• 한국통신학회논문지
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• 제34권5A호
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• pp.355-362
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• 2009

In real-time communication services, delay constraints are among the most important QoS (Quality of Service) factors. In particular, it is difficult to guarantee the delay requirement over wireless channels, since they exhibit dynamic time-varying behavior and even severe burst-errors during periods of deep fading. Channel throughput may be increased, but at the cost of the additional delays when ARQ (Automatic Repeat Request) schemes are used. For real-time communication services, it is very essential to predict data deliverability. This paper derives the delay distribution and the successful delivery probability within a given delay budget using a priori channel model and a posteriori information from the perspective of queueing theory. The Gilbert-Elliot burst-noise channel is employed as an a Priori channel model, where a two-state Markov-modulated Bernoulli process $(MMBP_2)$ is used. for a posteriori information, the channel parameters, the queue-length and the initial channel state are assumed to be given. The numerical derivation is verified and analyzed via Monte Carlo simulations. This numerical derivation is then applied to a rate control scheme for real-time video transmission, where an optimal encoding rate is determined based on the future channel capacity and the distortion of the reconstructed pictures.

• BLOOD RESEARCH
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• 제53권4호
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• pp.299-306
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• 2018

Background IgG-mediated anaphylaxis occurs after infusion of certain monoclonal antibody-based therapeutics. New in vitro tests are urgently needed to diagnose such reactions. We investigated whether allergens trigger neutrophil oxidative burst (OB) and if neutrophil OB occurs due to allergen-specific IgG (sIgG). Methods Neutrophil OB was measured by dihydrorhodamine 123 flow cytometry using a leukocyte suspension spiked with a very small patch of the allergen crude extract, Dermatophagoides farinae (Der f). The mean fluorescence intensity ratio of stimulated to unstimulated samples was calculated as the neutrophil oxidative index (NOI). Results The Der f-specific NOI (Der f-sNOI) showed a time-dependent increase after Der f extract addition. At 15 min activation, higher Der f-sIgG levels were associated with lower Der f-sNOI values in 31 subjects (P<0.05). This inverse relationship occurs due to the initial blocking effect of free Der f-sIgG. Additionally, neutrophil OB was nearly absent (Der f-sNOI of -1) in two cases: a subject with undetectable Der f-sIgG levels and washed leukocyte suspensions deprived of Der f-sIgG. Conclusion Allergens can trigger neutrophil OB via preexisting allergen-sIgG. Neutrophil OB can be easily measured in a leukocyte suspension spiked with the allergen. This assay can be used to diagnose IgG-mediated anaphylaxis.

• 미생물학회지
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• 제24권2호
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• pp.161-167
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• 1986

Some of the physiological properties of Sp816 bacteriophage of Bacillus subtilis SNU816 were characterized. It could form plaques on either B. subtilis SNU816 or B. natto 8102, but not on any other bacillus strains investrgated. Its plaque morphology was circular with a diameter of less than 1.0mm and had a narrow halo surrounding the clear center. Its latent period was 34-36 min and had a burst size of 547. It was most stable at pH 6.0, and rapidly inactivated at $60^{\circ}C$ with a initial deaty rate of -0.216 $min^{-1}$. Host range, thermal inactivation rate at $60^{\circ}C$, pH stability, and UV sensitivity revealed that SP816 was quite different from any other phages investigated together but seemed to be rather related to B. natto phages.

• 약학회지
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• 제44권6호
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• pp.511-520
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• 2000

Various bupivacaine-loaded microspheres were prepared from poly (d,l-lactide) (PLA) or poly (d,l-lactic-co-glycolide) (PLGA) by a solvent evaporation method for the sustained release of drug. PLA and PLGA microspheres were prepared by w/o/w and w/o/o multiple emulsion solvent evaporation, respectively. The effects of process conditions such as emulsification speed, emulsifier type, emulsifier concentration and internal/external phase ratio on the characteristics of microspheres were investigated. The prepared microspheres were characterized for their drug loading, size distribution, surface morphology and release kinetics. Drug loading efficiency was higher in the microspheres prepared by w/o/o multiple emulsion than that by w/o/w multiple emulsion method, because the solubility of bupivacaine HCI was decreased in oil phase compared with water phase. The prepared microspheres had an average diameter between 1 and $2\;{\mu}M$ in all conditions of two methods. In morphology studies the PLA microspheres showed an irregular shape and smooth surface, but PLGA microspheres had a spherical shape and smooth surface. The release pattern of the drug from microspheres was evaluated on the basis of the burst effect and the extent of the release after 24h. The in vitro release of bupivacaine HCl from microspheres showed a large initial burst release and $60{\sim}80%$ release within one day in all conditions of two methods. The extents of the burst release against PLA and PLGA microspheres were $30{\sim}50%$ and $50{\sim}80%$ within 20min, respectively. This burst release seems to be due to the smaller size of microspheres and the solubility of drug in water.

• Bulletin of the Korean Chemical Society
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• 제29권2호
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• pp.422-426
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• 2008

Hemodialysis graft coated with paclitaxel prevents stenosis; however, large initial burst release of paclitaxel causes many negative effects such as drug toxicity and inefficient drug loss. Therefore we developed and tested a novel coating method, double dipping, to provide controlled and sustained release of paclitaxel locally. Expanded polytetrafluoroethylene (ePTFE) grafts were dipped twice into a solution of several different paclitaxel concentrations. In vitro release tests of the double dipping method showed that early burst release could be somewhat retarded and followed by sustained release for a long time. We observed the effect of paclitaxel coating by double dipping in porcine model of arterio-venous (AV) grafts between the common carotid artery and the external jugular vein. 12 weeks after constructing AV grafts, cross sections of the graft venous anastomosis were obtained and analyzed. Paclitaxel coated ePTFE grafts by double dipping were observed to prevent neointimal hyperplasia and therefore reduced stenosis of the arteriovenous hemodialysis grafts, especially at the graft venous anastomosis sites. Our results demonstrate that second dipping of ePTFE graft, which was already coated once with paclitaxel, washes off the drug on a surface of the graft and affects the ratio of paclitaxel on the surface to that of the inner space, possibly by diffusion: thus the early burst of drug can be somewhat reduced.

• 대한음성학회:학술대회논문집
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• 대한음성학회 1996년도 10월 학술대회지
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• pp.390-398
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• 1996

Acoustic analysis study was performed on 20 normal subjects by speaking nonsense syllables composed of Korean bilabial stops(/p, $p^{*}$/, ph/) and their Preceding and/or following vowel /a/(that is, [pa, $p^{*}a$, pha, apa, $ap^{*}a$, apha]) with an ultraminiature pressure sensor in their mouths. Speech materials were phonated twice, once with a moderate voice, another time with a loud voice. The acoustic signal and intraoral pressure were recorded simultaneously on computer. By these procedures, we were to measure the intraoral pressure, closure duration and VOT of Korean bilabial stops, and to compare the values one another according to the intensity of phonation and the position of the target consonants. Intraoral pressure was measured by the peak intraoral pressure value of its wave; closure duration by the time interval between the onset of intraoral pressure build-up and the burst meaning the release of closure; Voice onset time(VOT) by the time interval between the burst and the onset of glottal vibration. Heavily aspirated bilabial stop consonant /ph/ showed the highest intraoral pressure value, unaspirated /p$^{*}$/, the second, slightly aspirated /p/, the lowest. The syllable initial bilabial stops showed higher intraoral pressure than word initial stops, and the value of loudly phonated consonants were higher than moderate consonants. The longest closure duration period was that of /$p^{*}$/ and the shortest, /p/, and the duration was longer in word initial position and in the moderate voice. In VOT, the order of the longest to shortest was /ph/, /p/, /$p^{*}$/, and the value was shorter when the consonant was in intervocalic position and when it was phonated with a loud voice.

• 대한후두음성언어의학회지
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• 제7권1호
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• pp.50-55
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• 1996

Acoustic analysis study was performed on 20 normal subjects by speaking nonsense syllables composed of Korean bilabial stops$(/P, P^{\star}, P^{h}/)$ and their preceding and/or following vowel /a/ (that is, $[pa, p^{\star}a, p^{h}a, apa, ap^{\star}a, ap^{h}a]$) with an ultraminiature pressure, sensor. in their mouths. Speech materials were phonated twice, once with a moderate voice, another time with a loud voice. The acoustic signal and intraoral pressure were recorded simultaneously on computer. By these procedures, we were to measure the intraoral pressure, closure duration and VOT of Korean bilabial stops, and to compare the values one another according to the intensity of phonation and the position of the target consonants. Intraoral pressure was measured by the peak intraoral pressure value of Its wave closure duration by the time interval between the onset of intraoral pressure build-up and the burst meaning the release of closure ; Voice onset time(VOT) on by the time interval between the burst and the onset or glottal vibration. Heavily aspirated bilabial stop consonant /$p^h$/ showed the highest intraoral pressure value, unaspirated /$p^{\star}$/, the second, slightly aspirated /P/, the lowest. The syllable initial bilabial stops showed higher intraoral pressure than word initial stops, and the value of loudly phonated consonants were higher than moderate consonants. The longest closure duration period was that of /$p^{\star}$/ and the shortest, /P/, and the duration was longer in word initial position and in the moderate voice. In VOT, the order of the longest to shortest was $/{p^h}/, /p/, /{p^\star}/$, and the value was shorer when the consonant was in intervocalic position and when it was phonated with a loud voice.

• 한국통신학회논문지
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• 제30권11A호
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• pp.1073-1080
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• 2005

MBC(meteor burst communications)는 그 전송로의 많은 장점에도 불구하고 도통율이 수$\%$이하로 낮다는 큰 결점이 있다. 이를 위해 큰 경제적 부담 없이 전송 채널의 도통율을 향상시키는 방법으로서 기존의 DS(Direct Sequence) 간이 수신시스템에 정귀환회로를 적용하였다. 기존의 DS 간이 수신방식은 동기신호의 포착이나 유지에 소요되는 시스템을 생략할 수가 있어서 MBC가 가지는 경제성을 만족시킬 수 있으나, 잡음의 영향을 크게 받아 도통율이 떨어지는 단점이 있다. 이를 위해 DS 간이 수신시스템에 정귀환회로를 적용하여 SNR을 6dB이상 향상 시켰다. 이 방법으로 개선되는 효과는 수신신호가 약한 환경에서 보다 더 큰 것으로 나타나는데 시뮬레이션에 의하면 SNR이 약 6dB 개선되었을 때 평균 버스트 길이가 100ms인 것은 $70\%$로 개선되어 170ms로 되고, 50ms환경에서는 $130\%$개선되어 115ms가 되어 수신신호가 약한 환경에서 도통율이 크게 개선점을 확인할 수 있었다.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2008년도 정기 학술대회
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• pp.624-629
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• 2008

When TBM excavates a tunnel, existing concrete lining segments are used as supporting structures for driving force. Axial stress on the lining segments are apt to be large in case of direct driving force. However, it drastically decline as it is farther and father from TBM and later, it tends to converge after a certain point. Such tendencies show similar results of finite element analysis. At the initial intervals, the values of finite element analysis are larger, while at the later intervals, the actual stress values are larger. It concludes that such tendencies are attributable to that the concrete lining segments have partially burst and cracked in the axial direction at the initial intervals. And differences of stresses at the later intervals are created by the changed plasticity of ground and the friction on the external sides of the lining segments.

• 폴리머
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• 제26권1호
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• pp.128-138
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• 2002

종양부위 또는 종양을 수술로 제거한 부위에 직접 이식하여 항암제를 투여함으로써 종양 또는 종양재발을 억제하는 악성뇌종양치료에 이용하기 위한 국소서방성 항암제제로서 항암제 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU, Carmustine)가 함유된 poly(D,L-lactide-co-glycolide) (PLGA, 락타이드와 글리콜라이드 몰비 75 : 25) 미분말을 제조하여 웨이퍼로 성형하였다. BCNU가 함유된 PLGA 미분말은 분사건조법에 의해 제조하였으며 주사전자현미경으로 관찰한 결과 제조된 미분말은 미립구의 형태를 나타내었다. XRD와 DSC를 통하여 PLGA에 포접된 BCNU의 결정성이 현저히 감소하였음을 확인하였다. 생체외 방출시험조건에서 BCNU의 방출경향은 PLGA의 분자량 및 농도, BCNU의 함량 등에 의존하였으며 초기 burst effect 이후 거의 0차 방출의 경향으로 8주 이상 지속적인 방출경향을 나타내었다. 방출시험기간 동안 웨이퍼의 형태변화를 관찰하고 방출시험액의 pH 변화를 측정함으로써 BCNU의 함량이 증가할수록 PLGA의 수화와 분해가 촉진됨을 확인하였다.