• Tuberculosis and Respiratory Diseases
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• v.86 no.1
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• pp.1-13
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• 2023

Lung cancer ranks first in cancer mortality in Korea and cancer incidence in Korean men. More than half of Korean lung cancer patients undergo chemotherapy, including adjuvant therapy. Cytotoxic agents, targeted therapy, and immune checkpoint inhibitors are used in chemotherapy according to the biopsy and genetic test results. Among chemotherapy, the one that has developed rapidly is targeted therapy. The National Comprehensive Cancer Network (NCCN) guidelines have been updated recently for targeted therapy of multiple gene mutations, and targeted therapy is used not only for chemotherapy but also for adjuvant therapy. While previously targeted therapies have been developed for common genetic mutations, recently targeted therapies have been developed to overcome uncommon mutations or drug resistance that have occurred since previous targeted therapy. Therefore, this study describes recent, rapidly developing targeted therapies.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.20 no.4
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• pp.78-85
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• 2006

A person's body resistance in the waterpark, public bath and similar places is much lower than any other places due to effect of water. So low voltage may create a shock hazard for the human body in case of leakage or fault currents from lighting unit etc. We researched the related regulations which are internal standards, NEC, IEC and investigated the actual conditions for the prevention of electric shock due to lighting units in the waterpark, public bath and similar places. As a results internal standard is obscure as compared with NEC, IEC which is the limit of application and distinction of environment condition. And then internal standard's using voltage is higher than NEC, IEC in filed of water. Studies show that internal standard should be revision that raise the installation height of lighting unit, mark IP level surface of lighting unit and limit using voltage to line-to-line voltage

• Tribology and Lubricants
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• v.35 no.6
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• pp.362-368
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• 2019

In this study, mechanical and tribological properties were investigated by varying the process temperature (50, 100, 125 and 150℃) to reduce internal stress. The internal stress reduction by thermal dissociation ta-C coating film with increasing temperature is confirmed through the curvature radius of the ta-C coating according to the temperature of the SUS plate. As the coating temperature increased, the mechanical properties (hardness, modulus, toughness) deteriorated, which is in agreement with the Raman analysis results. As the temperature increased, the sp² phase ratio increased owing to the dissociation of the sp³ phase. The friction and wear properties are related to the process temperature during ta-C coating. Low friction and wear properties are observed in high hardness samples manufactured at 50℃, and wear resistance properties decreased with increasing temperature. The contact area is expected to increase owing to the decrease of hardness(72 GPa to 39 GPa) and fracture toughness with increasing temperature which accelerated wear because of the debris generated. It was confirmed that at process temperature of over than 100℃, the bond structure of the carbon film changed, and the effect of excellent internal stress was reduced. However, the wear resistance simultaneously decreased owing to the reduction in fracture toughness. Therefore, in order to increase industrial utilization, optimum temperature conditions that reduce internal stress and retain mechanical properties.

• Journal of the Korea Concrete Institute
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• v.20 no.6
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• pp.821-826
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• 2008

This study evaluated spalling and internal temperature distribution after elevated temperatures test for high strength concrete ($f_{ck}=60\;MPa$) column member with various polypropylene fiber volume fractions. The ISO-834 time-temperature curve was used for measurement of fire resistance properties. As the result of test, average internal temperature results indicated to low temperature in increased polypropylene fiber volume fraction. But, the highest internal temperature results show that does not difference in proportion of polypropylene fiber volume fractions.

• Corrosion Science and Technology
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• v.7 no.5
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• pp.283-287
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• 2008

The drag reduction agency (DRA) for gas pipeline, a novel method used for reducing friction or drag on a gas flowing to increase the transmission efficiency of gas pipeline, is a more flexible and economical technology than internal flow efficient coatings. In this paper, an effective DRA has been developed in Authors' Institute by analyzing the hydrodynamic friction resistance on internal gas pipeline and then studying the work mechanism and molecular structure of DRA. In the meantime, a group of property test for selecting DRA material has been determined, including viscosity, contact angle, volatility, corrosion, slab extending, and flow behavior in horizontal tube. The inhibition efficiency and drag reduction efficiency of the developed DRA have been investigated finally based on the relevant test methods. Results of corrosion test show that the developed DRA has very good inhibition effect on mild steel by brushing a thin layer of DRA on steel specimens, giving inhibition efficiency of 91.2% and 73.1% in 3%NaCl solution and standard salt fog environment respectively. Results of drag-reducing test also show that the Colebrook formula could be used to calculate friction factors on internal pipes with DRA as the Reynolds number is in the range of $0.75\times10^5\sim2.0\times10^5$. By comparing with normal industrial pipes, the friction resistance coefficient of the steel pipe with DRA on internal wall decreases by 13% and the gas flux increases by 7.3% in testing condition with Reynolds number of $2.0\times10^5$.

• Journal of Korean Medical Science
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• v.33 no.52
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• pp.335.1-335.17
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• 2018

Background: Spontaneous bacterial peritonitis (SBP) is a serious infectious complication in patients with liver cirrhosis. However, information about prognosis of SBP in hepatocellular carcinoma (HCC) patients is limited. We investigated the clinical course of SBP in HCC patients. Methods: This study enrolled patients diagnosed with SBP between 2005 and 2017. Medical records of patients were reviewed and clinical course was compared between the non-HCC and HCC groups. Results: In total, 123 SBP cases including 49 HCC cases were enrolled. Men were predominant (48/74, 64.9% vs. 34/49, 69.4%; P = 0.697); median age was 58 years in both non-HCC and HCC groups (P = 0.887). The most common etiology was alcohol (32/74, 43.2%) in non-HCC group and hepatitis B (30/49, 61.2%) in HCC group (P = 0.009). Antibiotic resistance rate was higher in non-HCC than in HCC group (29.7% vs. 12.2%; P = 0.028); in-hospital mortality did not differ between the groups (25/74, 33.8% vs. 13/49, 26.5%; P = 0.431). Development rate of hepatorenal syndrome did not differ between non-HCC and HCC group (14/74, 18.9% vs. 10/49, 20.4%; P = 1.000), but hepatic encephalopathy was less common in HCC group (26/74, 35.2% vs. 9/49, 18.3%; P = 0.008). The most important predictor of in-hospital mortality in patients with HCC was white blood cell count above $11,570cells/mm^3$ (odds ratio, 6.629; 95% confidence interval, 1.652-26.590; P = 0.008). Conclusion: Prognosis of SBP in HCC patients is relatively less severe. This result may be related with reduced antibiotics resistance and lower development rates of other complications, such as hepatic encephalopathy. Degree of systemic inflammation may be the most important factor for in-hospital mortality.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.17 no.6
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• pp.53-60
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• 2018

In this paper, the effect of different 3D printing parameters including laminated angle and annealing temperature is observed their effect on FDM conductive 3D printing. In FDM 3D printing, a conductive filament is heated quickly, extruded, and then cooled rapidly. FDM 3D Print conductive filament is a poor heat conductor, it heats and cools unevenly causing the rapid heating and cooling to create internal stress. when the printed conductive specimens this internal stress can be increase electrical resistance and decrease electrical conductivity. Therefore, This experiment would like to use annealing to remove internal stress and increase electrical conductivity. The result of experiment when 3D printing conductive specimen be oven cooling of annealing temperature $120^{\circ}C$ electrical resistance appeared decrease than before annealing. So We have found that 3D printing annealing removes internal stresses and increases the electrical conductivity of printed specimens. These results are very useful for making conductive 3D printing electronic circuit, sensor ect...with electrical conductance suitable for the application.

• The Transactions of the Korean Institute of Power Electronics
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• v.26 no.6
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• pp.421-428
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• 2021

Lithium-ion secondary batteries exhibit advantageous characteristics such as high voltage, high energy density, and long life, allowing them to be widely used in both military and daily life. However, the lithium-ion secondary battery does have its limitation; for example, the output power and capacity are readily decreased due to the increased internal impedance during discharging at a lower temperature (-32℃, military requirement). Also, during charging at a lower temperature, lithium dendrite growth is accelerated at the anode, thereby decreasing the battery capacity and life as well. This paper describes a study that involves increasing the internal temperature of lithium-ion secondary battery by energy circulation operation in a low-temperature environment. The energy circulation operation allows the lithium-ion secondary battery to alternately charge and discharge, while the internal resistance of lithium-ion battery acts as a heating element to raise its own temperature. Therefore, the energy circulation operation method and device were newly designed based on the electrochemical impedance spectroscopy of the lithium-ion secondary battery to mediate the battery performance at a lower temperature. Through the energy circulation operation of lithium ion secondary battery, as a result of the heat generated from internal resistance in an extremely low-temperature environment, the temperature of the lithium-ion secondary battery increased by more than 20℃ within 10 minutes and showed a 75% discharging capacity compared with that at room temperature.

• Tuberculosis and Respiratory Diseases
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• v.85 no.1
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• pp.18-24
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• 2022

Background: Neutrophilic asthma (NeuA) is usually resistant to corticosteroids. Tiotropium bromide (TIO) is a bronchodilator that is used as an add-on therapy to inhaled corticosteroid and long-acting β2 agonist in asthma treatment. However, the role of TIO in NeuA is not fully known. Thus, the aim of this study was to evaluate the effect of TIO on NeuA compared to that of corticosteroids. Methods: C57BL/6 female mice were sensitized with ovalbumin and lipopolysaccharide to induce neutrophilic inflammation. Dexamethasone (DEX) was administered on days 14, 17, 20, and 23. TIO was inhaled on days 21, 21, and 23. On day 24, mice were sacrificed. Airway hyper-responsiveness, levels of cytokines in bronchoalveolar lavage (BAL) and lung homogenates, and lung tissue histopathology were compared between the two groups. Results: Neutrophil counts, T helper 2 cells (T_H2)/T_H17 cytokines, and pro-inflammatory cytokine in BAL fluids were elevated in the NeuA group. TIO group showed lower total cells, neutrophil counts, and eosinophil counts in BAL fluids than the DEX group (p<0.001, p<0.05, and p<0.001, respectively). Airway resistance was attenuated in the TIO group but elevated in the NeuA group (p<0.001). Total protein, interleukin (IL)-5, and IL-17A levels in BAL fluids were lower in the TIO group than in the NeuA group (all p<0.05). Conclusion: TIO showed more potent effects than DEX in improving airway inflammation and attenuating airway resistance in NeuA.

• The Journal of Internal Korean Medicine
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• v.42 no.2
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• pp.175-183
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• 2021

Diabetes mellitus, commonly known as diabetes, comprises a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time. Diabetes is classified into type 1 diabetes and type 2 diabetes, and the incidence and prevalence of diabetes, mostly type 2, have increased remarkably in recent decades. A diagnosis of type 2 diabetes is greatly influenced by heredity, and it is important to prevent diabetes in people with a family history by improving lifestyle and environmental factors. Controlling overeating, obesity, lack of exercise, and stress is effective to prevent diabetes. The patient in this case report had impaired fasting glucose and mild hyperlipidemia. The patient experienced improvements in these sequelae after the administration of herbal medicine (Yangkyuksanwha-tang) for 12 weeks and the implementation of a plant-based diet. The complete blood count, XXXX, fasting blood sugar, HbA1c, insulin, and C-peptide levels were measured, and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and HOMA-β were calculated according to the FBS and fasting insulin levels. Total cholesterol, triglyceride, FBS, and HbA1c levels all decreased after 12 weeks compared with baseline measures. There was no change in the insulin secretory ability; the C-peptide level did not change as a result of β-cell function; and the HOMA-β level reflected an improved insulin secretory ability.