• The Journal of Internal Korean Medicine
• /
• v.24 no.4_2
• /
• pp.1037-1045
• /
• 2003

Objectives: Dementia is a kind of chronic, progressive, degenerative disease. The symptoms results in troubles in intellectual functions. memory, orientation, intelligence, judgement, common sense and calculating ability. The Korean version of Mini-Mental State Examination(MMSE-K) has been used widely to screen cognitive impairment of the elderly in Korea. This instrument has been specifically developed and evaluated for the assessment of cognitive function in older Korean populations. Methods: Cognitive function was evaluated by the Korean version of Mini-Mental State Examination(MMSE-K). This patient was diagnosed as Vascular dementia and We treated her cognitive impairment with Gagambosim-tang(Jiajianbuxin-tang). Results: After treated with Gagambosim-tang(Jiajianbuxin-tang), Cognitive function was improved. Conclusion: This report may have a meaning to treat Vascular dementia.

• The Journal of Internal Korean Medicine
• /
• v.26 no.4
• /
• pp.820-827
• /
• 2005

연구목적: 본 연구는 Poloxamer-407로 유발시킨 고지혈증에 대한 청간탕의 효과를 알아보기 위해 수행되어졌다. 실험방법: Poloxamer-407로 쥐에 고지혈증을 유발시킨후 청간탕과 Lipidil을 경구 투여하여 혈청 cholesterol, 고밀도 지단백, 중성지질을 측정하였으며, 지질대사와 관련된 ACAT, DGAT, $CYP7{\alpha}H$, LDL receptor의 gene expression을 RT-PCR를 통해 비교 분석하였다. 실험결과: 청간탕 투여군은 혈청 콜레스테롤을 각각 32% 와 65% (p<0.05)로, 혈청 중성지방을 각각 21% 와 51% (p<0.05)로 감소시켰다. 또한, 청간탕은 LDL 수용체와 $CYP7{\alpha}H$ 유전자 발현을 증가시켰다. 결론: 이상의 연구로부터 우리는 청간탕이 지질의 흡수, 저장을 억제하고 콜레스테롤의 분비를 촉진함으로써 고지혈증에 일정한 효과가 있음을 알 수 있었다.

• The Journal of Internal Korean Medicine
• /
• v.26 no.2
• /
• pp.506-511
• /
• 2005

Hiccup is a common clinical symptom, and may be caused from over 100 medical origins. Generally hiccup happens temporarily, and continues only a few seconds or minutes, and is cured easily by physical methods or even by itself. But in some cases, hiccup is so refractory that patients may be tired and very troubled by it. At worst, it may cause death. Intractable hiccup is defined as hiccup persisting for more than 48 hours, and this appears in various diseases. Persistent hiccup is very difficult to treat by conventional methods. A 69-year-old man was admitted due to intractable hiccup without gastroenteral system abnormalities or peripheral nervous systemic involvement. So Paljung-san(八正散) was prescribed. The intensity and frequency of hiccup dramatically improved.

• The Journal of Internal Korean Medicine
• /
• v.28 no.4
• /
• pp.838-849
• /
• 2007

Backgrounds & Objectives : The aim of study was to evaluate post stroke cognitive deficit. We applied CERAD-K for post-stroke cognitive deficit, and revalued after treatment for 4 weeks. Methods : We applied CERAD-K test to 25 patients with post stroke cognitive deficit and compared with previous literature. After acupuncture treatment, moxa treatment, herb medicines, physical and occupational therapy for 4 weeks, we revalued changes by CERAD-K to 13 people that received treatment. Results : The stroke group's points were lower than the normal group in general cognition. Verbal fluency, MMSE-KC, and constructional praxis scores was lower than the AD group. Boston Naming Test, word list immediate recall, word list delayed recall, wordlist recognition, and praxis delayed recall scores were higher than the AD group. Verbal fluency (p=0.017), MMSE-KC (p=0.026), and word list immediate recall (p=0.005) scores of 13 patients participating in this study showed a statistically significant increase after treatment. Conculsions : Acupuncture treatment, moxa treatment, herb medicines, physical and occupational therapy are effective for improvement of post-stroke cognitive deficit, but this study could not demonstrate whether some treatments influenced cognition and there was a limitation in lacking a control group.

• The Journal of Internal Korean Medicine
• /
• v.21 no.4
• /
• pp.671-676
• /
• 2000

Pleural effusion is a state, retention of a mount of liquid in pleural cavity. Main causes of pleural effusion is Congestive Heart Failure that is caused by left ventricular heart failure. And that of Congestive heart failure is caused by increase of pleural capillary pressure or remain of effusion in pleural cavity. Bilateral venous pressure of pleura make worse pleural effusion and one way of venous pressure of that bring out pleural effusion. The purpose of this study is to examine the efficacy of oriental treatment for pleural effusion is caused by heart failure. One woman of 86 years old complained the symptom of general weakness, dyspnea, flank pain, anorexia, insomnia, coughing, secretion mixed blood. The symptom is caused by effusion that is brought out acute pneumonia, heart failure. At the time of Admission, in the diagnosis of Admission, in the diagnosis of Hyuneum(懸飮) she had taken Kungha-tang hap pleurisy-bang,(芎夏湯合助膜炎方), so improved dyspnea, flank pain, insomnia, coughing. In views of examination, decrease of heart failure' s symptom and pleural effusion. After 13days of admission, she had taken palmul-tang.(八物湯). As a conseguence of that, the symptom of general weakness. anorexia is improved and she was discharged.

• The Journal of Internal Korean Medicine
• /
• v.34 no.1
• /
• pp.100-111
• /
• 2013

Objectives : This study investigated the impact of Caesalpinia sappan L. on oxidative damage and inflammatory relevant factor in RAW 264.7 cells and human umbilical vein endothelial cells (HUVEC). Methods : We determined whether fractionated EtOH extracts of Caesalpinia sappan L. (CSL) inhibit free radical generation such as 2,2-diphenyl-1-picrylhydrazyl (DPPH), reactive oxygen species (ROS) and nitric oxide (NO) and pro-inflammatory cytokines in lipopolysaccharide (LPS)-treated RAW 264.7 cells and HUVEC. Result : 1. DPPH removal capacity was increased by CSL. 2. LPS-induced ROS, and NO inhibitory capacity were increased by CSL. 3. LPS-induced cell death of Raw 264.7 cells was decreased by CSL. 4. The amount of cytokine generation in Raw 264.7 cell was decreased significantly by CSL. 5. The amount of cytokine generation in HUVEC was decreased significantly by CSL. Conclusions : These results suggest that CSL supplement may attenuate oxidative stress by elevated antioxidative processes, and suppress inflammatory mediator activation.

• The Journal of Internal Korean Medicine
• /
• v.25 no.4
• /
• pp.383-390
• /
• 2004

The most common causes of severe sleepiness beginning or progressively worsening in adults are SLEEP APNEA and RELATED BREATHING DISORDERS DURING SLEEP. Idiopathic hypersomnia is excessive sleeping without obvious cause. Idiopathic hypersomnia diagnosis can be explained as follows: One could be chronically sleepy due to either something wrong with sleep that makes it non-refreshing, or a problem with the brain mechanisms which normally should keep one alert whether caused by primary problems within the brain or its chemistry, or by other factors (such as sedating medications or thyroid problems). A 71-year-old male who had suffered from excessive sleeping was admitted to our department for oriental treatment on 7th of July, 2003. He was diagnosed as an idiopathic hypersomnia for excessive sleeping without obvious cause. Initial treatment modalities with administration of "SoonHwanGi1HoBang(循環器1號方)" were not effective. However, after administration of "YukMiGiHwangTang(六味地黃湯)" desirable effects were seen.

• The Journal of Internal Korean Medicine
• /
• v.22 no.2
• /
• pp.245-250
• /
• 2001

Paraquat is one of the widely used herbicides. But it is fatal, if it is consumed by people. Paraquat poisoning causes acute renal failure, hepatic dysfunction, and progressive respiratory failure. There are no effective antidotes to paraquat. This report is about one case's treatment for acute hepatitis caused by paraquat. The patient was hospitalized in the Department of Internal Medicine, Wonkwang University Oriental Medical Hospital in Chonju. The patient received the following treatments while in an acute stage : Gamdutanggamibang(甘豆湯加味方), which consists of Radix glycyrrhizae(甘草), Semen mungo(綠豆), burned powder of Rhizoma rhei(大黃炒炭末), Succus phyllostachyos(竹瀝), chinese ink(墨汁) and fluid therapy. The patient received Sagunjatanggamibang(四君子湯加味方) while in a chronic stage. The patient improved faster with the above treatments than with the conventional treatment. We hope that this report will help widening the clinical range of oriental medicine, and improve systemic efforts in treating paraquat poisoning cases.

• The Journal of Internal Korean Medicine
• /
• v.27 no.3
• /
• pp.762-769
• /
• 2006

A callosal disconnection syndrome results in the functional independence of each hemisphere caused by ACA infarction, head injury or callosal operation for epilepsy. Clinical features are characterized by left unilateral tactile anomia, left unilateral agraphia, left unilateral apraxia, difficulty in copying drawings, dyscalculia and alien hand syndrome. Taeumchowe-tang(太陰調胃湯) is used to treat Taeumin(太陰人) Wewansuhanpyohanbyung(胃脘受寒表寒病). A 47 year-old man, following callosal infarction, was detected on MRI with left agraphia, dyscalculia and alien hand syndrome, but no left ideomotor apraxia or left apraxia. He was treated with Taeumchowe-tang. Significant improvement of clinical symptoms was seen, so it is here reported.

• The Journal of Internal Korean Medicine
• /
• v.27 no.3
• /
• pp.629-638
• /
• 2006

This study was carried out to examine the relaxational response to the water extract of Sobokchuko-tang (SCT) in rat thoracic aorta. Segments of thoracic aorta obtained from rats immediately after delivery were mounted in organ baths superfused on a polygraph. It was found that the thoracic aorta segments responded to the SCT with dose-dependent vasorelaxation. At $10^{-7}M$ phenylephrine-induced contraction, the contractile response of thoracic aortic rings were inhibited by 99.2%. 75.3%. 42.4% and 35.8% after addition of the respective concentration (1O. 30. 100. $300{\mu}g$/ml) of SCT. This vasorelaxation of rat thoracic aorta was endothelium-dependent. The action mechanisms of vasorelaxation are thought to be concerned with the role of NO. cAMP and cyclooxygenase. but not with cGMP.