• 동남아시아연구
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• 제21권2호
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• pp.183-216
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• 2011

이 글은 잠재적 이주노동자들이 거버넌스에 중요성을 부여하는 정도가 이주의도가 없는 경우와 비교하여 어떻게 다른지를 필리핀의 자료를 이용하여 분석한 연구이다. 2011년 기준으로 전 세계 인구의 3.2퍼센트가 국제이주자이며 이들이 본국에 보내는 노동송금은 4천 4백억 달러에 달한다. 기존연구에서 파악하듯 세계인구이동의 대부분을 차지하는 노동이주의 주요 결정요인은 출신국과 이주대상국의 소득격차, 기존 이주 네트워크, 이주대상국의 이주정책 등을 포함한 경제적 요인들이다. 그러나 대규모 송출국들이 대부분 경제적 저발전과 취약한 정부(ineffective government)의 구조적인 문제를 함께 가지고 있다는 점에 착안한다면 비록 경제적 고려가 우선시 되는 노동이주에 있어서도 잠재적 이주자들이 "정치적" 으로 여타의 사회와 구분되는 특수한 정치적 태도를 가질 수 있다고 생각할 수 있다. 이주자들의 정치적 태도를 올바르게 이해하는 것은 노동이주가 송출국에 미치는 정치적 영향을 분석하는 데 있어 매우 중요하다. 해당 이주자들의 부재와 이들이 본국으로 보내는 노동송금이 송출국 정치에 영향을 미칠 수 있는데 그 영향의 방향은 이주자의 기본적인 정치적 관심과 의제에 따라 달라질 것이기 때문이다. 이러한 배경에서 이 글은 다음과 같은 연구 질문에 답하고자 한다. 첫째, 이주노동의사가 있는 시민들이 취약한 정부능력에 대한 염려가 그렇지 않은 경우보다 높은가? 둘째, 이러한 관계가 성립된다면 그 관계는 민주주의에 대한 지지를 저해하는가? 이 연구는 2002년과 2003년 필리핀에서 실시된 전국적 설문조사인 Social Weather Survey 자료와 2008년 및 2009 년 필리핀 현지조사에서 수집한 인터뷰와 2차 자료를 근거로, 정부능력에 대한 평가와 이주노동의사의 관계를 분석하였다. 연구결과, 기존 연구가 제시하는 통제변인들을 감안하더라도 효과적인 정부운영이 필리핀이 당면한 가장 중요한 과제라고 생각할수록 해외로 취업할 것을 고려할 가능성이 높은 것으로 나타났다. 또한 다행히도 이러한 태도가 민주주의에 대한 원칙적인 지지에는 영향을 미치지 않는 것으로 드러났다. 그러나 효과적인 정부에 대한 관심이 이주노동을 고려하는 시민들에게 높다는 사실은 장기적으로 이들이 해외로 이주할 경우 정부개혁을 요구하고 추진할 국내적 정치적 기반이 줄어들 수 있다는 부정적 함의를 가지기도 한다.

• 영어영문학
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• 제55권6호
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• pp.1035-1056
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• 2009

Korean adoptee narratives have proliferated over the last ten years as adopted Koreans have begun to represent their own experiences of violent dislocation, displacement and loss in various forms of literary and artistic works, including poems, autobiographical works, novels, documentaries and films. These narratives by Korean adoptees have intervened in the current diaspora discourse to question further the traditional categories of race, ethnicity, culture and nation by representing the unique experiences of the forced and involuntary migration of adopted Koreans. For a long time, the adoption discourse has been mostly constructed from the perspectives of adoptive parents. Therefore the voice of adoptees as well as that of the birth mothers have not been properly heard or represented in adoption discourse. According to Hosu Kim, the U. S. adoption discourse, feeling pressured to deal with the stigma of the commodification of children, changed from viewing the adoptees as children who had been rescued from poverty and abandonment to considering them as a gift from the birth mothers. With the emergence of the gift rhetoric in transnational adoption, the birth mothers erased from adoption discourse have begun to be acknowledged as one of the central characters in the adoption triad. If Korean adoptees are the "the ghostly children of Korean history," the birth mothers are their "ghostly doubles" who "bear the mark of a repressed national trauma." Somebody's Daughter represents the female experiences of becoming an adopted child and of being a birth mother. In particular, the novel makes a birth mother, the forgotten presence in adoptee narratives, into a central figure in the triangular relationship created by international adoption. The novel historicizes the experiences of a Korean adoptee growing up in America as well as those of a mother who had suffered silently from feelings of unbearable loss, guilt, grief and from unforgettable memories. In addition, narrating the birth mother's story is a way to give humanity back to these forgotten women in Korean adoption history. Revisiting the site of loss both for a mother and a daughter through the novel is an act of collective mourning. The narratives about and by Korean adoptees force Korean intellectuals to reflect seriously upon Korean society and its underlying ideology which prevents a woman from mothering her own baby, and to take an ethical and political stand on this current social and political issue.

• International Journal of Oral Biology
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• 제46권2호
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• pp.85-93
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• 2021

Asarum sieboldii Miq. (Aristolochiaceae) is a perennial herbaceous plant and has been used as traditional medicine for treating diseases, cold, fever, phlegm, allergies, chronic gastritis, and acute toothaches. Also, it has various biological activities, such as antiallergic, antiinflammatory, antinociceptive, and antifungal. However, the anticancer effect of A. sieboldii have been rarely reported, except anticancer effect on lung cancer cell (A549) of water extracts of A. sieboldii. This study investigated the anticancer activity of methanol extracts of A. sieboldii (MeAS) and the underlying mechanism in human FaDu hypopharyngeal squamous carcinoma cells. MeAS inhibited FaDu cells grown dose-dependently without affecting normal cells (L929), as determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide and live and dead assay. In addition, concentration of MeAS without cytotoxicity (0.05 and 0.1 mg/mL) inhibited migration and colony formation. Moreover, MeAS treatment significantly induced apoptosis through the proteolytic cleavage of caspase-3, -7, -9, poly (ADP-ribose) polymerase, and downregulation of Bcl-2 and upregulation of Bax in FaDu cells, as determined by fluorescence-activated cell sorting analysis, 4'6-diamidino-2-phenylindole stain, and western blotting. Altogether, these results suggest that MeAS exhibits strong anticancer effects by suppressing the growth of oral cancer cells and the migration and colony formation via caspase- and mitochondrial-dependent apoptotic pathways in human FaDu hypopharyngeal squamous carcinoma cells. Therefore, MeAS can serve as a natural chemotherapeutic for human oral cancer.

• 한국환경과학회지
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• 제30권3호
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• pp.195-206
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• 2021

Contaminated marine sediment is a secondary pollution source in the coastal areas, which can result in increased nutrients concentrations in the overlying water. We analyzed the nutrients release characteristics into overlying water from sediments and the interaction among benthic circulation of nitrogen, phosphorus, iron, and sulfur were investigated in a preset sediment/water column. Profiles of pH, ORP, sulfur, iron, nitrogen, phosphorus pools were determined in the sediment and three different layers of overlying water. Variety types of sulfur in the sediments plays a significant role on nutrients transfer into overlying water. Dissimilatory nitrate reduction and various sulfur species interaction are predominantly embodied by the enhancing effects of sulfide on nitrogen reduction. Contaminant sediment take on high organic matter, which is decomposed by bacteria, as a result promote bacterial sulfate reduction and generate sulfide in the sediment. The sulfur and iron interactions had also influence on phosphorus cycling and released from sediment into overlying water may ensue over the dissolution of ferric iron intercede by iron-reducing bacteria. The nutrients release rate was calculated followed by release rate equation. The results showed that the sediments released large-scale quantity of ammonium nitrogen and phosphate, which are main inner source of overlying water pollution. A mechanical migration of key nutrients such as ammonia and inorganic phosphate was depicted numerically with Fick's diffusion law, which showed a fair agreement to most of the experimental data.

• 국제지역연구
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• 제13권1호
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• pp.17-38
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• 2009

이 연구의 목적은 이주민과 HIV/AIDS에 대한 한국정부의 정책과 대응방식 및 이것들의 법적인 근거를 밝히고 그러한 법과 규제가 HIV/AIDS의 확산을 방지하는 데 지니는 효과성을 검토하는데 있다. 이러한 목적을 위해 이 연구는 광범위한 문헌연구와 한국, 일본, 대만, 홍콩, 중국, 몽골을 포함한 동아시아 국가들의 관련 정부 당국자, 전문가, 비정부조직 지도자들을 상대로 심층면접을 실시했다. 연구의 결과는 한국이 HIV감염 외국인의 입국과 체류를 어떻게든지 금지시키는 매우 엄격한 정책을 유지하고 강력한 규칙과 규제를 시행하고 있음을 보여준다. 이와 관련해 이 연구는 이러한 한국정부의 이주민 HIV/AIDS정책이 제기할 수 있는 논란과 문제를 공중보건과 인권의 측면에서 논의한다.

• International Journal of Stem Cells
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• 제16권1호
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• pp.93-107
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• 2023

Background and Objectives: Chronic periodontitis can lead to alveolar bone resorption and eventually tooth loss. Stem cells from exfoliated deciduous teeth (SHED) are appropriate bone regeneration seed cells. To track the survival, migration, and differentiation of the transplanted SHED, we used super paramagnetic iron oxide particles (SPIO) Molday ION Rhodamine-B (MIRB) to label and monitor the transplanted cells while repairing periodontal bone defects. Methods and Results: We determined an appropriate dose of MIRB for labeling SHED by examining the growth and osteogenic differentiation of labeled SHED. Finally, SHED was labeled with 25 ㎍ Fe/ml MIRB before being transplanted into rats. Magnetic resonance imaging was used to track SHED survival and migration in vivo due to a low-intensity signal artifact caused by MIRB. HE and immunohistochemical analyses revealed that both MIRB-labeled and unlabeled SHED could promote periodontal bone regeneration. The colocalization of hNUC and MIRB demonstrated that SHED transplanted into rats could survive in vivo. Furthermore, some MIRB-positive cells expressed the osteoblast and osteocyte markers OCN and DMP1, respectively. Enzyme-linked immunosorbent assay revealed that SHED could secrete protein factors, such as IGF-1, OCN, ALP, IL-4, VEGF, and bFGF, which promote bone regeneration. Immunofluorescence staining revealed that the transplanted SHED was surrounded by a large number of host-derived Runx2- and Col II-positive cells that played important roles in the bone healing process. Conclusions: SHED could promote periodontal bone regeneration in rats, and the survival of SHED could be tracked in vivo by labeling them with MIRB. SHED are likely to promote bone healing through both direct differentiation and paracrine mechanisms.

• Molecules and Cells
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• 제38권7호
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• pp.643-650
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• 2015

The use of conditioned medium from mesenchymal stem cells may be a feasible approach for regeneration of bone defects through secretion of various components of mesenchymal stem cells such as cytokines, chemokines, and growth factors. Mesenchymal stem cells secrete and accumulate multiple factors in conditioned medium under specific physiological conditions. In this study, we investigated whether the conditioned medium collected under hypoxic condition could effectively influence bone regeneration through enhanced migration and adhesion of endogenous mesenchymal stem cells. Cell migration and adhesion abilities were increased through overexpression of intercellular adhesion molecule-1 in hypoxic conditioned medium treated group. Intercellular adhesion molecule-1 was upregulated by microRNA-221 in mesenchymal stem cells because microRNAs are key regulators of various biological functions via gene expression. To investigate the effects in vivo, evaluation of bone regeneration by computed tomography and histological assays revealed that osteogenesis was enhanced in the hypoxic conditioned medium group relative to the other groups. These results suggest that behavioral changes of endogenous mesenchymal stem cells through microRNA-221 targeted-intercellular adhesion molecule-1 expression under hypoxic conditions may be a potential treatment for patients with bone defects.

• International Journal of Stem Cells
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• 제16권2호
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• pp.191-201
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• 2023

Background and Objectives: O-cyclic phytosphingosine-1-phosphate (cP1P) is a synthetic chemical and has a structure like sphingosine-1-phosphate (S1P). S1P is known to promote cell migration, invasion, proliferation, and anti-apoptosis through hippocampal signals. However, S1P mediated cellular-, molecular mechanism is still remained in the lung. Acute lung injury (ALI) and its severe form acute respiratory distress syndrome (ARDS) are characterized by excessive immune response, increased vascular permeability, alveolar-peritoneal barrier collapse, and edema. In this study, we determined whether cP1P primed human dermal derived mesenchymal stem cells (hdMSCs) ameliorate lung injury and its therapeutic pathway in ALI mice. Methods and Results: cP1P treatment significantly stimulated MSC migration and invasion ability. In cytokine array, secretion of vascular-related factors was increased in cP1P primed hdMSCs (hdMSC^cP1P), and cP1P treatment induced inhibition of Lats while increased phosphorylation of Yap. We next determined whether hdMSC^cP1P reduce inflammatory response in LPS exposed mice. hdMSC^cP1P further decreased infiltration of macrophage and neutrophil, and release of TNF-α, IL-1β, and IL-6 were reduced rather than naïve hdMSC treatment. In addition, phosphorylation of STAT1 and expression of iNOS were significantly decreased in the lungs of MSC^cP1P treated mice. Conclusions: Taken together, these data suggest that cP1P treatment enhances hdMSC migration in regulation of Hippo signaling and MSC^cP1P provide a therapeutic potential for ALI/ARDS treatment.

• 방사성폐기물학회지
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• 제11권4호
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• pp.293-301
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• 2013

처분공 처분 개념은 아프리카의 방사성폐기물관리 방안의 향상을 위해서 남아프리카에너지주식회사(NECSA)에서 처음으로 제시되었다. 초기에 방사성폐기물의 지층처분방안이 고려되었으나, 지하수를 방사성폐기물 오염으로부터 보호하는 방안과 토양과 지하 암석의 균열지대를 통한 방사성 물질의 이동에 대한 조사가 불가피하게 필요했다. 이러한 이유로 처분공 처분개념이 연구되었다. 처분공 처분 개념은 폐기된 밀봉선원을 상대적으로 좁은 직경(260 mm)의 처분공 시설을 통해 처리 및 처분한다. 탄자니아는 장반감기 및 단반감기의 폐기된 밀봉선원을 방사성폐기물관리시설에 저장하고 있으며 폐기된 밀봉선원의 방사능은 1E-6 Ci 에서 8.8E+3 Ci의 범위로 분포한다. 그러나 영구 처분 문제는 여전히 해결하지 못하고 있다. 본 연구에서는 처분부지 면적이 적고, 이에 따라 인간침입 위험이 줄어드는 처분공 처분개념을 제시하였다.

• 한국콘텐츠학회논문지
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• 제15권1호
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• pp.276-285
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• 2015

이 연구의 목적은 우리나라의 지역사회 건강관련 삶의 질에 영향을 미치는 지역사회 요인을 확인하기 위함이다. 2012년 단면연구이며, 국가통계포털의 209개의 시군구별 2차 자료를 사용하였다. 기본 틀은 International Council of Science(ICSU)에서 제시한 지역사회 건강결정요인을 바탕으로 구성하였고, 6가지 측면으로 분류하였다. 분석방법은 지역사회 EQ-5D지수와 지역사회 요인들에 다변량 회귀분석을 실시하였다. 분석결과로, 흡연율, "양호한" 주관적 건강수준 인식률, 상수 및 하수도 보급률 그리고 재정자립도가 EQ-5D에 통계적으로 유의하게 긍정적인 연관성이 있었다. 순인구이동률, 비만율, 필요서비스 미치료율 그리고 지역사회 유형이 EQ-5D에 통계적으로 유의하게 부정적인 연관성이 있었다. 이 연구는 지역사회 수준의 건강관련 삶의 질에 영향을 미치는 지역사회 요인들의 연관성을 확인했으며, 이것은 지역사회 건강 정책 개발에 유용한 증거를 제공할 수 있다.