• Journal of Acupuncture Research
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• 제37권4호
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• pp.241-246
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• 2020

The intelligent tissue theory states that organ information is conveyed on electromagnetic waves and these are interpreted by bodily tissue, so that real-time organ states are reflected in the tissue at each organ's related meridian. This article describes the practical implications of this, how this relates to acupuncture, and how it accounts for the common acupuncture-related phenomena. The Chinese medicine notion of "chi" is also explored. Its history is described, including the 1970's reinterpretation. This article suggests that both the Nei Jing and also the 1970's model of how acupuncture works are merely metaphorical; do not describe reality; and that "chi" (which is central to these models) does not really exist. Alternative explanations are provided for all the common phenomena that are usually attributed to "chi", and a simple account of how acupuncture works is given.

• Journal of Acupuncture Research
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• 제36권1호
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• pp.21-27
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• 2019

Background: The intelligent tissue hypothesis holds that an organ's states (be it normal function or stressed states) are reflected in real time at its related acupuncture points (acupoints), causing physical, real-time changes in the local tissue. The experiment was devised to test this. Methods: The patient drank chilled water while the impedance at 6 stomach-related acupoints was monitored in real time (sample rate of 1 kHz). Any changes in the local tissue at the acupoints ought to be reflected in changes in the impedance. Results: The impedance at every test acupoint showed a response to the chilled water being ingested. Also, the duodenal pacesetter and the stomach's slow waves were clearly visible in the impedance pattern at all the acupoints. Conclusion: Hence, many separate details of the stomach's function were reflected at these acupoints. The duodenal features were consistent with the traditional indications for these acupoints, which are noted to be able to treat intestinal conditions. Therefore, the results were consistent with the hypothesis and also provided a possible explanation for how the use of these acupoints is able to treat intestinal conditions.

• 한국지능시스템학회논문지
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• 제15권2호
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• pp.257-263
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• 2005

현재 국내에서는 TMA(Tissue Mineral Analysis) 결과를 독자적이며 전문적으로 해석할 수 있는 의료 정보 데이터베이스가 없을 뿐 아니라, TMA 관련 데이터베이스가 있다 하더라도 의료기관에서 사용하기 어려운 매우 낮은 수준이므로 양질의 의료서비스를 제공하기 어려운 실정이다. 또한 국내에서 주로 사용되는 TMA 방법은 미국에 의뢰한 후 보내온 분석결과에 의존하게 되는데, 이때의 결과는 서구식 생활패턴에서 비롯된 데이터베이스에 의해 분석된 것이므로 동양인의 경우 특히 검사결과의 신뢰성 문제가 발생하게 된다. 따라서 본 논문에서는 이러한 문제점을 해결하기 위해 국내 임상자료를 바탕으로 TMA 관련 국내 최초 지능적 의료정보시스템(ITS: Intelligent TMA Information System)을 개발하였다. ITS는 TMA 자료를 다단계 통계분석 방법에 의한 결성트리 분류기를 이용하여 분류하고 다중 퍼지 규칙베이스를 구축하여 복잡한 자료론 추론하도록 구축하였다.

• 한국정보과학회논문지:소프트웨어및응용
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• 제31권2호
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• pp.137-152
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• 2004

모발분석(TMA: Tissue Mineral Analysis)은 머리카락 속에 있는 30여 가지의 미네랄과 8가지의 중금속의 양과 중요 미네랄 비율을 분석하여 체내에 과잉, 결핍 및 불균형 상태를 평가하고, 그 결과가 현재 인체에 미치는 영향을 예측하여, 건강을 유지하는 방향을 제시하는 임상 영양학 및 독성학 모발조직 검사방법을 말한다. 그러나 국내 TMA 분석방법은 몇 가지 문제점이 있다. 첫째, TMA 분석기기는 있으나 분석결과를 해석할 수 있는 한국형 의학 정보 데이타베이스가 없다. 둘째, 미국에서 보내오는 TMA 검사결과 자료가 영문이며 철저한 보안에 바탕을 둔 그래픽 파일 형태이므로 활용성이 적다. 셋째, TMA 관련 데이터베이스가 있어도 의료기관에서 사용하기 어려운 매우 낮은 수준이므로 TMA 분석 및 의료서비스를 위해 매번 미국에 의뢰해야 하므로 심각한 외화낭비를 초래한다. 넷째, TMA 결과가 서구식 생활패턴에서 비롯된 데이터 베이스로부터 구축된 것이므로 검사결과의 신뢰성 문제가 발생한다. 따라서 본 논문에서는 이러한 문제점을 해결하기 위해 국내 전문 기관으로부터 자료를 제공받아 TMA 관련 국내 최초 지능적 의학 전문가 시스템(IMES: Intelligent Medical Expert System)을 개발하였다. IMES는 TMA 자료를 다단계 통계분석 방법에 의한 결정 트리 분류기를 이용하여 분류하고 다중 퍼지 규칙베이스를 구축하여, 지능적 퍼지추론 방법에 의해 한글화된 데이터베이스로부터 복잡한 자료를 추론하도록 구축하였다. 본 IMES 시스템을 실제 적용한 결과 업무능률과 만족도가 각각 86%, 92% 증가함을 알 수 있었다.

• Journal of Acupuncture Research
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• 제36권2호
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• pp.88-91
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• 2019

Background: The intelligent tissue hypothesis on how acupuncture works, states that real-time organ states are reflected in the tissue at an organ's related acupuncture points (acupoints). Any such changes in the tissue would produce corresponding changes in the impedance at those locations. Methods: To test this hypothesis in relation to the lungs, the impedance at key lung-related acupoints was monitored in real time while the patient breathed normally, then breathed deeply, then quickly, then held his breath. Results: When breathing deeply this produced a notable decrease in the impedance at 1 acupoint, while breathing quickly produced a decrease at another acupoint, suggesting that these different functions taxed different aspects of the lungs, which was then reflected at different acupoints. The impedance at all the acupoints also contained low-amplitude waves that reflected the base rate of the respiration pacesetter, and the amplitude of these waves also varied to reflect different real-time states in the lungs. Conclusion: These real-time impedance patterns suggested that corresponding physical patterns were present in the tissue at these acupoints, and these physical patterns mirrored the real-time variations in function strength of the related organ (the lungs). These results were consistent with the hypothesis.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 추계학술대회 논문집
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• pp.139-143
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• 2005

As increasing gastrointestinal pathologies, general and thoracic surgeries using circular staplers have been dramatically increased. Because of convenience for surgical procedure, recently, various circular staplers for anastomosis have been used widely. Since the circular staplers conventional have used the displacement control method, however, the anastomosis could have various biomechanical conditions. To do that, biomechanical system of gastrointestinal soft tissue should be examined to control the anastomotic condition. In this study, a new intelligent robot used in circular anastomosis. The intelligent robot driven by a stepper motor and controlled by a digital signal processor.

• 한국지능시스템학회논문지
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• 제14권4호
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• pp.411-417
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• 2004

최근 바이오 관련산업의 발전과 함께 바이오 장비 및 장치들에 대한 연구 및 개발이 활발하게 진행되고 있다. 특히 바이오 세포 조작관련 연구들이 많이 진행되어 오고 있다. 일반적으로 바이오 세포들에 대해 기계적인 엔드 이펙터들이 조작을 위해 접촉될 때 과도한 힘이 발생될 경우가 발생하며 이런 힘들에 의해 세포막이나 조직들이 피해를 입을 수 있다. 본 논문에서는 상기 문제들을 극복하기 위해 바이오 세포 조작을 위한 새로운 시스템을 제안하였다. 제안된 시스템은 내장된 힘 센서를 이용하여 바이오 세포와 엔드 이펙터간의 발생 힘을 측정할 수 있다. 또한, 비전기술을 이용하여 엔드 이펙터의 피펫 팀을 바이오 세포막까지 정확하게 가이드 할 수 있다. 결과적으로 제안된 시스템은 바이오 세포에 피해를 주지 않고 안전하게 조작이 가능하다. 제안된 기술을 이용하여 실제 시작품을 제작하여 다양한 실험을 수행한 결과 향후 DNA 조작과 같은 바이오 세포 조작용 정밀 인젝션 시스템으로의 사용 가능성을 보여 주었다.

• Journal of Periodontal and Implant Science
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• 제40권6호
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• pp.257-264
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• 2010

Purpose: Connective tissue reattachment to periodontally damaged root surfaces is one of the most important goals of periodontal therapy. The aim of this study was to develop a root conditioning agent that can demineralize and detoxify the infected root surface. Methods: Dentin slices obtained from human teeth were treated with a novel root planing agent for 2 minutes and then washed with phosphate-buffered saline. Smear layer removal and type I collagen exposure were observed by scanning electron microscopy (SEM) and type I collagen immunostaining, respectively. Cell attachment and lipopolysaccharides (LPS) removal demonstrated the efficiency of the root conditioning agent. Results: SEM revealed that the smear layer was entirely removed and the dentinal tubules were opened by the experimental gel. Type I collagen was exposed on the surfaces of the dentin slices treated by the experimental gel, which were compared with dentin treated with other root planing agents. Dentin slices treated with the experimental gel showed the highest number of attached fibroblasts and flattened cell morphology. The agar diffusion assay demonstrated that the experimental gel also has effective antimicrobial activity. Escherichia coli LPS were effectively removed from well plates by the experimental gel. Conclusions: These results demonstrated that this experimental gel is a useful tool for root conditioning of infected root surfaces and can also be applied for detoxification of ailing implant surface threads.

• 대한방사성의약품학회지
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• 제8권2호
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• pp.119-128
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• 2022

2-Dimensional inorganic nanoparticles with high surface area and ion-exchangeable properties have been continuously growing based on nanotechnology in the field of nanomedicine. Among one of the 2-D nanoparticles, layered double hydroxide (LDH) has been intensively explored as drug delivery due to its low toxicity, enhanced cellular permeability, and high drug loading capacity. Moreover, controllable chemical composition makes possible varying isomorphic layered materials for therapy and imaging of diseases. In this review, specific structural characteristics of LDH were introduced, and its potential for application as a biocompatible therapeutic agent and diagnostic one was addressed in nuclear medicine, one of promising fields in nanomedicine.

• Journal of Periodontal and Implant Science
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• 제40권5호
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• pp.232-238
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• 2010

Purpose: To prolong the degradation time of collagen membranes, various cross-linking techniques have been developed. For cross-linking, chemicals such as formaldehyde and glutaraldehyde are added to collagen membranes, but these chemicals could adversely affect surrounding tissues. The aim of this study is to evaluate the ability of porous non-chemical cross-linking porcine-derived collagen nanofibrous membrane to enhance bone and associated tissue regeneration in one-wall intrabony defects in beagle dogs. Methods: The second and third mandibular premolars and the first molars of 2 adult beagles were extracted bilaterally and the extraction sites were allowed to heal for 10 weeks. One-wall intrabony defects were prepared bilaterally on the mesial and distal side of the fourth mandibular premolars. Among eight defects, four defects were not covered with membrane as controls and the other four defects were covered with membrane as the experimental group. The animals were sacrificed 10 weeks after surgery. Results: Wound healing was generally uneventful. For all parameters evaluating bone regeneration, the experimental group showed significantly superior results compared to the control. In new bone height (NBh), the experimental group exhibited a greater mean value than the control ($3.04{\pm}0.23\;mm/1.57{\pm}0.59$, P=0.003). Also, in new bone area (NBa) and new bone volume (NBv), the experimental group showed superior results compared to the control (NBa, $34.48{\pm}10.21%$ vs. $5.09{\pm}5.76%$, P=0.014; and NBv, $28.04{\pm}12.96$ vs. $1.55{\pm}0.57$, P=0.041). On the other hand, for parameters evaluating periodontal tissue regeneration, including junctional epithelium migration and new cementum height, there were no statistically significant differences between two groups. Conclusions: Within the limitations of this study, this collagen membrane enhanced bone regeneration at one-wall intrabony defects. On the other hand, no influence of this membrane on periodontal tissue regeneration could be ascertained in this study.