• BMB Reports
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• v.38 no.2
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• pp.218-224
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• 2005

Antioxidant enzymes are related to the resistance to various abiotic stresses including salinity. Barley is relatively tolerant to saline stress among crop plants, but little information is available on barley antioxidant enzymes under salinity stress. We investigated temporal and spatial responses of activities and isoform profiles of superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), non-specific peroxidase (POX), and glutathione reductase (GR) to saline stress in barley seedlings treated with 200 mM NaCl for 0, 1, 2, 5 days, respectively. In the control plant, hydrogen peroxide content was about 2-fold higher in the root than in the shoot. Under saline stress, hydrogen peroxide content was decreased drastically by 70% at 2 d after NaCl treatment (DAT) in the root. In the leaf, however, the content was remained unchanged by 2 DAT and increased about 14 % at 5 DAT. In general, the activities of antioxidant enzymes were increased in the root and shoot under saline stress. But the increase was more significant and consistent in the root. The activities of SOD, CAT, APX, POX, and GR were increased significantly in the root within 1 DAT, and various elevated levels were maintained by 5 DAT. Among the antioxidant enzymes, CAT activity was increased the most drastically. The significant increase in the activities of SOD, CAT, APX, POX, and GR in the NaCl-stressed barley root was highly correlated with the increased expression of the constitutive isoforms as well as the induced ones. The hydrogen peroxide content in the root was most highly correlated with the CAT activity, indicating an increased role of CAT in hydrogen peroxide detoxification under salinity stress. In addition, the results suggest the significance of temporal and spatial regulation of each antioxidant isoform in determining the competence of the antioxidant capacity under saline stress.

• Science of Emotion and Sensibility
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• v.13 no.3
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• pp.449-458
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• 2010

As occasion demands to obtain efficient information from many documents and reviews on the Internet in many kinds of fields, automatic classification of opinion or thought is required. These automatic classification is called sentiment classification, which can be divided into three steps, such as subjective expression classification to extract subjective sentences from documents, sentiment classification to classify whether the polarity of documents is positive or negative, and strength classification to classify whether the documents have weak polarity or strong polarity. The latest studies in Opinion Mining have used N-gram words, lexical phrase pattern, and syntactic phrase pattern, etc. They have not used single word as feature for classification. Especially, patterns have been used frequently as feature because they are more flexible than N-gram words and are also more deterministic than single word. Theses studies are mainly concerned with English, other studies using patterns for Korean are still at an early stage. Although Korean has a slight difference in the meaning between predicates by the change of endings, which is 'Eomi' in Korean, of declinable words, the earlier studies about Korean opinion classification removed endings from predicates only to extract stems. Finally, this study introduces the earlier studies and methods using pattern for English, uses extracted sentimental patterns from Korean documents, and classifies polarities of these documents. In this paper, it also analyses the influence of the change of endings on performances of opinion classification.

• Korean Journal of Food Science and Technology
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• v.39 no.2
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• pp.175-180
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• 2007

Toll-like receptors induce innate immune responses recognizing conserved microbial structural molecules that are known as pathogen-associated molecular patterns (PAMPs). Ligand-induced homotypic oligomerization was found to proceed in LPS-induced activation of TLR4 signaling pathways. TLR2 is known to heterodimerize with TLR1 or TLR6 and recognize diacyl- or triacyl-lipopeptide, respectively. These results suggest that ligand-induced receptor dimerization of TLR4 and TLR2 is required for the activation of downstream signaling pathways. Therefore, receptor dimerization may be one of the first lines of regulation in the activation of TLR-mediated signaling pathways and induction of subsequent innate and adaptive immune responses. Here, we report biochemical evidence that curcumin from the plant Curcuma longa inhibits activation of $NF-{\kappa}B$, expression of COX-2, and dimerization of TLRs induced by TLR2, TLR3 and TLR4 agonists. These results imply that curcumin can modulate the activation of TLRs and subsequent immune/inflammatory responses induced by microbial pathogens.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.5 no.2
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• pp.89-100
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• 2019

In our previous studies, we developed a ¹⁸F-labeled TSPO-binding ligand, named [¹⁸F]CB251, which has been proved to be a promising TSPO-binding PET radiotracer for the detection and monitoring of TSPO expression in pathological diseases. (Ki = 0.27 nM for TSPO, 1.96% ID/g of tumor uptake at 1h post-injection) Based on these results, we utilized 6,8-dichloro-2-phenylimidazo[1,2-a]pyridineacetamide analogs, CB185 (1) as a targeting moiety for the selective delivery of probes and anticancer molecules to TSPO-overexpressed tissues. In this study, we designed CB185 derivatives contains different PEG chains (n = 1, 3 and 5) and fluorescence dye (Cy5) to identify the necessary space between a TSPO-binding ligand and an anticancer agent. Three CB185 derivatives (11a-c) which contains Cy5 and PEG chain, were synthesized and the effect of PEG additive on their TSPO-binding affinities were evaluated using in vitro assays. The binding affinity for compounds 11a-c was lower than that of PK11195 (Ki = 3.2 nM), but still characterized by nanomolar binding affinity for TSPO (Ki = 46.5 nM for 11a, 51.0 nM for 11b, and 388.5 nM for 11c). These results showed that the conjugates are characterized by a moderate binding affinity toward TSPO except for compound 11c, which PEG chain consist of five PEG monomers. Our finding might add useful information to decide the appropriate PET chain length for developing new TSPO-targeting drug carriers.

• Bulletin of the Korean Chemical Society
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• v.32 no.6
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• pp.2051-2057
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• 2011

Several studies have demonstrated that nanoparticles (NPs) have toxic effects on cultured cell lines, yet there are no clear data describing the overall molecular changes induced by NPs currently in use for human applications. In this study, the in vitro cytotoxicity of three oxide NPs of around 100 nm size, namely, mesoporous silica (MCM-41), iron oxide ($Fe_2O_3$-NPs), and zinc oxide (ZnO-NPs), was evaluated in the human embryonic kidney cell line HEK293. Cell viability assays demonstrated that 100 ${\mu}g/mL$ MCM-41, 100 ${\mu}g/mL$ $Fe_2O_3$, and 12.5 ${\mu}g/mL$ ZnO exhibited 20% reductions in HEK293 cell viability in 24 hrs. DNA microarray analysis was performed on cells treated with these oxide NPs and further validated by real time PCR to understand cytotoxic changes occurring at the molecular level. Microarray analysis of NP-treated cells identified a number of up- and down-regulated genes that were found to be associated with inflammation, stress, and the cell death and defense response. At both the cellular and molecular levels, the toxicity was observed in the following order: ZnO-NPs > $Fe_2O_3$-NPs > MCM-41. In conclusion, our study provides important information regarding the toxicity of these three commonly used oxide NPs, which should be useful in future biomedical applications of these nanoparticles.

• Journal of KIISE:Databases
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• v.34 no.1
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• pp.18-34
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• 2007

In order to provide various business analysis methods, OLAP(On-Line Analytical Processing) systems represent their data with multidimensional structures. These multidimensional data are often delivered to users in the horizontal format of tables whose columns are corresponding to values of dimension attributes. Since the horizontal tables nay have a large number of columns, they cannot be stored directly in relational database systems. Furthermore, the tables are likely to have many null values (i.e., sparse tables). In order to manage the horizontal tables efficiently, we can store them as the vertical format of tables which has dimension attribute names as their columns thus transforms the columns of horizontal tables into rows. In this way, every queries for horizontal tables have to be transformed into those for vertical tables. This paper proposed a technique for transforming horizontal table queries into vertical table ones by utilizing not only traditional relational algebraic operators but also the PIVOT operator which recent DBMS versions are providing. For achieving this goal, we designed a relational algebraic expression equivalent to the PIVOT operator and we formally proved their equivalence. Then, we developed a transformation technique for horizontal table queries using the PIVOT operator. We also performed experiments to analyze the performance of the proposed method. From the experimental results, we revealed that the proposed method has better performance than existing methods.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.11 no.1
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• pp.41-54
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• 2013

Radionuclide sorption data is necessary for the safety assessment of radioactive waste disposal. However the use of sorption database is often limited due to the accessability. A web-based sorption database program named KAERI-SDB has been developed to provide information on the sorption of radionuclides onto geological media as a function of geochemical conditions. The development of KAERI-SDB was achieved by improving the performance of pre-existing sorption database program (SDB-21C) developed in 1998 and considering user's requirements. KAERI-SDB is designed that users can access it by using a web browser. Main functions of KAERI-SDB include (1) log-in/member join, (2) search and store of sorption data, and (3) chart expression of search results. It is expected that KAERI-SDB could be widely utilized in the safety assessment of radioactive waste disposal by enhancing the accessibility to users who wants to use sorption data. Moreover, KAERI-SDB opened to public would also improve the reliability and public acceptance on the radioactive waste disposal programs.

• Journal of The Korean Society of Agricultural Engineers
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• v.62 no.2
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• pp.97-109
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• 2020

Drought is one of the most influential disasters in sustainable agriculture and food security of nations. In order to preemptively respond to agricultural droughts, vulnerability assessments were conducted to predict the possibility of drought in the region, the degree of direct or indirect damage, and the ability to cope with the damage. Information on agricultural drought vulnerability status of different regions is extremely useful for implementation of long term drought management measures. The purpose of this study is to develop and implement a quantitative approach for measuring agricultural drought vulnerability at sub-district level based on agricultural water and reservoirs. To assess the vulnerability in a quantitative manner and also to deal with different physical and socioeconomic data on the occurrence of agricultural drought, we selected the appropriate factors for the assessment of agricultural drought vulnerability through preceding studies, and analyzed the meteorological and agricultural reservoir data from 2015 to 2018. Each item was weighted using AHP (Analytic Hierarchy Process) analysis and evaluated through the agricultural drought vulnerability estimation. The entire national vulnerability assessments showed that Ganghwa, Naju, and Damyang were the most vulnerable to agricultural droughts. As a result of analyzing spatial expression, Gyeongsang-do is relatively more vulnerable to drought than Gangwon-do and Gyeonggi-do. The results revealed that the methodology and evaluation items achieved good performance in drought response. In addition, vulnerability assessments based on agricultural reservoir are expected to contribute supporting effective drought decisions in the field of agricultural water management.

• Journal of Biomedical Engineering Research
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• v.21 no.6
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• pp.615-621
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• 2000

A social phobia is an anxiety disorder characterized by extreme fear and phobic avoidance of social and performance situations. Medications or cognitive-behavior methods have been mainly used in treating it. These methods have some shortcomings such as being inefficient and difficult to apply to treatment. Lately the virtual rcality technology has been applied to dcal with the anxiety disorders in order to compcnsate for these defects. A virtual environment provides a patient with stimuli which cvokes a phobia. and the patient's exposure to the virtual phobic situation make him be able to overcome it. In this study, we suggested the public speaking simulator based on a personal computer for the treatment of social phobia. The public speaking simulator was composed of a position sensor. head mount display and audio system. And a virtual environment for the treatment was suggested to be a seminar room where 8 avatars are sitting. The virtual environment includes a tracking system the trace a participant's head-movement using a HMD with position sensor and 3D sound is added to the virtual environment so that he might fcel it realistic. We also made avatars' motion and facial expression change in reaction to a participant's speech. The goal of developing public speaking simulator is to apply to treat fear of public speaking efficiently and economically. In a future study. we should get more information about immergence and treatment efficiency by clinical test and apply it to this simulator.

• Journal of the Korean association of regional geographers
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• v.14 no.3
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• pp.254-268
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• 2008

Jang Sang-Hoon(장상훈) concluded that Dongyeo(東輿) seemed to be made between 1859 and 1866 but it was ahead of Cheonggudo(靑邱圖) in terms of the content and format. Accordingly he insisted that Cheonggudo was compiled based on the original version of Dongyeo which was supposed to be drawn between 1790 and 1834. This paper reappraised critically the previous researches and got several findings. Firstly, the changes of place names-4 places names were selected for the Jang Sang-Hoon's research and 2 were added in this paper-are reflected in the Yeodobiji(輿圖備志) and Dongyeo compiled by Choi Seonghwan(최성환) and Kim Jeongho(金正浩) between 1853 and 1856. Secondly, the sectioning format of Dongye shows some transitional character from the book style such as Cheonggudo to the folding style that was shown in Dongyeodo(東輿圖) and Daedongyeojido(大東輿地圖). Thirdly, the expression of the mountains in Dongyeo shares the same style which is shown in Dongyeodo and Daedongyejido. Fourth, Dongyeo contains the same information about old military bases and the castle locations in small local town centers that appear in Dongyeodo and Daedongyeojido but not in Cheonggudo and similar kinds of maps. In conclusion, Dongyeo and the original version of it are likely to be drawn by Kim Jeongho between 1853 and 1856 after Cheonggudo was made.