• 제목/요약/키워드: internal reduction

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Development of non-destructive testing method to evaluate the bond quality of reinforced concrete beam

  • Saleem, Muhammad;Almakhayitah, Abdulmalik Mohammed
    • Structural Engineering and Mechanics
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    • 제74권3호
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    • pp.313-323
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    • 2020
  • Non-destructive tests are commonly used in construction industry to access the quality and strength of concrete. However, till date there is no non-destructive testing method that can be adopted to evaluate the bond condition of reinforced concrete beams. In this regard, the presented research work details the use of ultra-sonic pulse velocity test method to evaluate the bond condition of reinforced concrete beam. A detailed experimental research was conducted by testing four identical reinforced concrete beam samples. The samples were loaded in equal increments till failure and ultra-sonic pulse velocity readings were recorded along the length of the beam element. It was observed from experimentation that as the cracks developed in the sample, the ultra-sonic wave velocity reduced for the same path length. This reduction in wave velocity was used to identify the initiation, development and propagation of internal micro-cracks along the length of reinforcement. Using the developed experimental methodology, researchers were able to identify weak spots in bond along the length of the specimen. The proposed method can be adopted by engineers to access the quality of bond for steel reinforcement in beam members. This allows engineers to carryout localized repairs thereby resulting in reduction of time, cost and labor needed for strengthening. Furthermore, the methodology to apply the proposed technique in real-world along with various challenges associated with its application have also been highlighted.

Comprehensive overview of the role of mitochondrial dysfunction in the pathogenesis of acute kidney ischemia-reperfusion injury: a narrative review

  • Min-Ji Kim;Chang Joo Oh;Chang-Won Hong;Jae-Han Jeon
    • Journal of Yeungnam Medical Science
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    • 제41권2호
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    • pp.61-73
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    • 2024
  • Acute kidney ischemia-reperfusion (IR) injury is a life-threatening condition that predisposes individuals to chronic kidney disease. Since the kidney is one of the most energy-demanding organs in the human body and mitochondria are the powerhouse of cells, mitochondrial dysfunction plays a central role in the pathogenesis of IR-induced acute kidney injury. Mitochondrial dysfunction causes a reduction in adenosine triphosphate production, loss of mitochondrial dynamics (represented by persistent fragmentation), and impaired mitophagy. Furthermore, the pathological accumulation of succinate resulting from fumarate reduction under oxygen deprivation (ischemia) in the reverse flux of the Krebs cycle can eventually lead to a burst of reactive oxygen species driven by reverse electron transfer during the reperfusion phase. Accumulating evidence indicates that improving mitochondrial function, biogenesis, and dynamics, and normalizing metabolic reprogramming within the mitochondria have the potential to preserve kidney function during IR injury and prevent progression to chronic kidney disease. In this review, we summarize recent advances in understanding the detrimental role of metabolic reprogramming and mitochondrial dysfunction in IR injury and explore potential therapeutic strategies for treating kidney IR injury.

균형성과표를 활용한 전자의무기록시스템의 성과측정 모형개발 (Development of the Performance Measurement Model of Electronic Medical Record System - Focused on Balanced Score Card -)

  • 이경희;김영훈;부유경
    • 한국병원경영학회지
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    • 제21권4호
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    • pp.1-12
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    • 2016
  • The purpose of this study are suggest to performance measurement model of Electronic Medical Record(EMR) and Key Performance Index(KPI). For data collection, 665 questionnaires were distributed to medical record administrators and insurance reviewers at 31 hospitals, and 580 questionnaires were collected(collection rate: 87.2%). Regarding methodology, Critical Success Factor(CSF) and index of the information system were derived based on previous studies, and these were set as performance measurement factors of EMR system. The performance measurement factors were constructed by perspective using BSC, and analysis on causal relationship between factors was conducted. A model of causal relationship was established, and performance measurement model of EMR system was proposed through model validation. Analysis on causal relationship between performance management factors revealed that utility cognition of the learning & growth perspective factor had causal relationship with job efficiency(${\beta}=0.20$) and decision support(${\beta}=0.66$) of the internal process perspective factors, and security had causal relationship with system satisfaction(${\beta}=0.31$) of the customer perspective factor. System quality had causal relationship with job efficiency(${\beta}=0.66$) and decision support(${\beta}=0.76$) of the internal process perspective factors, all of which were statistically significant(P<0.01). Job efficiency of the internal process perspective had causal relationship with system satisfaction(${\beta}=0.43$), and decision support had causal relationship with decision support satisfaction(${\beta}=0.91$) and job satisfaction (${\beta}=0.74$), all of which were statistically significant(P<0.01). System satisfaction of the customer perspective had causal relationship with job satisfaction(${\beta}=0.12$), job satisfaction had causal relationship with cost reduction(${\beta}=0.53$) of the financial perspective, and decision support satisfaction had causal relationship with productivity improvement(${\beta}=0.40$)of the financial perspective(P<0.01). Also, cost reduction of the financial perspective had causal relationship with productivity improvement(${\beta}=0.37$), all which were statistically significant(P<0.05). Suitability index verification of the performance measurement model whose causal relationship was found to be statistically significant revealed that $X^2/df=2.875$, RMR=0.036, GFI=0.831, AGFI=0.810, CFI=0.887, NFI=0.838, IFI=0.888, RMSEA=0.057, PNFI=0.781, and PCFI=0.827, all of which were in suitable levels. In conclusion, the performance measurement indices of EMR system include utility cognition, security, and system quality of the learning & growth perspective, decision support and job efficiency of the internal process perspective, system satisfaction, decision support satisfaction, and job satisfaction of the customer perspective, and productivity improvement and cost reduction of the financial perspective. In this study, it is expected that the performance measurement indices and model of EMR system which are suggested by the author, will be a measurement tool available for system performance measurement of EMR system in medical institutions.

Locking Compression Plate를 이용한 전위성 쇄골 간부 골절의 수술적 치료 (Operative Treatment of Fractures of the Midshaft Clavicle using Locking Compression Plate)

  • 정남식;홍기도;하성식;박성준;강정호;심재천
    • 대한정형외과스포츠의학회지
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    • 제5권1호
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    • pp.63-68
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    • 2006
  • 목적: 전위성 쇄골 간부 골절의 치료로 관혈적 정복술 후 LCP를 사용하여 내고정을 시행한 환자를 대상으로 방사선학적, 임상적 결과를 분석하여 전위성 쇄골 간부 골절의 치료에 있어서 LCP의 유용성을 알아보고자 하였다. 대상 및 방법: 2003년 5월부터 2004년 11월까지 본원에서 쇄골 간부 골절에 대해 LCP를 이용한 관혈적 정복, 금속내 고정술을 시행하고 6개월 이상 추시가 가능하였던 26례를 대상으로 하였다. 수술 후 최종 평가는 방사선 결과와 fang s criteria를 이용한 임상적 결과로 분석하였다. 결과: 수술 후 평균 9.3주에 모든 예에서 지연유합 없이 골유합 되었으며 임상적으로 Kangs criteria에 따라 구분한 결과, 우수 이 상이 22례로 나타났다. 특히, 견관절 운동은 상완골 골절이 동반된 두 경우를 제외한 24례에서 2.9주내에 정상 범위로 빠른 회복을 보였다. 합병증으로는 견관절 운동 장애 2례, 수술 절개 부위의 켈로이드 형성 1례였으며 그 이외에 다른 주요 합병증은 없었다. 결론: 전위성 쇄골 간부 골절에서 LCP를 이용한 관혈적 정복 및 금속내 고정술은 기존의 금속판에 비해 수술 후 합병증을 줄이고 효과적인 골유합과 조기 견관절 운동에 도움을 줄 수 있는 좋은 치료 방법 중 하나라고 사료된다.

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개에서 복막투석 적용: 20 증례 (2006-2008) (Peritoneal Dialysis in Dogs: 20 cases (2006-2008))

  • 남소정;최란;오원석;현창백
    • 한국임상수의학회지
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    • 제26권1호
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    • pp.23-28
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    • 2009
  • 복막투석은 정상적인 생리적 상태의 장애를 야기하는 체내의 독성물질을 치료적으로 제거하는 임상적 방법이다. 본 연구에서는 신부전으로 내원한 환자에게 복막투석을 적용한 20증례의 임상적 결과와 합병증을 후향적으로 평가하였다. 복막투석을 실시하는 동안 적혈구수, 혈구용적, 신기능과 관련된 혈액 화학적 수치 및 전해질 등의 혈액학적 분석과 합병증, 임상적 결과 등을 기록하였다. 복막투석의 결과로 19마리의 개에서 혈중 요소 질산 농도가 유의하게 감소하였고 (p<0.05), 17마리의 개에서 혈중 크레아티닌의 농도가 유의하게 감소하였다 (p<0.05). 복막투석의 부작용으로는 저알부민혈증(12/20, 60%), 빈혈(10/20, 50%), 투석액의 피하 누출(9/20, 45%), 세균성 복막염 (6/20, 30%), 투석액의 저류 (5/20, 25%)와 사지의 부종(4/20, 20%)이 나타났다. 본 증례고찰을 통하여 복막투석은 신부전(특히 급성기)에 이환된 개에서 질소혈증을 개선하는데 효과적임을 알 수 있었다.

견봉 쇄골 관절 탈구의 관혈적 정복술시 오구 쇄골 인대 봉합의 필요성 (The Necessity of Coracoclavicular Ligament Repair in Open Reduction for the Acromioclavicular Joint Dislocations)

  • 김유진;신헌규;정화재;최재열;박세진;최규보;임종준
    • Clinics in Shoulder and Elbow
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    • 제13권2호
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    • pp.194-201
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    • 2010
  • 목적: 오구 쇄골 인대를 봉합하지 않고 견봉 쇄골 관절의 관혈적 정복만 시행한 환자군에서의 임상적, 방사선학적 추시 결과를 확인하고자 하였다. 대상 및 방법: 1998년부터 2007년까지 변형 Phemister 술식과 갈고리 금속판 (AO hook 금속판, Wolter 금속판)을 사용하여 견봉 쇄골 관절 탈구로 수술 받은 환자 중 삽입물 제거한 53예를 대상으로 하였다. 변형 Phemister 술식을 사용한 군이 21명, 갈고리 금속판을 사용한 군이 32명 이였다. 임상적 평가는 Constant score를 이용하였으며, 양측 쇄골과 오구돌기 사이의 수직 거리를 비교하여 방사선적 평가를 하였다. 결과: Constant score는 변형 Phemister 술식을 사용한 군에서는 $87.59{\pm}7.8$, 갈고리 금속판을 사용한 군에서는 $89.35{\pm}5.3$로 통계학적 차이는 없었다. 두 군에서 수술 전 손상 부위의 쇄골 오구돌기의 평균 거리는 15.9 mm이였으며, 건측 견관절은 평균 8.0 mm이였다. 갈고리 금속판 환자군에서 건측과 비교하여 평균 1.0 mm, 변형 Phemister 환자군에서는 평균 1.2 mm의 수직 전위가 관찰되었으며 통계학적 차이는 없었다. 결론: 오구쇄골 인대를 복원 하지 않은 견봉 쇄골 관절 탈구의 관혈적 정복술 및 내고정술은 양호한 임상적, 방사선학적 결과를 보였다.

개선되지 않는 질소혈증 동반한 만성신부전 환자에서 지속적 신대체 요법의 적용 (Continuous Renal Replacement Therapy of Chronic Kidney Disease with Uncontrolled Azotemia in Six Dogs)

  • 한세명;김종택;이종복;서경원;송우진;유민옥;황철용;윤화영
    • 한국임상수의학회지
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    • 제32권5호
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    • pp.440-444
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    • 2015
  • 본 케이스는 요독증이 해소되지 않는 말기 만성 신부전 환자에서의 지속적 신대체요법에 관한 보고이다. 본 원에 내원하여 만성신부전으로 진단 내려진 6마리의 환자에서 수액요법과 같은 일반적인 대증요법에 개선이 없었다. 따라서 혈액투석방법을 진행하였다. 평균 57-72%의 요소감소율을 보인 4마리의 환자와 37.3%의 요소감소율을 보인 1마리의 환자견에서 좋은 개선을 보였다. 하지만 6마리의 환자견에서의 93회 혈액투석 동안 체외흐름 폐색, 항응고제 사용에 의한 과도한 출혈등과 같은 부작용이 12회 발생하였다. 따라서 요독증이 개선되지 않는 만성 신부전 환자에서의 지속적 신대체요법은 유용하다 할 수 있으며 혈액투석동안 면밀한 부작용 관찰이 중요하다 여겨진다.

오미자(五味子)(Fructus Schisandrae)가 흰쥐 해마신경세포의 저산소증 모델에서 세포사에 미치는 영향 (Prevention of ROS Production and MMP Dissipation by Fructus Schisandrae(FS) in a Hypoxic Model of Cultured Rat Hippocampal Neurons)

  • 주대환;신길조;문일수
    • 대한한방내과학회지
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    • 제29권4호
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    • pp.835-845
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    • 2008
  • Objectives : The purpose of this study was to investigate the effect of FS for the modulation of ROS and MMP in a hypoxic model of cultured rat cortical cells. Methods : For the effect of FS on the viability, FS was added to culture media (neurobasal supplemented with B27) and cell viability was measured by LDH assay. To investigate the effects of FS on ROS generation and MMP preservation, cells grown in FS-containing media were given a hypoxic shock(2% $O_2/5%$ $CO_2$, $37^{\circ}C$, 3 hrs) on DIV 10, stained with $H_2DCF-DA$(10 nM) and JC-1, respectively, and observed by fluorescent microscope. Results : 1. FS has a protective effect of cortical cells in both normoxia and hypoxia. 2. FS reduced the generation of ROS and this reduction was especially significant at 3 days after hypoxia. 3. FS was effective for the maintenance of MMP in hypoxia, and this efficacy was especially significant at 3 days after hypoxia. Conclusions : Taken together, these results indicate that FS attenuates ROS generation and MMP dissipation, which eventually protects from neuronal cell death in hypoxia.

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한양방 병용치료를 통한 만성적 농흉의 완화 치험 1례 (A Case Report of a Patient with Chronic Thoracic Empyema Treated with a Combination of East-West Medicine)

  • 정영은;김종대
    • 대한한방내과학회지
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    • 제38권2호
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    • pp.252-258
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    • 2017
  • Objectives: The purpose of this case report is to describe the clinical effectiveness of Korean medicine, especially Jungcheonwhadam-tang and Bopyeoyangyeong-jun, in a patient with chronic thoracic empyema while receiving treatment for this condition. Methods: The patient who had been diagnosed with empyema complained of a cough, with sputum. The patient was diagnosed with pe-ong (肺癰) based on his symptoms and x-ray findings. He was treated with a range of Korean medicines, including a herbal decoction, acupuncture, moxibustion, and cupping. A visual analogue scale and percentage pain reduction scale were administered after treatment. Results: After 20 days of the treatment, the patient's cough decreased by 80%, and sputum decreased by 50%. Conclusion: According to this study, Korean medicine, including Jungcheonwhadam-tang and Bopyeoyangyeong-jun, is effective in the treatment of chronic thoracic empyema.

동신기혈양수방(東新氣血養睡方) 액상 스틱 파우치의 취침전 투여가 입면시간에 미치는 효과 (The Effect of pre-bedtime administration of Liquid stick Packs of Dongshingihyeolyangsubang on Time to Sleep)

  • 이혜인;최창원;이영수;문영호;김경옥
    • 대한한의학방제학회지
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    • 제26권1호
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    • pp.59-64
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    • 2018
  • Objectives : This study is to identify the effects of taking Liquid stick Packs of DS Gihyeolyangsubang(DSGYSB) on the time to sleep. Methods : From August 2016 to October 2017, 19 patients who were admitted to Dongshin Univ. Oriental Medicine Hospital due to sleep disturbance were included in this study. The result of changing time to sleep and the effect of the duration of administration on the time to sleep were statistically analyzed. Results : as follows. 1. DSGYSB administration before bedtime showed the time to sleep reduction effect. 2. The administration was effective for more than 4-7 days before 1-3 days of DSGYSB. Conclusions : These results suggest that Liquid stick Packs of DSGihyeolyangsubang are effective in reducing the time of the time to sleep.