• 한국안전학회지
• /
• 제35권2호
• /
• pp.34-46
• /
• 2020

Unlike research focused on existing technologies and individual errors to analyze the causes of incidents, this study approached them from an organization and culture. And this study is not a one way study but cyclical study what can track cause down using causal loop diagram methodology. Four diagnostic criteria for the negative state of the safety culture : secretive, blame, failure to learning, and incremental learning, combine literature study and expert opinion to derive 41 variables. Connecting these variable make 4 causal loop diagrams and total causal loop diagram. Case accumulation in secretive, accident report in blame, knowledge accumulation in failure to learning, near miss discovery in incremental learning are the main variables. Safety incident is the objective variable by classifying them into 4 stages in total loop, leading track as the most affect is case accumulation, and Step 4 as you can see accident report and near miss discovery are the result of tracking down the cause. This study can be used as a basis for improving the management priority and the system in incident prevention.

• Annals of Occupational and Environmental Medicine
• /
• 제34권
• /
• pp.5.1-5.10
• /
• 2022

Background: Some epidemiological studies have estimated exposure among flight attendants with and without breast cancer. However, it is difficult to find a quantitative evaluation of occupational exposure factors related to cancer development individually in the case of breast cancer in flight attendants. That is, most, if not all, epidemiological studies of breast cancer in flight attendants with quantitative exposure estimates have estimated exposure in the absence of individual flight history data. Case presentation: A 41-year-old woman visited the hospital due to a left breast mass after a regular check-up. Breast cancer was suspected on ultrasonography. Following core biopsy, she underwent various imaging modalities. She was diagnosed invasive ductal carcinoma of no special type (estrogen receptor positive in 90%, progesterone receptor positive in 3%, human epidermal growth factor receptor 2/neu equivocal) with histologic grade 3 and nuclear grade 3 in the left breast. Neoadjuvant chemotherapy was administered to reduce the tumor size before surgery. However, due to serious chemotherapy side effects, the patient opted for alternative and integrative therapies. She joined the airline in January, 1996. Out of all flights, international flights and night flights accounted for 94.9% and 26.2, respectively. Night flights were conducted at least four times per month. Moreover, based on the virtual computer program CARI-6M, the estimated dose of cosmic radiation exposure was 78.81 mSv. There were no other personal triggers or family history of breast cancer. Conclusions: This case report shows that the potentially causal relationship between occupational harmful factors and the incidence of breast cancer may become more pronounced when night shift workers who work continuously are exposed to cosmic ionizing radiation. Therefore, close attention and efforts are needed to adjust night shift work schedules and regulate cosmic ionizing radiation exposure.

• 한국항공운항학회지
• /
• 제29권4호
• /
• pp.37-44
• /
• 2021

In case of South Korea, the airspace which airlines can operate is extremely limited due to the military operational area located within the Incheon flight information region. As a result, safety problems such as mid-air collision between aircraft or Traffic alert and Collision Avoidance System Resolution Advisory (TCAS RA) may occur with higher probability than in wider airspace. In order to prevent such safety problems, an mid-air collision risk detection model based on Detect-And-Avoid (DAA) well clear metrics is investigated. The model calculates the risk of mid-air collision between aircraft using aircraft trajectory data. In this paper, the practical use of DAA well clear metrics based model has been validated. Aviation safety data such as aviation safety mandatory report and Automatic Dependent Surveillance Broadcast is used to measure the performance of the model. The attributes of individual aircraft track data is analyzed to correct the threshold of each parameter of the model.

• 한국식품위생안전성학회지
• /
• 제26권3호
• /
• pp.248-253
• /
• 2011

우리나라는 2인 이상의 집단 식중독에 대해서 식중독 발생건수와 환자수에 대해서 통계집계를 실시하고 있지만 산발적으로 발생하는 1인 식중독에 대해서는 집계 되고 있지 않다. 실제 발생하는 식중독을 식중독 통계에 근접하게 집계하는 방안의 하나로써 l인 식중독의 비중 및 패턴을 파악하고자 한국과 식이 패턴이 유사한 일본의 통계 (2002-2003)를 이용하여 1인 식중독과 2인 이상 집단식중독을 비교분석 하였다. 아울러 한국의 인구수 대비 식중독 발생 및 보고 비율을 일본과 비교하였다. 일본의 1인 식중독이 전체 식중독에서 차지하는 비율은 발생 건수에서 43.5%이며 발생장소는 장소불명 (90-92.3%)과 가정집 (6.2-8.5%)이 대부분이었다. 일본의 l인 식중독에서 C. jejuni (51.9%), Salmonella spp. (35.3%), V parahaemolyticus (9.5%)가 원인균의 대부분을 차지하였다. 한편 2인 이상 집단 식중독의 원인균은 norovirus (3l.3%), Salmonella spp. (20.8%), C. jejuni (15.5%)로 나타났다. 특히, 집단 식중독이 자주 발생한 장소는 음식점 (46.6-50.1%)과 여관(9.2-9.8%)이었고 1인 식중독보다 주로 집단 식중독에서만 발생한 식중독 원인균은 norovirus, S. aureus, Cl. perfringens, unknown였다. 한국과 일본의 식중독 발생 및 보고 비율은 2002-2009년 통계를 비교한 결과 2인 이상의 집단 식중독을 기준으로 1:1.5 수준이었다.

• 동의생리병리학회지
• /
• 제27권2호
• /
• pp.268-272
• /
• 2013

This study is designed as pilot study to report the efficacy and safety of long term medication of Oncheongeum-gamibang on atopic dermatitis. The patient of atopic dermatitis was asked to take Oncheongeum-gamibang for 3 months. Every end of month, he had gotten hematological test and SCORAD Index examination. After the clinical trial was done, he had additional examination to see the changes and duration of medicinal effect. During the period of taking Onchung-um, estimation of symptoms by SCORAD Index examination showed little bit of improvement while taking medicine and after one month, the improvement was maintained. There were no significant changes in hematologic test and liver function test during and at the end of the clinical trial. We were able to find out that it is effective and safe to take long term medication of Oncheongeum-gamibang for an individual. However, due to deficiency of the cases and immunological values, there will be additional study to make up for better result.

• 한국임상약학회지
• /
• 제32권3호
• /
• pp.226-237
• /
• 2022

Background: Monoclonal antibodies for the treatment of patients with different types of cancer, such as cetuximab, have been widely used for the past 10 years in oncology. Although drug information package insert contains some representative adverse events which were observed in the clinical trials for drug approval, the overall adverse event patterns on the real-world cetuximab use were less investigated. Also, there have been no published papers that deal with the full spectrums of adverse drug events of cetuximab using national-wide drug safety surveillance systems. Methods: In this study, we detected new adverse event signals of cetuximab in the Korea Adverse Event Reporting System (KAERS) by utilizing proportional reporting ratios, reporting odds ratios, and information components indices. Results: The KAERS database included 869,819 spontaneous adverse event reports, among which 2,116 reports contained cetuximab. We compared the labels of cetuximab among the United States, European Union, Australia, Japan, and Korea to compare the current labeling information and newly detected signals of our study. Some of the signals including hyperkeratosis, tenesmus, folliculitis, esophagitis, neuralgia, disseminated intravascular coagulopathy, and skin/throat tightness were not labeled in the five countries. Conclusion: We identified new signals that were not known at the time of market approval.

• Safety and Health at Work
• /
• 제5권1호
• /
• pp.27-31
• /
• 2014

Background: Carpal tunnel syndrome (CTS) is a common work-related peripheral neuropathy. In addition to grip force and repetitive hand exertions, wrist posture (hyperextension and hyperflexion) may be a risk factor for CTS among workers. However, findings of studies evaluating the relationship between wrist posture and CTS are inconsistent. The purpose of this paper was to conduct a meta-analysis of existing studies to evaluate the evidence of the relationship between wrist posture at work and risk of CTS. Methods: PubMed and Google Scholar were searched to identify relevant studies published between 1980 and 2012. The following search terms were used: "work related", "carpal tunnel syndrome", "wrist posture", and "epidemiology". The studies defined wrist posture as the deviation of the wrist in extension or flexion from a neutral wrist posture. Relative risk (RR) of individual studies for postural risk was pooled to evaluate the overall risk of wrist posture on CTS. Results: Nine studies met the inclusion criteria. All were cross-sectional or case-control designs and relied on self-report or observer's estimates for wrist posture assessment. The pooled RR of work-related CTS increased with increasing hours of exposure to wrist deviation or extension/flexion [RR = 2.01; 95% confidence interval (CI): 1.646-2.43; p < 0.01: Shore-adjusted 95% CI: 1.32-2.97]. Conclusion: We found evidence that prolonged exposure to non-neutral wrist postures is associated with a twofold increased risk for CTS compared with low hours of exposure to non-neutral wrist postures. Workplace interventions to prevent CTS should incorporate training and engineering interventions that reduce sustained non-neutral wrist postures.

• 한국식품위생안전성학회지
• /
• 제32권4호
• /
• pp.262-266
• /
• 2017

식품의약품안전처는 효율적인 식중독 예방 교육 홍보를 위하여 모바일 증강현실 게임인 '식중독잡GO'를 개발하고 식품안전의 날 등 11개 행사에서 시범운영을 하였다. 행사장에서 '식중독잡GO'를 체험한 사람을 대상으로 식중독에 대한 인지정도를 설문조사를 통해 살펴보았다. 설문조사 결과 '식중독잡GO' 게임 전후대비 식중독예방 3대 요령 인지도는 게임 전 51.8%에서 게임 후 78.8%로 향상되었고, 개별 식중독균 인지도는 평균 2.1배 향상되었다. 설문조사자의 95%가 식중독 이해에 도움이 되었다고 응답하였으며, 90%가 게임이 재미있었다고 응답하였다. 따라서, '식중독잡GO'를 유 초 중 고등 교육에 적용을 하면 식중독균의 주요증상, 원인식품 등 식중독 예방요령의 다양한 교육적 효과를 기대할 수 있을 것으로 사료된다.

• Genomics & Informatics
• /
• 제16권3호
• /
• pp.52-58
• /
• 2018

In this report, we present a case study of how pharmacogenomics and pharmacometabolomics can be useful to characterize safety and pharmacokinetic profiles in early phase new drug development clinical trials. During conducting a first-in-human trial for a new molecular entity, we were able to determine the mechanism of dichotomized variability in plasma drug concentrations, which appeared closely related to adverse drug reactions (ADRs) through integrated omics analysis. The pharmacogenomics screening was performed from whole blood samples using the Affymetrix DMET (Drug-Metabolizing Enzymes and Transporters) Plus microarray, and confirmation of genetic variants was performed using real-time polymerase chain reaction. Metabolomics profiling was performed from plasma samples using liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. A GSTM1 null polymorphism was identified in pharmacogenomics test and the drug concentrations was higher in GSTM1 null subjects than GSTM1 functional subjects. The apparent drug clearance was 13-fold lower in GSTM1 null subjects than GSTM1 functional subjects (p < 0.001). By metabolomics analysis, we identified that the study drug was metabolized by cysteinylglycine conjugation in GSTM functional subjects but those not in GSTM1 null subjects. The incidence rate and the severity of ADRs were higher in the GSTM1 null subjects than the GSTM1 functional subjects. Through the integrated omics analysis, we could understand the mechanism of inter-individual variability in drug exposure and in adverse response. In conclusion, integrated multi-omics analysis can be useful for elucidating the various characteristics of new drug candidates in early phase clinical trials.

• 해양환경안전학회지
• /
• 제26권1호
• /
• pp.57-64
• /
• 2020

IOPC펀드 총회에서 위험·유해물질(HNS)의 피해보상에 대한 국제협약이 2021년과 2022년 사이에 협약의 발효요건을 충족할 것으로 보고하는 등 각 국의 협약비준과 국제적인 관심이 증가하고 있다. 협약이 발효되면 HNS 운송선박은 책임제한액까지 보험가입이 강제화 되고, 동 물질을 수령하는 화주는 선박 책임보험 제한액을 초과하는 피해 보상을 위한 국제기금 보상금에 대하여 분담금을 납부하게 된다. 우리나라는 세계적인 주요 해운국가이며 화주국가로 동 협약이 관련 산업계에 미치는 영향을 분석할 필요성에 의해 이 연구를 착안하였다. 동 협약의 대상 선박과 분담금 납부 대상자의 조사는 해양수산부 자료를 통해 분석 하였고, 보험료 추계는 한국해운조합과 K P&I에 보험가입 선박으로 검토하였으며, HNS 화물량에 따른 분담금에 대한 검토는 화물별 국제적인 대표협회의 연차보고서를 통해 분석하였다. 우리나라 외항선박 및 내항선박 1,500여척이 협약 대상선박으로 파악되었고, 대부분의 선박은 협약에 따른 보험료 변동 영향은 미미하였으나, 내항 급유선박 150여척이 협약에 따른 보험료 상승이 예상되는 등 해운업계의 영향이 예상되는 것으로 분석된다. 화주 등 관련 산업계의 경우 화물터미널 52개사가 국제기금 분담금 납부 대상으로 파악되었으며, HNS 개별 회계별로 우리나라의 화물량 비중이 세계 3~4위권으로 분석되어 협약비준에 따른 분담금 납부의무도 상당부분 예상되었다. 우리나라의 HNS 운송선박의 입출항 실태와 화물량 등을 고려할 때 우리나라의 협약비준 타당성은 충분한 것으로 분석되었으며, 협약의 비준시기는 세계 주요 화주국가들과 조율하는 것이 필요할 것으로 판단된다.