• 한국철도학회:학술대회논문집
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• 한국철도학회 2010년도 춘계학술대회 논문집
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• pp.1478-1485
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• 2010

In this paper, the nonlinear dynamic response of Vehicle-Bridge interaction with the coupled equations of motion including nonlinear Hertzian contact is presented. The moving train model is chosen to have 10 degrees of freedom (DOF). The bridge is modeled as 2D Euler-Bernoulli beam element with 4 DOF for each element, two for rotations and another two for translations. The nonlinear Hertzian contact is used to simulate the interaction between vehicle and bridge. Base on the relationship of wheel displacement of the vehicle and the vertical displacement of the bridge in Hertzian contact, the coupled equations of motion of the whole system is derived. The convenient formulation was encoded into a computer program. The contact forces, contact area and stress of the rail surface were also computed. The accuracy and efficiency of the proposed program are verified and compared with exact analytical solution and other previous studies. Various numerical examples and parametric studies have demonstrated the versatility and applicability of the proposed program.

• 아동학회지
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• 제26권6호
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• pp.267-285
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• 2005

This ethnography explored, the emergent writing and literacy of two-year-old children in classroom. The specific purpose of the study focuses on toddler's text appropriation from text environment and on social interaction between teachers and toddlers. The result showed that toddlers appropriated writing signs or words from their own text-environment and used it as the instrument for social interaction and communication. Specifically, they initiated social interaction by giving messages of their appropriated signs to adults as teachers, who were easily capable of communication. This led to all toddlers' involvement in message exchange in the classroom. Toddlers' marks of scribbles were also consisted of different kinds of lines and circles. Those marks have different meaning and. symbolic systems: drawing and writing graphics. Even though drawing and writing graphics developed as different symbol systems in toddlers' marks, each system helped to extend each other.

• 아동학회지
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• 제28권5호
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• pp.109-126
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• 2007

A sample of 322 18-month-old infants and their mothers were assessed longitudinally at 24 and 30 months. Maternal utterances and styles of linguistic interaction were measured during a 10 minute free play session. Mothers completed a vocabulary checklist for infants. Longitudinal data were analyzed by multilevel modeling. Results indicated that vocabulary increased with age of infants and the growth rate was highly predictable by the size of vocabulary at 18 months. The growth rate was strongly influenced by maternal questioning and feedback. The effect of the maternal linguistic input was constant with age. Gender differences in size of vocabulary did not vary systematically with age.

• Asian Pacific Journal of Cancer Prevention
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• 제16권12호
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• pp.5005-5006
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• 2015

Gastric cancer as one of the most common cancers worldwide has various genetic and environmental risk factors including Helicobacter pylori (H.pylori) infection. Recently, loss of a tumor suppressor gene named promyelocytic leukemia (PML) has been identified in gastric cancer. However, no mutation has been found in this gene in gastric cancer samples. Cag A H.pylori protein has been shown to exert post transcriptional regulation of some tumor suppressor genes. In order to assess such a mechanism for PML degradation, we performed in silico analyses to establish any interaction between PML and Cag A proteins. In silico interaction and docking studies showed that these two proteins may have stable interactions. In addition, we showed that imatinib kinase inhibitor can restore PML function by inhibition of casein kinase 2.

• Journal of Microbiology and Biotechnology
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• 제24권11호
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• pp.1455-1463
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• 2014

In the past, reactive oxygen species (ROS) have been considered a harmful byproduct of aerobic metabolism. However, accumulating evidence implicates redox homeostasis, which maintains appropriate ROS levels, in cell proliferation and differentiation in plants and animals. Similarly, ROS generation and signaling are instrumental in fungal development and host-fungus interaction. In fungi, NADPH oxidase, a homolog of human $gp91^{phox}$, generates superoxide and is the main source of ROS. The mechanism of activation and signaling by NADPH oxidases in fungi appears to be largely comparable to those in plants and animals. Recent studies have shown that the fungal NADPH oxidase homologs NoxA (Nox1), NoxB (Nox2), and NoxC (Nox3) have distinct functions. In particular, these studies have consistently demonstrated the impact of NoxA on the development of fungal multicellular structures. Both NoxA and NoxB (but not NoxC) are involved in host-fungus interactions, with the function of NoxA being more critical than that of NoxB.

• 대한가정학회지
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• 제47권5호
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• pp.107-121
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• 2009

The purpose of this study was to examine leadership-related variables of young children. Subjects were 467 fiveyear-olds from the region. Data were subjected to descriptive statistical analysis. Pearson’s correlation, and multiple regression analysis. Results showed that leadership in young children was related to their temperament, peer interaction, verbal control modes of mothers, and home environment. Positive peer interaction was the strongest predictor for leadership of young children.

• Genomics & Informatics
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• 제16권4호
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• pp.38.1-38.3
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• 2018

Gene-gene interaction (GGI) analysis is known to play an important role in explaining missing heritability. Many previous studies have already proposed software to analyze GGI, but most methods focus on a binary phenotype in a case-control design. In this study, we developed "Hierarchical structural CoMponent analysis of Gene-Gene Interactions" (HisCoM-GGI) software for GGI analysis with a continuous phenotype. The HisCoM-GGI method considers hierarchical structural relationships between genes and single nucleotide polymorphisms (SNPs), enabling both gene-level and SNP-level interaction analysis in a single model. Furthermore, this software accepts various types of genomic data and supports data management and multithreading to improve the efficiency of genome-wide association study data analysis. We expect that HisCoM-GGI software will provide advanced accessibility to researchers in genetic interaction studies and a more effective way to understand biological mechanisms of complex diseases.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2022년도 추계학술발표대회
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• pp.63-65
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• 2022

DDI(Drug-Drug Interaction)는 병원에서 발생하는 약물이상반응의 30%를 유발하는 부작용이지만, 현실적으로 모든 약물쌍의 DDI 를 기존 in vivo, in vitro 방식으로 예측하는 것은 불가능하다. 그렇기에, 다양한 in silico 방식의 DDI 예측 모델이 연구되고 있다. 본 연구에서는, 단백질 네트워크 상에서 RWR(Random Walk with Restart) 알고리즘을 통해 약물과 직접적으로 상호작용하는 단백질과 간접적으로 상호작용하는 단백질의 정보를 사용하여 DDI 를 예측하는 모델을 개발하였다. 이 모델을 통하여 기존에 발견하지 못한 DDI 를 새롭게 발견하고, 신약 개발 시에도, 신약과 함께 복용 시 문제를 일으킬 수 있는 약물을 예측하여 약물 이상반응을 방지하고자 한다.

• 한국디자인학회:학술대회논문집
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• 한국디자인학회 1999년도 추계 학술발표대회 논문집
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• pp.28-29
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• 1999

제품을 사용한다는 것은 어떤 목적을 달성하기 위한 제품과 사용자 사이의 입력과 출력과정으로 해석할 수 있다. 이런 측면에서 제품과 사용자와의 관계를 고찰해 볼 때 최근에 부쩍 그 수가 늘어난 지능형 제품들은 이전의 제품들이 물리적이고 신체적인 자원의 투입과 이에 따른 기계적인 제품반응에 의해 사용자와 직접적이고 단순한 제어-피제어의 관계를 가졌던 것과는 달리 지적인 자원의 투입과 함께 제품으로부터 지적인 결과물을 출력받아 사용자가 이를 다시 해석해야하는 간접적이면서도 쌍방향적인 교류관계를 가진다.(중략)

• 한국디자인학회:학술대회논문집
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• 한국디자인학회 2005년도 춘계 학술발표대회 논문집
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• pp.248-249
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• 2005