• Phonetics and Speech Sciences
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• v.7 no.3
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• pp.55-64
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• 2015

Previous research on syntactic processing shows that the interpretation of a syntactically ambiguous sentence is frequently strongly biased towards one meaning over another. The current study investigated the effect of bias strength on the production of disambiguating prosody for English ambiguous sentences. In Experiment 1, 40 speakers gave default readings of 18 syntactically ambiguous sentences. Questioning was used to prove intended meanings behind default readings. Intended meanings were treated as interpretation biases when a majority of speakers read a sentence with the same intended meaning. The size of the majority was used to establish bias strength. In Experiment 2, 10 speakers were instructed to use prosody to disambiguate given alternate meanings of the sentences from Experiment 1. The results indicated an effect of bias strength on disambiguating prosody: speakers used temporal juncture cues to reliably disambiguate alternate meanings for sentences with a weak interpretation bias, but not for those with a strong bias. Overall, the results indicated that interpretation biases strongly affect the production of prosody.

• Genomics & Informatics
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• v.5 no.3
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• pp.113-117
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• 2007

The development of microarray technology has facilitated the understanding of gene expression profiles. Despite its convenience, the cause of dye-bias that confounds data interpretation in dual-color DNA microarray experiments is not well known. In order to economize time and money, it is necessary to identify the cause of dye bias, since designing dye-swaps to reduce the dye-specific bias tends to be very expensive. Hence, we sought to determine the reliable cause of systematic dye bias after treating murine macrophage RAW 264.7 cells with 2-keto-3-deoxyoctonate (KDO), interferon-beta $(IFN-{\beta})$, and 8-bromoadenosine (8-BR). To find the cause of systematic dye bias from the point of view of fluorescence quenching, we examined the correlation between systematic dye bias and the proportion of each nucleotide in mRNA and oligonucleotide probe sequence. Cy3-dye bias was highly correlated with the proportion of adenines. Our results support the fact that systematic dye bias is affected by fluorescence quenching of each feature. In addition, we also found that the strength of fluorescence quenching is based on not only dye-dye interactions but also dye-nucleotide interactions as well.

• Journal of The Korean Society of Integrative Medicine
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• v.11 no.2
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• pp.231-242
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• 2023

Purpose : This study aimed to identify ways to improve the quality of physical therapy research and ultimately review the current situation to improve evidence-based decision-making in physical therapy. Methods : For better evidence-based decision-making in physical therapy, researchers should review the quality assessment of articles in more detail and report their findings for valid and appropriate level of evidence and strength of recommendations. The level of evidence affects how well the findings are derived from well-designed literature. The evaluation of the evidence focuses primarily on the study design and the degree of bias that may compromise the validity of the findings. The final recommendation is based on a combination of the study design and literature quality. To uncover gems of information in each paper, a risk of bias assessment should be performed after the literature has been initially selected. Results : Researchers should consider the complexity of the intervention, appropriate grouping, and calculation of effect sizes for the intervention. Researchers conducting systematic reviews should provide a detailed description of the quality assessment performed and present a detailed analysis of their interpretation of the results. The results of systematic reviews and meta-analyses should be interpreted with caution and include a risk of bias assessment. Guidelines for the level of evidence and strength of recommendations should be developed and utilized more broadly to improve reporting practices in physical therapy. Conclusion : Researchers should be knowledgeable about the strengths and limitations of each study design and methodology. In the future, researchers will also need to improve their ability to critically evaluate their findings, given the potential for their results to influence clinical practice.