• Journal of the Korean Society of Food Science and Nutrition
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• v.20 no.4
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• pp.401-407
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• 1991

Anticarcinogenic conjugated dienoic derivatives of linoleic acid (CLA) is present in grilled beef, cheese, and related foods, CLA is generated via isomerization of linoleic acid in the cow's rumen by anaerobic bacteria and food proceessing as well. Another source of CLA is its endogenous generation via the carbon centered free radical oxdation of linoleic acid. We propose that the formation and generation of CLA in vivo represents a previously unrecognized in situ "defense mechanism" against membrane attack by oxygen free radicals. The cis, 9-trans, 11 CLS isomer is selectively incorporated into cellular phospholipid, which exhibits a potent antioxidant, reduces the activation of 2-amino-3-methylimidazo, [4,5-f] quinoline (IQ) for baxterial mutagenesis, and inhibits ornithine decarboxylase(ODC) activity induced by 12-0-tetradecanoylphorbol-13-acetate (TPA). We believe that at least these biological activities of CLA explain the anticarcinogenic activity of CLA.

• Bulletin of the Korean Chemical Society
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• v.33 no.11
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• pp.3618-3624
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• 2012

Photodissociation dynamics of propiolic acid ($HC{\equiv}C-COOH$) at 212 nm in the gas phase was investigated by measuring rotationally resolved laser-induced fluorescence spectra of OH ($^2{\Pi}$) radicals exclusively produced in the ground electronic state. From the spectra, internal energies of OH and total translational energy of products were determined. The electronic transition at 212 nm responsible for OH dissociation was assigned as the ${\pi}_{C{\equiv}C}{\rightarrow}{\pi}^*{_{C=O}}$ transition by time-dependent density functional theory calculations. Potential energy surfaces of both the ground and electronically excited states were obtained employing quantum chemical calculations. It was suggested that the dissociation of OH from propiolic acid excited at 212 nm should take place along the $S_1/T_1$ potential energy surfaces after internal conversion and/or intersystem crossing from the initially populated $S_2$ state based upon the potential energy calculations and model calculations for energy partitioning of the available energy among products.

• Tuberculosis and Respiratory Diseases
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• v.74 no.1
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• pp.32-36
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• 2013

A 43-year-old woman with breast cancer who was on neoadjuvant chemotherapy presented with cough, sputum and mild fever. High-resolution computed tomography showed diffuse ground glass opacities in bilateral lungs and subpleural patchy consolidations. Initially, she was thought to have pneumonia or interstitial lung diseases such as drug-induced pneumonitis and treated with antibiotics and steroids. She subsequently got breast cancer surgery because of disease progression, and concurrent thoracoscopic lung biopsy revealed metastatic carcinoma of the lung from breast cancer. The diagnosis of suspected interstitial lung disease can be made without lung biopsy, but malignancy should always be considered and lung biopsy should be performed in the absence of a definitive clinical diagnosis.

• Structural Engineering and Mechanics
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• v.39 no.5
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• pp.621-642
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• 2011

Passive tuned mass dampers (TMDs) efficiently suppress vibrations induced by quasi-stationary dynamic inputs, such as winds, sea waves or traffic loads, but may prove of little use against pulse-like excitations, such as near-field (NF) ground motions. The extent of such impairment is however controversial, partly due to the different evaluation criteria adopted within the literature, partly to the limited number of seismic records used in most investigations. In this study, three classical techniques and two new variants for designing a TMD on an SDOF structure are tested under 338 NF records from the PEER NGA database, including 156 records with forward-directivity features. Percentile response reduction spectra are introduced to statistically assess TMD performance, and TMD robustness is verified through Monte Carlo simulations. The methodology is extended to a variety of MDOF bending-type and shear-type frames, and simulated on a case study building structure recently constructed in Central Italy.Results offer an interesting insight into the performance of TMDs against NF earthquakes, ultimately showing that, if properly designed and sufficiently massive, TMDs are effective and robust even in the face of pulse-like ground motions. The two newly proposed design techniques are shown to generally outperform the classical ones.

• Advances in aircraft and spacecraft science
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• v.2 no.3
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• pp.303-328
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• 2015

A design methodology is presented to develop the hingeless control surfaces for MAV using adhesively bonded Macro Fiber Composite (MFC) actuators. These actuators have got the capability to deflect the trailing edge surfaces of the wing to attain the required maneuverability, besides achieving the set aerodynamic trim condition. A scheme involving design, analysis, fabrication and testing procedure has been adopted to realize the trailing edge morphing mechanism. The stiffness distribution of the composite MAV wing is tailored such that the induced deflection by piezoelectric actuation is approximately optimized. Through ground testing, the proposed concept has been demonstrated on a typical MAV structure. Electromechanical analysis is performed to evaluate the actuator performance and subsequently aeroelastic and 2D CFD analyses are carried out to see the functional requirements of wing trailing edge surfaces to behave as elevons. Efforts have been made to obtain the performance comparison of conventional control surfaces (elevons) with morphing wing trailing edge surfaces. A significant improvement in lift to drag ratio is noticed with morphed wing configuration in comparison to conventional wing. Further, it has been shown that the morphed wing trailing edge surfaces can be deployed as elevons for aerodynamic trim applications.

• Structural Engineering and Mechanics
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• v.39 no.1
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• pp.147-168
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• 2011

To ensure safety and long term performance, structural control has rapidly matured over the past decade into a viable means of limiting structural responses to strong winds and earthquakes. Nonlinear response history analysis requires rigorous procedure to compute seismic demands. Therefore the simplified nonlinear analysis procedures are useful to determine performance of the structure. In this investigation, application of improved capacity demand diagram method in the control of structural system is presented for the first time. Developed pole assignment method (DPAM) in structural systems control is introduced. Genetic algorithm (GA) is employed as an optimization tool for minimizing a target function that defines values of coefficient matrices providing the placement of actuators and optimal control forces. The ground acceleration is modified under induced control forces. Due to this, performance of structure based on improved nonlinear demand diagram is selected to threshold of nonlinear behavior of structure. With small energy consumption characteristics, semi-active devices are especially attractive solutions for limiting earthquake effects. To illustrate the efficiency of DPAM, a 30-story steel moment frame structure employing the semi-active control devices is applied. In comparison to the widely used linear quadratic regulation (LQR), the DPAM controller was shown to be just as effective and better in the reduction of structural responses during large earthquakes.

• The Journal of Engineering Geology
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• v.13 no.4
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• pp.445-456
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• 2003

Backfill grouting and consolidation grouting are major reinforcing methods that enhance the stability of tunnel by filling the gap between the tunnel lining and the ground and increasing the stiffness of the ground. However, the effect of the grouting on the tunnel lining is not well established. Field measurements such as pressuremeter test, Lugeon test, and lining instruments were peformed to analyze the grouting effect on the tunnel lining for a waterway tunnel. The elastic modulus was increased up to 5 times than that of original rock mass due to consolidation grouting. This study shows that only 10% of grout pressure was acting on the back face of the tunnel lining. The final results are expected to be used for the design of the concrete lining.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.17 no.4
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• pp.94-99
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• 2003

A strong need to improve the quality of electric power is increased because of increasing use of the sensitive and small-sized electronic devices. The transient overvoltages on low-voltage AC power distribution systems are induced by direct or indirect lightning return strokes, and they can cause damage and/or malfunction of the utility systems for home automation, office automation and factory automation as well as medical equipment. The behaviors of lightning overvoltages transferred through the transformer to the low voltage AC power distribution systems were experimentally investigated using a Marx generator. The surge voltages in low-voltage ac power systems are rarely limited by the application of the surge arrester to the primary side of distribution transformer and a custom service ground.

• Geomechanics and Engineering
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• v.11 no.6
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• pp.821-845
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• 2016

Extensive researches on distribution of earthquake induced damages in different regions have shown that geological and geotechnical conditions of the local soils significantly influence behavior of alluvial areas under seismic loading. In this article, the site of Babol city which is formed up of saturated fine alluvial soils is considered as a case study. In order to reduce the uncertainties associated with earthquake resistant design of structures in this area (Babol city), the required design parameters have been evaluated with consideration of site's dynamic effects. The utilized methodology combines experimental ground ambient noise analysis, expressed in terms of horizontal to vertical (H/V) spectral ratio, with numerical one-dimensional response analysis of soil columns using DEEPSOIL software. The H/V spectral analysis was performed at 60 points, experimentally, for the region in order to estimate both the fundamental period and its corresponding amplification for the ground vibration. The investigation resulted in amplification ratios that were greater than one in all areas. A good agreement between the proposed ranges of natural periods and alluvial amplification ratios obtained through the analytical model and the experimental microtremor studies verifies the analytical model to provide a good engineering reflection of the subterraneous alluviums.

• Journal of Ecology and Environment
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• v.45 no.2
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• pp.78-87
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• 2021

Background: To understand shade and wind effects on seedling traits of common reed (Phragmites australis), we conducted a mesocosm experiment manipulating day length (10 h daytime a day as open canopy conditions or 6 h daytime a day as partially closed canopy conditions) and wind speed (0 m/s as windless conditions or 4 m/s as windy conditions). Results: Most values of functional traits of leaf blades, culms, and biomass production of P. australis were higher under long day length. In particular, we found sole positive effects of long day length in several functional traits such as internode and leaf blade lengths and the values of above-ground dry weight (DW), rhizome DW, and total DW. Wind-induced effects on functional traits were different depending on functional traits. Wind contributed to relatively low values of chlorophyll contents, angles between leaf blades, mean culm height, and maximum culm height. In contrast, wind contributed to relatively high values of culm density and below-ground DW. Conclusions: Although wind appeared to inhibit the vertical growth of P. australis through physiological and morphological changes in leaf blades, it seemed that P. australis might compensate the inhibited vertical growth with increased horizontal growth such as more numerous culms, indicating a highly adaptive characteristic of P. australis in terms of phenotypic plasticity under windy environments.