• 한국방재학회 논문집
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• 제10권5호
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• pp.109-116
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• 2010

강우로 인한 침투 및 지하수위 상승은 산사태나 사면 활동의 주요 원인이다. 이러한 경우 사면의 안전율을 확보하기 위하여 사면 경사를 완만하게 하거나, 보강재를 이용하여 저항력을 높여주는 공법이 사용된다. Mass Nail 공법은 Nail 보강공과 경사면 배수공, 표면 녹화공을 동시에 적용할 수 있는 환경 친화적인 경사면 보강 공법이다. 본 연구에서는 Mass Nail로 보강된 사면의 보강효과를 확인하기 위해 강우로 인한 사면의 함수비 변화를 고려하여 실내 모형 실험을 수행하였다. 그 결과, 무보강 사면에 대한 Mass Nail 보강 사면의 안전율은 약 1.4~2.3배 증가하였고, 함수비를 10%에서 22%로 증가 할 경우 무보강 사면에서 최대 응력은 12%~24%, 평균 18% 감소하였고, Mass Nail 경사면 보강법을 적용한 사면은 4%~23%, 평균 14% 감소함을 알 수 있었다.

• Nutrition Research and Practice
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• 제8권3호
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• pp.272-277
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• 2014

BACKGROUND/OBJECTIVES: This study investigated the antioxidant activities and hepatoprotective effects of Schisandra chinensis Baillon extract (SCE) against tert-butyl hydroperoxide (t-BHP)-induced oxidative hepatic damage in rats. MATERIALS/METHODS: Sprague-Dawley (SD) rats were pretreated with SCE (300, 600, and 1,200 mg/kg BW) or saline once daily for 14 consecutive days. On day 14, each animal, except those belonging to the normal control group, were injected with t-BHP (0.8 mmol/kg BW/i.p.), and all of the rats were sacrificed 16 h after t-BHP injection. RESULTS: Although no significant differences in AST and ALT levels were observed among the TC and SCE groups, the high-dose SCE group showed a decreasing tendency compared to the TC group. However, erythrocyte SOD activity showed a significant increase in the low-dose SCE group compared with the TC group. On the other hand, no significant differences in hepatic total glutathione (GSH) level, glutathione reductase (GR), and glutathione peroxidase (GSH-Px) activities were observed among the TC and SCE groups. Hepatic histopathological evaluation revealed that pretreatment with SCE resulted in reduced t-BHP-induced incidence of lesions, such as neutrophil infiltration, swelling of liver cells, and necrosis. In particular, treatment with a high dose of SCE resulted in induction of phase II antioxidant/detoxifying enzyme expression, such as glutathione S-transferase (GST) and glutamate-cysteine ligase catalytic subunit (GCLC). CONCLUSIONS: Based on these results, we conclude that SCE exerts protective effects against t-BHP induced oxidative hepatic damage through the reduction of neutrophil infiltration, swelling of liver cells, and necrosis. In addition, SCE regulates the gene expression of phase II antioxidant/detoxifying enzymes independent of hepatic antioxidant enzyme activity.

• KIEAE Journal
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• 제10권4호
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• pp.9-17
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• 2010

The purpose of this study is to draw out objective bases for selecting various applicable facilities in case of the establishment of rainwater management strategies. To do so, sixteen facilities were selected from decentralized rainwater management systems that induce rainwater infiltration and detention as well as centralized end-of-pipe type infiltration and detention facilities in local areas. With these facilities, it attempted to evaluate them in terms of sustainability, pollutant elimination, flood control capacity and costs and subsequently analyzed correlations between each characteristic. The outcomes of the analysis were as follows: First was the analysis of characteristics between decentralized rainwater management systems and end-of-pipe rainwater management systems. From the decentralized rainwater management systems, the mulden-rigolen system and grass swale at street level had the highest in the total of the four items while the totals of the underground detention tank and temporary detention site were highest in end-of-pipe rainwater management systems. After analyzing the correlation between different types of facilities and each variable, it can be said that decentralized rainwater management systems have a higher correlation than end-of-pipe rainwater management systems in terms of sustainability whereas the latter are better in flood control capacity than the former. Second, the analysis of correlation in variables of each facility is as follows: first, there is a negative correlation between sustainability value and flood control capacity value; and there is a positive correlation between flood control capability and pollutants elimination. In addition, it revealed that the higher the flood control and pollutant elimination capability the higher the facility costs. Based on these assessments, it is possible to use them as objective selection criteria for facility application in case of site development project or complex plan.

• Tuberculosis and Respiratory Diseases
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• 제76권1호
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• pp.38-41
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• 2014

Immunoglobulin G4 (IgG4)-related disease is a newly recognized condition characterized by fibroinflammatory lesions with dense lymphoplasmacytic infiltration, storiform-type fibrosis and obliterative phlebitis. The pathogenesis is not fully understood but multiple immune-mediated mechanisms are believed to contribute. This rare disease can involve various organs and pleural involvement is even rarer. We report a case of IgG4-related disease involving pleura. A 66-year-old man presented with cough and sputum production for a week. Chest radiography revealed consolidation and a pleural mass at right hemithorax. Treatment with antibiotics resolved the consolidation and respiratory symptoms disappeared, but the pleural mass was unchanged. Video-assisted thoracoscopic surgery was performed. Histopathology revealed dense lymphoplasmacytic infiltration and storiform fibrosis with numerous IgG4-bearing plasma cells. The serum IgG4 level was also elevated. Further examination ruled out the involvement of any other organ. The patient was discharged without further treatment and there is no evidence of recurrence to date.

• 한국지반환경공학회 논문집
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• 제18권12호
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• pp.13-23
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• 2017

본 논문에서는 운영 중인 철도노반의 침하에 대응하고자 노반보강 재료와 공법에 대한 내용을 다루었다. 국내에서는 도시철도와 고속철도, 그리고 일반철도에 콘크리트궤도가 도입되고 있지만 최근 시공된 일부구간에서 콘크리트궤도의 노반침하가 발생되고 있고, 유지보수에 어려움을 겪고 있는 실정이다. 철도 안전운행을 위해 침하된 철도노반의 보강이 시급하지만 현재까지 운영중인 철도노반의 보강에 대한 시공사례는 전무한 상태로서 노반 보강에 어려움이 있다. 따라서 본 연구에서는 최초로 시도되는 운영 중인 철도노반을 보강하기 위해 지반보강 재료들을 통해 노반 보강의 목표성능을 선정하였고, 이에 침투성능 및 고결성 주입효과 등을 확인하여 목표성능의 만족여부를 판단하였다. 연구 결과 일반적으로 쓰이는 지반보강재료 및 공법들은 철도노반 보강의 적용을 위해 개선이 필요하다는 것이 확인되었다.

• 대한한방소아과학회지
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• 제23권3호
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• pp.263-291
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• 2009

Objectives The purpose of this study is to investigate the effect of YHJST on atopic dermatitis in an experiment using an NC/Nga mice induced by DNCB, which has histological and clinical similarities to the condition in humans. Methods To investigate the effect of YHJST on atopic dermatitis(AD), we evaluated atopic dermatitis-like skin lesions by clinical skin index and analyzed immunological parameters in peripheral blood mononuclear cells(PBMCs) and performed skin histology in ears and dorsal skin of NC/Nga ato-mouse. Results YHJST medicines decreased Serum level of IgE, IL-6, TNF-$\alpha$. Also total number of $CD69^+$, $CD3^+$ in PBMCs, absolute cell number of $CCR3^+CD3^+$, $CD11b^+Gr-1^+$ in Dorsal skin tissue, Serum IgG1, IgM, IgG2a and IgG2b decreased significantly. Furthermore YHJST is extremely effective to histological symptoms; dermal and epidermal thickening, hyperkeratosis and inflammatory cell infiltration and suppressed histologic infiltration of $CD4^+$ & $CCR3^+$ in ear and dorsal skin lesions significantly. YHJST decreased gene-expression of IL-6, TNF-$\alpha$, CCR3, Eotaxin mRNA than that of control group. Conclusions YHJST on atopic dermatitis to atopic dermatitis NC/Nga mouse induced DNCB was incredibly effective.

• 한국물환경학회지
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• 제22권6호
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• pp.1068-1074
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• 2006

For receiving water quality protection a control systems of urban drainage for CSOs reduction is needed. Examples in combined sewer systems include downstream storage facilities that detain runoff during periods of high flow and allow the detained water to be conveyed by an interceptor sewer to a centralized treatment plant during periods of low flow. The design of such facilities as storm-water detention storage is highly dependant on the temporal variability of storage capacity available as well as the infiltration capacity of soil and recovery of depression storage. For the continuous long-term analysis of urban drainage system this study used analytical probabilistic model based on derived probability distribution theory. As an alternative to the modeling of urban drainage system for planning or screening level analysis of runoff control alternatives, this model has evolved that offers much ease and flexibility in terms of computation while considering long-term meteorology. This study presented rainfall and runoff characteristics of the subject area using analytical probabilistic model. Runoff characteristics manifested the unique characteristics of the subject area with the infiltration capacity of soil and recovery of depression storage and was examined appropriately by sensitivity analysis. This study presented the average annual CSOs, number of CSOs and event mean CSOs for the decision of storage volume.

• 한국패류학회지
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• 제9권2호
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• pp.85-93
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• 1993

Contamination of heavy metals in water and sediments along Mantyeong (river) has reached up to critical level, The object of the study is to dlucidate some macroinvertebrates which inhabit along the river in respect to the modulatory role in reducing the pollution. For the purpose, Scapharca subcrenata(sea shell) which is common in numbers and biomass in the area was collected, and cadmium (Cd) was subjected as a reference metal in the experiment. The seashell was dried and autoclaved, followed by pellet preparation under various concentration of Cd: 50,100,250,500 and 1,500 ug /pellet. Mice were fed for 3 months, althrough last group(5 mice), 1,500 ug/pellet, died within 4 weeksof the administration.MT-Cd in liver and kidney increased in correlation with the amont of Cd concentration in pellet, especially in kidney than in liver. Liver and kidney of the mice showed pathological changes such as cellular infiltration and focal necrosis in liver, and peri-tubular cell infiltration or tubular necrosis etc. The changes were more intensive by amount of the Cd. Overall results in the present study suggest that Cd may eventually combine with soluble-protein forming metalloprotein, then reduce the toxicity of heavy metal, How the formed Mt-Cd is discharged from the kidney and the mechanism shall be the further subject to be clarified.

• 한국수의병리학회:학술대회논문집
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• 한국수의병리학회 2002년도 추계학술대회초록집
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• pp.132-132
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• 2002

Mostly, hypercholesterolemia has been focused on atherosclerosis and coronary heart disease and can be produced by intake of high cholesterol diet. However, toxic effects of cholesterol itself on liver and relationship between intake of high cholesterol diet and hepatic fibrosis have not been clearly investigated. Male Wistar rats were fed diet supplemented with 1.0 ％ cholesterol and 0.3 ％ sodium cholate for 12 weeks. Rats were sacrificed at 0, 3, 6, 9 and 12, respectively. Histopathological and blood chemical studies were performed on these animal sets. Total cholesterol, AST, ALT and LDH levels increased from week 3 and maintained around that level throughout the experiment compared to control. However, TG and albumin levels were the same or lower than those of control. Intake of high cholesterol and sodium cholate diet caused hepatic necrosis, macrophage infiltration, steatosis and fibrosis. Following feeding this diet to rats, hepatic necrosis, macrophage infiltration and steatosis markedly increased throughout the experiment, comparing to control. Collagen deposition and myofibroblasts were detected from at week 9 to 12 in the liver. Mast cell increased in proportion to the degree of hepatic damages. In conclusion, these results suggest that intake of high cholesterol diet is a risk factor on hepatic steatosis and fibrosis as well as atherosclerosis and coronary heart disease. Furthermore, this animal model for hepatic fibrosis can be use for application of anti-fibrogenic agents screening in vivo.

• 동의생리병리학회지
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• 제21권2호
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• pp.392-398
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• 2007

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by inflammatory cell infiltration in the skin. This study was performed to assess the therapeutic effects of YHYBT on the DNCB-induced dermatitis in NC/Nga mice, characterized by the onset of AD along with an increase the number of Th2 cells and dysregulation of inflammaroty mediators including cytokines and chemokines. YHYBT administration significantly reduced clinical dermatitis severity including pruritus, edema, eczematous and erythema. Histological findings indicated that the thickening of epidermis/dermis and dermal infiltration of inflammatory cells including mast cells were dramatically reduced. The suppression of dermatitis by YHYBT was accompanied by a decrease in the total number of immune cells in drained lymph node (DLN) and skin. Especially CD3+, CD4+ and CD3+CD69+ T cells in PBMC and DNL were greatly reduced. The level of IL-4 in CD3/CD28 activated splenocyte was downregulated, whereas that of IFN-'처리불가‘ was increased. Furthermore, the expression of eotaxin2 and CCR3 in skin were significanlty decreased. These data suggest that YHTBT may be effective therapeutic agents for the treatment of AD.