• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.32-34
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• 2002

Over the past two decades there has been a tremendous growth in the number of synchrotron radiation facilities in the world and also in Japan. The high flux and brightness radiation which derive from the third generation low emittance rings provide an ideal source for many applications in the medical sciences. The application of synchrotron radiation to medical imaging started in the early 80's in U.S.A, followed by European countries such as Germany and Russia. In Japan, researchs on intravenous coronary angiography started in 1884 at the Institute for High Energy Phisics(KEK) in Tsukuba. At present, it is the only application of syncrotron radiation which is at the stage of human study. In '90s, newer techniques such as phase and refraction contrast imaging appeared which are at the in vitro or animal study stage. Various types of x-ray CT have also been developed for three-dimensional imaging of the subjects. The present status of medical applications of synchrotron radiation in Japan is reviewed.

• 천문학회보
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• 제35권1호
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• pp.74.2-74.2
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• 2010

We present a multi-wavelength study of a supercluster in the NEP region at z=0.087, using AKARI (Infrared space telescope) NEP-Wide (5.8 deg2) survey which has obtained an unique IR imaging dataset with contiguous wavelength coverage from 2 to $24{\mu}m$, overcoming the Spitzer limitation of imaging capability at $10-20{\mu}m$. The NEP-Wide survey is also covered in other wavelength such as X-ray, Radio, GALEX UV in the archive, optical (BRI from Maidanak 1.5m and CFHT's MegaPrime), and NIR imaging data (JH from KPNO 2.1m), with nearly 1900 optical spectra, mostly obtained by our group using MMT/Hectospec and WIYN/Hydra. Armed with the multiwavelength datasets, we investigate the connection between IR properties of galaxies and their environments as a tool to understand the evolution of galaxies in a supercluster environment. Specific attention will be given to MIR emission which can trace star formation activities and passive phases right after post-starbursts, and its relation to other wavelength data.

• 한국의학물리학회지:의학물리
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• 제7권1호
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• pp.19-23
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• 1996

정상조직과 지방조직의 화학적 결합의 차이는 화학적 이동 artifact를 발생시킨다. 이러한 화학적 이동으로 생긴 결과는 주로 공명신호 위치의 부정확으로 나타나지만 횡적완화시간의 변화도 일으키게 된다. 물분자 수소원자핵의 횡적완화시간 T$_2$ 과 지방분자 수소원자핵의 횡적완화시간 T$_{2}$$^{*}$ 를 신호대 잡음비, 신호응답도, 그리고 영상시간에 각각 넣어 비교해 보았다. 그 결과 신호대 잡음비와 신호응답도는 각각 약 5%와 8%가 감소하였고, 영상시간은 약 10% 가량 증가하였다. 따라서, 화학적 이동은 영상의 왜곡 외에도 영상과정의 효율을 저하시킴을 알았다.

• 한국의학물리학회지:의학물리
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• 제24권4호
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• pp.205-212
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• 2013

Cone Beam CT (CBCT)와 On Board Imaging (OBI)를 비롯하여 최근에 개발되고 있는 방사선 치료용 영상 장치(Image Guided Radiation Therapy, IGRT)의 사용으로 방사선 치료가 더욱 정확해지고 있다. 점차 사용 범위가 넓어지면서 표준치료법으로 자리잡았고 앞으로 사용하는 기관과 빈도가 더 늘어날 것으로 전망한다. IGRT는 그러나 안전하고 용도에 맞게 사용할 때만 효능을 볼 수 있다. 이를 위해 IGRT를 임상에 적용하기 전에 장치의 특성을 이해하고 병원의 임상 요구에 적합한 지침서를 미리 만들 필요가 있다. QA 프로그램과 환자가 받을 추가 선량에 대한 고려도 미리 준비해둘 필요가 있다.

• 한국의학물리학회지:의학물리
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• 제31권4호
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• pp.189-193
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• 2020

An MR-based attenuation correction (MRAC) map plays an important role in quantitative positron emission tomography (PET) image evaluation in PET/magnetic resonance imaging (MRI) systems. However, the MRAC map is affected by the magnetic field inhomogeneity of MRIs. This study aims to evaluate the characteristics of MRAC maps of physical phantoms on PET/MRI images. Phantom measurements were performed using the Siemens Biograph mMR. The modular type physical phantoms that provide assembly versatility for phantom construction were scanned in a four-channel Body Matrix coil. The MRAC map was generated using the two-point Dixon-based segmentation method for whole-body imaging. The modular phantoms were scanned in compact and non-compact assembly configurations. In addition, the phantoms were scanned repeatedly to generate MRAC maps. The acquired MRAC maps show differently assigned values for void areas. An incorrect assignment of a void area was shown on a locally compact space between phantoms. The assigned MRAC values were distorted using a wide field-of-view (FOV). The MRAC values also differed after repeated scans. However, the erroneous MRAC values appeared outside of phantom, except for a large FOV. The MRAC map of the phantom was affected by phantom configuration and the number of scans. A quantitative study using a phantom in a PET/MRI system should be performed after evaluation of the MRAC map characteristics.

• Nuclear Engineering and Technology
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• 제52권4호
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• pp.835-840
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• 2020

A position-sensitive CsI(Tl) crystal array coupled with the multi-anode position sensitive photomultiplier tube (PS-PMT), Hamamatsu H8500C, has been developed at the Institute of Modern Physics. An effective, fast, and economical readout circuit based on discretized positioning circuit (DPC) bridge was designed for the 64-channel multi-anode flat panel PSPMT. The horizontal and vertical position resolutions are 0.58 mm and 0.63 mm respectively for the 1.0 × 1.0 × 5.0 ㎣ CsI(Tl) array, and the horizontal and vertical position resolutions are 0.86 mm and 0.80 mm respectively for the 2.0 × 2.0 × 10.0 ㎣ CsI(Tl) array. These results show that the CsI(Tl) crystal array with low cost could be applied in the fields of medical imaging and high-resolution gamma camera.

• 한국광학회:학술대회논문집
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• 한국광학회 2000년도 하계학술발표회
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• pp.164-165
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• 2000

There has recently been a considerable amount of interest in two-photon(TP) processes because of their applications to 3-D optical data storage and imaging, up-conversion lasing, and optical power limiting. Recently, the role of Dithienothlophene(DTT) as $\pi$-center of two-photon absorption(TPA) molecules was reported to give a large enhancement of TPA, compared with the benzeniods counterparts.$^{[1]}$ In this report, we carried out two experiments to investigate nonlinear optical absorption of the molecules in which central DTT is attached through conjugation to either a D/D or a D/A pair at the ends, forming a D-$\pi$-D(1 and 3) or D-$\pi$-A(2 and 4) sequence(Fig.1). All the samples were prepared in solutions with the same molar concentration. (omitted)

• 한국의학물리학회지:의학물리
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• 제31권3호
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• pp.81-98
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• 2020

This review aims to provide a brief, comprehensive overview of advanced technologies of nuclear medicine physics, with a focus on recent developments from both hardware and software perspectives. Developments in image acquisition/reconstruction, especially the time-of-flight and point spread function, have potential advantages in the image signal-to-noise ratio and spatial resolution. Modern detector materials and devices (including lutetium oxyorthosilicate, cadmium zinc tellurium, and silicon photomultiplier) as well as modern nuclear medicine imaging systems (including positron emission tomography [PET]/computerized tomography [CT], whole-body PET, PET/magnetic resonance [MR], and digital PET) enable not only high-quality digital image acquisition, but also subsequent image processing, including image reconstruction and post-reconstruction methods. Moreover, theranostics in nuclear medicine extend the usefulness of nuclear medicine physics far more than quantitative image-based diagnosis, playing a key role in personalized/precision medicine by raising the importance of internal radiation dosimetry in nuclear medicine. Now that deep-learning-based image processing can be incorporated in nuclear medicine image acquisition/processing, the aforementioned fields of nuclear medicine physics face the new era of Industry 4.0. Ongoing technological developments in nuclear medicine physics are leading to enhanced image quality and decreased radiation exposure as well as quantitative and personalized healthcare.

• 한국광학회지
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• 제15권6호
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• pp.519-526
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• 2004

초 미약 생물광자의 이차원적 영상을 얻기 위해 고속 초고감도 CCD 사진기를 검출기로 사용한 실험 장치를 고안하였다. 본 장치에는 식물의 잎으로부터 방출하는 지연광 (delayed luminescence)를 발생시키기 위한 조명 장치를 설치하였으며, 조명 장치와 검출기에 있는 셔터들은 서로 연동되어 동작하도록 이루어졌다. CCD 사진기에 사용된 렌즈계는, 상용렌즈들로만 구성되었는데, 시료에서 나오는 생물광자의 집광 효율 (collection efficiency)을 높이도록 최적화된 렌즈 설계에서 나온 결과를 기초로 하였다. 이 장치들을 다용도 암 상자에 장착하여 사철나무 잎에서 나오는 지연광의 영상을 성공적으로 얻었다.

• Journal of the Optical Society of Korea
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• 제20권1호
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• pp.94-100
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• 2016

A novel optical design for high resolution, large field of view (FOV) and multispectral remote sensing is presented. An f/7.3 Korsch and two f/17.9 Cook three-mirror optical systems are integrated by sharing the primary and secondary mirrors, bias of the FOV, decentering of the apertures and reasonable structure arrangement. The aperture stop of the Korsch system is located on the primary mirror, while those of the Cook systems are on the exit pupils. High resolution image with spectral coverage from visible to near-infrared (NIR) can be acquired through the Korsch system with a focal length of 14 m, while wide-field imaging is accomplished by the two Cook systems whose focal lengths are both 13.24 m. The full FOV is 4°×0.13°, a coverage width of 34.9 km at the altitude of 500 km can then be acquired by push-broom imaging. To facilitate controlling the stray light, the intermediate images and the real exit pupils are spatially available. After optimization, a near diffraction-limited performance and a compact optical package are achieved. The sharing of the on-axis primary and secondary mirrors reduces the cost of fabrication, test, and manufacture effectively. Besides, the two tertiary mirrors of the Cook systems possess the same parameters, further cutting down the cost.