• Genomics & Informatics
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• v.1 no.2
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• pp.94-100
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• 2003

Motivation: Many have observed a nonlinear relationship between the signal intensity and the transcript abundance in microarray data. The first step in analyzing the data is to normalize it properly, and this should include a correction for the nonlinearity. The commonly used linear normalization schemes do not address this problem. Results: Nonlinearity is present in both cDNA and oligonucleotide arrays, but we concentrate on the latter in this paper. Across a set of chips, we identify those genes whose within-chip ranks are relatively constant compared to other genes of similar intensity. For each gene, we compute the sum of the squares of the differences in its within-chip ranks between every pair of chips as our statistic and we select a small fraction of the genes with the minimal changes in ranks at each intensity level. These genes are most likely to be non-differentially expressed and are subsequently used in the normalization procedure. This method is a generalization of the rank-invariant normalization (Li and Wong, 2001), using all available chips rather than two at a time to gather more information, while using the chip that is least likely to be affected by nonlinear effects as the reference chip. The assumption in our method is that there are at least a small number of non­differentially expressed genes across the intensity range. The normalized expression values can be substantially different from the unnormalized values and may result in altered down-stream analysis.

• 한국인삼전략화협의회:학술대회논문집
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• v.2003 no.09
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• pp.54-63
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• 2003

"Korea ginseng (Panax ginseng C.A Meyer) is an important medicinal plant. Its root has been used as an herbal medicine that provides resistance to stress and disease, and prevents exhaustion since the ancient time. Ginsenosides, glycosylated triterpene (saponin), are considered to be the main active compounds of the ginseng root. Despite of considerable commercial interests of ginsenosides, very little is known about the genes and their biochemical pathways for ginsenoside biosynthesis. This work will focus on the identification of genes involved in ginsenoside biosynthesis and the dissection of ginsenoside biosynthetic pathway using a functional genomics tool. Expression sequence tags (ESTs) provide a valuable tool to discovery the genes in secondary metabolite biosynthesis. We generated over 21,155 ginseng ESTs that is now sufficient to facilitate discovering the genes involved in ginsenoside biosynthesis such as oxidosqualene cyclase(OSC), cytochrome P450 and glycosyltransferase. With ESTs information, microarray technology will be used for the analysis of gene expression, and the identification of genes including transcription factors expressed in tissues under given experimental condition. Heterogous system such as yeast and plants will allow us to do the functional analysis. And selected ginseng hairy root which show variation in ginsenoside production will be used as a material for functional analysis of candidate gene. Functional genomics approach will successfully accelerate gene discovery, and also provide promises of metabolic engineering for the ginsenoside production."

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.41 no.5
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• pp.283-290
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• 2004

In this paper, a low-power structure for 512 tap FIR filter in MPEG audio algorithm is proposed. By using CSD(Canonic Signed Digit) form filter coefficients and maximum sharing of input signal sample, it is shown that the number of adders of proposed structure can be minimized. To minimize the number of adders, the proposed structure utilizes the 4 steps of sharing, i.e., common input sharing, linear phase symmetric filter coefficient sharing, block sharing for common input, and common sub-expression sharing. Through Verilog-HDL coding, it is shown that reduction rates in the implementation area and relative power consumption of the proposed structure are 60.3% and 93.9% respectively, comparison to those of the conventional multiplier structure.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.37 no.11
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• pp.96-104
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• 2000

This paper presents a simple method to estimate short-circuit power dissipation for static CMOS logic circuits. Short-circuit current expression is derived by accurately interpolating peak points of actual current curves which is influenced by the gate-to-drain coupling capacitance. It is shown through simulations that the proposed technique yields better accuracy than previous methods when signal transition time and/or load capacitance decreases, which is a characteristic of the present technological evolution. The proposed analytical expressions can be easily applied in such applications as power estimation even when the current expression is changed.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.17 no.8 s.111
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• pp.788-794
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• 2006

In this paper, a Sommerfeld integral for an impedance half-plane is considered, which is one of classical problems in electromagnetic theory. First, the integral is evaluated into two series representations which are expressed in terms of exponential integral and Lommel function, respectively. Then based on the Lommel function expansion, an exact, closed-form expression of the integral is formulated, written in terms of incomplete Weber integrals. Additionally, based on the exponential integral expansion, an approximate expression of the integral is obtained. Validity of all formulations derived in this paper is demonstrated through comparisons with a numerical integration of the integral for various situations.

• BMB Reports
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• v.40 no.6
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• pp.966-972
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• 2007

Pituitary tumor transforming gene (PTTG1) is widely detected in many tumors. Increasing evidence reveals that PTTG1 is associated with cell proliferation, cellular transformation and apoptosis. However, the functions of PTTG1, especially its role in DNA damage-induced apoptosis, remain largely unclear. In this report, we used UV irradiation to induce apoptosis in HeLa cells to examine the role of PTTG1 in UV-induced apoptosis by RNAi-mediated knockdown and overexpression of PTTG1. RNAi-mediated knockdown of PTTG1 expression increased and overexpression of PTTG1 decreased the UV-induced apoptosis. Furthermore, UV irradiation decreased PTTG1 mRNA and protein expression. These effects were found to be mediated by JNK pathway. Therefore, PTTG1 had an important anti-apoptotic role in UV-induced apoptosis and this role was mediated by JNK pathway. These results may provide important information for understanding the exact role and the regulation mechanism of PTTG1 in UV-induced apoptosis.

• Fashion & Textile Research Journal
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• v.6 no.4
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• pp.440-446
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• 2004

The purpose of this study was to classify the In-line skate clothing interest of in-line skaters according to in-line skate involvement. The questionnaire was administrated to 124 male, 96 female in-line skaters aged over 20 living in Daegu. Data were analyzed by using Frequency, Factor analysis, One-way analysis of variance, Duncan test, T-test, Correlation analysis. The results of this study can be summarized as follows ; The factor of in-line skate clothing interest of in-line skater were classified into 5 factor, expression orientation, performance enhancement, information dependence, anti deviation, individual assertion. The in-line skate clothing interest, men have interests in performance enhancement, women have interest in individual assertion. The more experience of in-line skate they have. the more interest in performance enhancement they want. High involvement in-line skater have high cloth interesting of sub-factors which are expression orientation, performance enhancement and individual assertion etc. As a result, we need more deliberate marketing strategies for the experience degree, involvement degree and women in-line skater then men.

• Asian-Australasian Journal of Animal Sciences
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• v.28 no.2
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• pp.158-165
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• 2015

Marbling is an important trait regarding the quality of beef. Analysis of beef cattle transcriptome and its expression profile data are essential to extend the genetic information resources and would support further studies on beef cattle. RNA sequencing was performed in beef cattle using the Illumina High-Seq2000 platform. Approximately 251.58 million clean reads were generated from a high marbling (H) group and low marbling (L) group. Approximately 80.12% of the 19,994 bovine genes (protein coding) were detected in all samples, and 749 genes exhibited differential expression between the H and L groups based on fold change (>1.5-fold, p<0.05). Multiple gene ontology terms and biological pathways were found significantly enriched among the differentially expressed genes. The transcriptome data will facilitate future functional studies on marbling formation in beef cattle and may be applied to improve breeding programs for cattle and closely related mammals.

• The Journal of the Acoustical Society of Korea
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• v.16 no.1E
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• pp.41-48
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• 1997

The very purpose of subband codec is the attainment of data rate compression through the use of quantizer and optimum bit allocation for each decimated signal. Yet the question of floating-point quantization effects in subband codec has received scant attention. There has been no direct focus on the analysis of quantization errors, nor on design with quantization errors embedded explicitly in the criterion. This paper provides a rigorous theory for the modelling, analysis and optimum design of the general M-band subband codec in the presence of the floating-point quantization noise. The floating-point quantizers are embedded into the codec structure by its equivalent multiplicative noise model. We then decompose the analysis and synthesis subband filter banks of the codec into the polyphase form and construct an equivalent time-invariant structure to compute exact expression for the mean square quantization error in the reconstructed an equivalent time-invariant structure to compute exact expression for the mean square quantization error in the reconstructed output. The optimum design criteria of the subband codec is given to the design of the analysis/synthesis filter bank and the floating-point quantizer to minimize the output mean square error. Specific optimum design examples are developed with two types of filter of filter banks-orthonormal and biorthogonal filter bank, along with their perpormance analysis.

• Journal of the Korean Institute of Telematics and Electronics S
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• v.35S no.6
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• pp.19-24
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• 1998

In this paper, a new closed form expression for the average symbol error rate(SER) of generalized selection combining(SC), whereby the two(three) signals with the two(three) largest amplitudes are combined from the original diversity branches in the channel, for MPSK signals in a frequency-nonselective slowly m-distributed Nakagami fading channel is derived. In order to analyze the error performance for a generalized SC, the Order-Statistics is applied. To derive the SER of MPSK signals with SC, the new expression of pdf is introduced and many other mathematical methods are used. Comparing the derived SER with that of MRC, we find adequate diversity branch number from total Lth-order diversity branches.