• 대한암한의학회지
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• 제27권1호
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• pp.13-23
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• 2022

Objective: The purpose of this review is to analyze the clinical studies on tongue diagnosis in cancer patients. Methods: Domestic and foreign databases were used, such as Pubmed, google scholar, Wanfang med online, Scopus, and OASIS. Searching keywords were tongue diagnosis, tongue color, tongue fur, tongue inspection, cancer, tumor, neoplasm, carcinoma, etc. Studies on tongue diagnosis in cancer patients were included. The published year was limited from 2000 to June 2022. Results: Thirteen studies were enrolled. All selected studies were cross-sectional studies. Cancer patients tend to have a dark and blue-purple tongue, thick fur, yellow fur, fissure tongue, and red dots on the tongue compared with non-cancer patients. With the aggravation of cancer, the rate of patients having dark or blue, or purple tongues increased, and the patients' sublingual veins became wide and tortuous. Conclusion: This study suggests that cancer patients tend to have distinct features of tongue diagnosis. Further researches are warranted.

• 한국한의학연구원논문집
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• 제8권2호통권9호
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• pp.23-35
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• 2002

통과대명청대진단학발전사적고찰(通過對明淸代診斷學發展史的考察), 득도료여하결론(得到了如下結論):도료명대(到了明代), 출현료대량적유관망진적전문서적(出現了大量的有關望診的專門書籍), 정차(井且), 개시대소아지문진행요망진연구(開始對小兒指紋進行了望診硏究), 환유(還有), 대설진적발전이경유료탁월인식(對舌診的發展已經有了卓越認識). 명대적사진화변증학설적발전여오우가적(明代的四診和辨證學說的發展與吳又可的) ${\ulcorner}$온역론(溫疫論)${\lrcorner}$ 개시거두적온병학설적발전유밀녕접적연계(開始據頭的溫病學說的發展有密接的連繫). 도료명대(到了明代), 이경대륙경변증(已經對六經辨證), 장부변증화팔강변증유료계통면완선적변증체계(臟腑辨證和八綱辨證有了系統面完善的辨證體系), 특별시개시출현료온병변증(特別是開始出現了溫病辨證). 대우청대적망진적발전특징(對于淸代的望診的發展特徵), 가이귀납위대우설진적대량적연구화유관망진적전문서적적출현(可以歸納爲對于舌診的大量的硏究和有關望診的專門書籍的出現). 특별시수착온병학설약발전면공동발전적설진적만화야흔돌출.

• 대한한방종양학회지
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• 제9권1호
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• pp.89-97
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• 2003

Recently, the occurrence and death rates of cancer have increased rapidly. In oriental medicine, the tongue gives some kind of special physiological information on human body. Oriental medical doctors have used information about the color, degree of wetness and shape of the patient's tongue to determine patient's disease and body condition. This fact leads us that the tongue image is one of the most important clinical data for helping doctor's decision making. It also has significant meaning to cancer patients related with traditional theory of oriental medicine. In diagnosis and treatment of cancer, tongue diagnosis can give some prognosis and change o cancer. It also detect the sign of early stage cancer, but it cannot diagnose the kind of cancer and/or benign or malignant. Nowadays BioTechnology(BT) has developed rapidly, but there are a lot of limits(economy, accuracy, clinical significance, etc). Tongue diagnosis is very economic and practical way of diagnose and has a lot of possibility of development. The need for doctors and it also helps the development of tongue diagnosis related with cancer.

• 대한한방소아과학회지
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• 제16권2호
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• pp.23-37
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• 2002

We have plenty of study of adults diseases, but not much has been said about children. 79 children who had visited in the weak children of Dongeui Oriental Medical Hospital from March, 2002 to October, 2002, were the respondents of the Weak Child Questionnaire. The results obtained were as follows: 1. Their symptoms have been observed with sequences of respiratory diseases, Digestive diseases, Psycho-neurological diseases. 2. Distribution of sex and ages : male 38 cases, female 41 cases. $0{\sim}6$ years 60 cases, $7{\sim}12$ years 17 cases, $13{\sim}18$ years 2 cases. 3. The texture of complexion was resulted in face color and the region of the face : whitish-2/ cases. yellowish-27 cases, darkish-22 cases, blue-2 cases, flushed face-l case. Sangeun(山根)-blue : 59 cases, a lower eyelid- dark or light brown : 54 cases. the rests of color on face region didn't mean. 4. The texture of tongue was ended in tongue state : tongue form-not plump not haggard patten(57 cases), a pricky patten(12), a map patten(7), a fissured patten(3). tongue color- pink (57 cases), red(16), light white(6). coating color- thin white(61 cases), thin yellow(l0), lack(6), deep and white(2). tongue coating substance-thin(72 cases), moisten(5), dry(1), deep(1).

• Journal of Oral Medicine and Pain
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• 제22권2호
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• pp.261-282
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• 1997

This study was undertaken to compare and investigate the wound healing process following Nd:YAG laser wounds and scalpel incisions of the rat tongue dorsal mucosa. Laser wounds were made parallel on the right side of tongue dorsum and scalpel incisions were made on the left side with 5mm length, respectively Visual inspection and immunohistochemistry with CD44 antibody after immediately, 6 hours, 1 day, 2, 4, 7, 11, 21 days after surgery were carried out. The results were as follows : 1. There was macroscopically no treat difference between laser wounds and scalpel incisions. 2. Laser wounds appeared as dry, bloodless and irregular grooves with carbonization and whitening of superficial tissues compared to sharp, straight and bleeding incisions using scalpel. 3. In the epithelium of rat tongue mucosa, CD44 expression in healing laser wounds and scalpel incisions were similar. 4. In the lamina propria and muscle layer, CD44 expression in healing laser wounds gradually increased earlier and decreased faster than scalpel incisions. Conclusively, it is suggested that pulsed Nd:YAG laser has more beneficial effect on the healing of wounded oral mucosa than scalpel in knew of CD44 expression.

• 대한의용생체공학회:의공학회지
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• 제43권2호
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• pp.102-108
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• 2022

Purpose: To propose a deep learning-based clinical decision support technique for laryngeal disease on epiglottis, tongue and vocal cords. Materials and Methods: A total of 873 laryngeal endoscopic images were acquired from the PACS database of Pusan N ational University Yangsan Hospital. and VGG16 model was applied with transfer learning and fine-tuning. Results: The values of precision, recall, accuracy and F1-score for test dataset were 0.94, 0.97, 0.95 and 0.95 for epiglottis images, 0.91, 1.00, 0.95 and 0.95 for tongue images, and 0.90, 0.64, 0.73 and 0.75 for vocal cord images, respectively. Conclusion: Experimental results demonstrated that the proposed model have a potential as a tool for decision-supporting of otolaryngologist during manual inspection of laryngeal endoscopic images.

• 한국한의학연구원논문집
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• 제13권2호통권20호
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• pp.135-142
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• 2007

General health exanimation comes into operation to focus on physical inspection for industrial workers and doesn't contain oriental health care. Thus we need information of health status and disease prevention, so develop a questionnaire software for health examination in oriental medicine. Items of this soft ware consists of personal information and symptoms to could check oneself , pulse and tongue diagnosis by oriental medical doctor. Symptoms are made up of syndrome differentiation about Qi and blood, Yin and Yang, body fluid, five Zang organs, Sasang Constitutional Medicine. And we reconstruct 116 items by whole body, chest and abdomen, urine and feces, head, limbs, waist and back, five sensory organs, objective signs. A subject enter symptoms and a oriental medical doctor input diagnosis of pulse and tongue, then this software return the result of health index and explanation for oriental health care. This software would be used as tool not only health examination but also clinical research.

• Parasites, Hosts and Diseases
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• 제46권4호
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• pp.229-234
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• 2008

The prevalence of Sarcocystis spp. was investigated by gross and histopathological examinations in 250 camels (Camelus dromedarius) slaughtered from 2002 to 2005 in the Mashhad Slaughterhouse, eastern Iran. Samples were taken from the diaphragm, heart, tongue, esophagus and masseter muscles for histopathological studies. No macroscopic sarcocysts were found in the samples at gross inspection. Sarcocysts were detected in 209 of 250 (83.6%) examined camels at histopathological level. The infection rate of the esophagus, heart, masseter muscles, diaphragm, and tongue was 58.8%, 48.0%, 46.8%, 41.6%, and 28.0%, respectively. There was no significant difference in the rate of infection between male (85.8%) and female (81.0%) camels. The tissue response to vital cysts was minimal; however, reaction to the degenerating cysts was severe and caused tissue damages resulting in hyperemia, hemorrhages, mononuclear cell infiltration, necrotic changes, and fibrosis. The wild and domestic carnivores especially dogs may be the final hosts of Sarcocystis spp. in this area.

• 핵의학기술
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• 제20권2호
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• pp.14-20
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• 2016

Tongue cancer는 혀에 생기는 악성종양으로 전체 암의 1.8%, oral cancer의 75%를 차지할 정도로 발생 빈도가 높은 것으로 알려져 있으며 초기 진단, 전이유무, 병기설정 등을 위해 PET/CT 검사를 실시하고 있다. Tongue cancer 환자의 PET/CT 검사 시 close mouth 상태로 Torso를 촬영하고 있으며 그에 따른 겹침이나 인공물의 영향으로 병소부위가 명확히 관찰되지 않는 경우가 발생되었다. 이에 open mouth로 PET/CT 검사 시 발생되는 변화와 그에 따른 유용성을 알아 보고자 한다. 20명의 환자(남 15명, 여 5명)를 대상으로 시행하였으며 먼저 close mouth 상태로 Torso 촬영 후 open mouth 상태로 1bed 추가 촬영하였다. Tumor(T), Normal Tongue(NT), Lymph Node(LN)에 관심영역을 설정하여 표준화섭취계수(standardized uptake value, SUV) $SUV_{mean}$, $SUV_{max}$를 측정하여 Background(Carotid artery) SUV를 빼주었다. Tumor size 변화를 측정하였으며 육안적 영상 해상도 평가는 blind test를 진행하였다. 비모수검정(wilcoxon signed rank test)을 통해 통계 분석하였다. Tumor에서 SUV는 open mouth 검사 시 증가하는 변화를 보였으며, normal tongue과 lymph node에서는 소폭의 변화가 있었으나 유의한 차이는 없었다. tumor size 변화와 blind test를 통해 전체적으로 비슷하거나 높은 영상 해상도를 보여주는 것을 확인할 수 있었다. Open mouth PET/CT 검사가 close mouth시 발생하는 문제점에 대한 완벽한 대안법이 될 수는 없지만 open mouth를 통해 구강 내 다른 구조물과의 겹침이나 tumor의 경계면을 조금 더 명확하게 관찰할 수 있을 것으로 사료된다.

• 대한한의진단학회지
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• 제17권2호
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• pp.131-155
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• 2013

Objectives A study on the importance of observing face color in the Dongeuibogam and the other things to know when we observe face color. Methods We used Deyuk Dongeuibogam of Dongeuibogam publishing company from original photographic edition. Results (1) In all section(ex. Naekyungpyeon, Oehyeongpyeon and Japbyoungpyeon), the chapters related with observing face color were fifty-one. In Naekyungpyeon, the chapters related with observing face color were nineteen(37%). In Oehyeongpyeon, the chapters related with observing face color were ten(20%). In Japbyoungpyeon, the chapters related with observing face color were twenty-two(43%). In all section(ex. Naekyungpyeon, Oehyeongpyeon and Japbyoungpyeon), the statements related with observing face color were three-hundred and nine. In Naekyungpyeon, the statements related with observing face color were sixty-four(21%). In Oehyeongpyeon, the statements related with observing face color were fifty-two(17%). In Japbyoungpyeon, the statements related with observing face color were one hundred ninety-three(62%). (2) In each chapter, the number of statement related with observing face color was studied. Pediatric Chapter (75) were the most common, followed by The way of finding the cause of a disease (27) Face (26) Cold (24) Weak&Fatigue (12) Phlegm, Jaundice (8) Nose, Worm, Chronic indigestion (7) Mouth&Tongue, Woman, Stool (6) Bodyshape, Liver, Heart, Kidney, Cough (5) Eye, Carbunculosis (4) Blood, Voice, Spleen, Lung, Chest, Fire, Edema, Detoxification (3) in order. (3) In each section(ex. Naekyungpyeon, Oehyeongpyeon and Japbyoungpyeon), the rate of chapter related with observing face color was studied. Naekyungpyeon(73%) was the highest. Japbyoungpyeon(61%). Oehyeongpyeon(38%) was the lowest. Conclusions The importance of each chapter for observing face color in the Dongeuibogam was studied. In addition, the entire ocular inspection, the part ocular inspection, moisture and the difference of skin according to the personal constitution should be considered. There are not only the important parts of the past that does not mean but also the unimportant parts of the past that are meaningful now. Additional studies will be needed for the latter.