• Title/Summary/Keyword: inconclusive evidence)

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Young Children's Abilities to Differentiate Hypothesis from Evidence (초등학교 저학년 아동들의 증거로부터 가설을 분화하는 능력)

  • Lee, Moon Nam;Chu, Hye Eun
    • Korean Journal of Child Studies
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    • v.22 no.4
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    • pp.331-341
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    • 2001
  • This study is to investigate whether young Korean children have understanding for testing hypothesis. Questions explored are; First, do children have notions of testing hypothesis? Or, do they just produce an effect? Second, choosing between conflicting hypotheses, can children distinguish between experiments that would produce conclusive and inconclusive evidence? For this study, 15 first grade and 15 second grade children in elementary school located in Kyunggi area near Seoul participated. Data collection and analysis were based on interviews with children for two weeks. Children were presented two conflicted hypotheses to decide which one is correct through conclusive evidence and inconclusive evidence in the interview. The results showed that children(1st: 93.3%, 2nd: 81.3%) of each grade can distinguish between hypothesis and evidence to do testing hypothesis, and distinguish between conclusive and inconclusive evidence. In conclusion, most young children have understanding of testing hypothesis based on their familiar experiences, so it was possible for them to differentiate hypothesis from evidence in certain situations.

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Association between Praziquantel and Cholangiocarcinoma in Patients Infected with Opisthorchis viverrini: A Systematic Review and Meta-Analysis

  • Kamsa-Ard, Supot;Laopaiboon, Malinee;Luvira, Vor;Bhudhisawasdi, Vajarabhongsa
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.11
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    • pp.7011-7016
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    • 2013
  • Background: The liver fluke, Opisthorchis viverrini, and the associated incidence of subsequent cholangiocarcinoma (CCA) are still a public health problem in Thailand, and praziquantel (PZQ) remains the antihelminthic drug of choice for treatment. Evidence in hamsters shows that repeated infection and PZQ treatments could increase the risk of CCA. However, the existing evidence in humans is inconclusive regarding increased risk of CCA with frequency of PZQ intake. Objectives: To investigate the relationship between number of repeated PZQ treatments and CCA in patients with O viverrini infection. Materials and Methods: The reviewed studies were searched in EMBASE, MEDLINE, ProQuest, PubMed and SCOPUS from inception to October, 2012 using prespecified keywords. The risk of bias (ROB) of included studies was independently assessed by two reviewers using a quality scale from the Newcastle-Ottawa Scale (NOS). Risk effect of PZQ was estimated as a pooled odds ratio (OR) with its 95% confidence interval (95%CI) in the random-effects model using DerSimonian and Laird's estimator. Results: Three studies involving 637 patients were included. Based on the random effects model performed in two included studies of 237 patients, the association between PZQ treatments and CCA was not statistical significant with a pooled OR of 1.8 (95%CI; 0.81 to 4.16). Conclusions: The present systematic review and meta-analysis provides inconclusive evidence of risk effect of PZQ on increasing the risk of CCA and significant methodological limitations. Further research is urgently needed to address the shortcomings found in this review, especially the requirement for histological confirmation.

Review of Clinical Trials on Warming Acupuncture for Musculoskeletal Pain Diseases -A Systematic Review- (근골격계 통증성 질환에 대한 온침의 임상 연구 고찰 -계통적 고찰-)

  • Chung, Jie-Youn;Choi, Do-Young;Woo, Hyun-Su;Kang, Sung-Keel
    • Journal of Acupuncture Research
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    • v.26 no.4
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    • pp.11-18
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    • 2009
  • Objectives : The objective of this review was to evaluate clinical trials of warming acupuncture for musculoskeletal pain diseases, to assess the methodologic quality of the trials and determine whether low-quality trials are associated with positive outcomes, to document adverse effects and to identify the effectiveness of the warming acupuncture. Methods : Seven databases and the Journal ZHONGGUO ZHENJIU(中國鍼灸) published between 2004-2008 were searched. Korean and Chinese randomized trials were evaluated for methodologic quality using the modified Jadad scale. Outcome measurements were pain, function and global improvement. The best-evidence synthesis was performed to determine the strength of evidence by control group. Results : Six clinical trials representing 564 patients with musculoskeletal pain diseases were identified. For pain and function, there was moderate evidence that warming acupuncture is more effective than manual acupuncture. For patient global assesment, there was limited evidence that warming acupuncture is more effective than manual acupuncture. However, for function, there was inconclusive evidence that warming acupuncture is more effective than acupuncture with TDP or western medicine or acupoint-injection treatment. Conclusions : The evidence suggests that warming acupuncture is more effective for musculoskeletal pain diseases than manual acupuncture, acupuncture with TDP, western medicine and acupoint-injection treatment. But the evidence is moderate to inclusive due to the low methodologic quality of the trials. Further clinical trials with high methodologic quality is required to investigate the effectiveness of warming acupuncture.

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A Study on the Investment Strategy Using Neural Network Models in the Korean Stock Market (인공신경망 모델을 이용한 주식시장에서의 투자전략에 대한 연구)

  • 서영호;이정호
    • Journal of the Korean Operations Research and Management Science Society
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    • v.23 no.4
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    • pp.213-224
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    • 1998
  • Since the late 1980s, an Increasing number of neural network models have been studied in the areas of financial prediction and analysis. The purpose of this study is to Investigate the possibility of building a neural network model that is able to construct a profitable trading strategy in the Korean Stock Market. This study classifies stocks into the future market winners and losers from the publicly available accounting information and builds portfolios based on this information. The performances of the winner portfolios and the loser portfolios are compared with each other and against the market index. The empirical result of this research is consistent with the traditional fundamental analysis where it is claimed that the financial statements contain firm values that may not be fully reflected In stock prices without delay. Despite the supporting empirical evidence. It is somewhat Inconclusive as to whether or not the abnormal return in excess of market return is the result of the extra knowledge obtained in the neural network models derived from the historical accounting data. This research attempts to open another avenue using neural network models for searching for evidence against market efficiency where statistics and intuition have played a major role.

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The role of nuclear energy in the correction of environmental pollution: Evidence from Pakistan

  • Mahmood, Nasir;Danish, Danish;Wang, Zhaohua;Zhang, Bin
    • Nuclear Engineering and Technology
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    • v.52 no.6
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    • pp.1327-1333
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    • 2020
  • The global warming phenomenon emerges from the issue of climate change, which attracts the attention of intellectuals towards clean energy sources from dirty energy sources. Among clean sources, nuclear energy is getting immense attention among policymakers. However, the role of nuclear energy in pollution emissions reduction has remained inconclusive and demand for further investigation. Therefore, the current study contributes to extend knowledge by investigating the nexus between nuclear energy, economic growth, and CO2 emissions in a developing country context such as Pakistan for the period between 1973 and 2017. The auto-regressive distributive lag model summarizes the nuclear energy has negative effect on environmental pollution as it releases carbon emission in the environment. Moreover, vector error correction Granger causality provides evidence for bidirectional causality between nuclear energy and carbon emissions. These interesting findings provide new insight, and policy guidelines provided based on these results.

Effects of Myofacial Release and Mulligan Technique on Pain and Disability for Cervicogenic Headache Patients (근막이완술과 Mulligan 기법이 경부성 두통환자의 통증과 기능회복에 미치는 영향)

  • Jeon, Jae-Guk;Kim, Myung-Jun
    • The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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    • v.18 no.2
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    • pp.87-93
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    • 2012
  • Background: Headaches arising from cervical musculoskeletal disorders are common. Conservative therapies are recommended as the choice of first treatment. Evidence to the effects of manual therapy is inconclusive and available only during the short term. There is no evidence to exercise, and no study has investigated the effect of combined therapies for cervicogenic headache. Methods: In this study, 30 participants who met the diagnostic criteria for cervicogenic headache were randomized into two groups: experimental group and control group. The experimental group was performed myofascial release (MFR), Mulligan technique and self stretching exercises. The control group was performed electrical therapy and self stretching exercises. Assessments were performed to 30 participants before and after 4 weeks therapy. The components of assessments were headache intensity(HI), headcahe duration (HD), neck pain (NP) and neck disability index (NDI). Results: After 4 weeks therapy, HI, HD, neck pain and NDI were significantly reduced in both groups (p<.01). The HI, HD, neck pain and NDI were significantly reduced in experimental group more than in the control group (p<.01). Conclusions: Manual therapy could reduce the symptoms of cervicogenic headache.

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Efficacy of ablation and sclerotherapy for the management of ovarian endometrioma: A narrative review

  • Jee, Byung Chul
    • Clinical and Experimental Reproductive Medicine
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    • v.49 no.2
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    • pp.76-86
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    • 2022
  • Ovarian cystectomy is the preferred technique for the surgical management of ovarian endometrioma. However, other techniques such as ablation or sclerotherapy are also commonly used. The aim of this review is to summarize information regarding the efficacy of ablation and sclerotherapy compared to cystectomy in terms of ovarian reserve, the recurrence rate, and the pregnancy rate. Several studies comparing ablation versus cystectomy or sclerotherapy versus cystectomy in terms of the serum anti-Müllerian hormone (AMH) decrement, endometrioma recurrence, or the pregnancy rate were identified and summarized. Both ablation and cystectomy have a negative impact on ovarian reserve, but ablation results in a smaller serum AMH decrement than cystectomy. Nonetheless, the recurrence rate is higher after ablation than after cystectomy. More studies are needed to demonstrate whether the pregnancy rate is different according to whether patients undergo ablation or cystectomy. The evidence remains inconclusive regarding whether sclerotherapy is better than cystectomy in terms of ovarian reserve. The recurrence rates appear to be similar between sclerotherapy and cystectomy. There is not yet concrete evidence that sclerotherapy helps to improve the pregnancy rate via in vitro fertilization in comparison to cystectomy or no sclerotherapy.

Acid-Soil and Psyllid Tolerance of Interspecific Hybrids of Leucaena in Malaysia

  • Vadiveloo, J.
    • Asian-Australasian Journal of Animal Sciences
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    • v.11 no.4
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    • pp.434-440
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    • 1998
  • Seven hybrid lines of Leucaena leucocephala $\times$ L. diversifolia and two control lines of L. leucocephala were compared for their adaptation to acid-soils and tolerance to damage by the psyllid, Heteropsyla cubana, at four locations over two years in Peninsular Malaysia. Primary data on leaf composition and in vitro digestibility (nutrition variables) and secondary data on plant height, stem girth and psyllid damage (agronomy variables) were the measures of performance. Cluster solutions of the nine lines were different within locations, between locations and between years for nutrition and agronomy variables. Controls and hybrids did not cluster separately. Principal component scores of the nine lines gave rank orders which were different by location and by year. No performance trend could be detected between hybrids and controls. The conclusion is that nutritional and agronomic characteristics in Leucaena are independent, soil composition and weather did not consistently affect performance, and evidence is inconclusive as to the benefits of interspecific crossing with L. diversifolia.

Surgical Resection of Double Primary Cancer in Esophagus & Stomach (식도및 위의 원발성 중복암의 외과적절제술 2례)

  • 김효윤
    • Journal of Chest Surgery
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    • v.25 no.10
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    • pp.1087-1092
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    • 1992
  • We underwent two surgical resection of synchronous primary esophageal squamous cell carcinoma and gastric adenocarcinoma after obtaining histologic comfirmation 74-years old male pateint was recieved esophagectomy & total gastrectomy with esophagojejunostomy and 59-years old man was recieved near total esophagectomy and total gastrectomy with esophagocolo-gejunostomy. Their was no postoperative complications. The hospital day was 15 and 21 days postoperatively. All of them started oral intake at 7 days postoperatively and possible soft diet soon. We conclude that total resection of esophagus and stomach is the recommendable methods for prolong the life of double primary cancer patients of esophagus and stomach. Also, the reconstruction of the esophagus with colon or jejunal transposition is one of the recommenable procedure for curative surgical resection of double primary cancer in esophagus and stomach. And we also wish to emphasize the importance of detailed preopertive gastric examination for detect of gastric lesion and of careful intraoperative inspection of the gastric mucosa in patients with esophageal cancer whose preoperative gastric examination provide inconclusive evidence due to the severe esophageal stenosis.

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The Analysis of Research about Foot Reflexology in Nursing (발반사마사지에 관한 간호학 논문 분석)

  • Kim, Gyung-Duck;Suh, Soon-Rim
    • Journal of Korean Biological Nursing Science
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    • v.10 no.1
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    • pp.33-40
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    • 2008
  • Purpose: This study was performed to analyze the trend of foot reflexology research in nursing in Korea. Method: Of studies published in nursing literature between January 1990 and August 2007. The 74 articles were analyzed according to the published year and journal, type of research and study design, subject, and the outcome variables of interventions. Result: Prevailing research designs were experimental research (nonequivalent control group pretest-posttest design). Prevailing characteristics of subjects were patients with hypertension, diabetes mellitus, hemodialysis, cancer and others disease (osteoarthritis, cerebral vascular accident, pneumoconiosis). The most frequently performed intervention was Foot-Reflexo-Massage (FRM). The most frequently used outcome variables were fatigue and sleep. The effect of foot reflexology was inconclusive. Conclusion: The finding suggests that a robust research design in foot reflexology research is needed to accumulate a strong scientific evidence and to adopt nursing intervention from the foot reflexology modalities. Meta analysis of foot reflexology research should be done to analyze and integrate the results of various studies.

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