• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.14 no.9
• /
• pp.1979-1986
• /
• 2010

Biological early warning system detects toxicity by looking at behavior of organisms in water. The system uses classifier for judgement about existence and amount of toxicity in water. Boosting algorithm is one of possible application method for improving performance in a classifier. Boosting repetitively change training example set by focusing on difficult examples in basic classifier. As a result, prediction performance is improved for the events which are difficult to classify, but the information contained in the events which can be easily classified are discarded. In this paper, an incremental learning method to overcome this shortcoming is proposed by using the extended data expression. In this algorithm, decision tree classifier define class distribution information using the weight parameter in the extended data expression by exploiting the necessary information not only from the well classified, but also from the weakly classified events. Experimental results show that the new algorithm outperforms the former Learn++ method without using the weight parameter.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.8 no.4
• /
• pp.798-803
• /
• 2004

XML(extensible Markup Language) of W3C(World Wide Web Consortium) that is used the standard core technology of data exchange on the current Internet is an independent data type of usable at the all platforms. Especially, it can handle rapidly because of the integration of each other data types that is exchanged. Between each application and system that built at an enterprise in the past. However, W3C had notice to use XSLT(extensible Stylesheet Language Transformation) that is document transformable standard to descript expression information in XML documents because documents of XML only have a logical structure information. It is designed for XML that is developed for data exchange on the internet. Moreover, it is proposed to process and to change as other data type for expression XML documents for user. This thesis design and implement XSLT document editing system transformable as a un data type as a HTML data type applying XSLT at XML and developed the system. It can edit XSLT document that descript expression information in XML document that is used for data editing in the WYSIWYG environment.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2004.05b
• /
• pp.212-216
• /
• 2004

XML(extensible Markup Language) of W3C(World Wide Web Consortium) that is used the standard core technology of data exchange on the current Internet is an independent data type of usable at the all platforms. Especially, it can handle rapidly because of the integration of each other data types that is exchanged. Between each application and system that built at an enterprise in the past. However, W3C had notice to use XSLT(extensible Stylesheet Language Transformation) that is document transformable standard to descript expression information in XML documents because documents of XML only have a logical structure information. It is designed for XML that is developed for data exchange on the internet. Moreover, it is proposed to process and to change as other data type for expression XML documents for user. Tris thesis design and implement XSLT document editing system transformable as a HTML data type applying XSLT at XML and developed the system. It can edit XSLT document that descript expression information in XML document that is used for data editing in the WYSIWYG environment.

• Proceedings of the Korean Society for Bioinformatics Conference
• /
• 2003.10a
• /
• pp.147-154
• /
• 2003

Microarray information system is a complex system to manage, analyze and interpretate microarray gene expression data. Establishment of well-defined development process is very essential for understanding the complexity and organization of the system. We performed object-oriented analysis using Unified Modeling Language (UML) in specifying, visualizing and documenting microarray information system. The object-oriented analysis consists of three major steps: (i) use case modeling to describe various functionalities from the user's perspective (ii) dynamic modeling to illustrate behavioral aspects of the system (iii) object modeling to represent structural aspects of the system. As a result of our modeling activities we provide the UML diagrams showing various views of the microarray information system. We believe that the object-oriented analysis ensures effective documentations and communication of information system requirements. Another useful feature of object-oriented technique is structural continuity to standard microarray data model MAGE-OM (Microarray Gene Expression Object Model). The proposed modeling e(forts can be applicable for integration of biomedical information system.

• Journal of the Korea Society of Computer and Information
• /
• v.24 no.1
• /
• pp.57-65
• /
• 2019

In this paper, we propose a Rights Management Information(RMI) expression systems for individual sites are integrated and the performance evaluation is performed to find out an efficient comparing and updating method of RMI through various image feature point search techniques. In addition, we proposed a weighted scoring model for both public domain sites and posts in order to use the most latest RMI based on reliable data. To solve problem that most public domain sites are exposed to copyright infringement by providing inconsistent RMI(Rights Management Information) expression system and non-up-to-date RMI information. The weighted scoring model proposed in this paper makes it possible to use the latest RMI for duplicated images that have been verified through the performance evaluation experiments of SIFT and CNN techniques and to improve the accuracy when applied to search engines. In addition, there is an advantage in providing users with accurate original public domain images and their RMI from the search engine even when some modified public domain images are searched by users.

• Development and Reproduction
• /
• v.17 no.4
• /
• pp.329-335
• /
• 2013

TCR subunits are members of membrane-bound receptors which allow the fast and efficient elimination of the specific fish pathogens have regulated function in adaptive immunity. Sequence structure of TCR subunits have been reported for various teleosts, but the information of each TCR subunit functional characterization through expression analysis in fish was unknown. In this study, we examined the gene expression of TCR subunits in the early developmental stages and observed transcript levels in various tissues from healthy adult olive flounder by RT-PCR. The mRNA expression of alpha subunit was already detected in the previous hatching step. But the transcripts of another TCR subunit were not observed during embryo development and increased after hatching and maintained until metamorphosis at the same level. It was found that all TCR subunits mRNAs are commonly expressed in the immune-related organ such as spleen, kidney and gill, also weak expressed in fin and eye. TCR alpha and beta subunit were expressed in brain, whereas gamma and delta were not expressed same tissue. The sequence alignment analysis shows that there are more than 80% sequence homology between TCR subunits. Because it has a high similarity of amino acid sequence to expect similar in function, but expression analysis show that will have may functional diversity due to different time and place of expression.

• Proceedings of the Korean Institute of Interior Design Conference
• /
• 2007.05a
• /
• pp.231-236
• /
• 2007

The aspects of contemporary society change have been changed rapidly running for function value on the part of part industrialization and information-oriented. The transfer to the society focused on a human being emphasis and symbol value is in progress rising with natural desire of recurrence of human nature accordingly and desires of a human being inborn of sensitivity-oriented and pluralism-oriented are being expressed. Answering these social and cultural demands, concerns about an arbitrary mind world of a human being and pursuit dispositions about impractical and transcendental world are coincided with to the purpose and so various kinds of expressions except for art sphere are being experimented and applied. Here upon also in the field of the contemporary interior design, answering sensual desire of users, various arts and cultural tendency, the concept of surrealism is being applied in design introducing the concept of surrealism positive. And fantastical and unreasonable expression features of surrealism are being used as subjective essential elements to make new spaces. Especially amoung various kinds of the interiors designs, the features like surrealistic expressions in Food & Beverage Space which proper identity and strong symbolism will be expressed can be recognized as appropriate expression patterns to give still more sensitivity stimuli to customers. Thus this research disclosed conceptual and ideological background of surrealism and also analyzed and studied surrealistic expression features applied to the interiors designs of Contemporary Food & Beverage Space through expression disposition, study and classification of techniques. And standing on the result of analyzing surrealistic expression features of Contemporary Food & Beverage Space with a key word of expression features derived we groped for estatescape trend demanded in Food & Beverage Space and direction coming.

• Journal of KIISE:Computer Systems and Theory
• /
• v.35 no.8
• /
• pp.372-377
• /
• 2008

Multiclass cancer classification has been actively investigated based on gene expression profiles, where it determines the type of cancer by analyzing the large amount of gene expression data collected by the DNA microarray technology. Since gene expression data include many genes not related to a target cancer, it is required to select informative genes in order to obtain highly accurate classification. Conventional rank-based gene selection methods often use ideal marker genes basically devised for binary classification, so it is difficult to directly apply them to multiclass classification. In this paper, we propose a novel method for multiclass gene selection, which does not use ideal marker genes but directly analyzes the distribution of gene expression. It measures the class-discriminability by discretizing gene expression levels into several regions and analyzing the frequency of training samples for each region, and then classifies samples by using the naive Bayes classifier. We have demonstrated the usefulness of the proposed method for various representative benchmark datasets of multiclass cancer classification.

• Genomics & Informatics
• /
• v.15 no.3
• /
• pp.98-107
• /
• 2017

MicroRNAs (miRNAs) act as regulators of gene expression by binding to the 3' untranslated region (UTR) of target genes. They perform important biological functions in the various species. Among many miRNAs, miR-21-3p is known to serve vital functions in development and apoptosis in olive flounder. Using genomic and bioinformatic tools, evolutionary conservation of miR-21-3p was examined in various species, and expression pattern was analyzed in olive flounder. Conserved sequences (5'-CAGUCG-3') in numerous species were detected through the stem-loop structure of miR-21-3p. Thus, we analyzed target genes of miR-21-3p. Among them, 3' UTR region of PPIL2 gene indicated the highest binding affinity with miR-21-3p based on the minimum free energy value. The PPIL2 gene showed high expression levels in testis tissue of the olive flounder, whereas miR-21-3p showed rather ubiquitous expression patterns except in testis tissue, indicating that miR-21-3p seems to control the PPIL2 gene expression in a complementary repression manner in various tissues of olive flounder. Taken together, this current study contributes to infer the target gene candidates for the miR-21-3p using bioinformatics tools. Furthermore, our data offers important information on the relationship between miR-21-3p and target gene for further functional study.

• Toxicological Research
• /
• v.26 no.1
• /
• pp.21-28
• /
• 2010

As the frequency and the intensity of so called Asian dust (AD) events have increased, public concerns about the adverse health effects has spiked sharply over the last two decades. Despite the recent reports on the correlation between AD events and the risk for cardiovascular and respiratory disease, the nature of the toxicity and the degree of the risk are yet largely unknown. In the present study, we investigated the effects of the dichloromethane extract of AD (AD-X) and that of urban dust (NAD-X) collected during a non-AD period on gene expression in HL-60 cells using Illumina Sentrix HumanRef-8 Expression BeadChips. Global changes in gene expression were analyzed after 24 h of incubation with 50 or 100 ${\mu}g$/ml AD-X and NAD-X. By one-way analysis of variance (p < 0.05) and Benjamini-Hochberg multiple testing correction for false discovery rate of the results, 573 and 297 genes were identified as AD-X- and NAD-X-responsive, respectively. The genes were classified into three groups by Venn diagram analysis of their expression profile, i.e., 290 AD-X-specific, 14 NAD-X-specific, and 283 overlapping genes. Quantitative realtime PCR confirmed the changes in the expression levels of the selected genes. The expression patterns of five genes, namely SORL1, RABEPK, DDIT4, AZU1, and NUDT1 differed significantly between the two groups. Following rigorous validation process, these genes may provide information in developing biomarker for AD exposure.