• Child Health Nursing Research
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• 제9권2호
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• pp.149-161
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• 2003

Purpose: The purpose of this study is to identified patterns and trend of studies and to analyzed the nursing research related to the mother-child interaction in Korea and to improve direction of nursing research in mother-child interaction in Korea. Method: The research studies related to the mother-child interaction were selected from the Korean Nurses Academic Society Journal, and from dissertation, which were conducted between 1961 and 2002 with the consideration of the condition and the cultural specialty of Korea. The total numbers of the studies were 34. These studies were classified according to 1)time of publication or presentation, 2)research design, 3)type of interaction objects, 4)measurement tool, and 5)chief content of studies. Ressult: 1) Until 1984, there was no research studies related to mother-child interaction. The number of studies on the mother-child interaction on the mother-child interaction has been increased rapidly after 1985. The mother-child interaction studies were 13(38.2％) from the doctoral dissertation, 4(11.8％) from the Master's theses and 17(50％) other papers were published in academic journals. 2) Experimental studies of research design was used in these research studies was 13(38.2％). Descriptive studies was 8(23.6％), correlational studies was 4(11.8％) and comparative studies was 4(11.8％). Qualitative study was just one(2.9％) and literature review was 4(11.8％). Especially experimental studies has been increased. 3) Participants of these studies were mother and infant 29(85.5％), father and infant 2(5.9％), mother and fetus 2(5.9％) and nurse and infant 1(2.9％) 4) Utilization of instruments as follows: 13 studies used Walker et al(1986)'s MIPIS (Mother-Infant Play Interaction Scale), 6 studies used Barnard(1978)'s NCAFS (Nursing Child Assessment Feeding Scale), 4 studies used NCATS(Nursing child Assessment Teaching Scale) for assessing mother-infant interaction. 3 studies used Stainton(1981)'s Parent-Infant Interaction Scale. Choi(1987), Kim(1999) and Kim and Son(1997) used measurement tool researcher made which was modified from NCATS (Nursing child Assessment Teaching Scale) and AMIS(Assessment of Mother-Infant Sensitivity Scale). Other tools used to survey influencing factors of interaction. 5) Content of the research studies were classified 3 different types, such as ① studies about the mother-child interactions' pattern, ② studies about influencing factors of the mother-child interaction, ③ studies about effect of nursing intervention program to improve the mother-child interaction. Conclusion: Therefore we make following suggestions which are made based on the above research analysis : 1) In the future research studies need to compare with other area of discipline in mother-child interaction. 2) More attention and in depth research is needed to validate in terms of research design and statistical data analysis. 3) It is important to develop the instruments which is culturally acceptable in Korea society. 4) The results of correlational studies and experimental studies needs to the integrated by meta analysis.

• Journal of Photoscience
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• 제12권1호
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• pp.25-32
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• 2005

Binding of N-Alkyl phenothiazines (NAP) to bovine serum albumin (BSA) was studied by spectroscopic methods.It was found that the phenothiazine ring common to all drugs makes major contribution to interaction. However, the nature of alkylamino group at position 10 influences the protein binding significantly. Stern-Volmer plots indicated the presence of static component in the quenching mechanism. The high magnitude of rate constant of quenching indicated that the process of energy transfer occurs by intermolecular interaction and thus the drug-binding site is in close proximity to tryptophan residues of BSA. Binding studies in presence of hydrophobic probe, 8-anilino-1-naphthalein-sulphonic acid showed that there is hydrophobic interaction between drug and the probe and they do not share common sites in BSA. Thermodynamic parameters obtained from data at different temperatures showed that the binding of NAP to BSA predominantly involve hydrophobic forces. The effects of some cations and anions common ions were investigated on NAP-BSA interactions. The CD spectrum of BSA in presence of drug showedthat binding of drug leads to change in the helicity of the protein.

• Journal of Microbiology and Biotechnology
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• 제11권4호
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• pp.724-726
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• 2001

The growth of baceriophage T4 is inhibited by the presence of the tin gene product o bacteriophage P2. The interaction between purified Tin and gp32 proteins was observed using coimmunoprecipitation experiments. The in vivo interaction was confirmed by yeast two-hybrid experiments. A deletion analysis showed that the Asp 163 region of gp32 to DNA substrates was not affected by the presence of Tin, Thus, it would appear that the inhibition of 4 growth by Tin was due to a protein-protein interaction rather than affecting the DNA-binding ability of gp32.

• 대한예방한의학회지
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• 제15권1호
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• pp.1-16
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• 2011

Objectives : The mechanisms for korean traditional medicine-drug interaction has not been well reviewed in spite that the chance for co-administration with western drugs or diet supplements has been increased. Especially, it is well known that various cytochrome P450s play a major role in drug-drug interaction. Of course, Korean traditional medicines is not excluded in a view of metabolism or biotransformation by cytochrome P450. This article was focused on reviewing the possible roles of cytochrome P450 in Korean traditional medicine-drug interaction, Also, the directions for further studies were suggested in terms of Korean traditional medicine-drug interaction. Methods : New studies for korean traditional medicine-drug interaction were reviewed and summarized in terms of cytochrome P450 activities by various Korean traditional medicines and western drugs. Results and Conclusions : Even if a few studies related to Korean traditional medicine-drug interactions was carried out, almost no studies for Korean traditional medicine-drug interactions has been found in a view of cytochrome P450. It was suggested that Korean traditional medicines and their decoction should be analyzed that how they effects on cytochrome P450, expecially CYP 1, 2, 3 families and how they interact with western drugs.

• 아동학회지
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• 제23권1호
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• pp.71-85
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• 2002

This study examined the effects of different interaction styles, that is, interaction with an object and interaction with an adult, on young children's cognitive level. Subjects were 150 5-year-old children. The task required children to predict the working of a mathematical balance beam. Seven cognitive levels were identified based on the logic of prediction. Data were analyzed by t-test, F-test, Duncan Test and Wilcoxon Matched-Pairs Test. Results showed that both interaction styles caused improvement in children's cognitive level, but when interaction with an adult was divided into two categories, i.e., interaction with the higher group and interaction with the lower group, the latter experienced decline in cognitive level. Regardless of sex, interactions within the Zone of Proximal Development and with the object were found to be effective methods for children's cognitive improvement.

• 한국환경보건학회지
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• 제36권1호
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• pp.1-13
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• 2010

Evidences supporting gene-environment interaction are accumulating in terms of environmental exposure including lifestyle factors and related genetic variants. One form of defense mechanism against cancer development involves a series of genes whose role is to metabolize (activation/detoxification) and excrete potentially toxic compounds and to repair subtle mistakes in DNA. The purpose of this article is to provide a brief review of the notion of gene-environment interaction, environmental/occupational carcinogens and related cancers, and previous studies of gene-environment interaction on cancers caused by exposure to carcinogenesis. With a number of studies on the interaction between lifestyle factors (e.g., smoking and diet) and genetic polymorphisms in genes involved in xenobiotic metabolism and DNA repair excluded, only several studies have been conducted on the interactive effects between polymorphisms of CYPs, GSTs, ERCCs, XRCCs and environmental/occupational carcinogens such as vinyl chloride, benzo[a]pyrene, and chloroform on carcinogenesis or genotoxicity. Future studies may need to be conducted with sufficient number of subjects and based on occupational cohorts to provide useful information in terms of advanced risk assessment and regulation of exposure level.

• 아동학회지
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• 제26권5호
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• pp.15-30
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• 2005

The subjects of this study were 31 mothers and their first-born infants from middle class families living in Seoul. Mother-infant interactions were filmed at 5 and 13 months of age during naturalistic play situations at home. Questionnaire data were also collected. Results revealed that both maternal didactic and social interactions decreased over the 5 to 13 month time period but (only for infants) object-oriented interaction increased over time. Infant object-oriented interaction at 13 months was predicted by cumulative effects of both mother's social stimulation at 5 months and infant social interaction at 13 months. Infant's social interaction at 13 months was predicted by infant's object-oriented interaction at 13 months. Infant language development was predicted by mother's didactic stimulation.

• 아동학회지
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• 제27권3호
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• pp.207-223
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• 2006

Classroom teachers measured children's social competence(SC). Thirty-two children were observed while they participated in cooperative art activities in homogeneous(high SC with high SC, or low SC with low SC) and heterogeneous(mixed SC) groups. Results showed that positive peer interaction was the most frequent type of interaction. Children with lower levels of social competence worked alone rather than in peer interaction. Children with higher levels of social competence showed more positive peer interaction. 'Imitating', a sub-item of dependent peer interaction, was most frequent in children with lower levels of social competence. Higher SC children maintained high SC regardless of grouping, but lower SC children showed significant differences in peer interaction between homogeneous and heterogeneous groups.

• 아동학회지
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• 제26권5호
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• pp.105-121
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• 2005

Data were collected from 120 teachers at 67 childcare centers in Seoul and Kyunggi-Do. The Assessment Scale for Day Care Programs(Rhee et ai., 2003) was used to observe teachers' interaction behaviors. Subjects responded to the teachers' job stress scale developed by the author and a modified version of teachers' efficacy scale based on the Science Teaching Efficacy Belief Instrument(Enochs & Riggs, 1990). Data were analyzed with descriptive statistics, Pearson correlations, and hierarchical regressions. Results showed that quality of teachers' interaction behaviors correlated negatively with teachers' job stress, and positively with teachers' personal efficacy; teachers' belief of efficacy moderated the relationship between job stress and teachers' interaction behaviors.

• 아동학회지
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• 제29권5호
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• pp.151-164
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• 2008

The purpose of this study was to develop a mother-infant interaction intervention program based on enhancing sensitivity to infant cues. Subjects were 9 infants, 3-26 months of age and their mothers, 6 Korean, 2 Mongolian and 1 North Korean. The intervention program was based on the Nursing Child Assessment Satellite Training model(NCAST; Barnard, 1994); data were analyzed by Wilcoxon Signed Rank Test and Mann-Whitney Test. Results were that the interaction score and infant caring confidence score of the intervention group was higher than the non-intervention group. Mother's sensitive responses to infant cues enhanced the degree of mother-infant interaction.