• Advances in Traditional Medicine
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• v.6 no.4
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• pp.264-273
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• 2006

Epidemiological evidences and clinical as well as experimental observations have suggested a link between asthma and occupations. This relationship also involves other aspects like nonimmunologic exposures in the environment that can increase the chance of developing work related asthma and respiratory diseases. The purpose of this pamphlet is to supply information of work related diseases, which will give patients suffering with asthma, an intelligent understanding of their disease, and thus stimulate their interest so that they will cooperate more readily with their allergist. Recognizing the symptoms, causes, risk factors, diagnosis and treatment is an important part of managing occupational asthma and related diseases, so that it helps in decline of this rapidly increasing prevalence throughout the world.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.10 no.7
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• pp.1319-1325
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• 2006

Urine analysis is basic test in clinical medicine using visual examination by expert nurse. Recently, this test is measured by automatic urine analysis system. But, this system has different results by each instrument. So, a new classification algorithm is required for accurate classify and urine color collection. In this paper, a intelligent color classifier of urine analysis system was designed using neural network algorithm. The input parameters are three stimulus(RGB) after preprocessing using normalization. The fuzzy inference and neural network ware constructed for classify class according to 9 urine test items and $3{\sim}7$ classes. The experiment material to be used a standard sample of medicine. The possibility to adapt classifier designed for urine analysis system was verified as classifying measured standard samples and observing classified result. Of many test items, experimental results showed a satisfactory agreement with test results of reference system.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2005.11a
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• pp.535-541
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• 2005

It has been suggested that the endoscopic color of intramucosal gastric carcinoma is correlated with mucosal vascularity within the carcinomatous tissue. The development of electronic endoscopy has made it possible to quantitatively measure the mucosal hemoglobin volume, using a hemoglobin index. The aim of this study was to make a software program to calculate the hemoglobin index (IHb) and then investigate whether the mucosal IHb determined from the electronic endoscopic data is a useful marker for evaluating the color of intramucosal gastric carcinoma, in particular with regard to its value for discriminating between the histologic type. The mean values of IHb for the carcinoma (IHb-C) and the mean values of IHb for the surrounding non-cancerous mucosa ( IHb-N) were calculated in 75 intestinal-type and 34 diffuse-type gastric carcinomas. Then, we analyzed the ratio of the IHb-C to IHb-N. The mean IHb-C/IHb-N ratio in the intestinal-type carcinoma group was higher than that in the diffuse-type carcinoma group ($1.28{\pm}0.19$ vs. $0.81{\pm}0.18$, respectively, p<0.001). When the cut-off point of the C/N ratio was set at 1.00, the accuracy rate, the sensitivity, the specificity, and the positive and negative predictive values of a C/N ratio below 1.00 for the differential diagnosis of diffuse-type carcinoma from intestinal-type carcinoma were $94.5\%$, $94.1\%$, $94.7\%$, $88.9\%$ and $97.3\%$, respectively. IHb is useful for quantitative measurement of the endoscopic color in intramucosal gastric carcinoma and the IHb-C/IHb-N ratio would be helpful in distinguishing diffuse-type carcinoma from intestinal -type carcinoma.

• Journal of the Korean Institute of Intelligent Systems
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• v.1 no.1
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• pp.9-25
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• 1991

This tutorial paper has been written for biologists, physicians or beginners in fuzzy sets theory and applications. This field is introduced in the framework of medical diagnosis problems. The paper describes and illustrates with practical examples, a general methodology of special interest in the processing of borderline cases, that allows a graded assignment of diagnoses to patients. A pattern of medical knowledge consists of a tableau with linguistic entries or of fuzzy propositions. Relationships between symptoms and diagnoses are interpreted as labels of fuzzy sets. It is shown how possibility measures (soft matching) can be used and combined to derive diagnoses after measurements on collected data. The concepts and methods are illustrated in a biomedical application on inflammatory protein variations. In the case of poor diagnostic classifications, it is introduced appropriate ponderations, acting on the characterizations of proteins, in order to decrease their relative influence. As a consequence, when pattern matching is achieved, the final ranking of inflammatory syndromes assigned to a given patient might change to better fit the actual classification. Defuzzification of results (i.e. diagnostic groups assigned to patients) is performed as a non fuzzy sets partition issued from a "separating power", and not as the center of gravity method commonly employed in fuzzy control. It is then introduced a model of fuzzy connectionist expert system, in which an artificial neural network is designed to build the knowledge base of an expert system, from training examples (this model can also be used for specifications of rules in fuzzy logic control). Two types of weights are associated with the connections: primary linguistic weights, interpreted as labels of fuzzy sets, and secondary numerical weights. Cell activation is computed through MIN-MAX fuzzy equations of the weights. Learning consists in finding the (numerical) weights and the network topology. This feed forward network is described and illustrated in the same biomedical domain as in the first part.

• Journal of the Korean Institute of Intelligent Systems
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• v.16 no.3
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• pp.332-337
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• 2006

It has been suggested that the endoscopic color of intramucosal gastric carcinoma is correlated with mucosal vascularity within the carcinomatous tissue. The development of electronic endoscopy has made it possible to quantitatively measure the mucosal hemoglobin volume, using a hemoglobin index. The aim of this study was to make a software program to calculate the hemoglobin index (IHb) and then investigate whether the mucosal IHb determined from the electronic endoscopic data is a useful marker for evaluating the color of intramucosal gastric carcinoma, in particular with regard to its value for discriminating between the histologic types. The mean values of IHb for the carcinoma (IHb-C) and the mean values of IHb for the surrounding non-cancerous mucosa (IHb-N) were calculated in 75 intestinal-type and 34 diffuse-type gastric carcinomas. Then, we analyzed the ratio of the IHb-C to IHb-N. The mean IHb-C/IHb-N ratio in the intestinal-type carcinoma group was higher than that in the diffuse-type carcinoma group (1.28$\pm$0.19 vs. 0.81$\pm$0.18, respectively, p<0.001). When the cut-off point of the C/N ratio was set at 1.00, the accuracy rate, the sensitivity, the specificity, and the positive and negative predictive values of a C/R ratio below 1.00 for the differential diagnosis of diffuse-type carcinoma from intestinal-type carcinoma were 94.5%, 94.1%, 94.7%, 88.9% and 97.3%, respectively. IHb is useful for quantitative measurement of the endoscopic color in intramucosal gastric carcinoma and the IHb-C/IHb-N ratio would be helpful in distinguishing diffuse-type carcinoma from intestinal-type carcinoma.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2004.04a
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• pp.97-100
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• 2004

The identification of the DNA structure as a double-stranded helix consting of two nucleotide chain molecules was a milestone in modern molecular biology. The DNA chip technology is based on reverse hybridization that follows the principle of complementary binding of double-stranded DNA. DNA chip can be described as the deposition of defined nucleic acid sequences, probes, on a solid substrate to form a regular array of elements that are available for hybridization to complementary nucleic acids, targets. DNA chips based on cDNA clons, oligonucleotides and genomic clons have been developed for gene expression studies, genetic variation analysis and genomic changes associated with disease including cancers and genetic diseases. DNA chips for gene expression profiling can be used for functional analysis in human eel Is and animal models, disease-related gene studies, assessment of gene therapy, assessment of genetically modified food, and research for drug discovery. DNA chips for genetic variation detection can be used for the detection of mutations or chromosomal abnormalities in cnacers, drug resistances in cancer cells or pathogenic microbes, histocompatibility analysis for transplantation, individual identification for forensic medicine, and detection and discrimination of pathogenic microbes. The DNA chip will be generalized as a useful tool in clinical diagnostics in near future. Lab-on-a chip and informatics will facilitate the development of a variety of DNA chips for diagnostic purpose.

• Proceedings of the Korea Inteligent Information System Society Conference
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• 2005.11a
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• pp.425-428
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• 2005

Healthcare is a research field suitable for applying the recent ubiquitous techniques. As a test system, we developed a kind of CDSS (Clinical Decision Support System) running in ubiquitous environment. called as 'uCDSS'. The uCDSS is a core system of the ubiquitous healthcare and is composed of some 'uMLMs(Ubiquitous Medical Logic Modules)'. The uMLMs based on the class in C# programming language could be reused in development of CDSS, or another EHR system running in .NET environment. As a test system, we developed the DM(Diabetes Mellitus knowledge system using ASP.NET. This system shows the potential of C# class-based uMLMs and the extensibility to any .NET development project.

• Proceedings of the Korea Inteligent Information System Society Conference
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• 2001.01a
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• pp.330-335
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• 2001

The occurrences of occupational illness and injury have been seriously underestimated in Korea. Surveillance systems for occupational diseases have recently emerged as important strategies for the control of occupational hazards and the implementation of intervention programs to protect workers. However, health service providers do not actively diagnose occupational diseases and are unwilling to report occupational diseases. With the rapid growth of Internet usage in Korea, the computer network has become the predominant means of communicating and sharing information. Therefore, we developed a web-based updated information and education network to assist the health services providers in reporting occupational diseases. Information systems for occupational disease surveillance were also designed to support occupational disease reporting. Commonly available database systems, such as web databases, are useful to manage occupational diseases data efficiently. Standardized case definitions and report guidelines were also established, which included cumulative trauma disorder, occupational asthma, occupational contact dermatitis, and occupational cancer. This system may provide the basis of an efficient and continuously updated source of educational information and provide specific information concerning the occurrence of occupational diseases in specific areas. Background information on occupational diseases obtained in this way will be invaluable for preventing hazards and enforcing occupational disease prevention programs. Moreover, our experiences in establishing these information systems will be of great use in other countries and settings.

• BMB Reports
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• v.55 no.11
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• pp.547-552
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• 2022

Sorafenib, originally identified as an inhibitor of multiple oncogenic kinases, induces ferroptosis in hepatocellular carcinoma (HCC) cells. Several pathways that mitigate sorafenib-induced ferroptosis confer drug resistance; thus strategies that enhance ferroptosis increase sorafenib efficacy. Orphan nuclear receptor estrogen-related receptor γ (ERRγ) is upregulated in human HCC tissues and plays a role in cancer cell proliferation. The aim of this study was to determine whether inhibition of ERRγ with DN200434, an orally available inverse agonist, can overcome resistance to sorafenib through induction of ferroptosis. Sorafenib-resistant HCC cells were less sensitive to sorafenibinduced ferroptosis and showed significantly higher ERRγ levels than sorafenib-sensitive HCC cells. DN200434 induced lipid peroxidation and ferroptosis in sorafenib-resistant HCC cells. Mechanistically, DN200434 increased mitochondrial ROS generation by reducing glutathione/glutathione disulfide levels, which subsequently reduced mTOR activity and GPX4 levels. DN200434 induced amplification of the antitumor effects of sorafenib was confirmed in a tumor xenograft model. The present results indicate that DN200434 may be a novel therapeutic strategy to re-sensitize HCC cells to sorafenib.

• Korean Journal of Digital Imaging in Medicine
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• v.6 no.1
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• pp.51-64
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• 2003

This thesis describes the effective interfacing methods of PACS Modality based on the system installation andoperating experiences. PACS(Picture Archiving and Communication Systems) is a system for medical image archiving and communication using large storage device and high-speed network. The standard communication protocol of PACS is DICOM(Digital Imaging and Communication in Medicine) based on TCP/IP and point-to-point protocol. However, there are many Non-DICOM Modalities and DICOM Modalities having problems. First, we had interfaced almost modalities. Fuji CR, GE CT, MRI, Angio, Fluoro, Phillips Angio, Shimadzu Fluoro. Ultrasound PACS, with the main PACS in the Seoul S Hospital as large scale hospital. And we manipulated the intelligent image distribution and the CT. MRI Interfaces never experienced beforein the Anyang J Hospital and the Chungju C Hospital as mid or small scale hospital. Technically, we developed both the DICOM Interface and the Non-DICOM Interface. At the last, the DICOM Worklist and the DICOM Print Interface were implemented in the Seoul B Hospital, the Bucheon SJ Hospital and the Seoul K Hospital independently with PACS. The Oracle, Sybase and MS-SQL are used as database, and UNIX, Macintosh, MS Windows as operating systems. And the Visual C++ and UNIX C are the main programming tools. We have used UTP, coaxial and fiber optic cable under 10/100 mbps LAN for networking.