• 한국안전학회지
• /
• 제32권5호
• /
• pp.47-53
• /
• 2017

In this study, we propose a new control system that effectively utilizes the interaction effect of control force through the connection of stiffness member for seismic performance enhancement of two adjacent structures equipped with active tuned mass damper (ATMD). The efficiency of the proposed control system is verified by comparing with the existing independent control system through the numerical simulations of the 10th- and 12th-story buildings. From the numerical results, it is confirmed that the proposed method can show similar or better control performance even with more economical control capacity than the existing independent control system. Another advantage is that the existing system does not exhibit the adaptive control performance in emergency of failure of one control device, whereas the proposed system can achieve successful adaptive control performance by economically and efficiently utilizing the interacting control effect through the connection member.

• Journal of Electrical Engineering and Technology
• /
• 제7권2호
• /
• pp.255-263
• /
• 2012

This paper presents the smart interacting multiple model (SIMM) using the concept of predicted point and maximum noise level. Maximum noise level means the largest value of the mere noises. We utilize the positional difference between measured point and predicted point as acceleration. Comparing this acceleration with the maximum noise level, we extract the acceleration to recognize the characteristics of the target. To estimate the acceleration, we propose an optional algorithm utilizing the proposed method and the Kalman filter (KF) selectively. Also, for increasing the effect of estimation, the weight given at each sub-filter of the interacting multiple model (IMM) structure is varying according to the rate of noise scale. All the procedures of the proposed algorithm can be implemented by an on-line system. Finally, an example is provided to show the effectiveness of the proposed algorithm.

• 제어로봇시스템학회:학술대회논문집
• /
• 제어로봇시스템학회 1991년도 한국자동제어학술회의논문집(국내학술편); KOEX, Seoul; 22-24 Oct. 1991
• /
• pp.401-406
• /
• 1991

An integrated control design and modeling method of multibody space structures is presented as a tool to control an d describe the large rotational motions of the space structures. The structures representeed with three separated substructures have independent control systems but linked with joints interacting the dynamic motions of the substructures. The effect of the structural flexibility to the control performance was analyzed and the simulation results showed that effectiveness of the designed control logic in controlling the motions of the multi-body space structures.

• 한국공작기계학회논문집
• /
• 제10권5호
• /
• pp.96-103
• /
• 2001

The quality requirements for thickness accuracy in cold rolling continue to become more stringent, particularly in response to exacting design specification from automotive customers. One of the major impacts from the tighter tolerance level is more unusable product on the head end and tail end of tandem mill coils when the mill is in transition to or from steady state rolling condition. A strip thickness control system for a tandem cold steel rolling mills is composed with blocked non-interacting controller and controllers for strip thickness and tension control of each rolling stands. An intelligent mathematical model included an elastic deformation of strip has been developed and applied to the field in order to predict the rolling force. The simulated results showed that the effect of elastic recovery should be included the model, even if the effect of elastic compression was not important.

• Journal of Chest Surgery
• /
• 제50권3호
• /
• pp.153-162
• /
• 2017

Background: The mesenchymal-epithelial transition factor (MET) receptor can be overexpressed in solid tumors, including small cell lung cancer (SCLC). However, the molecular mechanism regulating MET stability and turnover in SCLC remains undefined. One potential mechanism of MET regulation involves the C-terminus of Hsp70-interacting protein (CHIP), which targets heat shock protein 90-interacting proteins for ubiquitination and proteasomal degradation. In the present study, we investigated the functional effects of CHIP expression on MET regulation and the control of SCLC cell apoptosis and invasion. Methods: To evaluate the expression of CHIP and c-Met, which is a protein that in humans is encoded by the MET gene (the MET proto-oncogene), we examined the expression pattern of c-Met and CHIP in SCLC cell lines by western blotting. To investigate whether CHIP overexpression reduced cell proliferation and invasive activity in SCLC cell lines, we transfected cells with CHIP and performed a cell viability assay and cellular apoptosis assays. Results: We found an inverse relationship between the expression of CHIP and MET in SCLC cell lines (n=5). CHIP destabilized the endogenous MET receptor in SCLC cell lines, indicating an essential role for CHIP in the regulation of MET degradation. In addition, CHIP inhibited MET-dependent pathways, and invasion, cell growth, and apoptosis were reduced by CHIP overexpression in SCLC cell lines. Conclusion: C HIP is capable of regulating SCLC cell apoptosis and invasion by inhibiting MET-mediated cytoskeletal and cell survival pathways in NCI-H69 cells. CHIP suppresses MET-dependent signaling, and regulates MET-mediated SCLC motility.

• The Korean Journal of Physiology and Pharmacology
• /
• 제8권1호
• /
• pp.27-31
• /
• 2004

${\Delta}^{12}-Prostaglandin$ $J_2\;({\Delta}^{12}-PGJ_2)$ is one of cyclopentenone prostaglandins. The ${\Delta}^{12}-PGJ_2$ is known to induce apoptosis of tumor cells, however, it's action mechanism is not clear. It has recently been reported that STAT3 is involved in tumorigenesis. In the present study, we investigated the role of STAT3-interacting protein (STIP1) in the cytotoxicity of ${\Delta}^{12}-PGJ_2$, since STIP1 was recently reported as a modulator of STAT3 activation by specifically binding to inactive (unphosphorylated) STAT3. The effect of ${\Delta}^{12}-PGJ_2$ was observed in stably overexpressing Neuro-2A cells transfected with full cDNA of STIP1, and cytotoxicity of ${\Delta}^{12}-PGJ_2$ in the transfected cells was increased, compared with the vector control cells. The cytotoxicity of ${\Delta}^{12}-PGJ_2$ treatment was significantly accentuated by pretreatment of the STIP1-transfected cells with protein kinase inhibitor, genistein, and less activation of STAT3 in STIP1-transfected cells was shown, compared with the vector control cells. Expression of bax was also increased in the STIP1-transfected cells. These data suggest that STIP1 inhibits cell growth via inhibition of STAT3 activation in ${\Delta}^{12}-PGJ_2$ treatment.

• 제어로봇시스템학회논문지
• /
• 제8권4호
• /
• pp.281-287
• /
• 2002

This paper investigates on the feasibility of fuzzy logic control for networked control systems. In order to evaluate its feasibility, a networked control system for motor speed control is implemented on a Profibus-DP network. The NCS consists of several inde-pendent, but interacting processes running on two separate stations. By using this NCS, the network-induced delay is analyzed to find the cause and effect of the delay. Furthermore, in order to prove the feasibility, the fuzzy logic controller's performance is compared with those of conventional PID controllers. Based on the experimental results, the fuzzy logic controller can be a viable choice far NCS due to its robustness against parameter uncertainty.

• 대한기계학회:학술대회논문집
• /
• 대한기계학회 2003년도 추계학술대회
• /
• pp.1614-1619
• /
• 2003

In this study, position and force simultaneous trajectory tracking control system with pneumatic cylinder driving apparatus is proposed. The pneumatic cylinder driving apparatus that consists of two pneumatic cylinders constrained in series and two proportional flow control valves offers a considerable advantage as to non-interaction of the actuators because of the low stiffness of the pneumatic cylinders. The controller applied to the driving system is composed of a non-interaction controller to compensate for interaction of two cylinders and a disturbance observer to reduce the effect of model discrepancy of the driving system in the low frequency range that cannot be suppressed by the non-interaction controller. The experimental results with the proposed control system show that the interacting effects of two cylinders are eliminated remarkably and the proposed control system tracks the given position and force trajectories accurately.

• 동력기계공학회지
• /
• 제7권3호
• /
• pp.40-47
• /
• 2003

In this study, position and force simultaneous trajectory tracking control apparatus with pneumatic cylinder driving system is proposed. The pneumatic cylinder driving system that consists of two pneumatic cylinders constrained in series and two proportional flow control valves offers a considerable advantage as to non-interaction of the actuators because of the low stiffness of the pneumatic actuators. The controller applied to the driving system is composed of a non-interaction controller to compensate for interaction of two cylinders and a disturbance observer to reduce the effect of model discrepancy of the driving system in the low frequency range that cannot be suppressed by the non-interaction controller. The experimental results with the proposed control apparatus show that the interacting effects of two cylinders are eliminated remarkably and the proposed control apparatus tracks the given position and force trajectory accurately.

• Communications for Statistical Applications and Methods
• /
• 제15권2호
• /
• pp.265-271
• /
• 2008

It is commonly believed that diseases of human or economic traits of livestock are caused not by single genes acting alone, but multiple genes interacting with one another. This issue is difficult due to the limitations of parametric-statistic methods of gene effects. So we introduce multifactor-dimensionality reduction(MDR) as a methods for reducing the dimensionality of multilocus information. The MDR method is nonparametric (i. e., no hypothesis about the value of a statistical parameter is made), model free (i. e., it assumes no particular inheritance model) and is directly applicable to case-control studies. Application of the MDR method revealed the best model with an interaction effect between the SNPs, SNP1 and SNP3, while only one main effect of SNP1 was statistically significant for LMA (p < 0.01) under a general linear mixed model.