• Title/Summary/Keyword: illegal additive

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Isolation and Identification of an Unauthorized Tadalafil Analogue in a Commercial Functional Food (시판 기능성식품으로부터의 타다라필 유도체 부정첨가물질의 분리 및 구조규명)

  • Baek, Du-Jong
    • YAKHAK HOEJI
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    • v.54 no.4
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    • pp.240-243
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    • 2010
  • High-performance liquid chromatography (HPLC) screening method revealed that a propolis product marketed as a functional food contained an undeclared substance similar to tadalafil, the active ingredient of the prescription drug Cialis$^{(R)}$ approved for the treatment of male erectile dysfunction. In order to identify the illegal additive, the propolis product was extracted with methylene chloride, and the extract was purified further using semipreparative HPLC. The chemical structure of the isolated substance was elucidated based on IR, LC/MS-ESI, and $^1H$- and $^{13}C$-NMR spectroscopy, which showed the characteristics similar to tadalafil. The only difference was the substitution of the methyl group at the piperazinedione ring of tadalafil to the amino group of the identified illegal additive.

Isolation and Identification of an Unauthorized Sildenafil Analogue in a Commercial Functional Food (시판 기능성식품으로부터의 실데나필 유도체 부정첨가물질의 분리 및 구조규명)

  • Baek, Du-Jong
    • Journal of the Korean Chemical Society
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    • v.54 no.4
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    • pp.443-446
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    • 2010
  • HPLC analysis of a commercial herb drink marketed as a functional food revealed to contain an unauthorized substance similar to sildenafil, the active ingredient of the prescription drug Viagra$^{(R)}$ approved for the treatment of male erectile dysfunction. In order to identify the illegal additive, the herb drink was extracted with methylene chloride, and the extract was purified further using semipreparative HPLC. The chemical structure of the isolated substance was elucidated based on IR, LC/MS-ESI, and NMR spectroscopy, which showed the characteristics similar to sildenafil with minor modification. The only difference was the substitution of the methylpiperazine moiety of sildenafil to the hydroxyethylpiperazine group of the illegal additive.

Enhancing Robustness of Information Hiding Through Low-Density Parity-Check Codes

  • Yi, Yu;Lee, Moon-Ho;Kim, Ji-Hyun;Hwang, Gi-Yean
    • Journal of Broadcast Engineering
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    • v.8 no.4
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    • pp.437-451
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    • 2003
  • With the rapid growth of internet technologies and wide availability of multimedia computing facilities, the enforcement of multimedia copyright protection becomes an important issue. Digital watermarking is viewed as an effective way to deter content users from illegal distributions. In recent years, digital watermarking has been intensively studied to achieve this goal. However, when the watermarked media is transmitted over the channels modeled as the additive white Gaussian noise (AWGN) channel, the watermark information is often interfered by the channel noise and produces a large number of errors. So many error-correcting codes have been applied in the digital watermarking system to protect the embedded message from the disturbance of the noise, such as BCH codes, Reef-Solomon (RS) codes and Turbo codes. Recently, low-density parity-check (LDPC) codes were demonstrated as good error correcting codes achieving near Shannon limit performance and outperforming turbo codes nth low decoding complexity. In this paper, in order to mitigate the channel conditions and improve the quality of watermark, we proposed the application of LDPC codes on implementing a fairly robust digital image watermarking system. The implemented watermarking system operates in the spectrum domain where a subset of the discrete wavelet transform (DWT) coefficients is modified by the watermark without using original image during watermark extraction. The quality of watermark is evaluated by taking Into account the trade-off between the chip-rate and the rate of LDPC codes. Many simulation results are presented in this paper, these results indicate that the quality of the watermark is improved greatly and the proposed system based on LDPC codes is very robust to attacks.

Analysis on elements of policy changes in character industry (캐릭터산업의 정책변인연구)

  • Han, Chang-Wan
    • Cartoon and Animation Studies
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    • s.33
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    • pp.597-616
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    • 2013
  • Character industry is not only knowledge-based industry chiefly with copyrights but also motive power for creative economy to take a role functionally over the fields of industries because it has industrial characteristic as complement product to promote sale value in manufacturing industry and service industry and increase profit on sales. Since 2003, the national policy related to character has aimed to maximize effect among connected industries, extend its business abroad, enforce copyrights through the improvement of marketing system, develop industrial infrastructure through raising quality of character products. With the result of this policy, the successful cases of connected contents have been crystallized and domestic character industry has stepped up methodically since 2007. It is needed to reset the scales of character industry and industrial stats because there are more know-how of self industry promotion and more related characters through strategy of market departmentalization starting with cartoon, animation, games, novels, movies and musicals. Especially, The Korea government set our target for 'Global Top Five Character Power' since 2009 and has started to carry out to find global star characters, support to establish network among connected industries, diversify promotion channels, and develop licensing business. Particularly, since 2013, There have been prospered the indoor character theme park with time management just like character experimental marketing or Kids cafes using characters, the demand market of digital character focusing on SNS emoticon, and the performance market for character musical consistently. Moreover, The domestic and foreign illegal black markets on off-line have been enlarged, so we need another policy alternative. To prepare for the era of exploding character demand market and diversifying platform, it is needed to set up a solid strategy that is required the elements of policy changes in character industry to vitalize character industry and support new character design and connected contents. the following shows that the elements of policy changes related to the existing policy, the current position of market. Nowadays, the elements of policy changes in domestic character industry are that variety of consumers in the digital character market according to platform diversification, Convergence contents of character goods for the Korean waves, legalization of the illegal black contents market, and controling the tendency of consumers in departmentalized market. This can help find the policy issue entirely deferent with the existing character powers like US, Japan or Europe. In its final analysis, the alternatives are the promotion of models with contract copyrights of domestic and foreign connected contents, the diversification of profit models of platform economy, the additive development of target market related to enlarging the Korean waves, and the strategy of character market for the age-specific tendency according to developing character demand market.