjects of the study were obese students with a body fat percentage of 30 % or higher after obtaining body fat percentage of high school girls in C-city. Among them, 20 students who wanted to participate in the program of this study and did not participate in special exercise and diet therapy within the last 6 months were radio-sampled into groups of exercise group and control group, but attendance rate was low and The final exercise group (9) and control group (9) were measured, except for one student who did not respond. Results : Analysis of the range of variation in body composition, BMI, lean body mass, and the interaction between the groups showed significant differences (p<.05). TC, TG, HDL-C, and LDL-C as variables of blood lipids, TC and TG were not significantly different and TG was significantly different (p<.05) in interactions. HDL-C showed a significant difference (p<.01) in interactions, an increase in exercise group, and a significant decrease in control group (p<.05). There was a significant difference (p<.05) in BDNF interaction, an increase in the exercise group and a decrease in the control group, but no significant difference. NGF tended to increase in both exercise and control groups. IL-6 had a significant difference in timing (p<.05) and significantly decreased (p<.01) in the exercise group, and TNF-α interacted with timing (p<.05), and a significant increase in the control group. Conclusion : This study confirmed 12-week compound exercise program was effective in increasing the expression of basal fitness or CNS factor, but not enough to actually improve brain function. Fat mass and obesity are also affecting vascular inflammatory factors.