• Tuberculosis and Respiratory Diseases
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• v.44 no.5
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• pp.992-1000
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• 1997

Background : Since up to 90% of a theophylline dose is biotransformed, probably by interaction with one or more the variants of the cytochrome P-450 drug metabolism system, anti-tuberculosis agents including drugs influencing microsomal enzyme systems, such as isoniazid and rifampicin. may be affect the elimination of theophylline. Method : The effect of combination therapy with isoniazid(INH), rifampicin(RFP), ethambutol(EMB) and pyrazinamide(PZA) on the pharmacokinetics of theophylline was evaluated by a computer program using Bayesian method. Three group were divided as follows. Group I is control, Group II is treated with INH. RFP, EMB and PZA and Group III is treated with INH, RFP and EMB. All of them were ilon-smoker who were normal in liver and renal functions, and not administered drugs affecting on the clearance of theophylline with exception of anti-tuberculous agents. Results : When it compared control with test groups, the clearance of theophylline in Group II and Group III was significantly decreased(p<0.001), and half life in Group II and Group III showed significant elevation(p<0.001). However there were no significant differences in clearance and half life between the Group II and Group III. Conclusion : These results suggest that theophylline dose may be need of readjustment in concurrent medication of anti-tuberculous agents including INH, RFP, and EMB.

• Tuberculosis and Respiratory Diseases
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• v.44 no.2
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• pp.338-348
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• 1997

Background : Endotoxin, the component of outermembrane of gram negative organism, plays an important role in the initiation and amplification of inflammatory reaction by its effects on inflammatory cells. Until recently, there have been continuing efforts to delinate the mechanisms of the signal trasduction pathway of endotoxin stimuli on inflammatory cells. By uncovering the mechanisms of signal transduction pathway of endotoxin stimuli, we can expect to have tools to control the excessive inflammatory responses which sometimes may be fatal to the involved host. It was generally accepted that endotoxin exerts its inflammatory effects through inflammatory cytokines that are produced by endotoxin-stimulated inflammatory cells and there were some reports on the importance of protein kinase C and protein tyrosine kinase activation in the production of inflammatory cytokines by endotoxin So we evaluated the effect of pretreatment of protein kinase C inhibitors (H7, Staurosporin) and protein tyrosine kinase inhibitors(Herbimycin, Genistein) on the endotoxin-stimulated cytokines(IL-8 & TNF-$\alpha$) mRNA expression. Method : Peripheral blood monocytes were isolated from healthy volunteers by Ficoll-Hypaque density gradient method and purified by adhesion to 60mm Petri dishes. Endotoxin(LPS 100ng/ml) was added to each dishes except one control dish, and each endotoxin-stimulated dishes was preincubated with H7, Staurosporin(protein kinase C inhibitor), Herbimycin or Genistein(protein tyrosine kinase inhibitor) respectively except one dish. Four hours later the endotoxin stimulation, total RNA was extracted and Northern blot analysis for IL-8 mRNA and TNF-$\alpha$ mRNA was done. Result : Endotoxin stimulation increased the expression of IL-8 mRNA and TNF-$\alpha$ mRNA expression in human peripheral blood monocyte as expected and the stimulatory effect of endotoxin on TNF-$\alpha$ mRNA expression was inhibited by protein kinase C inhibitors(H7, Staurosporin) and protein tyrosine kinase inhibitors (Herbimycin, Genistein). The inhibitory effect of each drugs was increased with increasing concentration. The stimulatory effect of endotoxin on IL-8 mRNA was also inhibited by H7 and protein tyrosine kinase inhibitors (Herbimycin, Genistein) dose-dependently but not by Staurosporin. Conclusion : Protein kinase C and protein tyrosine kinase are involved in the endotoxin induced signal transduction pathway in human peripheral blood monocyte.

• Journal of the Korean Society of Safety
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• v.35 no.1
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• pp.53-61
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• 2020

This study proposes a new damper configuration for seismic performance improvement of heavy sliding facilities inside a building. For this purpose, we deal with two connection types of control system, and the parametric study has been performed to investigate their comparative seismic performances according to the variations of the control capacity. In order to simulate the seismic responses of the proposed system, we employed a recently-developed seismic response analysis method that can deal with the two-mass system with nonlinear frictional sliding behavior. The numerical results demonstrate that the typical method of diagonal bracing damper connection can exhibit effective control performance both on structure and the heavy sliding facilities, whereas the structure-facilities connection method does not show any control effect on both responses. On the other hand, the typical method has some limitations that it can adversely cause excessive sliding of the facilities, depending upon the frequency characteristics of structure and earthquake. On the contrary, the structure-facilities connection method is very effective in reducing the sliding displacement of the heavy facilities, even with small amount of control capacity. Thus, the following potential expectations can be inferred from these results: The typical diagonal bracing damper connection method will have some promising benefits in controlling the sliding facilities inside the building as well as the building itself, and the structure-facilities connection method can be a cost-effective way of protecting the internal heavy important facilities inside the structure already designed with sufficient seismic performance.

• Proceedings of the KIEE Conference
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• 2000.11a
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• pp.139-141
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• 2000

High voltage direct current(HVDC) transmission system uses the phase controlled rectifier triggered by means of IPC(individual phase control) or EPC(equidistant pulse control). Most HVDC system has adopted EPC method that can solve the harmonic instability problem of IPC method in weak power system. But EPC has inherent indirect synchronizing problem requiring the closed loop control. This paper presents the new gate pulse generating method for 12-pulse HVDC converter, which combines IPC with EPC. Simulation and test results are presented. The basic concept is that it generates the gating pulse for 12-pulse converter by synthesizing the internal phase reference using the frequency and phase information of a sin91e phase voltage. To ensure the reliability of the external phase input, Potential transformer that detects the phase voltage has redundancy. Using fault detecting algorithm the healthy input is always guaranteed. And the frequency compensation function was reinforced.

• The Transactions of the Korean Institute of Power Electronics
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• v.10 no.4
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• pp.323-330
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• 2005

In order to increase reliability and reduce system cost, this paper studies particularly applicable method for sensorless PM BLDCM drive system. The waveform of the motor internal voltages(or back emf) contains a fundamental and higher order frequency harmonics. Therefore the third harmonic component is extracted from the stator phase voltage. The resulting third harmonic signal keeps a constant phase relationship with the rotor flux for any motor speed and load condition, and is practically free of noise that can be introduced by the inverter switching, making this a robust sensing method. In addition, a simple starting method and a speed estimation approach are also proposed. Some experimental results are Provided to demonstrate the validity of the proposed control method.

• The Journal of Korean Medicine
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• v.30 no.2
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• pp.79-87
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• 2009

Objective: This study assessed five respective herbs in Cheonggugamrosu (CGGRS) for ability to inhibit malodor in vitro. Methods: We used malodor modeling of the salivary sediment system. Incubation mixtures were prepared with sediment at 16.7% (v/v), amino acids (cysteine and tryptophan) at 6mM and either herb extract at 1% (w/v) or water as control. Mixtures were incubated at $37^{\circ}C$ and odor was monitored organoleptically and for volatile sulfur compounds with the Halimeter. Indole/skatole was determined by Kovac's colorimetric method. Results: Two of the herbs, Caryophilli Flos and Glycyrrhizae Radix, had inhibitory effect on malodor generation. Both of them significantly reduced VSC, organoleptic odor and indole/skatole formation (p<0.05). Conclusions: We found Caryophilli Flos and Glycyrrhizae Radix played a main role in CGGRS. Both herbs have potential as effective anti-malodor agents and this suggests they are worthy of further exploration.

• Proceedings of the KSME Conference
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• 2004.11a
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• pp.1715-1720
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• 2004

This paper presents the characteristics of internal clearances for the interstage of blades and shaft gland seals on the steam turbine which are installed in tandem compound. Internal clearances was changed when the rotor turned in the cylindrical sleeve bearing due to the generation of oil film wedge. This presented concern is very useful to prevent the rubbing damage of seal edge between the fixed and moving parts in steam turbine due to the misalignment at the rotating and stationary parts. This method is applied for the unbalanced clearances distribution to the left and right sides in the turbine casing. A considerable amount of unbalanced clearances distribution trend is determined according to the rotating speed of rotor, size and type of proceeding bearing, oil viscosity, surface roughness of bearing and shaft, oil temperature, oil pressure and bearing load.

• The Journal of Internal Korean Medicine
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• v.31 no.3
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• pp.513-525
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• 2010

Objectives : This study was carried out to investigate the effects of Goihwa-san(GHS) against ulcerative colitis induced by DSS (dextran sulfate sodium). Method : The sample group was divided into three. The control group consisted of mice that were not inflammation-induced. The pathological group was composed of untreated colitis elicited mice. The experimental group was administered GHS after colitis elicitation. The effects on ulcerative colitis were evaluated by the morphological change of colonic mucosa, the anti-oxidant effect, HSP 70, NF-${\kappa}$B, COX-1, COX-2 and iNOS. Results : In terms of immunohistochemical changes, the distribution of COX-1 in mice treated with GHS increased noticeably more than that in the pathological group. The distributions of HSP70, NF-${\kappa}$B, COX-2, iNOS in mice treated with GHS more decreased than those in the pathological group. Regeneration of surface epithelial cell and goblet cell in mucosa was observed by optical microscope. The colonic lengths in GHS-treated mice were more elongated than those of DSS only treated mice. Conclusion : GHS is a candidate treatment for ulcerative colitis.

• Korean Management Science Review
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• v.12 no.2
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• pp.129-146
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• 1995

As society's relience on computerized information systems to support a wide range of activities proliferates, the long recognized importance for adequate data quality becomes imperative. Furthermore, current trends in information systems such as dispersal of the data resource together with its management have increased the difficulty of maintaining suitable levels of data integrity. Especially, the importance of adequate accounting (transaction) data quality has been long recognized and many procedures (extensive and often elaborate checks and controls) to prevent errors in accounting systems have been introduced and developed. Nevertheless, over time, even in the best maintained systems, deficiencies in stored data will develop. In order to maintain the accuracy and reliability of accounting data at certain level, periodic internal checks and error corrections (internal audits) are required as a part of internal control system. In this paper we develop a general data quality degradation (error accumulation ) and cost model for an account in which we have both error occurrences and error amounts and provide a closed form of optimal audit timing in terms of the number of transactions that should occur before an internal audit should be initiated. This paper also considers the cost- effectiveness of various audit types and different error prevention efforts and suggests how to select the most economical audit type and error prevention method.

• Journal of Institute of Control, Robotics and Systems
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• v.13 no.1
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• pp.1-5
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• 2007

Many nonlinear controllers for the power system are based on nonlinear models involving the power angle as an element of the state, and therefore the reference value for the power angle is needed. As this reference value is not generally available, it is difficult to apply such nonlinear control methods in practice. To deal with this problem, we present an input-output feedback linearizing control scheme by selecting the output as a combination of the squared voltage and the relative frequency. It is shown that the internal dynamics are locally stable with controllable damping, and that the frequency remains bounded for all time. Simulations illustrate the effectiveness of the proposed method.