• Title/Summary/Keyword: interference element

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SAFB1, an RBMX-binding protein, is a newly identified regulator of hepatic SREBP-1c gene

  • Omura, Yasushi;Nishio, Yoshihiko;Takemoto, Tadashi;Ikeuchi, Chikako;Sekine, Osamu;Morino, Katsutaro;Maeno, Yasuhiro;Obata, Toshiyuki;Ugi, Satoshi;Maegawa, Hiroshi;Kimura, Hiroshi;Kashiwagi, Atsunori
    • BMB Reports
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    • v.42 no.4
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    • pp.232-237
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    • 2009
  • Sterol regulatory element-binding protein (SREBP)-1c plays a crucial role in the regulation of lipogenic enzymes in the liver. We previously reported that an X-chromosome-linked RNA binding motif (RBMX) regulates the promoter activity of Srebp-1c. However, still unknown was how it regulates the gene expression. To elucidate this mechanism, we screened the cDNA library from mouse liver by yeast two-hybrid assay using RBMX as bait and identified scaffold attachment factor B1 (SAFB1). Immunoprecipitation assay demonstrated binding of SAFB1 to RBMX. Chromatin immunoprecipitation assay showed binding of both SAFB1 and RBMX to the upstream region of Srebp-1c gene. RNA interference of Safb1 reduced the basal and RBMX-induced Srebp-1c promoter activities, resulting in reduced Srebp-1c gene expression. The effect of SAFB1 overexpression on Srebp-1c promoter was found only in the presence of RBMX. These results indicate a major role for SAFB1 in the activation of Srebp-1c through its interaction with RBMX.

A Design of the UWB Bandpass Filter with a Good Performance of the Stopband, and Notched Band in Passband (우수한 차단 대역 특성과 통과 대역 내에 저지 대역을 갖는 UWB 대역 통과 필터 설계)

  • An, Jae-Min;Kim, Yu-Seon;Pyo, Hyun-Seong;Lee, Hye-Sun;Lim, Yeong-Seog
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.21 no.1
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    • pp.28-35
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    • 2010
  • In this paper, we designed and fabricated a ultra-wideband(UWB) bandpass filter with a good performance of a stopband, and a notched band in passband. The transformed equivalent circuit of the highpass filter was realized by distributed element. A wide-passband with 3-dB fractional bandwidth of more than 100 % was achieved by using optimum response of the HPF. For improving lower and upper stopband characteristic, a cross coupling between feed lines was employed, which was analyzed by desegmentation technique. In order to reject interference of Wireless LAN and Hyper LAN(5.15~5.825 GHz), the narrow notched(rejection) band was realized by a spurline. The fabricated BPF indicated the passband from 3.1 to 10.55 GHz and the flat group delay of less than 0.94 ns over the entire passband except the rejection band. The filter shown sharp attenuation both inside and outside the band and notched band from 5.2 to 6.12 GHz.

Synecological Study of the Forest Vegetation in Mt. Naeyeon, Pohang City, Korea - Focusing on the Southern Area - (내연산 산림식생에 대한 군락생태학적 연구 - 남쪽 지역을 중심으로 -)

  • Kim, Hak-Yun;Kim, Jun-Soo
    • Korean Journal of Environment and Ecology
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    • v.31 no.3
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    • pp.318-328
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    • 2017
  • In order to provide basic data for the ecological management of forest vegetation in Southern Naeyeon Mountains, A total of 149 sample plots were selected and vegetation survey was carried out by the phytosociological method of the ZM school to classify vegetation types and to grasp ecological characteristics. The forest vegetation was divided into 10 types in terms of species composition, and had a unit hierarchy of 2 community groups, 4 communities, 6 sub-communities and 6 variants. A total of 19 types of physiognomic vegetation were identified based on uppermost dominant species, of which 18 were natural vegetation and 1 was artificial vegetation. As a result of the analysis of the importance values of constituent species, Quercus mongolica, a potentially natural vegetation element, was found to be relatively more important in most stands than other species, and excluding the artificial interference, most of the areas except for some sites would be changed to Q. mongolica forest. In order to understand the spatial distribution of forest vegetation, 1/5,000 large-scale physiognomic vegetation map was created by the uppermost dominant species. As a result, natural vegetation accounted for 98.2%, the number of vegetation patches was 733 and the average area per patch 3.93ha.

Effect of Separation Between Main and Divergent Tunnels in Divergence Section of Double-Deck Tunnel on the Stability (복층터널 분기구에서의 터널 이격에 따른 안정성 영향)

  • La, You-Sung;Kim, Bum-Joo
    • Journal of the Korean Geosynthetics Society
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    • v.15 no.2
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    • pp.45-54
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    • 2016
  • Double deck tunnels are considered to have a large demand in a near future for solving traffic congestion problems and overcoming the limitations in constructing new tunnels. This study presents a numerical investigation using finite element (FE) analysis on the behaviors of the tunnels and the stability of pillars in a divergence section where single tunnel is diverged from a main line double deck tunnel. The effects of the separation distance between the diverged and the main tunnels and the ground condition were examined through the FE analysis by varying the separation distance from 0.1D to 2.0D (D: diameter of main tunnel) and the rock class from class I to V, respectively, and the analysis results were compared with those using empirical methods, strength-stress ratio, and the volume of interference. The FE analysis results indicated that the separation distance has a larger effect on tunnel behaviors, compared with the rock strength, and a single tunnel with a large cross section is more favorable than two separated tunnels for tunnel stability when the separation distance is below 0.7D.

Visible Light Communication Based Wide Range Indoor Fine Particulate Matter Monitoring System (가시광통신 기반 광역 실내 초미세먼지 모니터링 시스템)

  • Shakil, Sejan Mohammad Abrar;An, Jinyoung;Han, Daehyun;Chung, Wan-Young
    • Journal of the Institute of Convergence Signal Processing
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    • v.20 no.1
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    • pp.16-23
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    • 2019
  • Fine particulate matter known as PM 2.5 refers to the atmospheric particulate matter that has a diameter less than 2.5 micrometer identified as dangerous element for human health and its concentration can provide us a clear picture about air dust concentration. Humans stay indoor almost 90% of their life time and also there is no official indoor dust concentration data, so our study is focused on measuring the indoor air quality. Indoor dust data monitoring is very important in hospital environments beside that other places can also be considered for monitoring like classrooms, cements factories, computer server rooms, petrochemical storage etc. In this paper, visible light communication system is proposed by Manchester encoding technique for electromagnetic interference (EMI)-free indoor dust monitoring. Important indoor environment information like dust concentration is transferred by visible light channel in wide range. An average voltage-tracking technique is utilized for robust light detection to eliminate ambient light and low-frequency noise. The incoming light is recognized by a photo diode and are simultaneously processed by a receiver micro-controller. We can monitor indoor air quality in real-time and can take necessary action according to the result.

A Study on Efficient Deconstruction of Supporters with Response Ratio (응답비를 고려한 효율적인 버팀보 해체방안에 관한연구)

  • Choi, Jung-Youl;Park, Sang-Wook;Chung, Jee-Seung
    • The Journal of the Convergence on Culture Technology
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    • v.8 no.5
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    • pp.469-475
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    • 2022
  • As the recent structure construction is constructed as a large-scale and deep underground excavation in close proximity to the building, the installation of retaining wall and supporters (Struts) has become complicated, and the number of supporters to avoid interference of the structural slab has increased. This construction process becomes a factor that causes an increase in construction joints of a structure, leakage and an increase in wall cracks. In addition, this reduced the durability and workability of the structure and led to an increase in the construction period. This study planned to dismantle the two struts simultaneously as a plan to reduce the construction joints, and corrected the earth pressure by assuming the reaction force value by the initial earth pressure and the measured data as the response ratio. After recalculating the corrected earth pressure through the iterative trial method, it was verified by numerical analysis that simultaneous disassembly of the two struts was possible. As a result of numerical analysis applying the final corrected earth pressure, the measured value for the design reaction force was found to be up to 197%. It was analyzed that this was due to the effect of grouting on the ground and some underestimation of the ground characteristics during design. Based on the result of calculating the corrected earth pressure in consideration of the response ratio performed in this study, it was proved analytically that the improvement of the brace dismantling process is possible. In addition, it was considered that the overall construction period could be shortened by reducing cracks due to leakage and improving workability by reducing construction joints. However, to apply the proposed method of this study, it is judged that sufficient estimations are necessary as there are differences in ground conditions, temporary facilities, and reinforcement methods for each site.

Improvement of analytical methods for arsenic in soil using ICP-AES (ICP-AES를 이용한 토양 시료 중 비소 분석 방법 개선)

  • Lee, Hong-gil;Kim, Ji In;Kim, Rog-young;Ko, Hyungwook;Kim, Tae Seung;Yoon, Jeong Ki
    • Analytical Science and Technology
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    • v.28 no.6
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    • pp.409-416
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    • 2015
  • ICP-AES has been used in many laboratories due to the advantages of wide calibration range and multi-element analysis, but it may give erroneous results and suffer from spectral interference due to the large number of emission lines associated with each element. In this study, certified reference materials (CRMs) and field samples were analyzed by ICP-AES and HG-AAS according to the official Korean testing method for soil pollution to investigate analytical problems. The applicability of HG-ICP-AES was also tested as an alternative method. HG-AAS showed good accuracies (90.8~106.3%) in all CRMs, while ICP-AES deviated from the desired range in CRMs with low arsenic and high Fe/Al. The accuracy in CRM030 was estimated as below 39% at the wavelength of 193.696 nm by ICP-AES. Significant partial overlaps and sloping background interferences were observed near to 193.696 nm with the presence of 50 mg/L Fe and Al. Most CRMs were quantified with few or no interferences of Fe and Al at 188.980 nm. ICP-AES properly assessed low and high level arsenic for field samples, at 188.980 nm and 193.696 nm, respectively. The importance of the choice of measurement wavelengths corresponding to relative arsenic level should be noted. Because interferences were affected by the sample matrix, operation conditions and instrument figures, the analysts were required to consider spectral interferences and compare the analytical performance of the recommended wavelengths. HG-ICP-AES was evaluated as a suitable alternative method for ICP-AES due to improvement of the detection limit, wide calibration ranges, and reduced spectral interferences by HG.

APPLICATION OF FUZZY SET THEORY IN SAFEGUARDS

  • Fattah, A.;Nishiwaki, Y.
    • Proceedings of the Korean Institute of Intelligent Systems Conference
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    • 1993.06a
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    • pp.1051-1054
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    • 1993
  • The International Atomic Energy Agency's Statute in Article III.A.5 allows it“to establish and administer safeguards designed to ensure that special fissionable and other materials, services, equipment, facilities and information made available by the Agency or at its request or under its supervision or control are not used in such a way as to further any military purpose; and to apply safeguards, at the request of the parties, to any bilateral or multilateral arrangement, or at the request of a State, to any of that State's activities in the field of atomic energy”. Safeguards are essentially a technical means of verifying the fulfilment of political obligations undertaken by States and given a legal force in international agreements relating to the peaceful uses of nuclear energy. The main political objectives are: to assure the international community that States are complying with their non-proliferation and other peaceful undertakings; and to deter (a) the diversion of afeguarded nuclear materials to the production of nuclear explosives or for military purposes and (b) the misuse of safeguarded facilities with the aim of producing unsafeguarded nuclear material. It is clear that no international safeguards system can physically prevent diversion. The IAEA safeguards system is basically a verification measure designed to provide assurance in those cases in which diversion has not occurred. Verification is accomplished by two basic means: material accountancy and containment and surveillance measures. Nuclear material accountancy is the fundamental IAEA safeguards mechanism, while containment and surveillance serve as important complementary measures. Material accountancy refers to a collection of measurements and other determinations which enable the State and the Agency to maintain a current picture of the location and movement of nuclear material into and out of material balance areas, i. e. areas where all material entering or leaving is measurab e. A containment measure is one that is designed by taking advantage of structural characteristics, such as containers, tanks or pipes, etc. To establish the physical integrity of an area or item by preventing the undetected movement of nuclear material or equipment. Such measures involve the application of tamper-indicating or surveillance devices. Surveillance refers to both human and instrumental observation aimed at indicating the movement of nuclear material. The verification process consists of three over-lapping elements: (a) Provision by the State of information such as - design information describing nuclear installations; - accounting reports listing nuclear material inventories, receipts and shipments; - documents amplifying and clarifying reports, as applicable; - notification of international transfers of nuclear material. (b) Collection by the IAEA of information through inspection activities such as - verification of design information - examination of records and repo ts - measurement of nuclear material - examination of containment and surveillance measures - follow-up activities in case of unusual findings. (c) Evaluation of the information provided by the State and of that collected by inspectors to determine the completeness, accuracy and validity of the information provided by the State and to resolve any anomalies and discrepancies. To design an effective verification system, one must identify possible ways and means by which nuclear material could be diverted from peaceful uses, including means to conceal such diversions. These theoretical ways and means, which have become known as diversion strategies, are used as one of the basic inputs for the development of safeguards procedures, equipment and instrumentation. For analysis of implementation strategy purposes, it is assumed that non-compliance cannot be excluded a priori and that consequently there is a low but non-zero probability that a diversion could be attempted in all safeguards ituations. An important element of diversion strategies is the identification of various possible diversion paths; the amount, type and location of nuclear material involved, the physical route and conversion of the material that may take place, rate of removal and concealment methods, as appropriate. With regard to the physical route and conversion of nuclear material the following main categories may be considered: - unreported removal of nuclear material from an installation or during transit - unreported introduction of nuclear material into an installation - unreported transfer of nuclear material from one material balance area to another - unreported production of nuclear material, e. g. enrichment of uranium or production of plutonium - undeclared uses of the material within the installation. With respect to the amount of nuclear material that might be diverted in a given time (the diversion rate), the continuum between the following two limiting cases is cons dered: - one significant quantity or more in a short time, often known as abrupt diversion; and - one significant quantity or more per year, for example, by accumulation of smaller amounts each time to add up to a significant quantity over a period of one year, often called protracted diversion. Concealment methods may include: - restriction of access of inspectors - falsification of records, reports and other material balance areas - replacement of nuclear material, e. g. use of dummy objects - falsification of measurements or of their evaluation - interference with IAEA installed equipment.As a result of diversion and its concealment or other actions, anomalies will occur. All reasonable diversion routes, scenarios/strategies and concealment methods have to be taken into account in designing safeguards implementation strategies so as to provide sufficient opportunities for the IAEA to observe such anomalies. The safeguards approach for each facility will make a different use of these procedures, equipment and instrumentation according to the various diversion strategies which could be applicable to that facility and according to the detection and inspection goals which are applied. Postulated pathways sets of scenarios comprise those elements of diversion strategies which might be carried out at a facility or across a State's fuel cycle with declared or undeclared activities. All such factors, however, contain a degree of fuzziness that need a human judgment to make the ultimate conclusion that all material is being used for peaceful purposes. Safeguards has been traditionally based on verification of declared material and facilities using material accountancy as a fundamental measure. The strength of material accountancy is based on the fact that it allows to detect any diversion independent of the diversion route taken. Material accountancy detects a diversion after it actually happened and thus is powerless to physically prevent it and can only deter by the risk of early detection any contemplation by State authorities to carry out a diversion. Recently the IAEA has been faced with new challenges. To deal with these, various measures are being reconsidered to strengthen the safeguards system such as enhanced assessment of the completeness of the State's initial declaration of nuclear material and installations under its jurisdiction enhanced monitoring and analysis of open information and analysis of open information that may indicate inconsistencies with the State's safeguards obligations. Precise information vital for such enhanced assessments and analyses is normally not available or, if available, difficult and expensive collection of information would be necessary. Above all, realistic appraisal of truth needs sound human judgment.

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