• Korean Journal of Poultry Science
• /
• v.44 no.4
• /
• pp.267-274
• /
• 2017

This study was conducted to investigate the effect of feeding with dietary silicate based complex mineral (SCM) on the performance of laying hens. SCM at five levels (0%, 0.2%, 0.4%, 0.6% and 0.8%) was added to commercial diets, and fed to four hundred fifty Hy-Line Brown from fifty four to sixty five weeks of age. Egg production increased as the addition of dietary SCM to basal diets increased up to 0.6% (P<0.05). Furthermore, Feed intake increased in a manner similar to that of egg production (P<0.05). However, there was no difference in feed efficiency among the treatments. Eggshell thickness and breaking strength were significantly higher for the chickens fed with SCM than control from sixty weeks old to the end of experiment (P<0.05). Similarly, albumen height and Haugh unit were significantly higher for the chickens fed with SCM compared to those of control group (P<0.05). AST of birds fed SCM showed significantly higher than control (P<0.05). However, blood neutral fat level tended to increase in SCM treatments. Moreover, bone mineral density increased with SCM addition up to 0.4% (P<0.05). IL-2 (Interleukin-2) and IL-6 (Interleukin-6) levels appeared to be improved in the chickens fed with SCM addition diets, although not statistically different from all treatments. The results of this study indicated that the optimum SCM for improving the performance, egg quality and immunological competence of laying hens from 54 to 65 weeks of age was 0.6%.

• Journal of Veterinary Science
• /
• v.19 no.6
• /
• pp.788-797
• /
• 2018

In many countries, vaccines are used for the prevention of foot-and-mouth disease (FMD). However, because there is no protection against FMD immediately after vaccination, research and development on antiviral agents is being conducted to induce protection until immunological competence is produced. This study tested whether well-known chemicals used as RNA virus treatment agents had inhibitory effects on FMD viruses (FMDVs) and demonstrated that ribavirin showed antiviral effects against FMDV in vitro/in vivo. In addition, it was observed that combining the administration of the antiviral agents orally and complementary therapy with vaccines synergistically enhanced antiviral activity and preserved the survival rate and body weight in the experimental animals. Antiviral agents mixed with an adjuvant were inoculated intramuscularly along with the vaccines, thereby inhibiting virus replication after injection and verifying that it was possible to induce early protection against viral infection prior to immunity being achieved through the vaccine. Finally, pigs treated with antiviral agents and vaccines showed no clinical signs and had low virus excretion. Based on these results, it is expected that this combined approach could be a therapeutic and preventive treatment for early protection against FMD.

• Food Science of Animal Resources
• /
• v.32 no.2
• /
• pp.149-154
• /
• 2012

It is known that lactic-acid bacteria (LAB) helps keeping the intestine healthy and to enhance its immunologic competence. In addition, it is known to control the composition of the enterobacteria and the intestinal inflammatory reaction by inducing immunological enhancement. This study was performed, in a mouse model, to test the treatment and preventive effects of LAB of inflammatory bowel disease (IBD), which was induced by a blend of LAB-administering trinitrobenzene sulfonic acid (TNBS). To obtain the animal model of IBD, 2% TNBS was rectally administered once to a five-week-old male Balbc/J mouse. A probiotic combination was administered to the prevention group five times a week for eight weeks before the inducement of enteritis, and the mixture was administered to the treatment group five times a week, after the administration of TNBS. The changes in the levels of the cytokines of the lymph nodes and the tissue of the large intestine were observed, both with the naked eye and with a microscope. The observation showed that the levels of inflammatory cells, infiltration, and necrosis were much lower in the LAB-administered groups than in that of the control group. In addition, the inflammatory cytokines (e.g., TNF-${\alpha}$, IL-17A) decreased in the lymph nodes and the tissues of the large intestine. The results indicated that the administration of the combination to the animal model suppressed the inflammatory cytokines in the large intestine and in the lymph nodes, which in turn suppressed the progression of colitis.

• Korean Journal of Poultry Science
• /
• v.44 no.4
• /
• pp.275-282
• /
• 2017

This study was conducted to investigate the effect of dietary silicate based complex mineral (SCM) on the performance of broiler chicks. Four hundred fifty one day old Cobb ${\times}$ Cobb broiler chicks were fed with commercial diets at 0%, 0.05%, 0.10%, 0.15% and 0.20% SCM with five replicates for five weeks. Weight gain, feed intake and feed conversion were measured weekly, and blood composition, immunity and meat quality were evaluated at the end of experiment. During overall period weight gain in chicks fed diet containing 0.1% SCM was significantly increased as compared with that of control (p<0.05). Feed intake showed no consistency among the treatments. Feed conversion appeared to increase in the chickens fed with SCM addition diets during prestarter period. Albumin, glucose and other blood parameters related to chicken health tended to improve at the level of 0.05% SCM addition treatments. Drip loss in breast meat was significantly decreased in more than 0.05% SCM addition (p<0.05). The expression of IL-2 (Interleukin-2) in blood increased significantly in the chickens fed with SCM of 0.05% or 0.10% level than other treatments (p<0.05). The optimum SCM concentration for commercial dietary supplementation for improving broiler performance and other health-related parameters was 0.10%.