• Journal of IKEEE
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• v.20 no.2
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• pp.152-162
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• 2016

Electrical resistivity tomography (ERT) is a technique to reconstruct the internal resistivity distribution using the measured voltages on the surface electrodes. ERT inverse problem suffers from ill-posedness nature, so regularization methods are used to mitigate ill-posedness. The reconstruction performance varies depending on the type of regularization method. In this paper, an interacting dual-mode regularization method is proposed with two different regularization methods, L1-norm regularization and total variation (TV) regularization, to achieve robust reconstruction performance. The interacting dual-mode regularization method selects the suitable regularization method and combines the regularization methods based on computed mode probabilities depending on the actual conditions. The proposed method is tested with numerical simulations and the results demonstrate an improved reconstruction performance.

• Proceedings of the KSME Conference
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• 2001.06b
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• pp.283-288
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• 2001

This study provides analytical evaluation of the Dual-Ann Work Module. The current hydraulic system was modeled using the HyPneu and analyzed to find the cause of the instability. The cause of the instability was determined to be primarily an interacting involving the pilot operated check valves and the counterbalance valves for fail safe mode of operation. A new design concept was developed to eliminate the potential for unstable operation while adequately meeting the need for a fail-safe feature.

• Journal of the Korean Society of Combustion
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• v.21 no.2
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• pp.29-37
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• 2016

This study described the experimental investigations of combustion instability in a model gas turbine combustor. Strong coupling between pressure oscillations and unsteady heat release excites a self-sustained acoustic wave, which results in a loud and annoyed sound, and may also lead to a structural damage to the combustion system. In this study, in order to examine the combustion instability phenomenon of a dual swirling combustor configuration, the information of heat release and pressure fluctuation period with respect to the variation in both thermal power and combustor length was collected experimentally. As a result, the fundamental acoustic frequency turned out to increase with the increasing thermal power without respect to the combustor length. The frequency response to the combustor length was found to have two distinct regimes. In a higher power regime the frequency significantly decreases with the combustor length, as it is expected from the resonance of gas column. However, in a lower power regime it is almost insensitive to the combustor length. This insensitive response might be a result of the beating phenomenon between the interacting pilot and main flames with different periods.

• Journal of the Ergonomics Society of Korea
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• v.25 no.2
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• pp.135-146
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• 2006

Multimodal interfaces are recognition-based technologies that interpret and encode hand gestures, eye-gaze, movement pattern, speech, physical location and other natural human behaviors. Modality is the type of communication channel used for interaction. It also covers the way an idea is expressed or perceived, or the manner in which an action is performed. Multimodal Interfaces are the technologies that constitute multimodal interaction processes which occur consciously or unconsciously while communicating between human and computer. So input/output forms of multimodal interfaces assume different aspects from existing ones. Moreover, different people show different cognitive styles and individual preferences play a role in the selection of one input mode over another. Therefore to develop an effective design of multimodal user interfaces, input/output structure need to be formulated through the research of human cognition. This paper analyzes the characteristics of each human modality and suggests combination types of modalities, dual-coding for formulating multimodal interaction. Then it designs multimodal language and input synchronization method according to the granularity of input synchronization. To effectively guide the development of next-generation multimodal interfaces, substantially cognitive modeling will be needed to understand the temporal and semantic relations between different modalities, their joint functionality, and their overall potential for supporting computation in different forms. This paper is expected that it can show multimodal interface designers how to organize and integrate human input modalities while interacting with multimodal interfaces.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3735-3742
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• 2013

Background: Cardamom (Elettaria cardamom), also known as "Queen of Spices", has been traditionally used as a culinary ingredient due to its pleasant aroma and taste. In addition to this role, studies on cardamom have demonstrated cancer chemopreventive potential in in vitro and in vivo systems. Nevertheless, the precise poly-pharmacological nature of naturally occurring chemo-preventive compounds in cardamom has still not been fully demystified. Methods:In this study, an effort has been made to identify the proapoptopic, anti-inflammatory, anti-proliferative, anti-invasive and anti-angiogenic targets of Cardamom's bioactive principles (eucalyptol, alpha-pinene, beta-pinene, d-limonene and geraniol) by employing a dual reverse virtual screening protocol. Experimentally proven target information of the bioactive principles was annotated from bioassay databases and compared with the virtually screened set of targets to evaluate the reliability of the computational identification. To study the molecular interaction pattern of the anti-tumor action, molecular docking simulation was performed with Auto Dock Pyrx. Interaction studies of binding pose of eucalyptol with Caspase 3 were conducted to obtain an insight into the interacting amino acids and their inter-molecular bondings. Results:A prioritized list of target proteins associated with multiple forms of cancer and ranked by their Fit Score (Pharm Mapper) and descending 3D score (Reverse Screen 3D) were obtained from the two independent inverse screening platforms. Molecular docking studies exploring the bioactive principle targeted action revealed that H- bonds and electrostatic interactions forms the chief contributing factor in inter-molecular interactions associated with anti-tumor activity. Eucalyptol binds to the Caspase 3 with a specific framework that is well-suited for nucleophilic attacks by polar residues inside the Caspase 3 catalytic site. Conclusion:This study revealed vital information about the poly-pharmacological anti-tumor mode-of-action of essential oils in cardamom. In addition, a probabilistic set of anti-tumor targets for cardamom was generated, which can be further confirmed by in vivo and in vitro experiments.

• BMB Reports
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• v.37 no.2
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• pp.153-158
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• 2004

The acid-labile subunit (ALS) is known to interact with the IGF binding protein (IGFBP) in the presence of insulin-like growth factors (IGFs). Studies, however, indicate that ALS forms a doublet with IGFBP3, independent of IGFs. To characterize the structural domain required for the IGF-free ALS-IGFBP3 interaction, seven recombinant human IGFBP3 mutants were generated: three deletion mutants and four site-specific mutants that had altering N-terminal regions of IGFBP3. ALS and IGFBP3 mRNAs were co-injected into Xenopus oocytes, and their products were cross-linked and immunoprecipitated using antisera against ALS or IGFBP3. Among the deletion mutants, the mutant of D40 (deleted in 11-40th amino acids) exerted no effect in the interaction with ALS, while D60 (${\Delta}11$-60) demonstrated a moderate reduction. D88 (${\Delta}11$-88), however, showed a significant decrease. In the case of site-specific mutants, the mutation that alterated the IGF binding site (codons 56 or 80) exerted a significant reduction in the interaction, whereas codons 72 or 87 showed no significant change in the interaction with ALS. The stability of the ALS-IGFBP3 interaction was analyzed according to a time-dependent mode. Consistent with the binding study, mutants on the IGF binding sites (56 or 80) consistently show a weakness in the ALS-IGFBP3 interaction when compared to the mutants that covered the non-IGF binding sites (72 or 87). This study suggests that the N-terminal of IGFBP3, especially the IGF binding site, plays an important role in interacting with ALS as well as in stabilizing the dual complex, independent of IGFs.