• Journal of Gastric Cancer
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• v.3 no.1
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• pp.38-43
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• 2003

Purpose: Caspase 2, a member of the family of ICE-like proteases, is activated by the Fas pathway and induces apoptosis by triggering the caspase cascade. The purpose of this study was to determine whether the expression pattern of caspase 2 might be associated with gastric cancer development and if so, to determine to which pathologic parameter it is linked. Materials and Methods: For the construction of the gastric cancer tissue microarray, 78 paraffin-embedded tissues containing gastric cancer areas were cored 3 times and transferred to the recipient master block. The expression pattern of caspase 2 was examined on tissue microarray slides by using immunohistochemistry and was compared with pathologic parameters, including histologic type, depth of invasion, lymph node metastasis, and peritoneal dissemination. Results: Caspase 2 was expressed on superficial and foveolar epithelial cells and lymphocytes in the gastric mucosa, mainly in cytoplasm. We found loss of caspase 2 expression in 41 ($52.6\%$) of the 78 gastric cancer tissues. Statistically, histologic type and other pathologic parameters were not related with loss of caspase 2 expression Conclusion: Our findings provide enough evidence that loss of caspase 2 expression may contribute to the development of Korean gastric cancer and that it might be one of the possible escape mechanisms from apoptosis in gastric cancer.

• Ocean and Polar Research
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• v.24 no.2
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• pp.123-134
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• 2002

Seasonal variations of settling particles and metal fluxes were monitored at a nearshore site of Marian Cove, King Geroge Island, Antarctica from 28th February 1998 to 22nd January 2000. Near-bottom sediment traps were deployed at 30m water depth of the cove, and sampling bottles were recovered every month by SCUBA divers. Total particulate flux and metal concentrations were determined from the samples. Total particulate flux showed a distinct seasonality, high in austral summer and low in austral winter: the highest flux $(21.97g\;m^{-2}d^{-1})$ was found in February of 1999, and the lowest $(2.47g\;m^{-2}d^{-1})$ in September of 1998, when sea surface was frozen completely. Lithogenic particle flux accounted for 90% of the total flux, and showed a significantly negative correlation with the thickness of snow accumulation around the study site. It was suggested that the most of the lithogenic particles trapped in the bottles was transported by melt water stream from the surrounding land. Fluxes of Al, Fe, Ti, Mn, Zn, Cii, Co, Ni, Cr, Cd, and Pb showed similar seasonal variations with the total flux, and their averaged fluxes were 34000, 9000,960, 180, 13.8, 17.6, 3.0,2.1, 5.4, 0.02, and $1.5nmol\;m^{-2}d^{-1}$ respectively. Among the metals, Cu and Cd showed the most noticeable seasonal patterns. The Cd flux correlated positively with the fluxes of biogenic components while the Cu flux correlated with both the lithogenic and biogenic particle fluxes. The Cu flux peak in the late summer is likely related to a substantial amount of inflow of ice melt water laden with Cu-enriched lithogenic particles. On the other hands, the Cd flux peak in the early spring may be associated with the unusually early occurred phytoplankton bloom.

• Journal of the Korean GEO-environmental Society
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• v.13 no.4
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• pp.27-36
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• 2012

The water in surface of the earth is frozen under freezing point. The freezing phenomenon, which causes the volume change of soils, affects on the behavior of soils and causes the significant damage on the geotechnical structures. The purpose of this study is to investigate the characteristics of elastic waves in sand-silt mixtures using small size freezing cells, which reflect the frozen ground condition due to temperature change. Experiments are carried out in a nylon cell designed to freeze soils from top to bottom. Bender elements and piezo disk elements are used as the shear and compressional wave transducers. Three pairs of bender elements and piezo disk elements are placed on three locations along the depth. The specimen, which is prepared by mixing sand and silt, is frozen in the refrigerator. The temperature of soils changes from $20^{\circ}C$ to $-10^{\circ}C$. The velocities, resonant frequencies and amplitudes of the shear and compressional waves are continuously measured. Experimental results show that the shear and compressional wave velocities and resonant frequencies increase dramatically near the freezing points. The amplitudes of shear and compressional waves show the different tendency. The dominant factors that affect on the shear wave velocity change from the effective stress to the ice bonding due to freezing. This study provides basic information about the characteristics of elastic waves due to the soil freezing.

• Journal of The Geomorphological Association of Korea
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• v.20 no.4
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• pp.101-115
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• 2013

11 alpine wetlands at the upper reaches of Bangtae River on a high flat summit around Mt. Jeombong were found. Two core samples(JB-1 and JB-2) among them were collected in order to reconstruct paleovegetation history and climate change using pollen analysis. Pinus and Quercus dominated at the wetland of JB-2 with a deep water depth were developed from 1,700 yr BP to 1,000 yr BP of the pollen zone I. Subsequently Quercus dominated in the pollen zone II from 1,000 to 400 yr BP, and it is supposed that warm weather prevailed with oak climax forest corresponding to the Medieval Warm Period. Moreover, sphagnum grew densely in the alpine wetlands and the wetlands were extended widely on the summit around Mt. Jeombong with the beginning of subzoneIIc at JB-2. The pollen zone III from 400 yr BP to the present with an increase in Pinus and a decrease in Quercus suggests cold climates under the Little Ice Age. Moreover, human disturbances at JB-2 were more significant than those at JB-1, based on the increase in Pinus.

• 한국노년학
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• v.40 no.1
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• pp.111-130
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• 2020

This qualitative study aims to understand family members' caregiving experience for middle-aged and elderly breast cancer survivors at early stages. A total of four families of breast cancer survivors were given focus group interviews(FGI), and an additional family was interviewed individually. The thematic analyses of the FGI and individual in-depth interview discussions revealed the following four themes: first, day-to-day feelings like walking on thin ice (entangled emotions with each treatment stage, regret of watching a survivor's pain, fear of recurrence and death, concerns of changes in family relationships, and various feelings experienced as a daughter), second, caregiving has become a mainstay in my life (unfamiliar and unskilled care, losing my life), third, beginning to recover and different experiences between a survivor and a family caregiver (not understanding a survivor's pain from the abyss, forgetting that the survivor is still a cancer patient and that treating him or her casually), and fourth, moving forward (hope that things will be better, taking care of myself to prevent exhaustion). Based on the results of this study, we proposed social welfare services and policy measures to reflect the psychosocial needs of family caregivers of breast cancer survivors and support family caregivers during the care process.

• Journal of the Mineralogical Society of Korea
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• v.28 no.1
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• pp.71-81
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• 2015

This study was carried out in order to investigate the mineralogical characteristics of the core sediments (03GHP-02 and HB13-2), obtained from the Ulleung Basin and Hupo Basin, Korea. The results on mineral compositions, clay mineral compositions, and the total contents and sequential extraction of different fractions of the phosphorus in core samples showed that those values are different in two cores and also at different depths. In both samples, mineral compositions were the same, composed mainly of quartz, microcline, albite, calcite, opal A, pyrite, and clay minerals (illite, chlorite, kaolinite, and smectite). However, the sample from Hupo Basin contains more opal A. Both samples, especially the ones from Hupo Basin contains more smectite than those reported from East Sea, indicating the influence of paleo-Hwangwei River and the Tertiary Formation of Korea Peninsula. For the samples from Uleung Basin, at 0.7-3.5 m range in depth, the low content of opal A and the low illite crystallinity index can be inferred to indicate the relatively cool climate, corresponding to the ice age. Also, the content of total phosphorus was low in those samples. It was reported that East Sea at that time was isolated from the neighboring seas due to the decrease of the sea level, and as a result, the influx of sediments was supposed to be little through the strait and rivers. For the samples from Hupo Basin, there is no significant changes in clay mineral composition and the distribution of phosphorus with increasing depth. This little change can be interpreted to indicate that the sediments comprising the core might be deposited in a relatively short period of time or deposited in sedimentary environment in which there's no significant changes in sediment supplies. The values of crystallinity index of clay minerals are high in those samples, indicating that it was relatively warm during that time. Although the increase of fluctuation pattern can be observed, showing that the climate of this period often changed, it is supposed that it was generally warm.

• Economic and Environmental Geology
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• v.53 no.4
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• pp.413-423
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• 2020

Over the wide area, King Sejong Station and the nearby land are uncovered with snow and ice conditions. Therefore, the active layer on the permafrost has been formed to be much thicker than the other Antarctica region. Electrical resistivity survey of Wenner and dipole-dipole arrays was undertaken at a series of time in the freezing season at the King Sejong Station to delineate subsurface structure and to monitor active layer in permafrost terrain. Time-lapse resistivity structures are well in terms of the vegetation distribution, ground surface temperature, and snow depth. Horizontal high resistivity belt(>1826 Ωm) at very shallow depth is thickening with the lapse of time, probably caused by the freezing of the water in the pore spaces with decrease of ground temperature. Subsurface structures for the area of low snow-cover and vegetated zone area are comprised of 0~0.5 m deep high-resistive gravel-rich soil, 0.5~3 m deep low-resistive active layer, and the underlying permafrost. In contrast, the unvegetated area and high snow-buildup is characterized with high resistivities larger than approximately 2000 Ωm due to freezing of the soil throughout the year. Data interpretation and correlation schemes explored in this paper can be applied to confirm the active layer, which is expected to get thinner in additional survey during the thawing season.

• Journal of the Mineralogical Society of Korea
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• v.32 no.3
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• pp.163-172
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• 2019

A long core (RS15-LC48) was collected at a site in the continental rise between the Southern Ocean and the Ross Sea (Antarctica) during the 2015 Ross Sea Expedition. The mineralogical characteristics and the origin of clay minerals in marine sediments deposited during the Quaternary in the Ross Sea were determined by analyzing sedimentary facies, variations in grain size, sand fraction, mineralogy, clay mineral composition, illite crystallinity, and illite chemical index. Core sediments consisted mostly of sandy clay, silty clay, or ice rafted debris (IRD) and were divided into four sedimentary facies (units 1-4). The variations in grain size distribution and sand content with depth were very similar to the variations in magnetic susceptibility. Various minerals such as smectite, chlorite, illite, kaolinite, quartz, and plagioclase were detected throughout the core. The average clay mineral composition was dominated by illite (52.7 %) and smectite (27.7 %), with less abundant clay minerals of chlorite (11.0 %) and kaolinite (8.6 %). The IC and illite chemical index showed strong correlation trends with depth. The increase in illite and chlorite content during the glacial period, together with the IC and chemical index values, suggest that sediments were transported from the bedrocks of the Transantarctic Mountains. During the interglacial period, smectite may have been supplied by the surface current from Victoria Land, in the western Ross Sea. High values for IC and the illite chemical index also indicate relatively warm climate conditions during that period.

• Korean Journal of Mineralogy and Petrology
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• v.34 no.4
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• pp.241-253
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• 2021

Manganese nodules have been found in the shallow water depth of the Arctic Ocean as well as in the abyssal plains of the Pacific and Indian Oceans, but detailed study for them were rarely investigated. Manganese nodules, collected from the East Siberian Sea through the Arctic Expedition using Araon ice braking vessel, have a high potential for Mn mineral resources because they have high Mn content with high Mn/Fe ratio. This study investigated the external form, size and weight, internal texture for the non-spherical manganese nodule, which has about 7 % of total nodule from the East Siberian Sea. This study also researched the relative Mn-oxide mineral composition using the peak area ratio of X-ray diffraction pattern and their chemical composition. All data obtained from non-spherical nodules were compared with the spherical ones. Ellipsoidal, platy and irregular types are common among 5 groups of non-spherical manganese nodule based on the external form, and major axis and weight have positive relationship. All non-spherical manganese nodules have core mainly composed of mud sediments. The average Mn oxide mineral contents in nodules are birnessite, buserite and todorokite in descending order. Although mineral composition does not show any correlation with the external form, kind of core or internal structure, todorokite and buserite contents tend to increase and birnessite content decrease from the surface to the core in the nodule. Non-spherical manganese nodules have higher Mn content and Mn/Fe ratio than those from the shallow water depth of the Arctic Sea and even in the deep-sea of the Pacific and Indian Ocean. Although non-spherical nodule is larger and heavier, and has lower Mn content and Mn/Fe ratio than spherical nodule, there are not any differences in mineral composition and internal structure between them. Almost all manganese nodules collected from the East Siberian Sea are attributed to diagenetic process, because they are higher than 5 in Mn/Fe ratio.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.28 no.1
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• pp.1-18
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• 2023

The East Sea, one of the regions where the most rapid warming is occurring, is known to have important implications for the response of the ocean to future climate changes because it not only reacts sensitively to climate change but also has a much shorter turnover time (hundreds of years) than the ocean (thousands of years). However, the processes underlying changes in seawater characteristics at the sea's deep and abyssal layers, and meridional overturning circulation have recently been examined only after international cooperative observation programs for the entire sea allowed in-situ data in a necessary resolution and accuracy along with recent improvement in numerical modeling. In this review, previous studies on the physical characteristics of seawater at deeper parts of the East Sea, and meridional overturning circulation are summarized to identify any remaining issues. The seawater below a depth of several hundreds of meters in the East Sea has been identified as the Japan Sea Proper Water (East Sea Proper Water) due to its homogeneous physical properties of a water temperature below 1℃ and practical salinity values ranging from 34.0 to 34.1. However, vertically high-resolution salinity and dissolved oxygen observations since the 1990s enabled us to separate the water into at least three different water masses (central water, CW; deep water, DW; bottom water, BW). Recent studies have shown that the physical characteristics and boundaries between the three water masses are not constant over time, but have significantly varied over the last few decades in association with time-varying water formation processes, such as convection processes (deep slope convection and open-ocean deep convection) that are linked to the re-circulation of the Tsushima Warm Current, ocean-atmosphere heat and freshwater exchanges, and sea-ice formation in the northern part of the East Sea. The CW, DW, and BW were found to be transported horizontally from the Japan Basin to the Ulleung Basin, from the Ulleung Basin to the Yamato Basin, and from the Yamato Basin to the Japan Basin, respectively, rotating counterclockwise with a shallow depth on the right of its path (consistent with the bottom topographic control of fluid in a rotating Earth). This horizontal deep circulation is a part of the sea's meridional overturning circulation that has undergone changes in the path and intensity. Yet, the linkages between upper and deeper circulation and between the horizontal and meridional overturning circulation are not well understood. Through this review, the remaining issues to be addressed in the future were identified. These issues included a connection between the changing properties of CW, DW, and BW, and their horizontal and overturning circulations; the linkage of deep and abyssal circulations to the upper circulation, including upper water transport from and into the Western Pacific Ocean; and processes underlying the temporal variability in the path and intensity of CW, DW, and BW.