• Title/Summary/Keyword: information expression

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A Study on the Moderating Effects of Social Support and Stress Coping Behaviors in between Parenting Stress and Depression of Grandparents of Grandparents and Grandchildren Family (조손가족 조부모의 양육스트레스와 우울 간 사회적 지지와 대처행동의 조절효과)

  • Song, Yoo-Mee;Lee, Seon-Ja
    • 한국노년학
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    • v.31 no.3
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    • pp.795-811
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    • 2011
  • Recently, an interest on how to moderate parenting stress of grandparents is rising according to rising depression of grandparents of grandparents and grandchildren family(GGF) because of parenting stress So, this study tried to analyze moderating effects by setting social support and stress coping behaviors as moderator variable in order to know how much parenting stress of grandparents would influence their depression. For this purpose, we selected 369 cases of grandparents who were being provided social welfare service and to 334 cases out of them, did multigroup analysis using hierarchical regression analysis and structural equation model under spss Vor. 19.0 program. Followings are the results. First, the more parenting stress was high, the more depression high. But when social support was high, parenting stress low. And the more parenting stress was high, faith dependence, negative emotional expression and passive evasion as stress coping behaviors also high while problem reestablishment low. Second, emotional support, information support, and material support as social support had moderating effects in which parenting stress influenced depression while appraisal support had not. Third, faith dependence and low passive evasion as stress coping behaviors had moderating effects in influence of parenting stress to depression while problem reestablishment has not. On the one hand, emotional expression was meaningless in explaining moderating effects in connection with parenting stress. Through these, we draw a social welfare practical implication that could lift moderating effect of social support and stress coping behavior in between parenting stress and depression of grandparents of grandparents and grandchildren Family.

Emotional Contagion as an Eliciting Factor of Altruistic Behavior: Moderating Effects by Culture (이타행동의 유발요인으로서 정서전염: 문화변인의 조절효과)

  • Jungsik Kim;Wan-Suk Gim
    • Korean Journal of Culture and Social Issue
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    • v.13 no.2
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    • pp.55-76
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    • 2007
  • This study investigated the relationship between emotional contagion and altruistic behaviors and also examined the moderating effect of self-construals(independent and interdependent self) in this relationship. It was hypothesized that the emotional expression of people in need would be caught by others through automatic mimicry, that emotional information would be internalized through the facial-feedback process and that the transferred emotion would eventually result in a motive to call for altruistic behaviors. In Study 1, participants watched a video clip about a disabled student reporting difficulties in school life but showing facial expression opposite to the contents of message to separate emotional contagion and empathy. Participants' decision to participate in voluntary works for the disabled student was measured. As a result, it was found that the more participants experienced emotional contagion, the more they participated in altruistic behaviors. Study 2 measured the vulnerability to emotional contagion, actual experiences of altruistic behaviors, and self-construals. The results of hierarchical regression showed that interdependent self moderated the influence of emotional contagion on altruistic behaviors whereas independent self moderated the relationship in an opposite direction. The implications of emotion and altruistic behaviors in human evolution process are discussed.

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Sulfasalazine Induces Apoptosis and Cell Cycle Arrest in RAW 264.7 Macrophages (마우스 대식세포에서 설파살라진의 세포사멸 및 세포주기 정체에 미치는 영향 연구)

  • Seong Mi Kim;Sohyeon Park ;Jin-Kyung Kim
    • Journal of Life Science
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    • v.33 no.10
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    • pp.767-775
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    • 2023
  • Sulfasalazine is a disease-modifying antirheumatic abiotic agent. It is a derivative of aminosalicylic acid and has been used for the treatment of various inflammatory diseases, such as rheumatoid arthritis, ulcerative colitis, and Crohn's disease, since it was first synthesized in 1941 and approved as a medicine in the United States in 1950. However, its mechanism of action has not yet been clearly identified. In this study, the effects of sulfasalazine on cell survival, apoptosis, and cell cycle progression in macrophages, which are major immune cells that regulate inflammatory responses, were investigated using mouse macrophage RAW 264.7 cells. Sulfasalazine inhibited the viability of RAW 264.7 cells in a dose-dependent manner, starting at a concentration of 0.25 mM. Annexin-V staining was used to confirm that the decrease in cell viability was due to apoptosis, and the number of Annexin-V-positive cells increased significantly at a concentration of 0.25 mM or higher. The effect of sulfasalazine on the expression of key proteins that regulate the G0/G1 phase of the cell cycle was also investigated. Sulfasalazine treatment significantly increased the expression of the cyclin-dependent kinase inhibitors p21 and p27 in RAW 264.7 cells. Although sulfasalazine is frequently used as a control drug in studies on inflammatory diseases, such as inflammatory colitis and rheumatoid arthritis, studies on its effect on macrophages are very limited. Therefore, the results of this study are expected to provide vital information on the use of sulfasalazine as a disease treatment.

Identification of relevant differential genes to the divergent development of pectoral muscle in ducks by transcriptomic analysis

  • Fan Li;Zongliang He;Yinglin Lu;Jing Zhou;Heng Cao;Xingyu Zhang;Hongjie Ji;Kunpeng Lv;Debing Yu;Minli Yu
    • Animal Bioscience
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    • v.37 no.8
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    • pp.1345-1354
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    • 2024
  • Objective: The objective of this study was to identify candidate genes that play important roles in skeletal muscle development in ducks. Methods: In this study, we investigated the transcriptional sequencing of embryonic pectoral muscles from two specialized lines: Liancheng white ducks (female) and Cherry valley ducks (male) hybrid Line A (LCA) and Line C (LCC) ducks. In addition, prediction of target genes for the differentially expressed mRNAs was conducted and the enriched gene ontology (GO) terms and Kyoto encyclopedia of genes and genomes signaling pathways were further analyzed. Finally, a protein-to-protein interaction network was analyzed by using the target genes to gain insights into their potential functional association. Results: A total of 1,428 differentially expressed genes (DEGs) with 762 being up-regulated genes and 666 being down-regulated genes in pectoral muscle of LCA and LCC ducks identified by RNA-seq (p<0.05). Meanwhile, 23 GO terms in the down-regulated genes and 75 GO terms in up-regulated genes were significantly enriched (p<0.05). Furthermore, the top 5 most enriched pathways were ECM-receptor interaction, fatty acid degradation, pyruvate degradation, PPAR signaling pathway, and glycolysis/gluconeogenesis. Finally, the candidate genes including integrin b3 (Itgb3), pyruvate kinase M1/2 (Pkm), insulin-like growth factor 1 (Igf1), glucose-6-phosphate isomerase (Gpi), GABA type A receptor-associated protein-like 1 (Gabarapl1), and thyroid hormone receptor beta (Thrb) showed the most expression difference, and then were selected to verification by quantitative real-time polymerase chain reaction (qRT-PCR). The result of qRT-PCR was consistent with that of transcriptome sequencing. Conclusion: This study provided information of molecular mechanisms underlying the developmental differences in skeletal muscles between specialized duck lines.

Application of Support Vector Regression for Improving the Performance of the Emotion Prediction Model (감정예측모형의 성과개선을 위한 Support Vector Regression 응용)

  • Kim, Seongjin;Ryoo, Eunchung;Jung, Min Kyu;Kim, Jae Kyeong;Ahn, Hyunchul
    • Journal of Intelligence and Information Systems
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    • v.18 no.3
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    • pp.185-202
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    • 2012
  • .Since the value of information has been realized in the information society, the usage and collection of information has become important. A facial expression that contains thousands of information as an artistic painting can be described in thousands of words. Followed by the idea, there has recently been a number of attempts to provide customers and companies with an intelligent service, which enables the perception of human emotions through one's facial expressions. For example, MIT Media Lab, the leading organization in this research area, has developed the human emotion prediction model, and has applied their studies to the commercial business. In the academic area, a number of the conventional methods such as Multiple Regression Analysis (MRA) or Artificial Neural Networks (ANN) have been applied to predict human emotion in prior studies. However, MRA is generally criticized because of its low prediction accuracy. This is inevitable since MRA can only explain the linear relationship between the dependent variables and the independent variable. To mitigate the limitations of MRA, some studies like Jung and Kim (2012) have used ANN as the alternative, and they reported that ANN generated more accurate prediction than the statistical methods like MRA. However, it has also been criticized due to over fitting and the difficulty of the network design (e.g. setting the number of the layers and the number of the nodes in the hidden layers). Under this background, we propose a novel model using Support Vector Regression (SVR) in order to increase the prediction accuracy. SVR is an extensive version of Support Vector Machine (SVM) designated to solve the regression problems. The model produced by SVR only depends on a subset of the training data, because the cost function for building the model ignores any training data that is close (within a threshold ${\varepsilon}$) to the model prediction. Using SVR, we tried to build a model that can measure the level of arousal and valence from the facial features. To validate the usefulness of the proposed model, we collected the data of facial reactions when providing appropriate visual stimulating contents, and extracted the features from the data. Next, the steps of the preprocessing were taken to choose statistically significant variables. In total, 297 cases were used for the experiment. As the comparative models, we also applied MRA and ANN to the same data set. For SVR, we adopted '${\varepsilon}$-insensitive loss function', and 'grid search' technique to find the optimal values of the parameters like C, d, ${\sigma}^2$, and ${\varepsilon}$. In the case of ANN, we adopted a standard three-layer backpropagation network, which has a single hidden layer. The learning rate and momentum rate of ANN were set to 10%, and we used sigmoid function as the transfer function of hidden and output nodes. We performed the experiments repeatedly by varying the number of nodes in the hidden layer to n/2, n, 3n/2, and 2n, where n is the number of the input variables. The stopping condition for ANN was set to 50,000 learning events. And, we used MAE (Mean Absolute Error) as the measure for performance comparison. From the experiment, we found that SVR achieved the highest prediction accuracy for the hold-out data set compared to MRA and ANN. Regardless of the target variables (the level of arousal, or the level of positive / negative valence), SVR showed the best performance for the hold-out data set. ANN also outperformed MRA, however, it showed the considerably lower prediction accuracy than SVR for both target variables. The findings of our research are expected to be useful to the researchers or practitioners who are willing to build the models for recognizing human emotions.

Efficient Linear Path Query Processing using Information Retrieval Techniques for Large-Scale Heterogeneous XML Documents (정보 검색 기술을 이용한 대규모 이질적인 XML 문서에 대한 효율적인 선형 경로 질의 처리)

  • 박영호;한욱신;황규영
    • Journal of KIISE:Databases
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    • v.31 no.5
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    • pp.540-552
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    • 2004
  • We propose XIR-Linear, a novel method for processing partial match queries on large-scale heterogeneous XML documents using information retrieval (IR) techniques. XPath queries are written in path expressions on a tree structure representing an XML document. An XPath query in its major form is a partial match query. The objective of XIR-Linear is to efficiently support this type of queries for large-scale documents of heterogeneous schemas. XIR-Linear has its basis on the schema-level methods using relational tables and drastically improves their efficiency and scalability using an inverted index technique. The method indexes the labels in label paths as key words in texts, and allows for finding the label paths that match the queries far more efficiently than string match used in conventional methods. We demonstrate the efficiency and scalability of XIR-Linear by comparing it with XRel and XParent using XML documents crawled from the Internet. The results show that XIR-Linear is more efficient than both XRel and XParent by several orders of magnitude for linear path expressions as the number of XML documents increases.

A Study of ePUB-based Interoperability Method of Rights Information Supporting Mutual Comparability of eBook DRM (전자책 DRM의 상호호환성을 지원하는 ePUB 기반의 권리정보 호환 방법에 관한 연구)

  • Kim, Tae-Hyun;Kang, Ho-Gap;Yoon, Hee-Don;Cho, Seong-Hwan
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.12 no.2
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    • pp.205-214
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    • 2012
  • IDPF, which builds formats and copyright protection standards of eBooks, has announced ePUB 3.0 as a technical standard of eBooks in October, 2011. This standard includes methods how to represent eBooks and technical specifications to protect eBook content. While technical specifications for content protection describe how to represent encryption and digital signature techniques, they do not identify any technical standards for rights expression but just file names for storages of rights information. It does not provide any unification of copyright information representation and formats used by eBook service companies. When copyright protection techniques for eBooks are used, comparability among eBook readers cannot be expected, even though there is a standard of ePUB. This study suggests a method to maintain compatibility toward eBook DRM by using unified rights information process under circumstances where different eBook service companies use diverse methods. The standard reference software of the model proposed in this study, together with other results of this study, will be offered as a registered open software.

Thermodynamics-Based Weight Encoding Methods for Improving Reliability of Biomolecular Perceptrons (생체분자 퍼셉트론의 신뢰성 향상을 위한 열역학 기반 가중치 코딩 방법)

  • Lim, Hee-Woong;Yoo, Suk-I.;Zhang, Byoung-Tak
    • Journal of KIISE:Software and Applications
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    • v.34 no.12
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    • pp.1056-1064
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    • 2007
  • Biomolecular computing is a new computing paradigm that uses biomolecules such as DNA for information representation and processing. The huge number of molecules in a small volume and the innate massive parallelism inspired a novel computation method, and various computation models and molecular algorithms were developed for problem solving. In the meantime, the use of biomolecules for information processing supports the possibility of DNA computing as an application for biological problems. It has the potential as an analysis tool for biochemical information such as gene expression patterns. In this context, a DNA computing-based model of a biomolecular perceptron has been proposed and the result of its experimental implementation was presented previously. The weight encoding and weighted sum operation, which are the main components of a biomolecular perceptron, are based on the competitive hybridization reactions between the input molecules and weight-encoding probe molecules. However, thermodynamic symmetry in the competitive hybridizations is assumed, so there can be some error in the weight representation depending on the probe species in use. Here we suggest a generalized model of hybridization reactions considering the asymmetric thermodynamics in competitive hybridizations and present a weight encoding method for the reliable implementation of a biomolecular perceptron based on this model. We compare the accuracy of our weight encoding method with that of the previous one via computer simulations and present the condition of probe composition to satisfy the error limit.

$\beta$-Subunit 94~96 Residues of Tethered Recombinant Equine Chorionic Gonadotropin are Important Sites for Luteinizing Hormone and Follicle Stimulating Hormone like Activities

  • Park, Jong-Ju;JarGal, Naidansuren;Yoon, Jong-Taek;Min, Kwan-Sik
    • Reproductive and Developmental Biology
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    • v.34 no.1
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    • pp.33-40
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    • 2010
  • Equine chorionic gonadotropin (eCG) is a heavily glycosylated glycoprotein composed of non-covalently linked $\alpha$- and $\beta$-subunits. To study the function and signal transduction of tethered recombinant-eCG (rec-eCG), a single chain eCG molecule was constructed, and the rec-eCG protein was prepared. In this study, we constructed 5 mutants (${\Delta}1$, ${\Delta}2$, ${\Delta}3$, ${\Delta}4$, and ${\Delta}5$) of rec-eCG using data about known glycoprotein hormones to analyze the role of specific follicle stimulating homone (FSH)-like activity. Three amino acids of certain specific sites were replaced with alanine. The expression vectors were transfected into CHO cells and subjected to G418 selection for 2~3 weeks. The media were collected and the quantity of secreted tethered rec-eCGs was quantified by ELISA. The LH- and FSH-like activities were assayed in terms of cAMP production by rat LH/CG and rat FSH receptors. Then, the metabolic clearance rate analyzed by the injection of rec-eCG (5 IU) into the tail vein was analyzed. The mutant eCGs (${\Delta}l$, ${\Delta}4$, and ${\Delta}5$) were transcripted, but not translated into proteins. Rec-eCG A2 was secreted in much lower amounts than the wild type. Only the rec-eCG ${\Delta}3$ ($\beta$-subunit: $Gln^{94}-Ile^{95}-Lys^{96}{\rightarrow}Ala^{94}-Ala^{95}-Ala^{96}$) was efficiently secreted. Although activity is low, its LH-like activity was similar to that of tethered $eCG{\beta\alpha}$. However, the FSH-like activity of rec-$eCG{\beta\alpha\Delta}3$ was completely flat. The result of the analysis of the metabolic clearance rate shoed the persistence of the mutant in the blood until 4 hours after the injection. After then, it almost disappeared at 8 hours. Taken together, these data suggest that 94~96 amino acid sequences in eCG $\beta$-subunit appear to be of utmost importance for signal transduction of the FSH receptor.

A Visualization Method of High Definition Weather Radar Information for various GIS Platforms (다양한 GIS 플랫폼을 위한 고해상도 기상레이더 정보 시각화 기법)

  • Jang, Bong-Joo;Lim, Sanghun;Lee, Suk-Hwan;Moon, Kwang-Seok;Chandrasekar, V.;Kwon, Ki-Ryong
    • Journal of Korea Multimedia Society
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    • v.16 no.11
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    • pp.1239-1249
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    • 2013
  • According to development of weather radar, researches about observation, analysis or forecast of weather phenomena such as tornado, flash-flood etc. were encouraged by reducing frequency interferences, transmission noises, attenuations of radar signal. In contrast, there is a growing interest in the visualization and expression methods for weather radar data but weather radar manufacturers or the organs of government for weather are just busy interpreting expressed weather images projected on GIS. We propose an effective high definition weather radar information visualization method able to apply various GIS platforms to observe and take actions against rapid local weather changes effectively. In this paper, first we change information acquired from weather radar to raster or vector type high definition data structures using specific algorithms. And then, we quadrate our processed raster/vector type weather data with various GIS platforms accurately to make observers can recognize and check weather situations over exact geographical positions and elevations intuitively. Experimental results verify that our method make observers can recognize and analyze weather changes, tornados, local downpours or flash floods accurately by analyzing high definition weather radar data combined with GIS platform including detailed target locations and elevations.