• 기술혁신학회지
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• 제9권1호
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• pp.26-51
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• 2006

최근 국가 연구개발 활동에 있어서 연구개발 성과의 측정 및 관리가 중요한 이슈가 되고 있다. 특히 기술의 사업화는 연구개발의 결과물을 최종 경제적 성과로 전환하는 것으로서, 연구개발 활동의 경제적 기여를 위해 필수적인 과정이다. 이 논문에서는 국가 R&D 정책에서 중요하게 다루어지고 있는 기술사업화의 현황 및 추세를 파악하기 위하여 국가 기술사업화와 관련된 다양한 정보들을 종합한 국가기술사업화지표를 개발하였다. 개발된 지표는 기술사업화 활동, 협력 및 네트워크, 기술사업화 성과 기술사업화 환경, 심리지수의 다섯 가지 부문으로 구성되어 있고 각 부문의 지수는 각각 다섯 개의 세부 지표로 구성되어 있다. 개발된 지표는 우리나라의 기술시장 및 사업화 정책 수립을 위한 유용한 기초 자료로서 기술사업화 현황 및 수준, 예측 등 다양한 정보를 제공할 것이다.

• 벤처창업연구
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• 제7권4호
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• pp.1-8
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• 2012

본 연구는 국내 중소기업에서 혁신활동을 이끌기 위한 기본요인으로 작용하는 것이 무엇인지를 확인하고, 이 요인이 혁신활동 추진에 따른 제조현장의 프로세스 관리뿐만 아니라 고객관리에 끼치는 영향을 살펴보며, 기업경영성과에는 어떤 영향을 미치는지를 실증분석을 통해 검증하고, 국내 중소기업의 효율적인 혁신활동을 위한 전략적 시사점을 제시하고자 하였다. 연구 결과, 혁신에 대한 조직의 전략적 접근과 교육지원이 프로세스의 효율적 관리에 유의한 영향을 미치며, 프로세스관리는 고객관리뿐만 아니라 경영성과에도 유의한 영향을 미치는 것으로 파악되었다. 그리고, 고객 니즈 파악을 토대로 고객만족과 고객감동을 실현하는 체계적인 고객관리는 경영성과를 높이는 것으로 파악되었다.

• 산업경영시스템학회지
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• 제35권2호
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• pp.147-154
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• 2012

In the manufacturing industry, fostering talented workers has become a core activity as well as an important resource leading to manufacturing enterprises' innovative activities, which has come to the fore as one of the biggest success factors for innovative activities indeed. In other countries, there are many researches actively conducted on talent-fostering programs related to manufacture innovation. In Korea, however, manufacturers or several different education agencies don't actively carry out manufacture innovation instructions and have failed to faster special competent workers since their instructions focus on theories most of the time. Therefore, this study was conducted to understand the present conditions of manufacture-innovative instructions in Korea by classifying them in a method of educational technology and to investigate various teaching methods through oversea cases and cases from non-manufacture fields so that it might make a proposal for a better manufacture-innovative instruction method.

• 복식문화연구
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• 제25권5호
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• pp.708-717
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• 2017

Industrial innovation in Britain, during the eighteenth and nineteenth centuries, stimulated the introduction of the factory system and the migration of people from rural agricultural communities to urban industrial societies. The factory system brought elevated levels of economic growth to the purveyors of capitalism, but forced people to migrate into cities where working conditions in factories were, in general, harsh and brutal, and living conditions were cramped, overcrowded and unsanitary. Industrial developments, known collectively as the 'Industrial Revolution', were driven initially by the harnessing of water and steam power, and the widespread construction of rail, shipping and road networks. Parallel with these changes, came the development of purchasing 'middle class', consumers. Various technological ripples (or waves of innovative activity) continued (worldwide) up to the early-twenty-first century. Of recent note are innovations in digital technology, with associated developments, for example, in artificial intelligence, robotics, 3-D printing, materials technology, computing, energy storage, nano-technology, data storage, biotechnology, 'smart textiles' and the introduction of what has become known as 'e-commerce'. This paper identifies the more important early technological innovations, their influence on textile manufacture, distribution and consumption, and the changed role of the designer and craftsperson over the course of these technological ripples. The implications of non-ethical production, globalisation and so-called 'fast fashion' and non-sustainability of manufacture are examined, and the potential benefits and opportunities offered by new and developing forms of social media are considered. The message is that hand-crafted products are ethical, sustainable and durable.

• STI Policy Review
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• 제1권1호
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• pp.23-42
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• 2010

The American Recovery and Reinvestment Act (ARRA), known widely as the "stimulus" bill, developed by the U.S. Congress and President-elect Obama in late 2008 and early 2009, is investing a significant portion of its $787 billion infusion of funds in future-oriented programs intended not only to "jump-start" the stalled American economy, but to promote the development of renewable energy sources and increase energy efficiency in appliances, buildings, transportation, and other sectors of the economy. These investments are expected both to create immediate employment in green industries and to build a more sustainable society in the long term. The Obama Administration's green energy initiatives are part of a larger emphasis on science and technology within its agenda. It has roots in the Obama campaign and is supported by an unusually strong science and technology team. Much of the activity is centered in the Department of Energy, which received a huge one-time increase in its fiscal year 2009 budget to support the new and expanded programs. Areas that have been neglected by the federal government R&D program for many years, including smart grid technology, solar, wind, and geothermal energy, received large boosts. Many of these programs - and, in fact, the broader concept of government involvement in commercial innovation - are politically controversial Previous attempts to expand research in these areas by liberal Democratic administrations and Congresses have been criticized and sometimes thwarted by conservatives. Whether President Obama's efforts will meet with more success, both politically and technologically, remains to be seen.

• 한국산업정보학회논문지
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• 제27권3호
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• pp.145-164
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• 2022

본 논문에서는 중소기업이 성공적인 산학협력을 위하여 필요한 요인을 확인하였다. 기업의 산학협력준비역량은 TOE(Technology, Organization, Environment) 구조의 구조를 고려하였으며, 산학협력준비역량과 기업성과 간의 매개효과로 개방형혁신협업과 회복탄력성을 활용하였다. 본 연구는 산학협력 경험이 있는 중소기업 204개를 대상으로 구조화된 설문을 통해 모형을 검증하였으며, 이를 통해 산학협력의 준비역량이 기업성과에 유의한 영향을 미치며 설정한 각 변수의 매개효과를 확인하였다. 결과적으로 산학협력으로 인한 성과를 얻기 위해서는 기업에서 산학협력을 수용하고자 하는 다각적인 노력 여부가 중요함을 확인하였다.

• Journal of Ginseng Research
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• 제43권4호
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• pp.600-605
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• 2019

Background: The leaves and roots of Panax ginseng are rich in ginsenosides. However, the chemical compositions of the leaves and roots of P. ginseng differ, resulting in different medicinal functions. In recent years, the aerial parts of members of the Panax genus have received great attention from natural product chemists as producers of bioactive ginsenosides. The aim of this study was the isolation and structural elucidation of novel, minor ginsenosides in the leaves of P. ginseng and evaluation of their antiinflammatory activity in vitro. Methods: Various chromatographic techniques were applied to obtain pure individual compounds, and their structures were determined by nuclear magnetic resonance and high-resolution mass spectrometry, as well as chemical methods. The antiinflammatory effect of the new compounds was evaluated on lipopolysaccharide-stimulated RAW 264.7 cells. Results and conclusions: Two novel, minor triterpenoid saponins, ginsenoside $LS_1$ (1) and 5,6-didehydroginsenoside $Rg_3$ (2), were isolated from the leaves of P. ginseng. The isolated compounds 1 and 2 were assayed for their inhibitory effect on nitric oxide production in LPS-stimulated RAW 264.7 cells, and Compound 2 showed a significant inhibitory effect with $IC_{50}$ of $37.38{\mu}M$ compared with that of NG-monomethyl-L-arginine ($IC_{50}=90.76{\mu}M$). Moreover, Compound 2 significantly decreased secretion of cytokines such as prostaglandin $E_2$ and tumor necrosis factor-${\alpha}$. In addition, Compound 2 significantly suppressed protein expression of inducible nitric oxide synthase and cyclooxygenase-2. These results suggested that Compound 2 could be used as a valuable candidate for medicinal use or functional food, and the mechanism is warranted for further exploration.

• IMMUNE NETWORK
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• 제23권6호
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• pp.43.1-43.10
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• 2023

The continuous emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants has provided insights for updating current coronavirus disease 2019 (COVID-19) vaccines. We examined the neutralizing activity of Abs induced by a BA.4/5-containing bivalent mRNA vaccine against Omicron subvariants BN.1 and XBB.1.5. We recruited 40 individuals who had received a monovalent COVID-19 booster dose after a primary series of COVID-19 vaccinations and will be vaccinated with a BA.4/5-containing bivalent vaccine. Sera were collected before vaccination, one month after, and three months after a bivalent booster. Neutralizing Ab (nAb) titers were measured against ancestral SARS-CoV-2 and Omicron subvariants BA.5, BN.1, and XBB.1.5. BA.4/5-containing bivalent vaccination significantly boosted nAb levels against both ancestral SARS-CoV-2 and Omicron subvariants. Participants with a history of SARS-CoV-2 infection had higher nAb titers against all examined strains than the infection-naïve group. NAb titers against BN.1 and XBB.1.5 were lower than those against the ancestral SARS-CoV-2 and BA.5 strains. These results suggest that COVID-19 vaccinations specifically targeting emerging Omicron subvariants, such as XBB.1.5, may be required to ensure better protection against SARS-CoV-2 infection, especially in high-risk groups.

• 벤처창업연구
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• 제12권4호
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• pp.1-14
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• 2017

기업을 둘러싼 외부 환경의 급격한 변화로 과거와는 다른 새로운 경영방법이 필요한 시대가 되었다. 국내 코스닥기업은 상장으로 인해 기업의 경영성과가 긍정적으로 나타날 것이라 기대하지만 대부분의 경우에는 낮은 경영성과의 문제를 안고 있는 것이 주지의 사실이다. 본 연구는 이러한 코스닥기업들의 문제에 대한 해결방법을 제시하고자 선행연구 분석과 실증적 연구를 통해 기업 혁신 제고와 경영 성과 향상에 미치는 영향 요인을 규명하고 그 실무적 방안을 제시하는 것을 목적으로 한다. 본 논문은 기업의 혁신경로의 복잡성과 경영성과간의 연관성 규명 한계에 대한 해결책중 하나로서 혁신 경로에 대한 세밀한 적용을 위해 기업 경영 성과에 미치는 요인으로 사내기업가정신과 인적자원혁신성을 제시하고, 기업혁신활동으로는 종래의 연구개발(R&D) 활동과 같은 정량적 지표에서 벗어나 최근 기업의 지식 경영 활동을 감안하여 지식경영활동과 외부네트워크 관리를 도입하였다. 실증적 분석결과는 기업혁신활동에 유의적인 영향을 주는 사내기업가정신과 인적자원혁신성 요인들로는 경쟁우위적극성, 위험감수성, 최고경영자혁신성으로 나타났다. 이를 통한 해석은 기업 혁신활동을 활발하게 하려면 최고경영자의 신기술 개발 및 신사업 발굴에 대한 관심도와 최고경영자의 직원들에 대한 혁신 교육 훈련 지원, 즉 최고경영자의 혁신성을 높여야 한다. 아울러 동종업계에서 경쟁우위를 높이려는 적극성을 기업내에 더욱 심화시킬 필요가 있다고 할 수 있다. 기업의 비재무적성과 지표인 경영성과인지에 영향을 미치는 사내기업가정신과 인적자원혁신성 요인들 중에는 경쟁우위적극성, 최고경영자 혁신성, 종업원 혁신성으로 나타났다. 이를 통해 기업의 경쟁우위 적극성과 최고경영자의 혁신성, 그리고 종업원의 혁신성이 높을수록 기업내 경영성과 인지도가 높아지고 이는 결국 기업내 종사원들의 기업의 매출액 증가 인지, 시장 점유율 증가 인지, 이익률 증가 인지, 고객선호도, 기업인지도 들을 높인다고 할 수 있다.

• Food Science and Biotechnology
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• 제17권5호
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• pp.899-903
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• 2008

This study was conducted in order to elucidate the optimum conditions for the extraction of clove that can be used to elicit antibacterial activity against Streptococcus mutans using the evolutionary operation (EVOP)-factorial design technique. Higher antibacterial activity was achieved in a higher extraction temperature of $80^{\circ}C$ ($r=0.7983^{**}$) and in a longer extraction time of 26 hr ($r=0.6867^*$). Antibacterial activity was not effected by differentiation of ethanol concentration in the extraction solvent (r=-0.0683). The maximum antibacterial activity of clove against S. mutans as determined by the EVOP-factorial design technique was obtained at an extraction temperature of $80^{\circ}C$, an extraction time of 26 hr and a 50% ethanol concentration. Furthermore, the population of S. mutans decreased from an initial concentration of 6.850 to 4.195 log CFU/mL in the third set that is more than 2.6 log cycles by EVOP-factorial design technique.