• Tuberculosis and Respiratory Diseases
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• v.62 no.5
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• pp.406-416
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• 2007

Background: Single nucleotide polymorphisms (SNPs), which consist of a substitution of a single nucleotide pair, are the most abundant form of genetic variations occurring with a frequency of approximately 1 per 1000 base pairs. SNPs by themselves do not cause disease but can predispose humans to disease, modify the extent or severity of the disease or influence the drug response and treatment efficacy. Single nucleotide polymorphisms (SNPs), particularly those within the regulatory regions of the genes often influence the expression levels and can modify the disease. Studies examining the associations between SNP and the disease outcome have provided valuable insight into the disease etiology and potential therapeutic intervention. Traditionally, the genotyping of SNPs has been carried out using polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP), which is a low throughput technique not amenable for use in large-scale SNP studies. Recently, TaqMan real-time PCR chemistry was adapted for use in allelic discrimination assays. This study validated the accuracy and utility of real-time PCR technology for SNPs genotyping Methods: The SNPs in promoter sequence (-37 and -524) of lung cancer suppressor gene, RRM1 (ribonucleotide reductase M1 subunit) with the genomic DNA samples of 89 subjects were genotyped using both real-time PCR and PCR-RFLP. Results: The discordance rates were 2.2% (2 mismatches) in -37 and 16.3% (15 mismatches) in -524. Auto-direct sequencing of all the mismatched samples(17 cases) were in accord with the genotypes read by real-time PCR. In addition, 138 genomic DNAs were genotyped using real-time PCR in a duplicate manner (two separated assays). Ninety-eight percent of the samples showed concordance between the two assays. Conclusion: Real-time PCR allelic discrimination assays are amenable to high-throughput genotyping and overcome many of the problematic features associated with PCR-RFLP.

• Korean Chemical Engineering Research
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• v.54 no.5
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• pp.612-620
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• 2016

Aqueous mineral carbonation process, in which $CO_2$ is captured through the reaction with aqueous calcium oxide (CaO) solution, is one of CCU technology enabling the stable sequestration of $CO_2$ as well as economic value creation from its products. In order to enhance the carbon capture efficiency, it is required to maximize the dissolution rate of solid reactants, CaO. For this purpose, the proper design of a reactor, which can achieve the uniform distribution of solid reactants throughout the whole reactor, is essential. In this paper, the effect of internal reactor designs on the solid dispersion quality is studied by using CFD (computational fluid dynamics) techniques for the pilot-scale reactor which can handle 40 ton of $CO_2$ per day. Various combination cases consisting of different internal design variables, such as types, numbers, diameters, clearances and speed of impellers and length and width of baffles are analyzed for the stirred tank reactor with a fixed tank geometry. By conducting sensitivity analysis, we could distinguish critical variables and their impacts on solid distribution. At the same time, the reactor design which can produce solid distribution profile with a standard deviation value of 0.001 is proposed.

• Journal of Korean Tunnelling and Underground Space Association
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• v.8 no.4
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• pp.335-344
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• 2006

The domestic standards which used the standards of Road Association of Japan standards presents the distances of between jet-fans by the caliber of jet-fan. However, the Permanent International Association of Road Congress (PIARC) encourages it to be ten times a diameter of the tunnel. The distance of jet-fans installed in bases of two standards differs as much as two times, as so the proper basis after analysis of internal air current is needed since such difference can lead to disadvantage for selection of ventilation configuration. Based on Froude modeling theory, 1/40 scale acrylic model of a tunnel (215mm in diameter and 6.9m in length) and jet-fan (26.3mm and 31.6mm in caliber) was made for the measurement of changes in pressure and velocity due to the extension of tunnel for analysis of internal air current. And we measured the changes in pressure of surroundings of a jet-fan for confirmation of recirculation due to the exterior airs when the jet-fan is on. The results of the model test show that internal air current was not influenced by the caliber of jet-fan and its changes in pressure and velocity were stable in the point where it was nine times of diameter of the tunnel. Also the recirculation when the jet-fan is on could be verified. According to such results, in the cases of installing jet-fan in tunnels, the distances between jet-fans needs to be more than nine times the diameter.

• Journal of Preventive Medicine and Public Health
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• v.29 no.1 s.52
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• pp.51-65
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• 1996

The purpose of this study was to examine the trends of length of hospital stay (LOS), which is most likely to be a major attribute to hospital performance. From 1984 to 1994, an average LOS of each hospital was analyzed by factors such as medical departments, bed size, occupancy rate, region and ownership. This study was analyzed changing rate of LOS during 11 years. This rate was calculated by simple regression, which was used only with hospital without missing data during 11 years. This study findings are as follows. 1. The results indicated that the average LOS was steadily increased until 1990 but it was slightly decreased after 1990. 2. This trend could be found in all hospital scale and all group of occupancy rate. Specifically this trends of LOS were found in internal medicine, corporate owned hospitals, and hospitals in major city. But LOS of individual owned hospital was continuously increased until 1994. 3. Means of changing rates of LOS were calculated from 1984 to 1994. If we devided it into two parts, before 1990 and after 1990, most changing rates of LOS before 1990 except individual owned hospital were found positive sign. The changing rates after 1990 were negative sign but small hospital(lesser then 200 bed), individual owned hospital, national & public hospital and hospital in small urban have little change of LOS after 1990. Finally from this results we thought that most hospitals in Korea began to be concerned with LOS. Nevertheless LOS of several hospital such as small hospital or individual owned hospital was increased. And this trend may be caused by a few patients, low occupancy rate, or low profit. This trend of LOS is different from that of other countries. Perhaps this phenomenon is resulted from the reimbursement method. Because of fee for service reimbursement system in Korea the hospitals didn't need to shorten LOS in order to save the cost and increase the profit. Therefore reform of hospital cost reimbursement method will be needed to reduce hospital cost in Korea. We thought that the Korean health authority should consider the reimbursement method by unit of bundle of services, for example DRG and prepayment in the United States. This study presents some limitations such as no insight of severity of disease, case-mix measurement of hospital, and other clinical characteristics that can. possibly affect LOS. However, this study reports an important trend in LOS from 1984 to 1994.

• Journal of the Korean Institute of Gas
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• v.9 no.3 s.28
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• pp.1-8
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• 2005

We studied on the nondestructive evaluation of the elastic wave signals of locally wall thinned straight pipe. Wavelet transform was applied for the time-frequency analysis of waveforms obtained by fracture wave detector due to the dropping steel ball. The time-frequency analysis provides time variation of each frequency component involved in a waveform, which makes it possible to evaluate the shape of local wall thinning at each frequency. In this study, comparison by wavelet transform of the AE signals and monotonic bending tests without internal pressure are conducted on 1.91 inch diameter full-scale carbon steel pipe specimens. As the results of tests, fracture behaviors could be shown by the characteristic of mechanical strength of locally wall thinned pipes and the waveforms could be evaluated for the integrity insurance of the piping system according to the length and depth range of the deffeted shape pipes in the real field.

• Steel and Composite Structures
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• v.26 no.6
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• pp.793-808
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• 2018

In this study, the seismic performance of the connections between L-shaped columns composed of concrete-filled steel tubes (L-CFST columns) and H-beams used in high-rise steel frame structures was investigated. Seven full-scale specimens were tested under quasi-static cyclic loading. The variables studied in the tests included the joint type, the axial compression ratio, the presence of concrete, the width-to-thickness ratio and the internal extension length of the side plates. The hysteretic response, strength degradation, stiffness degradation, ductility, plastic rotation capacity, energy dissipation capacity and the strain distribution were evaluated at different load cycles. The test results indicated that both the corner and exterior joint specimens failed due to local buckling and crack within the beam flange adjacent to the end of the side plates. However, the failure modes of the interior joint specimens primarily included local buckling and crack at the end plates and curved corners of the beam flange. A design method was proposed for the flexural capacity of the end plate connection in the interior joint. Good agreement was observed between the theoretical and test results of both the yield and ultimate flexural capacity of the end plate connection.

• Structural Engineering and Mechanics
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• v.70 no.4
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• pp.381-394
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• 2019

If an alternative path would not be considered for redistribution of loads, local failure in structures will be followed by a progressive collapse. When a vertical load-bearing element of a steel structure fails, the beams connected to it will lose their support. Accordingly, an increase in span's length adds to the internal forces in beams. The mentioned increasing load in beams leads to amplifying the moments there, and likewise in their corresponding connections. Since it is not possible to reinforce all the elements of the structure against this phenomenon, it seems rational to use other technics like specified strengthened connections. In this study, a novel connection is suggested to handle the stated phenomenon which is introduced as a passive connection. This connection enables the structure to tolerate the added loads after failing of the vertical element. To that end, two experimental models were constructed and thereafter tested in half-scale, one-story, double-bay, and bolted connections in three-dimensional spaces. This experimental study has been conducted to compare the ductility and strength of a frame that has ordinary rigid connections with a frame containing a novel passive connection. At last, parametric studies have been implemented to optimize the dimensions of the passive connection. Results show that the load-bearing capacity of the frame increased up to 75 percent. Also, a significant decrease in the displacement of the node wherein the column is removed was observed compared to the ordinary moment resisting frame with the same loads.

• Journal of the Korean Geotechnical Society
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• v.23 no.11
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• pp.49-58
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• 2007

Numerical experiments using a distinct element code (PFC3D) were carried out for the analysis of grout-material transfer in soil layers and also for the analysis of increase in mechanical strength after permeation grouting. For rapid analysis, up-scaling analysis in length scale was adopted, and the following observations were made from the numerical experiments. Firstly, the relative size of grout material with respect to the in situ soil particles controlled the transfer distance of the grout particles. When the size of grout particle was 0.2 to 0.25 times of the in situ soil particles, clogging of pore spaces among the in situ soil particles occurred, resulting in restricted propagation of grout particles. It was also found that there was a threshold value in the size of grout particle. Below the threshold value, the transfer distance of the grout particle did not increase with the decrease of particle size of the grout material. Secondly, the increase in cohesion and internal friction angle was observed in the numerical specimen with grouting treatment, but not with the untreated specimen.

• The Journal of Internal Korean Medicine
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• v.44 no.2
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• pp.167-177
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• 2023

Background: Pressure injuries are localized areas of damage to the skin and/or underlying tissue, usually over a bony prominence due to pressure. Cerebrovascular disease increases the risk of pressure injuries due to the immobility caused by physical paralysis. The general approach to managing a patient with pressure injuries should include pain relief, the treatment of the infection, optimizing nutritional intake, proper positioning, and contamination prevention. Nonetheless, the duration of treatment for pressure injuries varies from person to person. Case report: An 80-year-old female intracerebral hemorrhage patient developed a pressure injury. To improve the injury faster, a Radix Astragali pharmacoacupuncture solution was applied to the pressure sore. The pressure injury's width, length, and depth was assessed using a ruler, and the exudate amount and tissue types were assessed. The treatment was performed for 35 days. The rate at which the size of the pressure sore lessened increased since the Radix Astragali pharmacoacupuncture solution was applied to the pressure sore. In addition, the tissue type of the pressure injury improved, and the exudates decreased. There was no significant difference in the Pressure Ulcer Scale for Healing Tool 3.0, since the Radix Astragali pharmacoacupuncture solution was applied to the pressure injury. Conclusion: This clinical case study suggests that the Radix Astragali pharmacoacupuncture solution might be effective in speeding up the healing of pressure injuries.

• Journal of Acupuncture Research
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• v.34 no.4
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• pp.172-179
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• 2017

Background: This study was designed to evaluate the clinical effectiveness of traditional Korean medicine treatment for lumbar spinal stenosis as assessed by radiological criteria. Methods: This was an observational study of 122 patients who were diagnosed with lumbar spinal stenosis and admitted to Jaseng Hospital between January 2016 and June 2017. They were analyzed according to sex, age, cause of disease, disease stage, length of admission, type of stenosis, morphological grade, and dural sac cross-sectional area. All patients were treated with traditional Korean medicine. Patients were assessed with the Numeric Rating Scale (NRS), Oswestry Disability Index (ODI) and EQ-5D before and after treatment. Results: Regarding the distribution of the factors analyzed, these were of note: more females than males (1:3.52); and highest proportions were age more than 70 years (37.70%), cause of lumbar spinal stenosis unknown (67.21%), and subacute stage (42.62%). Comparing before and after treatment, the NRS score for low back and pelvic pain decreased from $6.14{\pm}1.71$ to $4.28{\pm}1.91$ (p < 0.001), and the NRS score for radiating pain and numbness decreased from $6.27{\pm}1.61$ to $2.02{\pm}1.54$ (p < 0.001). ODI decreased from $46.86{\pm}19.40$ to $33.63{\pm}18.66$ (p < 0.001), and gait-related ODI decreased from $3.34{\pm}1.23$ to $2.80{\pm}1.11$ (p < 0.001). There were no statistically significant differences in improvement of the NRS, ODI, gait-related ODI, and EQ-5D for morphological grade and dural sac cross-sectional area. Conclusion: Traditional Korean medicine is effective treatment for patients with lumbar spinal stenosis. Even in patients with severe radiological findings, it is possible to reduce pain and improve quality of life.