• Journal of Gastric Cancer
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• v.16 no.1
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• pp.34-42
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• 2016

Purpose: Early gastric cancer cases that are estimated to meet indications for treatment before endoscopic submucosal resection are often revealed to be out-of-indication after the treatment. We investigated the short-term treatment outcomes in patients with early gastric cancer according to the pretreatment clinical endoscopic submucosal resection indications. Materials and Methods: We retrospectively reviewed the medical records of patients with early gastric cancer that met the pretreatment endoscopic submucosal resection indications, from 2004 to 2011. Curative resection rate and proportion of out-of-indication cases were compared according to the pre-endoscopic submucosal resection indications. Pre-endoscopic submucosal resection factors associated with out-of-indication in the final pathological examination were analyzed. Results: Of 756 cases, 660 had absolute and 96 had expanded pre-endoscopic submucosal resection indications. The curative resection rate was significantly lower in the patients with expanded indications (64.6%) than in those with absolute indications (81.7%; P<0.001). The cases with expanded indications (30.2%) were revealed to be out-of-indication more frequently than the cases with absolute indications (13.8%; P<0.001). Age of >65 years, tumor size of >2 cm, tumor location in the upper-third segment of the stomach, and undifferentiated histological type in pre-endoscopic submucosal resection evaluations were significant risk factors for out-of-indication after endoscopic submucosal resection. Conclusions: Non-curative resection due to out-of-indication occurred in approximately one-third of the early gastric cancer cases that clinically met the expanded indications before endoscopic submucosal resection. The possibility of additional surgery should be empha-sized for patients with early gastric cancers that clinically meet the expanded indications.

• Journal of Korean Medical classics
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• v.25 no.1
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• pp.17-29
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• 2012

Indications of Hyeongbangpaedok-san for Soyang-type on "Donguisusebowon" are small. Therefore, indications of Hyeongbangpaedok-san for Soyang-type need to be extended for broader clinical use. There would be some methods to do that, and we could review "Dongeuibogam" that Four-Constitution Medicine formulas are based on. We reviewed Hyeongbangpaedok-san, Insampaedok-san which is the origin of Hyeongbangpaedok-san, and their modified formula(加減方) on "Dongeuibogam". As a result, we supposed 12 indications of non-classical formula(後世方) Hyeongbangpaedok-san, 2 indications of modified formula of non-classical formula Hyeongbangpaedok-san, and 12 indications of Insampaedok-san and its modified formula as possible indications of Hyeongbangpaedok for Soyang-type.

• Journal of Korean Medical classics
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• v.24 no.3
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• pp.27-47
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• 2011

Donguisusebowon(東醫壽世保元) doesn't have pretty large quantity of contents, so indications of Four-Constitution Medicine formulas on that medical book are small. Therefore, indications of Four-Constitution Medicine formula need to be extended for broader clinical use of Four-Constitution Medicine. There would be some methods to do that, and we could review the literatures that Four-Constitution Medicine formulas are based on. We reviewed Bojungyikgi-tang on "Dongeuibogam(東醫寶鑑)", and we found that if the Four-Constitution Medicine formula is based on Sanghan formula(傷寒方) or non-classical formula(後世方), it is worth adding more indications of base formulas to those of Four-Constitution Medicine formula. For exmaple, Indications of Bojungyikgi-tang for So-Eum type could be extended by indications of non-classical formula(後世方) Bojungyikgi-tang and modified formula(加減方) Bojungyikgi-tang on Dongeuibogam, We supposed 23 indications of non-classical formula(後世方) Bojungyikgi-tang, and 20 indications of modified formula(加減方) Bojungyikgi-tang as possible indications of Bojungyikgi-tang for So-Eum type.

• Korean Journal of Oriental Medicine
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• v.18 no.2
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• pp.91-100
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• 2012

Indications of Galgeunhaegi-tang(葛根解肌湯) for Taeeum-type on "Donguisusebowon" are small. Therefore, indications of Galgeunhaegi-tang for Taeeum-type need to be extended for broader clinical use. There would be some methods to do that, and we could review "Dongeuibogam" that Four-Constitution Medicine formulas are based on. We reviewed Galgeunhaegi-tang, which is the origin of Galgeunhaegi-tang, and their modified formula(加減方) on "Dongeuibogam". As a result, we supposed 10 indications of non-classical formula(後世方) Galgeunhaegi-tang as possible indications of Galgeunhaegi-tang for Taeeum-type.

• Korean Journal of Acupuncture
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• v.36 no.4
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• pp.292-299
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• 2019

Objectives : DongUiBoGam is one of the representative medical literatures in Korea. We used text mining methods and analyzed the characteristics of the indications of each meridian in the second chapter of DongUiBoGam, WaeHyeong, which addresses external body elements. We also visualized the relationships between the meridians and the disease sites. Methods : Using the term frequency-inverse document frequency (TF-IDF) method, we quantified values regarding the indications of each meridian according to the frequency of the occurrences of 14 meridians and 14 disease sites. The spatial patterns of the indications of each meridian were visualized on a human body template according to the TF-IDF values. Using hierarchical clustering methods, twelve meridians were clustered into four groups based on the TF-IDF distributions of each meridian. Results : TF-IDF values of each meridian showed different constellation patterns at different disease sites. The spatial patterns of the indications of each meridian were similar to the route of the corresponding meridian. Conclusions : The present study identified spatial patterns between meridians and disease sites. These findings suggest that the constellations of the indications of meridians are primarily associated with the lines of the meridian system. We strongly believe that these findings will further the current understanding of indications of acupoints and meridians.

• Translational and Clinical Pharmacology
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• v.26 no.4
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• pp.155-159
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• 2018

For regulatory approval of a new drug, the most preferred and reliable source of evidence would be randomized controlled trials (RCT). However, a great number of drugs, being developed as well as already marketed and being used, usually lack proper indications for children. It is imperative to develop properly evaluated drugs for children. And expanding the use of already approved drugs for other indications will benefit patients and the society. Nevertheless, to get an approval for expansion of indications, most often with off-label experiences, for drugs that have been approved or for the development of pediatric indications, either during or after completing the main drug development, conducting RCTs may not be the only, if not right, way to take. Extrapolation strategies and modelling & simulation for pediatric drug development are paving the road to the better approval scheme. Making the use of data sources other than RCT such as EHR and claims data in ways that improve the efficiency and validity of the results (e.g., randomized pragmatic trial and randomized registry trial) has been the topic of great interest all around the world. Regulatory authorities should adopt new methodologies for regulatory approval processes to adapt to the changes brought by increasing availability of big and real world data utilizing new tools of technological advancement.

• Journal of Korean Neurosurgical Society
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• v.56 no.5
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• pp.371-374
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• 2014

Neurosurgeons have been trying to reduce surgical invasiveness by applying minimally invasive keyhole approaches. Therefore, this paper clarifies the detailed surgical technique, its limitations, proper indications, and contraindications for a superciliary keyhole approach as a minimally invasive modification of a pterional approach. Successful superciliary keyhole surgery for unruptured aneurysms requires an understanding of the limitations and the use of special surgical techniques. Essentially, this means the effective selection of surgical indications, usage of the appropriate surgical instruments with a tubular shaft, and refined surgical techniques, including straightforward access to the aneurysm, clean surgical dissection, and the application of clips with an appropriate configuration. A superciliary keyhole approach allows unruptured anterior circulation aneurysms to be clipped safely, rapidly, and less invasively on the basis of appropriate surgical indications.

• Journal of Sasang Constitutional Medicine
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• v.21 no.3
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• pp.17-29
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• 2009

1. Objectives: We study on indications and directions of Euphorbiae Kansui Liou ex Wang in Sasang Constitutional Medicine by applications of Euphorbiae Kansui Liou ex Wang. 2. Methods: We analyzed indications and directions by bibliographical applications of Radix Euphorbiae Kansui Liou ex Wang in Traditional Oriental Medicine and Sasang Constitutional Medicine. 3. Results and Conclusions: 1) Euphorbiae Kansui Liou ex Wang is used for various indications which are congested fluids, accumulation, edema, and etc in Traditional Oriental Medicine and Sasang Constitutional Medicine. 2) In Sasang Constitutional Medicine, Euphorbiae Kansui Liou ex Wang is taken by powder in a single-medicine prescriptions and taken with calomelas by powder and tablet in prescriptions, and we have need of clinical study of Radix Euphorbiae Kansui in the future.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.569-575
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• 2014

Although mammography is the primary imaging modality for the breast, it has its limitations especially with dense breast parenchyma. Breast magnetic resonance imaging (MRI) has evolved into an important adjunctive tool as it is currently the most sensitive technique for breast cancer detection. Despite this high sensitivity, overlap in the appearances of some benign and malignant breast lesions results in additional unnecessary intervention with negative results. These false positives, in addition to high cost and limited availability, necessitate establishing proper indications for breast MRI. The literature was here reviewed for recent clinical trials, meta-analyses and review papers which have studied this important subject. PubMed; the US national library of medicine, was utilized to review the literature in the last twenty years. Using the obtained information, current uses of breast MRI are discussed in this paper to determine the indications which are relevant to clinical practice.

• Journal of the Korean Society for Nondestructive Testing
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• v.30 no.5
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• pp.479-483
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• 2010

9% nickel alloy steels used for LNG, cryogenic liquid, storage tank are welded with dissimilar Inconel or Hastelloy welding rod and the weldment shows similar characteristic with the dissimilar metal weld of low carbon steel and austenitic stainless steel. Band type indications are sometimes shown on the film during radiography test of the weldments. Thus this study identified whether the indications are non-relevant indications through material, radiographic test, ultrasonic test, liquid penetrant test and microstructure analysis and also proposed radiography film interpretation and cause of band type indications.