• Korean Journal of Acupuncture
• /
• 제17권1호
• /
• pp.101-121
• /
• 2000

The purpose of this morphological studies was to investigate the relation to the meridian, acupoint and nerve. The common locations of the spinal cord and brain projecting to the the gallbladder, GB34 and common peroneal nerve were observed following injection of transsynaptic neurotropic virus, pseudorabies virus(PRV), into the gallbladder, GB34 and common peroneal nerve of the rabbit. After survival times of 96 hours following injection of PRV, the thirty rabbits were perfused, and their spinal cord and brain were frozen sectioned($30{\mu}m$). These sections were stained by PRV immunohistochemical staining method, and observed with light microscope. The results were as follows: 1. In spinal cord, PRV labeled neurons projecting to the gallbladder, GB34 and common peroneal nerve were founded in thoracic, lumbar and sacral spinal segments. Densely labeled areas of each spinal cord segment were founded in lamina V, VII, X, intermediolateral nucleus and dorsal nucleus. 2. In medulla oblongata, The PRV labeled neurons projecting to the gallbladder, GB34 and common peroneal nerve were founded in the A1 noradrenalin cells/C1 adrenalin cells/caudoventrolateral reticular nucleus, rostroventrolateral reticular nucleus, medullary reticular nucleus, dorsal motor nucleus of vagus nerve, nucleus tractus solitarius, raphe obscurus nucleus, raphe pallidus nucleus, raphe magnus nucleus, gigantocellular nucleus, lateral paragigantocellular nucleus, principal sensory trigeminal nucleus and spinal trigeminal nucleus. 3. In Pons, PRV labeled neurons were parabrachial nucleus, Kolliker-Fuse nucleus and cochlear nucleus. 4. In midbrain, PRV labeled neurons were founded in central gray matter and substantia nigra. 5. In diencephalon, PRV labeled neurons were founded in lateral hypothalamic nucleus, suprachiasmatic nucleus and paraventricular hypothalamic nucleus. 6. In cerebral cortex, PRV labeled neuron were founded in hind limb area.This results suggest that PRV labeled common areas of the spinal cord projecting to the gallbladder, GB34 and common peroneal nerve may be first-order neurons related to the somatic sensory, viscero-somatic sensory and symapathetic preganglionic neurons, and PRV labeled common area of the brain may be first, second and third-order neurons response to the movement of smooth muscle in gallbladder and blood vessels.These PRV labeled neurons may be central autonomic center related to the integration and modulation of reflex control linked to the sensory system monitoring the internal environment, including both visceral sensation and various chemical and physical qualities of the bloodstream. The present morphological results provide that gallbladder meridian and acupoint may be related to the central autonomic pathways.

• 생명과학회지
• /
• 제26권6호
• /
• pp.651-656
• /
• 2016

벌 화분은 꿀벌로부터 생산되며 자연으로부터 얻을 수 있는 가장 균형 잡힌 영양 식품으로 받아들여지고 있다. 역사적으로도 벌 화분은 질병치료와 에너지 보충의 목적으로 사용되어 왔다. 최근의 연구 결과에서는 벌 화분의 항산화, 항염증, 심지어 항암작용과 같은 다양한 생리활성이 과학적으로 규명되고 있다. 그러나 벌 화분은 exine이라는 외피로 둘러싸여 있어 강산이나 고압 그리고 소화효소 등에 매우 저항성이 강한 것으로 밝혀졌고, 이로 인하여 생체이용률이 낮아 영양공급과 임상적 이용에 제한을 받고 있다. 본 연구는 벌 화분의 외피를 분쇄할 수 있는 습식분쇄기술을 개발하여 벌 화분의 생리활성을 분석하고자 기획되었다. 먼저 습식분쇄를 통해 벌 화분의 외피가 효과적으로 분쇄됨을 현미경을 통해 확인하였다. 게다가 습식분쇄에 의해 벌 화분의 활성성분으로 잘 알려진 polyphenol 화합물의 양이 약 11배 증가하였고 ABTS 항산화 분석법과 DPPH 라디칼 소거능 시험을 통해 항산화 효과가 증가함을 확인하였다. 이러한 결과는 습식분쇄기술을 통해 벌 화분을 임상적 및 향장 목적으로 사용할 수 있음을 증명한다.

• 한국가스학회지
• /
• 제16권3호
• /
• pp.22-28
• /
• 2012

BPA 공장의 메탄올 분리공정에서 HAZOP 평가를 실시하고, 사고 시나리오로부터 화재 및 폭발 사고의 피해범위를 예측하였다. 그 결과, 화재사고의 피해범위는 50 mm 직경의 안전밸브 토출배관 파열에 의한 제트화재에서는 20 m이었고, 설비가 전파되어 플래쉬화재가 발생되는 경우에는 267 m이었다. 또한 개방공간 증기운 폭발사고의 피해범위는 토출배관 파열에서는 22 m이었고, 설비 전파인 경우에는 542 m이었다. 그리고 최악의 누출 시나리오에 대한 안전대책으로는 메탄올 분리컬럼 내부의 이상압력 상승을 감지할 수 있는 압력계를 2 out of 3 voting으로 설비 상부에 설치하여 주공급라인 상에 설치된 컨트롤밸브와 긴급차단밸브를 동시에 차단할 수 있도록 하여야 한다.

• Journal of Animal Science and Technology
• /
• 제57권5호
• /
• pp.18.1-18.8
• /
• 2015

Background: Quantitative real time reverse transcription PCR (qRT-PCR) is one of the most important techniques for gene-expression analysis in molecular based studies. Selecting a proper internal control gene for normalizing data is a crucial step in gene expression analysis via this method. The expression levels of reference genes should be remained constant among cells in different tissues. However, it seems that the location of cells in different tissues might influence their expression. The purpose of this study was to determine whether the source of mesenchymal stem cells (MSCs) has any effect on expression level of three common reference genes (GAPDH, ${\beta}$-actin and ${\beta}2$-microglobulin) in equine marrow- and adipose-derived undifferentiated MSCs and consequently their reliability for comparative qRT-PCR. Materials and methods: Adipose tissue (AT) and bone marrow (BM) samples were harvested from 3 mares. MSCs were isolated and cultured until passage 3 (P3). Total RNA of P3 cells was extracted for cDNA synthesis. The generated cDNAs were analyzed by quantitative real-time PCR. The PCR reactions were ended with a melting curve analysis to verify the specificity of amplicon. Results: The expression levels of GAPDH were significantly different between AT- and BM-derived MSCs (p < 0.05). Differences in expression level of ${\beta}$-actin (P < 0.001) and B2M (P < 0.006.) between MSCs derived from AT and BM were substantially higher than GAPDH. In addition, the fold change in expression levels of GAPDH, ${\beta}$-actin and B2M in AT-derived MSCs compared to BM-derived MSCs were 2.38, 6.76 and 7.76, respectively. Conclusion: This study demonstrated that GAPDH and especially ${\beta}$-actin and B2M express in different levels in equine AT- and BM-derived MSCs. Thus they cannot be considered as reliable reference genes for comparative quantitative gene expression analysis in MSCs derived from equine bone marrow and adipose tissue.

• Restorative Dentistry and Endodontics
• /
• 제33권5호
• /
• pp.457-462
• /
• 2008

중합수축이 일어난 후 복합 레진 내에는 중합수축에서 기원한 응력이 내부에 남아있을 수 있는데 이를 "잔류응력"이라 한다. 수복물에 가해지는 총힘은 외부에서 가해지는 힘과 내부에 남아있는 응력의 합으로 결정이 되며 수복물의 실패를 이해하기 위해서 이 두 가지 요소가 반드시 고려되어야 한다. 본 연구에서는 ring slitting방법을 이용하여 최근 임상에 소개된 나노충진형 복합레진간의 잔류응력을 비교하였다. 실험에 사용한 복합레진은 대조군으로 microhybrid-type인 Z250과 nanofiller를 함유한 Grandio, Filtek Supreme, Ceram-X를 이용하여 복합레진 링을 제작하고 2개의 기준점을 표시한 후 이 사이의 거리를 링 절단 전과 후에 각각 측정하여 거리 변화를 측정하였다. 거리의 변화로부터 average circumferential residual stress $({\sigma}{\theta})$를 계산하였다. 10분과 1시간 경과 후 측정한 군에서는 Filtek Supreme이 Z250이나 Ceram-X보다 높은 잔류응력을 보여 주었고, 24시간 경과한 군에서는 Filtek Supreme이 나머지 군보다 높은 잔류응력을 보여주었다. 본 실험 결과에 의하면 nanofiller를 함유한 복합레진의 잔류응력은 대조군으로 사용한 Z250보다 높거나 같은 값을 나타냈으며 거의 비슷한 기질조성을 가진 Z250과 Filtek Supreme을 비교했을 때 Filtek supreme이 모든 측정시간대에서 높은 잔류응력을 보여주었다.

• 한국학교ㆍ지역보건교육학회지
• /
• 제2권1호
• /
• pp.41-52
• /
• 2001

The purpose of this research is to plan the activation of university health business through the appraisal of the function and role of university health centers. To be more specific: Firstly, analyze the facility, personnel, health service of the health centers, Secondly, appraise the role and function of the health centers, and Thirdly, consider the activation plans of health centers. The research method taken was the study of surveys conducted and written research materials on 5 women's universities in Seoul. These materials where descriptively analyzed by converting the surveys, facility and usage of health center and current personnel status in to percentage. The major results of the research are as follows: Unlike as stated in each university's additional clause on the number of personnel were working. This lack of specialized personnel resulted into lack of specialized and various services. Medicine for external application were stocked well whereas only simple medicine for internal application were on shelf and were issued only with a doctor's prescription. Universities with a full-time doctor had various available equipments. One university conducting dental treatment was equipped with indirect chest camera, dental X-ray, unit, chair(dental treatment chair) and even supersonic, electrocardiogram were available. In the case of D women's university, the number of beds compared to the number of students was lower than that of the other 3 universities, to the total size of the university was smaller than that of the other 3 universities. Among health prevention and care matters, health consultation was the only matter practised by all universities. Uniquely, there was one university that hosted epidemic prevention business. There are various tests given by each university, with each showing many differences, but some universities did not even conduct these tests. Vaccinations were usually being conducted through commission. All universities provided basic treatment, therefore matters concerning treatment at health centers were being conducted well. Concerning the management of equipment and documents, all the matters were being conducted except one university where instead of a student medical record, they were using a daily record. Because these were women's universities, most of the educations were on women's health. The subjects of these educations included: sex, contraception, prevention and control of tuberculosis, obesity, mouth hygiene, alcohol, geriatric disease, mental health and first-aid. The rate of health center usage is growing. Being women's universities, the service and treatment practised were mostly concerning sex education.

• Asia pacific journal of information systems
• /
• 제23권4호
• /
• pp.129-149
• /
• 2013

According to the development of new Information Technologies, firms consistently invest a significant amount of money in IT activities, such as establishing internal and external information systems. However, several anti-Information activities-such as hacking, leakage of information and system destruction-are also rapidly increasing, thus many firms are exposed to direct and indirect threats. Therefore, firms try to establish information security systems and manage these systems more effectively via an enterprise perspective. However, stakeholders or some managers have negative opinions about information security systems. Therefore, in this research, we study the relationship between multibusiness firms' performance and information security systems. Information security indicates physical and logical correspondence of information system department against threats and disaster. Studies on information security systems suggested frameworks such as IT Governance Cube and COBIT Framework to identify information security systems. Thus, this study define that information security systems is a controlled system on enterprise IT process and resource on IT Governance perspective rather than independent domain of IT. Thus, Information Security Systems should be understood as a subordinate concept of IT and business processes. In addition, this study incorporates information capability to information security system literature to show the positive relationship between Information Security Systems and Corporate Performance. The concept of information capability suggested that an interaction of human, information, technical and an effect on corporate performance using three types of capability (IT Practice, Information Management Practice, Information Behaviors and Values). Information capability is about firms' capability to manage IT infrastructure and information as well as individual employees who use IT infrastructure and information. Thus, this study uses information capability as a mediating variable for the relationship between information security systems and firms' performance. To investigate the relationship between Information Security Systems and multibusiness firms' performance, this study extends the IT relatedness concept into Information Security Systems. IT relatedness provides understanding of how corporations cope with conflicts between headquarters and business units to create a synergy effect and achieve high performance using IT resources. Based on the previous literature, this study develops the IT Security Relatedness model. IT Security Relatedness is our main independent variable, while Information Capability and Information Security Performance are mediating variables. To control for the common method bias, we collect each multibusiness firm's financial performance and use it as our dependent variable. We find that Information Security Systems influence Information Capability and Information Security Performance positively, and these two variables consequently influence Corporate Performance positively. In addition, this result indirectly shows that corporations under a multibusiness environment can obtain synergy effects using the integrated Information Security Systems. This positive impact of Information Security Systems on multibusiness firms' performance has an important implication to various stakeholders. Therefore, multibusiness firms need to establish Information Security Systems to achieve better financial performance.

• 한국산학기술학회논문지
• /
• 제20권5호
• /
• pp.155-162
• /
• 2019

최근 기업의 대 내외적 환경변화로 인해 상시 구조조정이 이루어져 베이비부머들은 미처 준비되지 못한 비자발적 퇴직으로 인해 자신의 일자리에 대한 심각한 위협에 직면하고 있다. 이러한 시대적 상황과 맞물려 회복탄력성은 퇴직이라는 개인의 심리적인 역경을 극복하는 관점에서 중요해졌다. 이에 본 연구는 비자발적으로 퇴직하는 베이비부머들을 대상으로 회복탄력성이 진로전환에 미치는 영향에 대해 연구를 하였다. 베이비부머 퇴직자의 개인특성이 진로전환에 미치는 영향을 확인한 결과 성별과 직종에서 유의한 차이가 검증되었다. 또한 회복탄력성이 진로전환에 미치는 영향을 검증한 결과 회복탄력성은 진로전환에 매우 유의한 영향을 미치는 것으로 검증되었으며, 하위요인 중 긍정성은 상황지각, 대처방식, 지지에서 매우 유의한 정(+)의 영향을 미치는 것으로 검증되었고 대인관계능력도 정(+)의 영향을 미치는 것으로 확인되었다. 그러나 자기조절능력은 유의미한 영향을 미치지 않았다. 따라서 퇴직 후 진로전환을 준비해야만 하는 베이비부머들에게 회복탄력성은 자신에게 처한 역경을 극복하고 성공적인 적응을 해나가는 과정에서 매우 필요한 능력으로 검증되었으며, 베이비부머들을 대상으로 진로전환의 상담과정에서 매우 유용하게 활용될 것으로 기대 된다.

• 한국표면공학회지
• /
• 제54권1호
• /
• pp.1-11
• /
• 2021

Porous dendrite structure AuCu alloy was formed using a hydrogen bubble template (HBT) technique by electroplating to improve the catalytic performance of gold, known as an excellent oxygen reduction reaction (ORR) catalyst in alkaline medium. The rich Au surface was maximized by selectively electrochemical etching Cu on the AuCu dendrite surface well formed in a leaf shape. The catalytic activity is mainly due to the synergistic effect of Au and Cu existing on the surface and inside of the particle. Au helps desorption of OH- and Cu contributes to the activation of O2 molecule. Therefore, the porous AuCu dendrite alloy catalyst showed markedly improved catalytic activity compared to the monometallic system. The porous structure AuCu formed by the hydrogen bubble template was able to control the size of the pores according to the formation time and applied current. In addition, the Au-rich surface area increased by selectively removing Cu through electrochemical etching was measured using an electrochemical calculation method (ECSA). The results of this study suggest that the alloying of porous AuCu dendrites and selective Cu dissolution treatment induces an internal alloying effect and a large specific surface area to improve catalyst performance.

• Korean Journal of Acupuncture
• /
• 제38권4호
• /
• pp.282-289
• /
• 2021

Objectives : The purpose of this study is to construct a model of the possible thermal runaway of electronic moxibustion and to implement an appropriate risk management method. Methods : To reproduce the system error situation of the electronic moxibustion circuit equipped with microcontroller unit, temperature sensor and heater, a code was set to disable the signal input to temperature sensor and maintain "high" heating signal to heater. The temperature change of electronic moxibustion was compared between 3 types of heater module; module 1 consisting of a combination of heater+0 ohm+0 ohm resistance, module 2 consisting of a combination of heater+Polymeric Positive Temperature Coefficient (PPTC)+0 ohm resistance, and module 3 consisting of a combination of heater+PPTC+10 ohm resistance. The temperature change was measured using a polydimethylsiloxane (PDMS) silicone phantom. After maintaining surface temperature of the phantom at 31~32℃ for 20 seconds, electronic moxibustion was applied. After operating electronic moxibustion, the temperature change was measured for 660 seconds on the surface and 900 seconds at 2 mm depth. Results : Regardless of the module type, the time-dependent change in temperature showed a rapid rise followed by a gentle curve, and a sharp drop in temperature after reaching the maximum temperature about 10 minutes after the switching the moxibustion on. Temperature measured at the depth of 2 mm below the surface increased slower and to a lesser extent. Module 1 reached highest peak temperature with largest change of temperature at both depths followed by module 2, and 3. Conclusions : Through the combination of PPTC+resistance with the heater of electronic moxibustion, it is possible to limit the rise in temperature even with the software error. Thus, this setting can be used as an independent safety measure for the electronic moxibustion control unit.