• 대한약침학회지
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• 제12권1호
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• pp.67-76
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• 2009

Objective : Following central nervous system(CNS) injury, inhibitory influences at the site of axonal damage occur. Glial cells become reactive and form a glial scar, gliosis. Also myelin debris such as MAG inhibits axonal regeneration. Astrocyte-rich gliosis relates with up-regulation of GFAP and CD81, and eventually becomes physical and mechanical barrier to axonal regeneration. MAG is one of several endogenous axon regeneration inhibitors that limit recovery from CNS injury and disease. It was reported that molecules that block such inhibitors enhanced axon regeneration and functional recovery. Recently it was reported that treatment with anti-CD81 antibodies enhanced functional recovery in the rat with spinal cord injury. So in this current study, the author investigated the effect of the water extract of Uncariae Ramulus et Uncus on the regulation of CD81, GFAP and MAG that increase when gliosis occurs. Methods : MTT assay was performed to examine cell viability, and cell-based ELISA, western blot and PCR were used to detect the expression of CD81, GFAP and MAG. Then also immunohistochemistry was performed to confirm in vivo. Results : Water extract of Uncariae Ramulus et Uncus showed relatively high cell viability at the concentration of 0.05%, 0.1% and 0.5%. The expression of CD81, GFAP and MAG in astrocytes was decreased after the administration of Uncariae Ramulus et Uncus water extract. These results was confirmed in the brain sections following cortical stab injury by immunohistochemistry. Conclusion : The authors observed that Uncariae Ramulus et Uncus significantly down-regulates the expression of CD81, GFAP and MAG. These results suggest that Uncariae Ramulus et Uncus can be a candidate to regenerate CNS injury.

• 한국해안·해양공학회논문집
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• 제20권1호
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• pp.25-33
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• 2008

파랑은 주로 바람에 의해서 발생하여 많은 에너지를 해안으로 전달하며 각종 수리현상을 야기하고 물질의 이송 등에 의하여 연안환경 뿐만 아니라 인간의 활동에도 큰 영향을 미친다. 또한, 해안 구조물과 파랑의 상호작용에 의한 효과를 정확히 예측하는 것은 구조물의 설계 및 거동특성 파악에 매우 중요하다. 본 논문에서는 이층 유체에서 수표면과 저층에 설치되어 있는 얇은 연직벽에 의한 표면파와 내부파의 분산을 선형파 이론을 이용하여 이차원으로 해석하였다. 반사계수를 계산하여 여러 경우에 대하여 효과를 분석한 결과 반사계수는 구조물의 형상과는 별도로 경계층의 위치와 유체간의 밀도차에 크게 영향을 받는 것으로 밝혀졌다.

• 대한한방내과학회지
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• 제42권3호
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• pp.351-374
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• 2021

Objectives: This study investigates the mechanism of Hwanggeum-tang (HGT) and Gamchosasim-tang (GST) on inflammatory bowel disease (IBD). Methods: The mice (C57BL/6N) were treated with distilled water and 3% dextran sulfate sodium (DSS) to experimentally induce ulcerative colitis. The mice were divided into 7 groups of (6 mice: normal, negative control, positive control (with sulfasalazine), 4 experimental groups (with HGT and GST, respectively). RAW 264.7 cells were used for cell experiments. The experiment was conducted in two ways: in vitro and in vivo. Results: In the experimental group (HGT, GST) of in vitro experiments, NO production decreased, and significant changes in gene expression and protein activation were observed. The length of the colon recovered in the experimental groups (HGT, GST) of the in vivo experiment was longer than that of the negative control group, and the mucosal barrier was recovered. Sone significant changes in the amount of mRNA expression were partially observed, and significant changes in protein activation also were confirmed. Conclusions: HGT and GST are effective in treating IBD caused by DSS. In the same herbal preparation group, the higher the concentration, the better the experimental effect, and when the same concentration was tested, HGT was more effective than GST. Herbal medicine has a higher antioxidant effect than sulfasalazine, so it is also excellent for cell protection.

• 대한지역사회영양학회지
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• 제22권3호
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• pp.207-217
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• 2017

Objectives: The aim of this study was to examine self-management status, nutritional knowledge, barrier factors in dietary management and needs of nutritional management program for women with Gestational Diabetes Mellitus (GDM). Methods: A total of 100 women with GDM were recruited from secondary and tertiary hospitals in Seoul. The questionnaire composed of general characteristics, status of self-management, dietary habits, nutrition knowledge, barrier factors in dietary management, needs for nutrition information contents and nutritional management programs. Data were collected by a self-administered questionnaire. All data were statistically analyzed using student's t-test and chi-square test using SAS 9.3. Results: About 35% of the subjects reported that they practiced medical nutrition and exercise therapy for GDM control. The main sources of nutrition information were 'internet (50.0%)' and 'expert advice (45.0%)'. More than 70% of the subjects experienced nutrition education. The mean score of nutrition knowledge was 7.5 point out of 10, and only about half of the subjects were reported to be correctly aware of some questions such as 'the cause of ketosis', 'the goal of nutrition management for GDM', 'the importance of sugar restriction on breakfast'. The major obstructive factors in dietary management were 'eating more than planned when dining out', 'finding the appropriate menu when dining out'. The preferred nutrition information contents in developing management program were 'nutritional information of food', 'recommended food by major nutrients', 'the relationship between blood glucose and food', 'tips on menu selection at eating out'. The subjects reported that they need management program such as 'example of menu by calorie prescription', 'recommended weight gain guide', 'meal recording and dietary assessment', 'expert recommendation', 'sharing know-how'. Conclusions: Based on the results of this study, it is necessary to develop a program that provide personalized information by identifying the individual characteristics of the subjects and expert feedback function through various information and nutrition information contents that can be used in real life.

• 대한한방내과학회지
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• 제36권4호
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• pp.486-497
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• 2015

Objectives Hataedock is an orally administered herbal extract treatment for newborn babies that dispels toxic heat and meconium gathered by the fetus. The purpose of this study was to evaluate whether Hataedock alleviates inflammatory skin damage in AD (Atopic Dermatitis)-induced NC/Nga mice through regulating and maintaining the skin barrier and anti-inflammation effects.Methods We established an AD model in three-week-old NC/Nga mice through the repeated application of DNFB (dinitrochlorobenzene) on days 28, 35, and 42 after Hataedock treatment was orally administered. We identified changes in the skin barrier and anti-inflammation effects through the histological and immunohistochemical changes of TNF- α, NF-κB p65, iNOS, COX-2, and apoptotic bodies.Results Skin damage and angiogenesis were mitigated in the HT (Hataedock) group. Damage to the intercellular space of the stratum corneum as well as hyperplasia, edema, the infiltration of lymphocytes, and the increase of capillaries decreased in the HT group. Our results suggest that Hataedock treatment significantly down-regulated levels of TNF- α by 38% (p<0.001) and of NF-κB p65 by 70% (p<0.001). But Hataedock up-regulated apoptosis by 183% in dermatitis-induced skin.Conclusions These results suggest that Hataedock alleviates AD through diminishing the various inflammatory cytokines in skin lesions that are involved in the initial steps of AD development. It might have potential applications for the prevention and treatment of atopic dermatitis.

• Journal of Yeungnam Medical Science
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• 제37권4호
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• pp.277-285
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• 2020

Tuberculosis (TB) is still a major health problem worldwide. Especially, multidrug-resistant TB (MDR-TB), which is defined as TB that shows resistance to both isoniazid and rifampicin, is a barrier in the treatment of TB. Globally, approximately 3.4% of new TB patients and 20% of the patients with a history of previous treatment for TB were diagnosed with MDR-TB. The treatment of MDR-TB requires medications for a long duration (up to 20-24 months) with less effective and toxic second-line drugs and has unfavorable outcomes. However, treatment outcomes are expected to improve due to the introduction of a new agent (bedaquiline), repurposed drugs (linezolid, clofazimine, and cycloserine), and technological advancement in rapid drug sensitivity testing. The World Health Organization (WHO) released a rapid communication in 2018, followed by consolidated guidelines for the treatment of MDR-TB in 2019 based on clinical trials and an individual patient data meta-analysis. In these guidelines, the WHO suggested reclassification of second-line anti-TB drugs and recommended oral treatment regimens that included the new and repurposed agents. The aims of this article are to review the treatment strategies of MDR-TB based on the 2019 WHO guidelines regarding the management of MDR-TB and the diagnostic techniques for detecting resistance, including phenotypic and molecular drug sensitivity tests.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2012년도 추계학술대회
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• pp.233-236
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• 2012

본 논문에서는 차단층 설계 변수에 따른 GaN 기반 LED의 출력 특성을 분석하였다. 사용된 LED의 기본 구조는 GaN 버퍼층을 기반으로 GaN 장벽과 InGaN 양자 우물로 이루어진 활성 영역이 AlGaN EBL(Electron Blocking Layer)과 AlGaN HBL(Hole Blocking Layer) 사이에 구성되어 있다. ISE-TCAD를 이용하여 GaN 기반 LED에서 EBL의 Al 몰분율과 두께, HBL의 Al 몰분율과 도핑 농도에 따른 출력 전력과 내부 양자 효율 특성을 분석하였다.

• 멤브레인
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• 제15권1호
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• pp.62-69
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• 2005

본 연구에서는 SEBS와 여러 가지의 유기화물로 처리된 MMT (montmorillonite) type의 clay를 이용하여 SEBS-clay 하이브리드 막을 용융삽입법으로 제조하였다. clay의 함량은 5 phr (per hundred resin)로 고정하였다. internal mixer를 사용하여 clay를 SEBS에 분산시켰으며, 제조된 SEBS-clay 하이브리드에서 clay의 특성피크가 완전히 박리되거나 이동하는 XRD 결과로부터 clay의 층간거리가 넓어지는 고분자의 clay 층간삽입을 확인하였다. Clay의 종류에 따라서 제조된 SEBS-clay 하이브리드 막의 가스투과도, 기계적 물성 및 열적 성질을 측정하였다. SEBS-clay 하이브리드 막은 clay 자체의 도입과 층간거리의 확대로 기체분자의 tortuosity를 증가시켜서 가스투과도를 저하시키는 것을 확인하였다.

• Smart Structures and Systems
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• 제24권6호
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• pp.803-812
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• 2019

Triplex composite is an epoxy-bonded joint structure, which constitutes the secondary barrier in a liquefied natural gas (LNG) carrier. Defects in the triplex composite weaken its shear strength and may cause leakage of the LNG, thus compromising the structural integrity of the LNG carrier. This paper proposes an autonomous triplex composite inspection (ATCI) system for visualizing and classifying hidden defects in the triplex composite installed inside an LNG carrier. First, heat energy is generated on the surface of the triplex composite using halogen lamps, and the corresponding heat response is measured by an infrared (IR) camera. Next, the region of interest (ROI) is traced and noise components are removed to minimize false indications of defects. After a defect is identified, it is classified as internal void or uncured adhesive and its size and shape are quantified and visualized, respectively. The proposed ATCI system allows the fully automated and contactless detection, classification, and quantification of hidden defects inside the triplex composite. The effectiveness of the proposed ATCI system is validated using the data obtained from actual triplex composite installed in an LNG carrier membrane system.

• 인지과학
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• 제14권2호
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• pp.49-56
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• 2003

이 논문은 한국어 내포 머리어 관계절의 통사적인 특징을 살펴보고 이 구문이 한국어를 모국어로 사용하는 아동들에 의해 어떻게 습득되는가를 조사하는데 그 목적이 있다. 먼저, 한국어 내포 머리어 관계절 구문의 통사적인 특징을 살펴보기 위하여 내포 머리어 관계절을 생성문법에 비추어 분석을 하였다. 이 분석을 통해, 한국어의 내포 머리어 관계절은 일반적인 외포 머리어 관계절에 비해 통사적으로 사용이 더 제한되어 있다는 것을 알 수 있었다. 다시 말해, 내포 머리어 관계절은 여러 개의 절을 넘어 관계화가 일어날 수 있는 외포 머리어 관계절과 달리 하나 이상의 절을 넘어 관계화가 일어날 수 없다. 또한 내포 머리어 관계절은 주어, 직접목적어, 간접목적어, 전치사의 목적어 등이 관계화될 수 있는 외포 머리어 관계절과 달리 단지 주어와 직접목적어만이 관계화가 가능하다. 그리고, 내포 머리어 관계절의 습득 연구를 위해 관찰 방법을 이용한 내포 머리어 관계절의 자료뿐만 아니라 이해도 측정 실험과 산출 실험을 이용한 자료도 같이 분석하였다. 이들 자료의 분석을 통해, 내포 머리어 관계절은 외포 머리어 관계절에 비하여 아동들이 이해하고 말하기가 더 쉽고 따라서 외포 머리어 관계절에 비해 아동들에 의해 더 일찍 습득됨을 알 수 있었다. 보통 내포 머리어 관계절은 성인들에게는 잘 사용되지 않는다고 알려져 있는데 아동들에게 특히 언어 발달 과정의 이른 시기에 있는 아동들에게 외포 머리어 관계절의 습득에 앞서 많이 사용되어진다는 습득 연구에서의 결과는 언어발달의 이른 시기에 있는 아동들이 내포 머리어 관계절을 어떻게 이용하는지를 말해준다. 다시 말해, 아동들은 언어 발달의 이른 시기에는 이해하고 말하기 어려운외포 머리어 관계절 대신 쉬운 내포 머리어 관계절을 임시적으로 사용하는 것으로 볼 수 있겠다. 실제, 외포 머리어 관계절은 언어 발달 과정에서 늦게 습득이 되는 것으로 보고되고 있다.