• Journal of Acupuncture Research
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• 제24권3호
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• pp.63-79
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• 2007

Objectives : Korean traditional acupuncture Theory, Sa-am's 5 phases acupuncture method was originated in 1644-1742, in the middle of the Cho Sun dynasty. This study was to verify the effect of Sa-am Acupuncture Treatment on dysmenorrhea of Women. Methods : The subjects were 49 volunteers who were suffering for dysmenorrhea, employed using Measure of Menstrual Pain (MMP) questionnaire. Subjects were divided into two groups including Sa-am acupuncture treatment group(n=23) and minimal acupuncture treatment group(n=26). They had agreed to take part in tIris experiment, with didn't take any anodyne drugs. In the acupuncture group, subjects were stimulated at $GB_{41}$, $SI_3$, $GL_{66}$, $SI_2$(Small intestine jung-guk) and $SP_6$. In the control group, subjects were needled at $L_{10}$, $S_{40}$, $P_5$, $G_{40}$ points have any effect on dysmenorrhea. A total of 5 acupuncture sessions were performed for each patient depending on the individual menstruation cycle. The MMP score by using 7 questions and the Menstrual Symptom Severity List(MSSL-D) were measured before and after menstruation cycle. Collected data were analyzed as frequency, percentage, paired t-test, independent t-test using SPSS 10.0 WIN Program. Results : Acupuncture treatment produced a significant improvement on dysmenorrhea in two groups, but a statistically significant difference was not shown in the acupuncture group compare to control group. Conclusions : Based on the above results, it was verified that Acupuncture Treatment was effective in decreasing the symptom of Dysmenorrhea.

• Asian-Australasian Journal of Animal Sciences
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• 제25권3호
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• pp.335-340
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• 2012

The data used came from two trials undertaken under the same climatic conditions (spring-summer). In both trials pluriparious buffaloes were utilized similar in weight, body condition score, and milk production from the previous year. From the first trial the data used was from the sub-period 23-88 DIM provided by seven animals fed ad libitum with diet A (6.69 MJ/kg DM; 158.30 g/kg of crude protein) with a forage/concentrate ratio of 48/52. From the second trial the data used was from the sub-period 33-90 DIM provided by seven animals fed ad libitum with diet B (6.63 MJ/kg DM; 179.50 g/kg of crude protein) and by seven animals fed ad libitum with diet C (5.99 MJ/kg DM; 155.40 g/kg of crude protein), each of the diets had the same forage/concentrate ratio (53/47). A significant difference was found in milk production between group B and C (13.08 vs. 11.56 kg/d, p<0.05), an intermediate production (12.10 kg/d) was noted in group A. A significant difference was found between fat (76.58 vs. 69.24 g/kg, p<0.05), protein (46.14 vs. 43.16 g/kg, p<0.05) and casein (39.94 vs. 34.98 g/kg, p<0.05) of the milk of group B with respect to group A. The milk of group C gave fat values (71.80 g/kg), protein (45.52 g/kg) and casein (39.06 g/kg) statistically equal to those of group B. The milk of groups B and C, in respect to the milk of group A, gave values of $K_{20}$ (1.77, 1.82 vs. 3.68 min, p<0.05), statistically lower and values of $A_{30}$ (48.28, 47.27 vs. 40.64 mm, p<0.05) statistically higher. Two simple linear regressions were calculated where the independent variable (x) was the daily standardized milk production, the dependent variable (y) or the daily intake of net energy or crude protein. Equation 1) NE (MJ/d) = 74.4049+2.8308${\times}$kg of normalized milk; equation 2) CP (kg/d) = 1.4507+0.1085${\times}$kg of normalized milk, both the equations were significant (p<0.05) with determination coefficients of 0.58 and 0.50 respectively. For a production of normalized milk that varies from 9 to 13 kg, the respective energy-protein concentrations fluctuate from 6.09 to 6.78 MJ/kg DM and from 148.00 to 174.46 g/kg DM.

• Journal of Acupuncture Research
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• 제27권1호
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• pp.65-74
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• 2010

Objectives : This study was to investigate the effects of Cervi Pantotrichum Cornu Pharmacopuncture and Bovis calculus Fel Ursi Pharmacopuncture on autonomic nervous system with Heart Rate Variability(HRV). Purpose of the trial was to observe what influence Cervi Pantotrichum Cornu Pharmacopuncture and Bovis calculus Fel Ursi pharmacopuncture have on the autonomic nervous system. Methods : 40 healthy male volunteers were divided into two experimental groups, such as Cervi Pantotrichum Cornu Pharmacopuncture group and Bovis calculus Fel Ursi Pharmacopuncture group. Study design was a randomized, double-blind clinical trial. 20 subjects in one experimental group were injected Cervi Pantotrichum Cornu Pharmacopuncture, 20 subjects in other experimental group were injected hydrolyzed Bovis calculus Fel Ursi Pharmacopuncture at GB21(Kyonjong). We measured HRV 7 times : baseline measurement and every 5 minutes for 30 minutes after injection. The SPSS 15.0 for Windows was used to analyze the data by the paired t-test(in group) and independent sample t-test(between the groups). Results A. Time Domain Analysis 1. Analysis of Mean HRV, SDNN and Complexity After injection of Cervi Pantotrichum Cornu Pharmacopuncture, Mean HRV was significantly decreased all the times after injection. SDNN was significantly increased at immediate and 25 minute after injection. Complexity was significantly decreased only at 15 minute after injection. After injection of Bovis calculus Fel Ursi Pharmacopuncture, Mean HRV was significantly decreased all the times after injection. Complexity was significantly decreased at 15 minutes after injection. 2. Analysis of HRV index, pNN50 After injection of Cervi Pantotrichum Cornu Pharmacopuncture, HRV index was significantly increased immediately after injection. pNN50 was significantly decreased at immediately, 20 and 25 minutes after injection. After injection of Bovis calculus Fel Ursi Pharmacopuncture, HRV index was significantly increased immediately after injection. pNN50 was significantly decreased at immediate and 25 minutes after injection. B. Frequency Domain Analysis 1. Analysis of Ln(TP), Ln(HF), Ln(LF), Ln(VLF) After injection of Cervi Pantotrichum Cornu Pharmacopuncture, Ln(TP) was significantly increased at immediate and 25 after injection. Ln(HF) was significantly increased all the times after injection. Ln(LF) was significantly increased at 15, 20 and 25 minutes after injection. Ln(VLF) was significantly increased at immediate and 25 minutes after injection. After injection of Bovis calculus Fel Ursi Pharmacopuncture, Ln(TP) was significantly increased at immediately and 25 after injection. Ln(LF) was significantly increased at 20 and 25 minutes after injection. Ln(VLF) was significantly increased at immediate and 25 minutes after injection. Conclusions : We results suggest that Cervi Pantotrichum Cornu Pharmacopuncture and Bovis calculus Fel Ursi Pharmacopuncture in healthy adult men tend to activate the autonomic nervous system and sympathetic nervous system within normal range.

• 한국심리학회지 : 문화 및 사회문제
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• 제21권3호
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• pp.497-510
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• 2015

국민참여재판에서 판사가 배심원에게 제시하는 법설시에는 범죄사실에 대해서 합리적인 의심이 없는 정도의 증명에 이르렀을 때 유죄를 인정해야 한다는 "합리적 의심의 초월 기준"에 대한 설명이 포함된다. 합리적 의심의 초월 기준은 일반적으로 배심원들이 평의를 시작하기 직전에 설명되는데, 본 연구에서는 설시절차(증거 이전, 증거 이후)에 따라 피고인에 대한 유죄/무죄 인정에 차이가 생긴다는 선행연구를 기반으로 그 인지과정을 알아보고자 하였다. 배심원 자격을 가진 만 20세 이상 성인남녀 189명을 대상으로 합리적 의심의 초월 기준에 대한 설명을 증거 전과 후에 받은 집단이 증거 후에만 설시를 받은 집단과 설시를 받지 않은 집단보다 피고인에 대한 유죄인정비율이 낮은지 분석한 후, 설시 제시절차와 유죄인정비율 사이의 두 가지 인지과정을 확인하였다: 1) 유죄판단 역치 생성, 2) 증거의 증명력 평가. 분석 결과, 설시를 증거 전후에 받은 집단은 다른 집단에 비해 피고인의 유죄를 판단하기 위한 역치가 높게 형성된 것을 확인하였으나, 증거의 증명력은 설시 제시절차 간에 유의한 차이가 없었다. 이러한 결과는 배심원이 재판에서 설시를 증거 전에 받았을 때, 각 증거의 증명력을 합리적 의심의 초월 기준으로 평가하기보다는 유죄결정을 위한 역치수준을 조정하여 그것을 기반으로 피고인에 대한 최종판단을 한다고 해석되었다.

• 만화애니메이션 연구
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• 통권29호
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• pp.37-60
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• 2012

본 논문은 1960년 일본에서 "애니메이션 3인의 회" 결성이 계기가 되어 이후 새로운 흐름을 형성한 애니메이션의 경향을 실험적 애니메이션으로서 규정하고 그 양상을 논한 것이다. 실험적 애니메이션은 대개 전통적인 애니메이션과 상반되는 경향을 보여준다. "애니메이션 3인의 회"는 종래의 만화 영화의 형식을 타파하는 다양한 시도를 통해 애니메이션의 개념을 새롭게 제시하고자 했다. 당시 일본에서 만화 영화 형식의 주류를 이룬 토에이 동화의 장편 작품과 "애니메이션 3인의 회"의 중심적인 역할을 한 쿠리 요지의 작품을 비교할 때 움직임의 표현과 소재 선택에서 상반된 특징이 나타난다. 이것은 주류의 대안적인 방법이었다. 한편 또 다른 멤버인 야나기하라 료헤이와 마나베 히로시는 각각 디자인과 일러스트를 애니메이션에 접목시켰다. "애니메이션 3인의 회"가 주최한 상영회 및 애니메이션 페스티발에 참여한 여러 장르 출신의 인디펜던트 작가들은 타 장르와 서로 교류하면서 창작 활동을 했다. 그들의 작품에 나타난 인터미디어적 특성은 애니메이션에서 움직임의 대상을 확대하여 새로운 표현의 가능성을 모색하고자한 시도로 볼 수 있겠다. 이렇게 3인을 비롯한 인디펜던트 작가들의 소재와 움직임의 표현 및 대상에 대한 탐구는 전통적인 애니메이션의 경향을 타파한 것으로서 실험적 애니메이션에 속하는 것이었다. 3인의 시도는 1960년대 일본의 실험적 애니메이션이 성립하는 바탕이 되었으며 그들의 실험 정신은 이후 시대별로 변용하여 최근 일본 애니메이션의 인디펜던트 작가들의 참신하고 진보적인 표현에 계승되고 있다고 여겨진다. 1960년대의 양상이 이러한 표현의 역사상의 출발점이라는 것을 강조한 데에 본 고찰의 의의가 있다고 하겠다.

• 벤처창업연구
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• 제4권1호
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• pp.89-111
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• 2009

점점 높아져 가는 프랜차이즈 사업에 대한 관심과 상반되게 프랜차이즈 사업에 관한 연구는 고객만족을 위한 연구와 단편적 운영 지침서들에 머무를 뿐 운영자 시각에서 성공요인을 분석하고, 창업단계 및 운영단계로 나눠 실증한 연구는 찾아보기 어렵다. 또한, 식품분야의 프랜차이즈 사업에 대한 연구가 주를 이루고 었어 식품과 비식품 프랜차이즈 사업에 영향을 미치는 요인에 관한 비교연구는 지금까지 제대로 이뤄져 오지 못했다. 이에 본 연구는 프랜차이즈 사업의 단계별 업종별 성과에 영향을 미치는 요인을 분석하고 이를 토대로 국내 프랜차이즈 사업을 준비하는 예비창업자들이 실천해야 할 성공전략을 제시하였다. 연구결과 창업단계의 성장요인으로 사업적성의 여부, 사업조직의 여부, 사업아이템의 적합성, 경쟁구도와 본사자문의 여부가 선별되었고, 운영단계의 성공요인으로는 슈퍼바이저의 능력, 본사와 가맹점의 마케팅 능력, 본사지원의 유무, 고객관리능력, 직원만족이 도출되었다.

• Journal of Gastric Cancer
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• 제17권2호
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• pp.132-144
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• 2017

Purpose: To identify baseline prognostic factors for survival in patients with disease progression, during or after chemotherapy for the treatment of advanced gastric or gastroesophageal junction (GEJ) cancer. Materials and Methods: We pooled data from patients randomized between 2009 and 2012 in 2 phase III, global double-blind studies of ramucirumab for the treatment of advanced gastric or GEJ adenocarcinoma following disease progression on first-line platinum- and/or fluoropyrimidine-containing therapy (REGARD and RAINBOW). Forty-one key baseline clinical and laboratory factors common in both studies were examined. Model building started with covariate screening using univariate Cox models (significance level=0.05). A stepwise multivariable Cox model identified the final prognostic factors (entry+exit significance level=0.01). Cox models were stratified by treatment and geographic region. The process was repeated to identify baseline prognostic quality of life (QoL) parameters. Results: Of 1,020 randomized patients, 953 (93%) patients without any missing covariates were included in the analysis. We identified 12 independent prognostic factors of poor survival: 1) peritoneal metastases; 2) Eastern Cooperative Oncology Group (ECOG) performance score 1; 3) the presence of a primary tumor; 4) time to progression since prior therapy <6 months; 5) poor/unknown tumor differentiation; abnormally low blood levels of 6) albumin, 7) sodium, and/or 8) lymphocytes; and abnormally high blood levels of 9) neutrophils, 10) aspartate aminotransferase (AST), 11) alkaline phosphatase (ALP), and/or 12) lactate dehydrogenase (LDH). Factors were used to devise a 4-tier prognostic index (median overall survival [OS] by risk [months]: high=3.4, moderate=6.4, medium=9.9, and low=14.5; Harrell's C-index=0.66; 95% confidence interval [CI], 0.64-0.68). Addition of QoL to the model identified patient-reported appetite loss as an independent prognostic factor. Conclusions: The identified prognostic factors and the reported prognostic index may help clinical decision-making, patient stratification, and planning of future clinical studies.

• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.437-441
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• 2012

Objective: Health risk appraisal is often utilized to modify individual's health behavior, especially concerning disease prevention, and web-based health risk appraisal services are being provided to the general public in Korea. However, little is known about the psychological effect of the health risk appraisal even though poorly communicated information by the web-based service may result in unintended adverse health outcomes. This study was conducted to explore the psychological effect of health risk appraisal using epidemiological risk factor profile. Methods: We conducted a randomized trial comparing risk factor list type health risk appraisal and risk score type health risk appraisal. We studied 60 women aged 30 years and older who had no cancer. Anxiety level was assessed using the Spielberger State-Trait Anxiety Inventory YZ. Results: The results of multivariate analysis showed that risk status was the independent predictors of increase of state anxiety after health risk appraisal intervention when age, education, health risk appraisal type, numeracy, state anxiety, trait anxiety, and health risk appraisal type by risk status interaction was adjusted. Women who had higher risk status had an odd of having increased anxiety that was about 5 times greater than women who had lower risk status. Conclusions: Our findings indicate that communicating the risk status by individual health risk appraisal service can induce psychological sequelae, especially in women having higher risk status. Hospitals, institutes, or medical schools that are operating or planning to operate the online health risk appraisal service should take side effects such as psychological sequelae into consideration.

• 대한한방부인과학회지
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• 제33권3호
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• pp.1-19
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• 2020

Objectives: The purpose of this study is to assess the efficacy and safety of electroacupuncture for women with overactive bladder (OAB) comparing with sham- acupuncture, and electroacupuncture plus drugs. Methods: We searched 8 databases upto May 26, 2020. Randomised controlled trials (RCTs) were eligible. The risk of bias was assessed by two independent authors using the Cochrane risk of bias tool. Study outcomes were calculated by standardized mean differences (SMD) with 95% confidence intervals (Cls) and mean differences (MD) with 95% Cls. Results: Of 146 screened, 5 RCTs were included. Number of participants per study ranged from 5 to 57. The combined results showed that electroacupuncture (EA) may be more effective than sham acupuncture or enhance solifenacin succinates in improving Overactive Bladder Symptom Score (OABSS) and urination frequency of 24 h. However, more trials with high quality and larger sample sizes will be needed to provide sufficient evidence. Only 5 of 187 OAB patients from the included studies reported mild adverse reactions related to EA, therefore, electroacupuncture is safe for treating OAB. Conclusions: Electroacupuncture might have effect in decreasing urination frequency of 24 h and OABSS. However, the evidences ins in sufficient to show the effect using electroacupuncture alone or additional effect to drugs in treating OAB.

• 대한약침학회지
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• 제11권3호
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• pp.123-131
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• 2008

Objective: This study was designed to evaluate the effect of Hominis placenta Pharmacopuncture treatment on Dysmenorrhea of Women. Methods: 49 subjects who were suffering from dysmenorrhea volunteered to answer the MMP(Measure of Menstrual Pain) and MSSL(Menstrual Symptom Severity List) questionnaire. They were divided into two groups, a Hominis placenta Pharmacopuncture treatment group(Experiment al group, n=25) and a Normal Saline(N/S) treatment group(Control group, n=24). The two groups were injected on the $CV_4,\;S_{36},\;Sp_9$ and $Sp_6$ acupuncture point. They were treated totally five times depending on the individual menstruation cycles. The scores of MMP and MSSL were measured overall three times before and after the menstruation cycle. The collected data were analyzed as paired t-test, independent t-test using SPSS 12.0 WIN Program. Results: As a result of the evaluation by MMP and MSSL, a significant improvement on dysmenorrhea was made in the two groups(p<0.05), and both scores of Experiment group were decreased more than Control group. But there was no significant difference between the two groups. Conclusions: The Hominis placenta Pharmacopuncture treatment and the Normal Saline treatment were effective in decreasing the symptom of Dysmenorrhea.