• 제목/요약/키워드: internal standard method

검색결과 703건 처리시간 0.027초

기본의학 교육과정 개선 방안 - 연세의대 광혜교육과정을 중심으로 - (Remarks for Basic Medical Education Quality Improvement of Yonsei University in Korea)

  • 류숙희;안덕선;이원택;박전한;정현수;박무석;양은배
    • 의학교육논단
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    • 제11권2호
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    • pp.15-24
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    • 2009
  • Medical Students' competencies depend on the medical school curriculum. Basic medical education, in particular, is an important starting point for further medical competency development. We aimed to identify the most important areas of reform in the basic medical education curriculum of Yonsei Medical School. To accomplish this, we sought case studies of different medical schools and discussion points for quality improvement methods. A qualitative comparison method saturated through the systematic discussions on the emerging thematic approaches to determine the current directions in medical school curriculum reform. The discussions, which involved 7 experts, spanned 8 months and were based on a literature review, with focus on the 7 selected case studies. From the discussions, we concluded that in order to improve basic medical education curriculum, the following measures need to be carried out. First, an outcome-based curriculum is to be designed. The expected outcome is to be deliberately and succinctly defined and should be expressed as teaching and learning objectives. Second, the core subjects and elective subjects are to be classified on the basis of the aim, content, and passage level of the subjects. Hence, the core curriculum must be treated as a standard part of medical knowledge, and the elective curriculum must be richer and more in-depth. Third, universities should institutionalize regular evaluation of their departments. Appropriate and just evaluations should be made, and feedback given to the school's administrative department. Fourth, the departmental and administrative management of the basic medical education curriculum should be harmonized with each other. Finally, teaching and learning resources are to be increased and diversified and made available to professors and students for basic medical education.

오염된 신발의 효율적인 살균과 탈취를 위한 신발장의 설계 (Design of a shoe rack for effective sterilization and deodorization of the shoes contaminated by various bacteria)

  • 이삼철;장용석
    • 한국산학기술학회논문지
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    • 제17권6호
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    • pp.199-206
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    • 2016
  • 본 연구는 다양한 세균에 오염된 신발을 효과적으로 살균하고 탈취할 수 있는 신발장을 설계하기 위한 최적의 조건을 확립하고자하는 목적으로 실시하였다. 신발장의 제작과 평가는 2014년 10월부터 2015년 9월까지 1년에 걸쳐 진행하였다. 항균성능의 평가는 JIS Z 2801:2010 규격에 따라 대장균과 황색포도상구균 균주에 대하여 실시하였고, 탈취효율은 한국공기청정협회 실내공기청정기 규격인 SPS-KACA002-132:2006 규격에 따라 실시하였다. 대장균과 황색포도상구균 균주에 대한 UV 조사시간에 대한 항균성능을 시험한 결과에서 30초 후에 99.9% 이상의 세균감소율을 보였고, 시험가스에 대한 평균 탈취효율은 42.5%를 보였다. UV램프로 5분의 점등과 25분의 소등을 반복하여 작동을 할 경우에 신발 내부와 신발장 내부 온도는 약 $40^{\circ}C$$25^{\circ}C$ 이하로 유지되었다. 신발장의 작동시간에 따른 온도 변화를 측정한 결과는 UV램프를 점등과 소등을 반복적으로 작동시켜 신발 내부의 온도를 적절하게 유지할 수 있었다. 결과적으로 실제 신발장 내부의 용적은 시험연구원의 챔버 용적보다 매우 작은 용적을 가지고 있기 때문에 시험결과의 값을 상대적으로 보정하게 되면 실제 탈취효율은 측정값보다 매우 클 것으로 판단이 된다. 또한 신발의 내부에서 악취를 유발하는 원인균인 박테리아를 반복적으로 살균하기 때문에 신발 내의 실제 탈취의 효과는 더욱 증가될 것이다. 추가 연구로 일정한 신발장 내부의 온도편차를 찾아야 할 것이다.

Development of RMRD and Moving Phantom for Radiotherapy in Moving Tumors

  • Lee, S.;Seong, Jin-Sil;Chu, Sung-Sil;Yoon, Won-Sup;Yang, Dae-Sik;Choi, Myung-Sun;Kim, Chul-Yong
    • 한국의학물리학회:학술대회논문집
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    • 한국의학물리학회 2003년도 제27회 추계학술대회
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    • pp.63-63
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    • 2003
  • Purpose: Planning target volume (PTV) for tumors in abdomen or thorax includes enough margin for breathing-related movement of tumor volumes during treatment. We developed a simple and handy method, which can reduce PTV margins in patients with moving tumors, respiratory motion reduction device system (RMRDs). Materials and Methods: The patients clinical database was structured for moving tumor patients and patient setup error measurement and immobilization device effects were investigated. The system is composed of the respiratory motion reduction device utilized in prone position and abdominal presser (strip device) utilized in the supine position, moving phantom and the analysis program, which enables the analysis on patients setup reproducibility. It was tested for analyzing the diaphragm movement and CT volume differences from patients with RMRDs, the magnitude of PTV margin was determined and dose volume histogram (DVH) was computed using a treatment planning software. Dose to normal tissue between patients with RMRDs and without RMRDs was analyzed by comparing the fraction of the normal liver receiving to 50% of the isocenter dose(TD50). Results: In case of utilizing RMRDs, which was personally developed in our hospital, the value was reduced to $5pm1.4 mm$, and in case of which the belt immobilization device was utilized, the value was reduced to 3$pm$0.9 mm. Also in case of which the strip device was utilized, the value was proven to reduce to $4pm.3 mm$0. As a result of analyzing the TD50 is irradiated in DVH according to the radiation treatment planning, the usage of the respiratory motion reduction device can create the reduce of 30% to the maximum. Also by obtaining the digital image, the function of comparison between the standard image, automated external contour subtraction, and etc were utilized to develop patients setup reproducibility analysis program that can evaluate the change in the patients setup. Conclusion: Internal organ motion due to breathing can be reduced using RMRDs, which is simple and easy to use in clinical setting. It can reduce the organ motion-related PTV margin, thereby decrease volume of the irradiated normal tissue.

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헤드스페이스 GC/MS를 이용한 폴리염화비닐/폴리염화비닐리덴 식품 포장 중 염화비닐/염화비닐리덴 잔류량 연구 (A Study on Residual Amounts of Vinyl Chloride/Vinylidene Chloride in Poly(vinyl chloride)/Poly(vinylidene chloride) Food Packaging using Headspace GC/MS)

  • 성준현;곽인신;박성관;김형일;임호수;이주영;변미연;김소희
    • 한국식품과학회지
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    • 제43권1호
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    • pp.6-11
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    • 2011
  • PVC 및 PVDC 재질의 식품포장에 잔류할 수 있는 원료물질인 VC 및 VDC를 PLOT Q 컬럼이 장착된 headspace-GC/MS를 이용하여 분석하였다. VC 및 VDC 각각에 대하여 m/z=61, 62, 64 및 m/z=61, 96, 98 이온을 선택 이온으로 하여 분석하였으며, 내부표준 물질로는 1-CP를 사용하였다. 분석법 검증결과 본 연구에서 도입한 분석법은 유럽연합의 재질규격 시험에 적합하였으며, 국내유통 PVC 및 PVDC 재질의 식품 포장 103 품목에 대한 분석 결과, PVDC 식품포장 1건에서 재질 중 VDC가 검출되었으나, 이는 유럽연합에서 설정하고 있는 재질규격 이내에 드는 미미한 수준이었으며, 나머지 모든 시료에서는 VC 및 VDC가 검출되지 않았다.

족삼리혈 뜸자극이 흰쥐 비장 자연살해세포 활성에 미치는 영향 (Effects of Moxibustion to Zusanli(ST36) on Alteration of Natural Killer cell Activity in rat spleen)

  • 최기순;오상덕;한재복;이기석;박준하;배현수;정승기;안현종;조영욱;민병일
    • 동의생리병리학회지
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    • 제16권2호
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    • pp.233-238
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    • 2002
  • Moxibustion is one of major healing technique in oriental medicine. It has been widely used in many diseases such as rheumatoid arthritis, Hashimoto disease, breech presentation, etc. However, till now, effects of moxibustion on NK cell activity and relations between sympathetic nerve system(SNS) and the immune alteration induced by moxibustion were not well studied. This study was designed to evaluate effects of moxibustion on NK cell activity and the intervention of SNS in the alteration of NK cell activity induced by moxibustion. Splenic NK cytotoxity was measured in a standard 4-h 51Cr release assay. We measured the NK cytotoxity at after moxibustion stimulation for 1,3,5, and 7 days, and also measured the NK cell cytotoxity after 3 and 7 days burn stimulation with similar temperature. IL-2, IL-4, INF-γ in serum were measured by rat IL-2, IL-4, INF-γ ELISA TEST KIT. To evaluate the effects of sympathectomy on alteration of NK cell cytotoxity, 6-hydroxydopamine(6-OHDA : 5Omg/kg) was used. We showed that NK cell activity of moxibustion stimulation group increased at the 3rd day, and declined at 7th day in comparison with that of contol group. In moxibustion stimulation group, NK cell activity of 3 day stimulation group was significantly higher than sham group. On the contrary, in burn stimulation group, NK cell activity was significantly higher than that of sham groups at 3rd, 7th days. Patterns between moxibustion and burns were different. INF- γ level of 3 days moxibustion stimulation group significantly higher than sham group. IL 2 level among groups were not different. IL-4 was not detected in serum with this method. Sympathectomy abolished the NK cell activity alteration induced by moxibustion. The results suggest that moxibustion induces the alteration of NK cell activity, along with INF-γ and SNS is related to these effects.

DETERMINATION OF MOISTURE AND NITROGEN ON UNDRIED FORAGES BY NEAR INFRARED REFLECTANCE SPECTROSCOPY(NIRS)

  • Cozzolino, D.;Labandera, M.;Inia La Estanzuela
    • 한국근적외분광분석학회:학술대회논문집
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    • 한국근적외분광분석학회 2001년도 NIR-2001
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    • pp.1620-1620
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    • 2001
  • Forages, both grazed and conserved, provide the basis of ruminant production systems throughout the world. More than 90 per cent of the feed energy consumed by herbivorous animals world - wide were provided by forages. With such world - wide dependence on forages, the economic and nutritional necessity of been able to characterize them in a meaningful way is vital. The characterization of forages for productive animals is becoming important for several reasons. Relative to conventional laboratory procedures, Near Infrared Reflectance Spectroscopy (NIRS) offers advantages of simplicity, speed, reduced chemical waste, and more cost-effective prediction of product functionality. NIR spectroscopy represents a radical departure from conventional analytical methods, in that entire sample of forage is characterized in terms of its absorption properties in the near infrared region, rather than separate subsamples being treated with various chemicals to isolate specific components. This forces the analyst to abandon his/her traditional narrow focus on the sample (one analyte at a time) and to take a broader view of the relationship between components within the sample and between the sample and the population from which it comes. forage is usually analysed by NIRS in dry and ground presentation. Initial success of NIRS analysis of coarse forages suggest a need to better understand the potential for analysis of minimally processed samples. Preparation costs and possible compositional alterations could be reduced by samples presented to the instrument in undried and unground conditions. NIRS has gained widespread acceptance for the analysis of forage quality constituents on dry material, however little attention has been given to the use of NIRS for chemical determinations on undried and unground forages. Relatively few works reported the use of NIRS to determine quality parameters on undried materials, most of them on both grass and corn silage. Only two works have been found on the determination of quality parameters on fresh forages. The objectives of this paper were (1) to evaluate the use of NIRS for determination of nitrogen and moisture on undried and unground forage samples and (2) to explore two mathematical treatments and two NIR regions to predict chemical parameters on fresh forage. Four hundred forage samples (n: 400) were analysed in a NIRS 6500 instrument (NIR Systems, PA, USA) in reflectance mode. Two mathematical treatments were applied: 1,4,4,1 and 2,5,5,2. Predictive equations were developed using modified partial least squares (MPLS) with internal cross - validation. Coefficient of determination in calibration (${R^2}_{CAL}$) and standard error in cross-validation (SECV) for moisture were 0.92 (12.4) and 0.92 (12.4) for 1,4,4,1 and 2,5,5,2 respectively, on g $kg^{-1}$ dry weight. For crude protein NIRS calibration statistics yield a (${R^2}_{CAL}$) and (SECV) of 0.85 (19.8) and 0.85 (19.6) for 1,4,4,1 and 2,5,5,2 respectively, on a dry weight. It was concluded that NIRS is a suitable method to predict moisture and nitrogen on fresh forage without samples preparation.

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소형동적콘관입시험을 이용한 전단강도 산정 및 N-Nc 상관관계 연구 (Study on Shear Strength Using a Portable Dynamic Cone Penetration Test and Relationship between N-Nc)

  • 김혁호;임희대
    • 자원환경지질
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    • 제50권2호
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    • pp.145-157
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    • 2017
  • 최근 집중강우로 인하여 전국적으로 산사태 및 사면붕괴 현상이 빈번히 발생하고 있다. 이러한 산지 및 비탈면에서 발생하는 자연재해에 대한 대책안 마련 및 설계 입력자료로서 지반의 강도정수(전단강도)를 도출해야만 한다. 그러나 현재 산지 및 비탈면에 접근하여 지반조사를 하기 위해서는 과다한 산림훼손과 많은 경제적인 비용 등이 요구되어진다. 따라서 본 연구에서는 현장에서 인력운반이 가능한 경량화된 소형동적콘관입시험기를 제작하여 다수의 지역에 대한 지반의 특성 및 강도정수를 산출하였다. 그리고 국내 및 외국의 소형동적콘관입시험 방법에 대해서 연구 분석하여 국내에 적합한 콘 재료와 시험방법을 제안하였으며, 대표적인 지역을 대상으로 현장에서 콘관입시험 Nc값과 표준관입시험 N값과 비교 분석하였다. 이와 더불어 직접전단시험 및 공내전단시험을 실시하여 토층심도별, 기반암별, 흙의 분류별 그리고 #200번체 통과량별로 Nc값과 전단강도와의 상관관계를 분석하였다. 특히 본 연구에서는 산지조건에서 가장 많이 분포하는 사질토를 대상으로 Nc값에 대응하는 전단강도(점착력 및 내부마찰각)와의 상관식을 제안하여 산지 토층에 대한 효율적인 지반강도정수를 산출하도록 하였다.

Bioequivalence Study of Toriem® Tablet to Motilium-M® Tablet (Domperidone Maleate 12.72 mg) Evaluated by Liquid Chromatography/Tandem Mass Spectrometry

  • Ryu, Ju-Hee;Choi, Sang-Jun;Lee, Myung-Jae;Lee, Jin-Sung;Kang, Jong-Min;Tak, Sung-Kwon;Seo, Ji-Hyung;Lee, Kyung-Tae
    • Journal of Pharmaceutical Investigation
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    • 제39권1호
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    • pp.65-71
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    • 2009
  • The aim of the present study was to evaluate the bioequivalence of two domperidone maleate tablets, Motilium-$M^{(R)}$ Tablet (Janssen Korea Ltd., reference product) and $Toriem^{(R)}$ Tablet (Daewon Pharm. Co., Ltd., test product). Domperidone was extracted by liquid-liquid extraction using tert-butyl methyl ether and separated in less than 3 min on $C_{18}$ reverse-phase column using an isocratic elution. A tandem mass spectrometer, as detector, was used for quantitative analysis in positive mode by a multiple reaction monitoring mode to monitor the m/z $426.1{\rightarrow}119.1$ and the m/z $837.4{\rightarrow}158.2$ transitions for domperidone and the internal standard (roxithromycin), respectively. Calibration curves, from $0.05{\sim}50$ ng/mL of domperidone, showed correlation coefficients (r) higher than 0.9941. Intra day and inter day precision (C.V. %) for quality control were ranged from 10.04 to 16.09% and from 10.87 to 18.69%, respectively. The lower limit of quantification (LLOQ) of domperidone was 0.05 ng/mL. The method described is precise and sensitive and has been successfully applied to the study of bioequivalence of domperidone in 24 healthy Korean volunteers. Twenty-four healthy male Korean volunteers received a single dose of each medicine ($2{\times}12.72\;mg$ domperidone maleate) in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Plasma concentrations of domperidone were monitored for over a period of 24 hr after the administration. $AUC_{0-t}$ (the area under the plasma concentration-time curve) was calculated by the linear trapezoidal rule. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. The 90% confidence intervals for the log transformed data were within acceptable range of log 0.8 to log 1.25 (e.g., $log\;0.92{\sim}log\;1.05$ for $AUC_{0-t}$, $log\;0.81{\sim}log\;1.05$ for $C_{max}$). The major parameters, $AUC_{0-t}$ and $C_{max}$ met the criteria of KFDA for bioequivalence indicating that $Toriem^{(R)}$ tablet is bioequivalent to Motilium-$M^{(R)}$ tablet.

제체 상태 평가를 위한 동적 콘 관입시험과 평판재하시험 결과의 상관관계 분석 (The Correlation Analysis between Dynamic Cone Penetration Test and Plate Loading Test Results for Evaluation of Dam Conditions)

  • 정영훈;김성민;임정열
    • 한국지반환경공학회 논문집
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    • 제19권4호
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    • pp.33-38
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    • 2018
  • 제체 재료의 다짐 불량에 의한 내부 침식은 국내 제방의 주요 붕괴 원인으로, 제방의 안전진단에 있어서 제체의 다짐 상태 평가는 매우 중요한 점검 사항이다. 본 연구에서는 제체의 다짐상태 평가 시 동적 콘 관입시험의 현장 적용성을 검증하기 위해 대표적인 다짐평가 기법인 평판재하시험에 대해 상관관계를 분석하였다. 시험 부지의 지반 특성 및 토층 심도를 파악하기 위해 표준관입시험을 6회 수행하였다. 평판재하시험 15회, 동적 콘 관입시험 47회 수행 후 크리깅(Kriging) 기법으로 공간분포를 얻었다. 평판재하시험의 공간분포와 일정 관입깊이에서의 동적 콘 관입시험 공간분포 간의 피어슨 상관 계수를 계산하였다. 평판재하시험의 지지력과 관입 깊이 5cm, 10cm, 15cm에서의 동적 콘 관입시험의 타격횟수는 약한 양의 상관관계를 갖는 것으로 나타났다.

뜨살리스-엔트로피 분석을 통한 무선 랜의 이기적인 노드 탐지 기법 (A Study on Detecting Selfish Nodes in Wireless LAN using Tsallis-Entropy Analysis)

  • 류병현;석승준
    • 한국지능시스템학회논문지
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    • 제22권1호
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    • pp.12-21
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    • 2012
  • IEEE 802.11 표준 무선 네트워크에서 사용되는 DCF(CSMA/CA) 방식의 MAC 프로토콜은 노드들 사이에서 공평한 채널 접근 확률을 보장하도록 설계되었다. 하지만 최근 급속히 확산되고 있는 무선 환경에서 다른 노드들보다 인위적으로 더 많은 데이터를 전송하는 노드가 존재하는 것이 사실이다. 이들 오동작 노드들은 더 많은 데이터를 보내기 위해서 자신의 MAC 프로토콜 동작을 변형시키거나 다른 노드들의 MAC 동작을 방해한다. 이러한 문제는 이기적(Selfish) 노드 문제라고 정의되어 왔으며, 지금까지의 대부분 연구들에서는 무선 랜 내부의 MAC 프로토콜 동작을 프레임 단위로 분석하여 이기적인 노드를 검색하는 방법을 제안하였으나 모든 종류의 이기적인 노드들을 효과적으로 검출할 수는 없었다. 이러한 단점을 보안하기 위해서 본 논문에서는 통계적 기법 중 하나인 뜨살리스-엔트로피(Tsallis-Entropy)를 사용하여 이기적인 노드 탐색 알고리즘을 제안한다. 뜨살리스-엔트로피는 확률 분포의 밀집도 혹은 분산정도를 효과적으로 나타낼 수 있는 척도이다. 제안한 알고리즘은 무선 랜을 구성하는 AP노드에서 동작하도록 설계되었으며, 무선 노드별로 데이터 간격에 대한 확률 분포를 추출해서 뜨살리스-엔트로피를 계산한 후 임계치와 비교하는 방법으로 이기적인 노드를 검출한다. 논문에서 제안한 이기적 노드 검출 알고리즘의 성능을 평가하기 위하여 다양한 무선 랜 환경(혼잡도, 이기적 노드 동작방법, 임계치)을 고려하여 시뮬레이션을 수행한다. 시뮬레이터는 ns2를 사용하였으며, 실험결과 제안한 방법의 이기적인 노드 검출률 이 매우 높음을 알 수 있다.